Hygienic insecticide composition containing pyriproxyfen and application thereof

Abstract

The invention relates to a sanitary insecticide composition containing pyriproxyfen and application of the sanitary insecticide composition, and belongs to the technical field of insecticides. The invention discloses a sanitary insecticide composition containing pyriproxyfen. The sanitary insecticide composition is prepared from the following raw materials: anise oil, piperonyl butoxide, methyleugenol, matrine derivatives, cyfluthrin and pyriproxyfen. The anise oil can prevent evaporation of components of the insecticide and is matched with piperonyl butoxide, so that the pesticide effect duration of the insecticide is prolonged; methyeugenol destroys information transmission and mating of pests and has the effects of repelling, food refusal and growth inhibition at the same time, the matrine derivative enables the pests to die through food refusal activity, in addition, cyfluthrin and pyriproxyfen are matched to influence metamorphism and reproduction of the pests, and the killing power of the insecticide is further enhanced. According to the invention, the purpose of killing pests is achieved by prolonging the drug property of the insecticide and preventing and killing the pests from multiple aspects of information transmission, mating, feeding and stage growth of the pests.

Description

Technical Field

[0001] The invention belongs to the technical field of insecticides and relates to a sanitary insecticide composition containing pyriproxyfen and application thereof. Background Art

[0002] At present, the main method of controlling mosquito and fly larvae is to use organophosphorus slow-release agents, but such insecticides are highly toxic and unsafe for humans and animals. With the improvement of people's environmental awareness, the concept of green control of mosquitoes and flies has gradually strengthened. Insect growth regulators are safe for humans and animals and do not pollute the environment. They are ideal agents for controlling mosquitoes and flies. The representative varieties are mainly pyriproxyfen, whose mechanism of action is to inhibit the emergence of mosquito and fly larvae and prevent them from developing normally into adults, thereby achieving the purpose of control. Current studies have shown that the killing rate of pyriproxyfen on mosquito and fly larvae is low, and the killing effect is not obvious. Most of them can still pupate normally, and only the pupae cannot normally emerge into adults and die. Therefore, the single pyriproxyfen effect is not very ideal for the elimination of mosquitoes and flies.

[0003] Aphids are a group of pests that harm gardening and farmland planting. Their species are complex, including bean root aphids, peach aphids, etc. ". Peach aphid (Myzus persicae) belongs to the genus Aphis in the family Aphididae of the order Hemiptera, and is a major economic pest in the world. Peach aphid is a broad-feeding pest with many hosts. In addition to harming Rosaceae fruit trees such as peach and pear, it also hosts a variety of crops such as cabbage and radish. It has a short life cycle and a large reproduction rate. It sucks plant sap to affect plant growth and spreads a variety of plant viruses, which seriously threatens crop production. At present, aphid control is mainly based on chemical control. Long-term use of chemical control leads to resistance in aphids, harming natural enemies of pests and other beneficial organisms, and pesticide residues endanger human health. Botanical insecticides refer to insecticides whose active ingredients are derived from plants. Their active ingredients are usually secondary metabolites produced by plants. They have the advantages of convenient material collection, low production cost, high insecticidal efficiency, and no pollution to the environment. They are the best pesticide choice in green vegetable production. Summary of the invention

[0004] The present invention relates to a sanitary insecticide composition containing pyriproxyfen and its use, belonging to the technical field of insecticides. The present invention discloses a sanitary insecticide composition containing pyriproxyfen, comprising the following raw materials: anise oil, piperonyl butoxide, methyl eugenol, matrine derivatives, cyfluthrin, and pyriproxyfen. Anise oil can prevent the evaporation of insecticide components, and when combined with piperonyl butoxide, the duration of the insecticide efficacy is prolonged; methyl eugenol destroys the information transmission and mating of pests, and has the effects of repelling, repelling food, and inhibiting growth; matrine derivatives kill pests through repelling food activity, and are combined with cyfluthrin and pyriproxyfen components to affect the metamorphosis and reproduction of pests, thereby further enhancing the lethality of the insecticide. The present invention prolongs the medicinal properties of the insecticide, and prevents and eliminates the pests from multiple aspects such as information transmission, mating, feeding, and stage growth, thereby achieving the purpose of eliminating pests.

