Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof

A technology of medicinal bacteria and hypoglycemia, which is applied to medical preparations containing active ingredients, botanical equipment and methods, and pharmaceutical formulations, etc., can solve the problems of less research and achieve blood sugar reduction with controllable quality and no increase in Effect of Insulin Concentration

Inactive Publication Date: 2012-05-02
DALIAN BAIXIANGJU BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] So far, there is still little research on the use of edible and medicinal fungal biological agents in the treatment of diabetes and its complications, let alone medicinal fungal products obtained by bidirectional fermentation engineering

Method used

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  • Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof
  • Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof
  • Fungal pharmaceutical mycoplasm with blood sugar lowering efficacy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] (1) Preparation of medicinal fungus

[0074] (a) After drying the Chinese herbal medicine at 50-60°C, weigh and mix the dried medicinal matrix raw materials according to the following mass percentages: Cornus officinalis 2000g, Gynostemma gynostemma 3000g, Momordica grosvenori 1500g, ghost arrow feather 1500g, bitter gourd 1500g, pseudo black Spiny ants 500g. Crush the above-mentioned raw materials to 1-2 mm.

[0075] (b) Put the mixture obtained in step a into a container, add tap water with a pH of 7.5 at a weight ratio of 1:1, sterilize at 127° C. for 2 hours, and cool to below 30° C. to obtain a medicinal matrix.

[0076] (c) Under aseptic conditions, insert Inonotus obliquus bacterial strain into 2000g medicinal matrix; insert Cordyceps sinensis bacterial strain into 4000g medicinal matrix; insert Phellinus bacterial strain into 2000g medicinal matrix; Inject the Grifola frondosa bacterial strain; insert the Yunzhi strain into 1000g medicinal matrix; the inoculat...

Embodiment 2

[0082] (1) Preparation of medicinal fungus

[0083] (a) After drying the Chinese herbal medicine at 50-60°C, weigh and mix the dried medicinal matrix raw materials according to the following mass percentages: Cornus officinalis 1000g, Gynostemma gynostemma 2500g, Momordica grosvenori 1000g, Guijian feather 2000g, Bitter melon 3000g, Heihei Spiny ants 500g. Crush the above-mentioned raw materials to 1-2 mm.

[0084] (b) Put the mixture obtained in step a into a container, add tap water with a pH of 7.5 at a weight ratio of 1:1, sterilize at 127° C. for 2 hours, and cool to below 30° C. to obtain a medicinal matrix.

[0085] (c) Under aseptic conditions, insert Inonotus obliquus bacterial strain into 3000g medicinal matrix; insert Cordyceps sinensis bacterial strain into 3000g medicinal matrix; insert Phellinus bacterial strain into 2000g medicinal matrix; Inject the Grifola frondosa bacterial strain; insert the Yunzhi strain into 1000g medicinal matrix; the inoculation ratio ...

Embodiment 3

[0091] (1) Preparation of medicinal fungus

[0092] (a) After drying the Chinese herbal medicine at 50-60°C, weigh and mix the dried medicinal matrix raw materials according to the following mass percentages: Cornus officinalis 2400g, Gynostemma gynostemma 2000g, Luo Han Guo 2000g, Guijianyu 500g, Bitter gourd 1000g, Heihei Spiny ants 100g. After pulverizing the above-mentioned raw materials to 1-2 mm, add 2000 g of rice.

[0093] (b) Put the mixture obtained in step a into a container, add tap water with a pH of 7.5 at a weight ratio of 1:1, sterilize at 127° C. for 2 hours, and cool to below 30° C. to obtain a medicinal matrix.

[0094] (c) Under aseptic conditions, insert Inonotus obliquus bacterial strain into 4000g medicinal matrix; insert Cordyceps sinensis bacterial strain into 2000g medicinal matrix; insert Phellinus bacterial strain into 2000g medicinal matrix; Inject the Grifola frondosa bacterial strain; insert the Yunzhi strain into 1000g medicinal matrix; the inoc...

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Abstract

The invention belongs to the field of biofermentation engineering. A pharmaceutical medium and a fungal strain which have blood sugar lowering efficacy are used as bidirectional fermentation raw materials, wherein the pharmaceutical medium is mainly composed of the following raw materials: cornel, gynostemma, momordica grosvenori, winged euony twigs, balsam pear and polyrhachis vicina; the fungalstrain is composed of the following strains: inonotus obliquus, cordyceps, phellinus igniarius, polystictus versicolor, and grifola frondosa; and bi-directional multi-fungi fermentation is carried out between multiple edible and pharmaceutical fungi and Chinese herbal medicines by a bidirectional fermentation process, thus organisms in two kingdoms or three kingdoms are organically combined to obtain an entirely new blood-sugar-lowering pharmaceutical mycoplasm product. The obtained product can generate 1+1>2 physiological function efficiency for hypoimmunity, has the actions of obviously lowering blood sugar but not increasing insulin concentration, has significant positive effects on helping treating and controlling diabetic complications, and can be used as an oral medicament for preventing and treating diabetes or a health-care product for adjusting blood sugar.

Description

technical field [0001] The invention belongs to the field of biological fermentation engineering, and in particular relates to a fungal fermented medicinal substance with the effect of lowering blood sugar. Background technique [0002] Diabetes treatment is difficult and expensive, and has become a global issue that governments of all countries pay attention to. At present, there are only six or seven kinds of medicines for treating diabetes in my country's pharmaceutical market, which are divided into three categories: biological medicine insulin, chemical medicine sulfonylurea biguanides, and Chinese patent medicines. Insulin preparations are expensive, difficult to promote and have 8 major side effects; although chemical drugs have obvious hypoglycemic effects, they have relatively toxic side effects on the liver and kidneys, and can easily lead to aggravation of cardiovascular complications. Although Chinese patent medicines have a certain therapeutic effect, most of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01G1/04C05G3/00A61K36/87A61K36/07A61K9/16A61K9/20A61K9/48A61P3/10A61K36/06A61K36/068A61K36/37A61K36/40A61K36/42A61K35/64
Inventor 邢英孟震
Owner DALIAN BAIXIANGJU BIOLOGICAL TECH
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