47 results about "Implant electrode" patented technology

The invention provides an artificial cochlea which comprises an implant and an extracorporeal machine, the implant and the extracorporeal machine both adopt a magnet-free design, the extracorporeal machine is configured to receive a sound signal and transmit the sound signal to the implant after first processing, the implant is configured to perform second processing on the sound signal after first processing, and the implant is configured to perform second processing on the sound signal after second processing. The auditory neuron is stimulated by implanting an electrode; the in-vitro machine comprises an electrode array, the electrode array comprises a base and a plurality of electrode assemblies, and the electrode assemblies are inserted into a target scalp area in a semi-intrusive mode so that at least part of the in-vitro machine can be fixed to the target scalp area; wherein the implant is arranged on the inner side of the target scalp area, and the extracorporeal machine is arranged on the outer side of the target scalp area. And due to the non-magnet design, the artificial cochlea can improve the use experience of the user.

A method and system for protecting electrode arrays while implanted on a brain including a flexible electrode array including non-penetrating cortical surface microelectrodes, a ceramic layer covering the electrode array and a polymer layer adjacent the ceramic layer, wherein the ceramic layer and the polymer layer hermetically seal the electrode array. The ceramic layer can be configured to exhibit sufficient flexibility to allow the electrode array to be implanted using minimally invasive surgical techniques, while still hermetically sealing the electrode array from a biological environment.

An example method for electrically stimulating a subject includes creating a plurality of circuits using an implantable electrode placed within a subject, transmitting a signal at a first frequency through a first circuit of the plurality of circuits, and generating a first electric field, and transmitting a signal of a second frequency through a second circuit of the plurality of circuits, and the second circuit generating a second electric field. The implantable electrode is placed in a substantially linear configuration along a same axis such that the first electric field and the second electric field are in an axially biased configuration, and the first electric field and the second electric field interfere with each other in an overlapping region to produce a beat signal.

Presented is a system and method for implanting a flexible electrode array in a biological organ. The system includes an electrode implant tool that includes an elongate rod and an electrode implant assembly having a plurality of attachment members. The electrode implant assembly further includes a ring member connected to each of the attachment members. A variable magnetic field generator is arranged in the ring member. The system uses electromagnetic force to temporarily strengthen the flexible electrodes allowing the penetration into the brain.

Systems and methods for cortical mapping to optimize placement of a neural interface in a brain of a patient are provided. A method for cortical mapping of a brain of a patient includes implanting an electrode array proximate to the brain of the patient at a position. The electrode array may include a flexible substrate and a plurality of electrodes arranged on the flexible substrate. The method may further include monitoring and electrophysiological mapping of the brain by causing the patient to perform, attempt to perform, or imagine performing an action over a period of time, recording, via the electrode array, neural activity exhibited by the patient in response to the action or imagined action performed by the patient, decoding the neural activity to determine a correspondence between the neural activity and the action, and determining a level of confidence, wherein the level of confidence is based on the correspondence.

The present invention belongs to the field of brain-computer interface, and specifically relates to an ECoG electrode and a preparation method thereof. The implantable electrode of the present invention includes a flexible support layer, an electrode metal layer and a packaging layer, wherein the electrode metal layer includes an electrode contact array area, a pad area and a conductive wire; the electrode contact array area contains one or more electrode contacts, and the pad area contains one or more solder joints; each of the electrode contacts and a corresponding solder joint is connected by a conductive wire to form a connection path, and different connection paths are electrically isolated from each other. The present invention sets different materials on the exposed surfaces of the electrode contacts and solder joints, so that different materials can give full play to their respective advantages, which not only optimizes the electrode performance, but also helps to maintain the consistency of signal transmission. At the same time, the manufacturing process required for the electrode is also relatively simple, the cost is lower, and it is also more environmentally friendly.

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

In an electrostatic chuck which electrostatically adsorbs and fixes a workpiece placed on a placement surface by applying a voltage to an electrode implanted therein, the placement surface has a concavo-convex structure comprising a plurality of convex portions two-dimensionally spaced apart from each other at a predetermined pitch and flat concave portions between the convex portions, and the convex portions comprise: flat portions; the substrate is provided with a flat surface which is vertical to the thickness direction of the electrostatic chuck and is uniform in height; and an inclined portion located around the flat portion, the height of the inclined portion decreasing from the flat portion toward the recessed portion, and the inclination angle of the upper surface of the inclined portion with respect to the thickness direction of the electrostatic chuck being 65-84 degrees.