[0005] The purpose of the present invention can be achieved through the following technical solutions:

[0006] A sanitary insecticide composition containing pyriproxyfen comprises the following raw materials in parts by weight: 0.5-1 part of anise oil, 0.5-1 part of piperonyl butoxide, 1-5 parts of methyl eugenol, 1-4 parts of matrine derivatives, 0.5-3 parts of cyfluthrin and 2-4 parts of pyriproxyfen.

[0007] Furthermore, the preparation method of anise oil comprises the following steps:

[0008] (1) Chop the stems and leaves of fennel, wash them, and then put them into a distillation pot and pass water vapor into it for distillation;

[0009] (2) The water vapor is passed into a condenser to condense into a mixed liquid, and then the water is removed through a water separator to obtain anise oil.

[0010] Furthermore, the distillation pressure in step (1) is 1.1-1.2 atm, and the condensation temperature in step (2) is 10-20°C.

[0011] Furthermore, the preparation method of piperonyl butoxide comprises the following steps:

[0012] A1: mixing safrole and ethanol, heating, then introducing hydrogen and keeping the temperature, then cooling and filtering, recovering ethanol, to obtain dihydrosafrole;

[0013] A2: dihydrosafrole, paraformaldehyde, a catalyst and petroleum ether are stirred to form a mixture, and then concentrated hydrochloric acid is added, the temperature is increased and kept, and then the temperature is reduced, and petroleum ether is added and stirred, and then the mixture is allowed to stand until layers are separated, and the hydrochloric acid is removed to obtain chloromethyldihydrosafrole;

[0014] A3: industrial caustic soda flakes, ethylene glycol monobutyl ether and petroleum ether are stirred and mixed, chloromethyl dihydrosafrole is added dropwise, the mixture is refluxed, and the etherified liquid is obtained after cooling;

[0015] A4: The etherified liquid is mixed with sodium hydroxide and heated, the petroleum ether is removed under vacuum, and then vacuum distillation is performed to obtain piperonyl butoxide.

[0016] Furthermore, in step A1, the solid-liquid ratio of safrole to ethanol is 1:1.5-2, wherein the mass fraction of ethanol is 70-80%, the heating temperature is 120° C., and the insulation time is 2-3 h.

[0017] Furthermore, in step A2, the mass ratio of dihydrosafrole, paraformaldehyde, catalyst and petroleum ether is 100:20-25:0.4:120, the amount of concentrated hydrochloric acid added accounts for 20-30% of the mass of the mixture, the insulation temperature and time are 55-65° C. and 3-4 h, respectively, and the volume ratio of petroleum ether to concentrated hydrochloric acid is 1:5.

[0018] Furthermore, in the step A3, the mass ratio of industrial caustic soda flakes, ethylene glycol monobutyl ether, petroleum ether and chloromethyl dihydrosafrole is 3:5:2:10-20, the reflux temperature and time are 50-60° C. and 3-4 h, respectively, the solid-liquid ratio of sodium hydroxide and etherified liquid in the step A4 is 0.5-1:100 g / mL, and the mixed heating temperature is 60-80° C.

[0019] Furthermore, the preparation method of the matrine derivative is: dissolving sophoracarpine in dichloromethane, stirring in a constant temperature water bath, adding 1,6-hexanedithiol and triethylamine to form a mixed solution a, and performing reduced pressure distillation on the mixed solution a to remove dichloromethane to obtain the matrine derivative.

[0020] Furthermore, the mass ratio of the sophocarpine, dichloromethane, 1,6-hexanedithiol and triethylamine is 1:3-5:4:0.5, and the temperature of the constant temperature water bath is 40-60°C.

[0021] Furthermore, the sanitary insecticide composition is used to disinfect agricultural pests and urban sanitary pests.

[0022] Beneficial effects of the present invention:

[0023] 1. Anise oil can prevent the evaporation of pesticide ingredients, increase the residence time of pesticides on the surface of crops or in the bodies of pests, and extend the duration of pesticide efficacy when combined with piperonyl butoxide;

[0024] 2. Methyl eugenol destroys the information transmission and mating of pests, and has the effects of repelling, repelling feeding and inhibiting growth. Matrine derivatives kill pests through repelling feeding activity. In addition, the combination of cypermethrin and pyriproxyfen components affects the metamorphosis and reproduction of pests, further enhancing the lethality of the insecticide. In addition, the combination with piperonyl butoxide further enhances the lethality of the insecticide. The insecticide prepared by the present invention prevents and eliminates pests from multiple aspects such as information transmission, mating, feeding and stage growth, thereby achieving the purpose of completely eliminating pests. DETAILED DESCRIPTION

[0025] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with embodiments.

[0026] Example 1

[0027] A sanitary insecticide composition containing pyriproxyfen comprises the following raw materials in parts by weight: 10 parts of a solvent consisting of 4-terpineol, ethyl acetate and tributyl phosphate, 4 parts of a 3-phenylphenol emulsifier, 0.5 parts of anise oil, 0.5 parts of piperonyl butoxide, 1 part of methyl eugenol, 1 part of a matrine derivative, 0.5 parts of cyfluthrin and 2 parts of pyriproxyfen, wherein the mass ratio of 4-terpineol, ethyl acetate and tributyl phosphate is 1:1:1.

[0028] The preparation method of anise oil comprises the following steps:

[0029] (1) Chop the stems and leaves of fennel, wash them, and then put them into a distillation pot and pass water vapor into it for distillation;

[0030] (2) The water vapor is passed into a condenser to condense into a mixed liquid, and then the water is removed through a water separator to obtain anise oil.

[0031] The distillation pressure in step (1) is 1.1 atm, and the condensation temperature in step (2) is 10°C.

[0032] The preparation method of piperonyl butoxide comprises the following steps:

[0033] A1: mixing safrole and ethanol, heating, then introducing hydrogen and keeping the temperature, then cooling and filtering, recovering ethanol, to obtain dihydrosafrole;

[0034] A2: dihydrosafrole, paraformaldehyde, a catalyst and petroleum ether are stirred to form a mixture, and then concentrated hydrochloric acid is added, the temperature is increased and kept, and then the temperature is reduced, and petroleum ether is added and stirred, and then the mixture is allowed to stand until layers are separated, and the hydrochloric acid is removed to obtain chloromethyldihydrosafrole;

[0035] A3: industrial caustic soda flakes, ethylene glycol monobutyl ether and petroleum ether are stirred and mixed, chloromethyl dihydrosafrole is added dropwise, the mixture is refluxed, and the etherified liquid is obtained after cooling;

[0036] A4: The etherified liquid is mixed with sodium hydroxide and heated, the petroleum ether is removed under vacuum, and then vacuum distillation is performed to obtain piperonyl butoxide.

[0037] In the step A1, the solid-liquid ratio of safrole to ethanol is 1:1.5, wherein the mass fraction of ethanol is 70%, the heating temperature is 120° C., and the insulation time is 2 hours.

[0038] In the step A2, the mass ratio of dihydrosafrole, paraformaldehyde, catalyst and petroleum ether is 100:20:0.4:120, the amount of concentrated hydrochloric acid added accounts for 20% of the mass of the mixture, the insulation temperature and time are 55° C. and 3 h, respectively, and the volume ratio of petroleum ether to concentrated hydrochloric acid is 1:5.

[0039] In the step A3, the mass ratio of industrial caustic soda flakes, ethylene glycol monobutyl ether, petroleum ether and chloromethyl dihydrosafrole is 3:5:2:10, the reflux temperature and time are 50° C. and 3 h, respectively, the solid-liquid ratio of sodium hydroxide and etherified liquid in the step A4 is 0.5:100 g / mL, and the mixed heating temperature is 60° C.