The present invention relates to a deep brain electrical stimulation system, and more particularly to a neural electrical stimulation system capable of being equipped with multiple electrodes, comprising a pulse generator, an extension wire, an electrode, and a fixing device, wherein the pulse generator is a multi-channel, multi-contact pulse generator, the extension wire is connected to the multi-channel, multi-contact pulse generator via contacts, the electrode is connected to the extension wire, and the fixing device is used to fix the electrode during use. The electrical stimulation system of the present invention can adjust the matching relationship between the number of pulse contacts and the number of electrodes according to the requirements of system precision, thereby achieving multi-channel, multi-pulse electrical stimulation output; the present invention also adjusts the structure of the extension wire so that, while the number of pulse contacts remains unchanged, more electrodes can be added as needed, thereby meeting the requirements of more complex electrode stimulation.

A patient-specific frequency mapping procedure, a fitting system for carrying out said procedure and computer program product for a cochlear implant or an electric-acoustic stimulation device having an electrode array that has been implanted into the cochlea of said patient is disclosed.

The invention relates to the technical field of metal material preparation, in particular to a tantalum-tungsten-based nano composite target material and a preparation method thereof. The method comprises the following steps: smelting a high-purity tantalum block and a high-purity tungsten block, and casting to obtain a tantalum-tungsten prealloy cast ingot; the tantalum-tungsten pre-alloy cast ingot is subjected to atomization powder making, and Ta-W alloy powder is obtained; the Ta-W alloy powder is mixed with a nano carbon material, and TaW-C mixed powder is obtained; and the TaW-C mixed powder is subjected to magnetic field assisted sintering, grain oriented growth is induced, aftertreatment is conducted, and the tantalum-tungsten-based nano composite target material is obtained. The magnetic field assisted sintering adopts a one-way static magnetic field along the direction vertical to the target surface, and the magnetic field intensity is 2-10T. According to the preparation method, the Ta-W-based nano composite target material with high density, uniform tissue and texture orientation can be prepared, and the deposited film has the characteristics of low stress, high flexibility and the like, and meets the use requirements of a flexible implanted electrode.

An implantable electrode device is provided comprising a first layer and a second layer, the second layer being on top of the first layer and including at least one electrode contact. The at least one electrode contact is exposable to a nerve of a nervous tissue of a human or of an animal. A connecting means electrically connects the electrode contact, where the connecting means is made up of at least one conducting wire, and the conducting wire is arranged within the first layer and is fixed to the electrode contact. Also provided is a method for forming an implantable electrode device.

A system for implanting an electrode wire (1) is configured for implanting the electrode wire (1) into a brain of an organism, and includes an implantation apparatus (100), a first light source (410), a second light source (420), a first camera (430), a second camera (440), a brain surface camera (450), and a processing apparatus, wherein the implantation apparatus is provided with an implantation movement mechanism that is configured to enable the implantation apparatus (100) to implant the electrode wire (1) at different angles in different orientations.

A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.

The present invention discloses a device and method for monitoring cerebral stroke based on non-contact electrical impedance imaging and current focusing. The device is composed of a non-contact current focusing sensor, an electrode switching module, a data acquisition module and an image reconstruction host computer. The non-contact current focusing sensor includes a focusing electrode layer, a detection electrode layer and two insulating layers. Among them, the focusing electrode is used to achieve a current focusing effect, thereby improving the detection depth and sensitivity of the signal; the detection electrode is responsible for obtaining the detection current containing brain electrical impedance information. The image reconstruction host computer is used to achieve image reconstruction and obtain real-time images and quantitative parameters of cerebral stroke. The present invention has the advantages of being non-contact, wearable, safe and friendly, highly sensitive, low cost, and having a fast imaging speed. It is suitable for scenarios such as homes, clinics, ambulances, etc. that require rapid diagnosis or real-time monitoring and are not covered by equipment such as CT / MRI, and avoids the measurement requirements of existing electrical impedance imaging equipment where patients need to shave their heads or implant electrodes.

The present invention provides a universal connector for implanted electrodes, a device and an injection voltage testing device. The universal connector for implanted electrodes includes a plurality of conductive terminals. When a columnar implanted electrode is installed in the universal connector, some of the conductive terminals will contact the electrode contacts to achieve electrical connection. Since each conductive terminal is connected to a connecting wire, and the other end of the connecting wire is set as a free end, the tester can connect the connecting wires of all the conductive terminals connected to the same electrode contact to the same test channel to achieve the test of the electrode contact. Due to the different specifications of the columnar implanted electrodes, the conductive terminals that achieve electrical connection with the electrode contacts are also different. In order to achieve the universality of the connection of different specifications of implanted electrodes, the tester can adjust the connection of each connecting wire to the test channel according to the contact situation between the conductive terminal and the electrode contact.