[0040] The preparation method of the matrine derivative is as follows: dissolving sophoracarpine in dichloromethane, stirring the mixture in a constant temperature water bath, adding 1,6-hexanedithiol and triethylamine to form a mixed solution a, and performing reduced pressure distillation on the mixed solution a to remove dichloromethane, thereby obtaining the matrine derivative.

[0041] The mass ratio of the sophocarpine, dichloromethane, 1,6-hexanedithiol and triethylamine is 1:3-5:4:0.5, and the temperature of the constant temperature water bath is 40-60°C.

[0042] The sanitary insecticide composition is used for disinfecting agricultural pests and urban sanitary pests.

[0043] The preparation method of the sanitary insecticide composition is as follows: 4-terpineol, ethyl acetate, tributyl phosphate, 3-phenylphenylphenol, anise oil, piperonyl butoxide, methyl eugenol, matrine derivatives, flucythrin and pyriproxyfen are mixed to obtain an oil phase, sodium dodecylbenzene sulfonate is mixed with water to obtain an aqueous phase, and finally the oil phase and the aqueous phase are mixed and dispersed to prepare an emulsion, namely the sanitary insecticide composition, wherein the mass ratio of sodium dodecylbenzene sulfonate to water is 2:50, and the volume ratio of the oil phase to the aqueous phase is 1:20.

[0044] The purchase source of the pyriproxyfen is: pyriproxyfen / Hubei Ruiboxin-95737-68-1, the purchase source of paraformaldehyde is: paraformaldehyde / Qiyun Chemical-30525-89-4, the catalyst is aluminum chloride, the purchase source of industrial caustic soda flakes is: industrial caustic soda flakes / Shanghai Jupeng, the purchase source of tea saponin: tea saponin / Qiansheng Chemical, the purchase source of 4-pineneol is: 4-pineneol / l ul l aby-562-74-3.

[0045] Example 2

[0046] A sanitary insecticide composition containing pyriproxyfen comprises the following raw materials in parts by weight: 15 parts of a solvent consisting of 4-terpineol, ethyl acetate and tributyl phosphate, 6 parts of a 3-phenylphenol emulsifier, 0.8 parts of anise oil, 0.8 parts of piperonyl butoxide, 3 parts of methyl eugenol, 2.5 parts of a matrine derivative, 2 parts of cyfluthrin and 3 parts of pyriproxyfen, wherein the mass ratio of 4-terpineol, ethyl acetate and tributyl phosphate is 1:1:1.

[0047] The preparation method of anise oil comprises the following steps:

[0048] (1) Chop the stems and leaves of fennel, wash them, and then put them into a distillation pot and pass water vapor into it for distillation;

[0049] (2) The water vapor is passed into a condenser to condense into a mixed liquid, and then the water is removed through a water separator to obtain anise oil.

[0050] The distillation pressure in step (1) is 1.1 atm, and the condensation temperature in step (2) is 15°C.

[0051] The preparation method of piperonyl butoxide comprises the following steps:

[0052] A1: mixing safrole and ethanol, heating, then introducing hydrogen and keeping the temperature, then cooling and filtering, recovering ethanol, to obtain dihydrosafrole;

[0053] A2: dihydrosafrole, paraformaldehyde, a catalyst and petroleum ether are stirred to form a mixture, and then concentrated hydrochloric acid is added, the temperature is increased and kept, and then the temperature is reduced, and petroleum ether is added and stirred, and then the mixture is allowed to stand until layers are separated, and the hydrochloric acid is removed to obtain chloromethyldihydrosafrole;

[0054] A3: industrial caustic soda flakes, ethylene glycol monobutyl ether and petroleum ether are stirred and mixed, chloromethyl dihydrosafrole is added dropwise, the mixture is refluxed, and the etherified liquid is obtained after cooling;

[0055] A4: The etherified liquid is mixed with sodium hydroxide and heated, the petroleum ether is removed under vacuum, and then vacuum distillation is performed to obtain piperonyl butoxide.

[0056] In the step A1, the solid-liquid ratio of safrole to ethanol is 1:1.8, wherein the mass fraction of ethanol is 75%, the heating temperature is 120° C., and the insulation time is 2.5 h.

[0057] In the step A2, the mass ratio of dihydrosafrole, paraformaldehyde, catalyst and petroleum ether is 100:22:0.4:120, the amount of concentrated hydrochloric acid added accounts for 25% of the mass of the mixture, the insulation temperature and time are 60° C. and 3.5 h, respectively, and the volume ratio of petroleum ether to concentrated hydrochloric acid is 1:5.

[0058] In the step A3, the mass ratio of industrial caustic soda flakes, ethylene glycol monobutyl ether, petroleum ether and chloromethyl dihydrosafrole is 3:5:2:15, the reflux temperature and time are 55° C. and 3.5 h, respectively, the solid-liquid ratio of sodium hydroxide and etherified liquid in the step A4 is 0.8:100 g / mL, and the mixed heating temperature is 70° C.

[0059] The preparation method of the matrine derivative is as follows: dissolving sophoracarpine in dichloromethane, stirring the mixture in a constant temperature water bath, adding 1,6-hexanedithiol and triethylamine to form a mixed solution a, and performing reduced pressure distillation on the mixed solution a to remove dichloromethane, thereby obtaining the matrine derivative.

[0060] The mass ratio of the sophocarpine, dichloromethane, 1,6-hexanedithiol and triethylamine is 1:4:4:0.5, and the temperature of the constant temperature water bath is 50°C.

[0061] The sanitary insecticide composition is used for disinfecting agricultural pests and urban sanitary pests.

[0062] The preparation method of the sanitary insecticide composition is as follows: 4-terpineol, ethyl acetate, tributyl phosphate, 3-phenylphenylphenol, anise oil, piperonyl butoxide, methyl eugenol, matrine derivatives, flucythrin and pyriproxyfen are mixed to obtain an oil phase, sodium dodecylbenzene sulfonate is mixed with water to obtain an aqueous phase, and finally the oil phase and the aqueous phase are mixed and dispersed to prepare an emulsion, namely the sanitary insecticide composition, wherein the mass ratio of sodium dodecylbenzene sulfonate to water is 2:50, and the volume ratio of the oil phase to the aqueous phase is 1:20.

[0063] The purchase source of the pyriproxyfen is: pyriproxyfen / Hubei Ruiboxin-95737-68-1, the purchase source of paraformaldehyde is: paraformaldehyde / Qiyun Chemical-30525-89-4, the catalyst is aluminum chloride, the purchase source of industrial caustic soda flakes is: industrial caustic soda flakes / Shanghai Jupeng, the purchase source of tea saponin: tea saponin / Qiansheng Chemical, the purchase source of 4-pineneol is: 4-pineneol / l ul l aby-562-74-3.

[0064] Example 3

[0065] A sanitary insecticide composition containing pyriproxyfen comprises the following raw materials in parts by weight: 20 parts of a solvent consisting of 4-terpineol, ethyl acetate and tributyl phosphate, 8 parts of a 3-phenylphenol emulsifier, 1 part of anise oil, 1 part of piperonyl butoxide, 5 parts of methyl eugenol, 4 parts of a matrine derivative, 3 parts of cyfluthrin and 4 parts of pyriproxyfen, wherein the mass ratio of 4-terpineol, ethyl acetate and tributyl phosphate is 1:1:1.

[0066] The preparation method of anise oil comprises the following steps:

[0067] (1) Chop the stems and leaves of fennel, wash them, and then put them into a distillation pot and pass water vapor into it for distillation;

[0068] (2) The water vapor is passed into a condenser to condense into a mixed liquid, and then the water is removed through a water separator to obtain anise oil.

[0069] The distillation pressure in step (1) is 1.2 atm, and the condensation temperature in step (2) is 20°C.

[0070] The preparation method of piperonyl butoxide comprises the following steps:

[0071] A1: mixing safrole and ethanol, heating, then introducing hydrogen and keeping the temperature, then cooling and filtering, recovering ethanol, to obtain dihydrosafrole;

[0072] A2: dihydrosafrole, paraformaldehyde, a catalyst and petroleum ether are stirred to form a mixture, and then concentrated hydrochloric acid is added, the temperature is increased and kept, and then the temperature is reduced, and petroleum ether is added and stirred, and then the mixture is allowed to stand until layers are separated, and the hydrochloric acid is removed to obtain chloromethyldihydrosafrole;

[0073] A3: industrial caustic soda flakes, ethylene glycol monobutyl ether and petroleum ether are stirred and mixed, chloromethyl dihydrosafrole is added dropwise, the mixture is refluxed, and the etherified liquid is obtained after cooling;

[0074] A4: The etherified liquid is mixed with sodium hydroxide and heated, the petroleum ether is removed under vacuum, and then vacuum distillation is performed to obtain piperonyl butoxide.

[0075] In the step A1, the solid-liquid ratio of safrole to ethanol is 1:2, wherein the mass fraction of ethanol is 80%, the heating temperature is 120° C., and the insulation time is 3 hours.

[0076] In the step A2, the mass ratio of dihydrosafrole, paraformaldehyde, catalyst and petroleum ether is 100:25:0.4:120, the amount of concentrated hydrochloric acid added accounts for 30% of the mass of the mixture, the insulation temperature and time are 65° C. and 4 h, respectively, and the volume ratio of petroleum ether to concentrated hydrochloric acid is 1:5.

[0077] In the step A3, the mass ratio of industrial caustic soda flakes, ethylene glycol monobutyl ether, petroleum ether and chloromethyl dihydrosafrole is 3:5:2:20, the reflux temperature and time are 60° C. and 4 h, respectively, the solid-liquid ratio of sodium hydroxide and etherified liquid in the step A4 is 1:100 g / mL, and the mixed heating temperature is 80° C.

[0078] The preparation method of the matrine derivative is as follows: dissolving sophoracarpine in dichloromethane, stirring the mixture in a constant temperature water bath, adding 1,6-hexanedithiol and triethylamine to form a mixed solution a, and performing reduced pressure distillation on the mixed solution a to remove dichloromethane, thereby obtaining the matrine derivative.

[0079] The mass ratio of the sophocarpine, dichloromethane, 1,6-hexanedithiol and triethylamine is 1:5:4:0.5, and the temperature of the constant temperature water bath is 60°C.

[0080] The sanitary insecticide composition is used for disinfecting agricultural pests and urban sanitary pests.

[0081] The preparation method of the sanitary insecticide composition is as follows: 4-terpineol, ethyl acetate, tributyl phosphate, 3-phenylphenylphenol, anise oil, piperonyl butoxide, methyl eugenol, matrine derivatives, flucythrin and pyriproxyfen are mixed to obtain an oil phase, sodium dodecylbenzene sulfonate is mixed with water to obtain an aqueous phase, and finally the oil phase and the aqueous phase are mixed and dispersed to prepare an emulsion, namely the sanitary insecticide composition, wherein the mass ratio of sodium dodecylbenzene sulfonate to water is 2:50, and the volume ratio of the oil phase to the aqueous phase is 1:20.

[0082] The purchase source of the pyriproxyfen is: pyriproxyfen / Hubei Ruiboxin-95737-68-1, the purchase source of paraformaldehyde is: paraformaldehyde / Qiyun Chemical-30525-89-4, the catalyst is aluminum chloride, the purchase source of industrial caustic soda flakes is: industrial caustic soda flakes / Shanghai Jupeng, the purchase source of tea saponin: tea saponin / Qiansheng Chemical, the purchase source of 4-pineneol is: 4-pineneol / l ul l aby-562-74-3.

[0083] Comparative Example 1

[0084] On the basis of Example 2, anise oil in the sanitary insecticide composition containing pyriproxyfen was removed and replaced with an equal weight portion of piperonyl butoxide, and other conditions were consistent with Example 2.

[0085] Comparative Example 2

[0086] On the basis of Example 2, piperonyl butoxide in the sanitary insecticide composition containing pyriproxyfen was removed and replaced with anise oil in equal parts by weight. Other conditions were the same as in Example 2.

[0087] Comparative Example 3

[0088] On the basis of Example 2, the methyl eugenol in the sanitary insecticide composition containing pyriproxyfen was removed and replaced with an equal weight portion of a matrine derivative, and other conditions were the same as in Example 2.

[0089] Comparative Example 4

[0090] On the basis of Example 2, the matrine derivative in the sanitary insecticide composition containing pyriproxyfen was removed and replaced with an equal weight portion of methyl eugenol. Other conditions were the same as in Example 2.

[0091] Comparative Example 5

[0092] On the basis of Example 2, cyfluthrin in the sanitary insecticide composition containing pyriproxyfen was removed and replaced with an equal weight portion of a matrine derivative, and other conditions were the same as in Example 2.

[0093] Comparative Example 6

[0094] On the basis of Example 2, pyriproxyfen in the sanitary insecticide composition containing pyriproxyfen was removed and replaced with an equal weight portion of cyfluthrin, and other conditions were the same as in Example 2.

[0095] The purchase source of the pyriproxyfen is: pyriproxyfen / Hubei Ruiboxin-95737-68-1.

[0096] 1. Performance Testing

[0097] The sanitary insecticide compositions containing pyriproxyfen prepared in Examples 1-3 and Comparative Examples 1-6 were diluted with water to obtain insecticides, and the dilution ratio (volume ratio) was 1:2000.

[0098] Examples 1-3 and Comparative Examples 1-6 were tested indoors: Culex pipiens larvae and adults: 10 white porcelain basins were taken, and 3 L of dechlorinated tap water, 10 g / m 2 Sprinkle the insecticide in the water, add 100 healthy larvae and adults of instar II to III respectively. Housefly larvae: Take 10 white square plates, put them into 3cm thick housefly larvae bran medium, press 30g / m 2 The insecticide was spread on the surface of the wheat bran culture medium, and 100 healthy housefly larvae of instar II to III and adults were placed in each plate. The mosquito and fly larvae were fed normally after the indoor test according to the dosage, and feed was added to observe the death of mosquito and fly larvae and pupae and the emergence of pupae into adults within a development cycle. The dead larvae or pupae were taken out, and the corresponding number of test insects was recorded until all the test insects died or emerged. The test was repeated 3 times. In addition, after the insecticide was spread, larvae and adults were placed in 12h and 48h respectively, and the mortality rate was tested and calculated and the average value was taken. The laboratory environment was temperature: (26±1)℃, relative humidity: (60±10)%.

[0099] The above test results are shown in Table 1.

[0100] Table 1 Test results

[0101]

[0102]

[0103] From the data analysis in Table 1, it can be concluded that the larval mortality rate and adult mortality rate of Examples 1-3 are both 100%. In Comparative Examples 1-2, anise oil or piperonyl butoxide is removed, the duration of the insecticide effect is significantly shortened, the mortality rate of adults and larvae decreases significantly over time, and the mortality rate is below 50% at 48 hours, so it can be determined that anise oil and piperonyl butoxide have a synergistic effect of enhancing the duration of the efficacy. It can be seen that the data of Comparative Example 2 is significantly worse than that of Comparative Example 1, because piperonyl butoxide has the effect of enhancing the efficacy in addition to extending the duration of the efficacy; Comparative Examples 3-6 are removed from methyl eugenol or matrine derivatives, flucythrin, and pyriproxyfen, and the mortality rates of larvae and adults are all reduced, and the eclosion rates of Comparative Examples 5-6 are not 0, because the removal of flucythrin and pyriproxyfen has a greater impact on eclosion.

[0104] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A sanitary insecticide composition containing pyriproxyfen, characterized in that: The sanitary insecticide composition containing pyriproxyfen comprises the following raw materials in parts by weight: 0.5-1 part of anise oil, 0.5-1 part of piperonyl butoxide, 1-5 parts of methyl eugenol, 1-4 parts of matrine derivatives, 0.5-3 parts of cyfluthrin and 2-4 parts of pyriproxyfen.

2. A sanitary insecticide composition containing pyriproxyfen according to claim 1, characterized in that: The preparation method of anise oil comprises the following steps: (1) Chop the stems and leaves of fennel, wash them, and then put them into a distillation pot and pass water vapor into it for distillation; (2) The water vapor is passed into a condenser to condense into a mixed liquid, and then the water is removed through a water separator to obtain anise oil.

3. A sanitary insecticide composition containing pyriproxyfen according to claim 2, characterized in that: The distillation pressure in step (1) is 1.1-1.2 atm, and the condensation temperature in step (2) is 10-20°C.

4. A sanitary insecticide composition containing pyriproxyfen according to claim 1, characterized in that: The preparation method of piperonyl butoxide comprises the following steps: A1: mixing safrole and ethanol, heating, then introducing hydrogen and keeping the temperature, then cooling and filtering, recovering ethanol, to obtain dihydrosafrole; A2: dihydrosafrole, paraformaldehyde, a catalyst and petroleum ether are stirred to form a mixture, and then concentrated hydrochloric acid is added, the temperature is increased and kept, and then the temperature is reduced, and petroleum ether is added and stirred, and then the mixture is allowed to stand until layers are separated, and the hydrochloric acid is removed to obtain chloromethyldihydrosafrole; A3: industrial caustic soda flakes, ethylene glycol monobutyl ether and petroleum ether are stirred and mixed, chloromethyl dihydrosafrole is added dropwise, the mixture is refluxed, and the etherified liquid is obtained after cooling; A4: The etherified liquid is mixed with sodium hydroxide and heated, the petroleum ether is removed under vacuum, and then vacuum distillation is performed to obtain piperonyl butoxide.

5. A sanitary insecticide composition containing pyriproxyfen according to claim 4, characterized in that: In the step A1, the solid-liquid ratio of safrole to ethanol is 1:1.5-2, wherein the mass fraction of ethanol is 70-80%, the heating temperature is 120° C., and the insulation time is 2-3 hours.

6. A sanitary insecticide composition containing pyriproxyfen according to claim 4, characterized in that: In step A2, the mass ratio of dihydrosafrole, paraformaldehyde, catalyst and petroleum ether is 100:20-25:0.4:120, the amount of concentrated hydrochloric acid added accounts for 20-30% of the mass of the mixture, the insulation temperature and time are 55-65° C. and 3-4 h, respectively, and the volume ratio of petroleum ether to concentrated hydrochloric acid is 1:

5.

7. A sanitary insecticide composition containing pyriproxyfen according to claim 4, characterized in that: In the step A3, the mass ratio of industrial caustic soda flakes, ethylene glycol monobutyl ether, petroleum ether and chloromethyl dihydrosafrole is 3:5:2:10-20, the reflux temperature and time are 50-60° C. and 3-4 h, respectively, the solid-liquid ratio of sodium hydroxide and etherified liquid in the step A4 is 0.5-1:100 g / mL, and the mixed heating temperature is 60-80° C.

8. A sanitary insecticide composition containing pyriproxyfen according to claim 1, characterized in that: The preparation method of the matrine derivative is as follows: dissolving sophoracarpine in dichloromethane, stirring the mixture in a constant temperature water bath, adding 1,6-hexanedithiol and triethylamine to form a mixed solution a, and performing reduced pressure distillation on the mixed solution a to remove dichloromethane, thereby obtaining the matrine derivative.

9. A sanitary insecticide composition containing pyriproxyfen according to claim 8, characterized in that: The mass ratio of the sophocarpine, dichloromethane, 1,6-hexanedithiol and triethylamine is 1:3-5:4:0.5, and the temperature of the constant temperature water bath is 40-60°C.

10. A sanitary insecticide composition containing pyriproxyfen according to claim 1, characterized in that: The sanitary insecticide composition is used for disinfecting agricultural pests and urban sanitary pests.

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