The current invention relates to a flexible electrode comprising a porous flexible substrate material having a first surface and a second surface diametrically opposed to the first surface; at least one through hole in the porous flexible substrate material, where the at least one through hole extends from the first surface to the second surface, the at least one through hole having an internal surface; a conductive material attached to the first and second surfaces of the porous flexible substrate material, wherein: the at least one through hole is formed such that a first entry hole, having a first entry hole diameter, in the first surface has a larger diameter than a corresponding second entry hole in the second surface, or vice versa, such that the internal surface of the through hole is tapered; the conductive material is also attached to the internal surface of the at least one through hole to provide a continuous conductive film attached to the first and second surfaces, where the first and second surfaces are conductively connected by the conductive material in the at least one through hole; and the conductive material penetrates into the porous flexible substrate to form a mechanical interlock between the conductive material and the porous flexible substrate.

The application provides a method and device for determining the position of an implanted electrode in an MR image, the method comprising: obtaining an MR image of a human body after an electrode is implanted; performing binary processing on the MR image to obtain a binary image; extracting the coordinates of voxels with a value of 1 in the binary image to obtain dot array data, performing principal component analysis on the dot array data to obtain principal component values in multiple dimensions; weighting principal component images in multiple dimensions formed by the principal component values in multiple dimensions to obtain a weighted image; extracting a skeleton image from the weighted image; determining a straight line where the electrode is located from the skeleton image; performing dilation on the straight line and performing coincidence calculation with the binary image or the weighted image, and determining the maximum connected region according to the calculation result; and determining the position of the electrode based on the end points of the maximum connected region.

A system may include a signal generator configured to be in electrical communication with at least one implantable electrode. A system may include a controller configured in electrical communication with the signal generator, wherein the controller is configured to cause the signal generator to generate a first electrical signal configured to cause partial or full block of action potential conduction and / or initiation in an off-target neural component of a first target electrically excitable tissue. The controller may be further configured to cause the signal generator to generate a second electrical signal having a shorter pulse width than the first electrical signal. The second electrical signal can be configured to activate an on-target neural component of a second target electrically excitable tissue.

Disclosed is a neural stimulation system comprising: an implantable device for controllably delivering neural stimuli, and a processor. The device comprises: a pulse generator configured to deliver neural stimuli via one or more stimulus electrode configurations (SECs), each SEC comprising one or more stimulation electrodes of an implanted electrode array, to a neural pathway of a patient, the neural stimuli being configured to evoke neural responses from the neural pathway; and a control unit configured to control the pulse generator to deliver neural stimuli via an SEC of the one or more SECs. The processor is configured to: select, from a predetermined ranked list of possible SECs associated with a predetermined first location on the electrode array, the first possible SEC in rank order that does not contain an unusable electrode; and instruct the control unit to control the pulse generator to deliver the neural stimuli via the selected SEC.

Systems for facilitating electrical stimulation within a patient's brain and of recording electrical activity within a patient's brain during the implantation of electrode leads in the patient's brain are described. The systems include a modified operating room (OR) cable and / or a sensing adapter that provide electrical connections with the electrode lead(s) and also provide electrical connections to off-lead electrodes that may be configured in electrical contact on the patient's body remote from the electrodes of the electrode lead(s). The off-lead electrodes may be reference electrodes, for example.

The invention discloses a multi-channel multi-mode active electrode integrated nerve probe chip for an implantable brain-computer interface, which comprises a non-implantable circuit part and an implantable electrode part, wherein the non-implanted circuit part integrates a multi-channel electroneurographic signal detection front end, a chemical signal detection front end, a multi-bit adjustable stimulation circuit, a reconfigurable switch array and digital control logic; the implantable electrode part is of a silicon needle structure, electrical electrodes and chemical electrodes are longitudinally distributed on the surface of the implantable electrode part, and dynamic gating and closed-loop regulation and control are supported. Through the electrode-circuit integrated design, the multi-mode function of synchronous high-precision detection and electrical stimulation output of the electroneurographic signals and the chemical signals is achieved, the problems that in the prior art, the mode is single, and the integration degree is low are solved, and the device has the advantages of being high in channel density and low in noise; 5 [mu] Vrms) and a fast closed-loop response (lt; the method is suitable for acute and long-term brain science research and nerve disease treatment.

The application relates to the technical field of electroencephalogram data processing, and discloses a stereotactic electroencephalogram electrode contact calibration method and device. The application can clearly and accurately distinguish discrete electrode contact coordinates. Even in the case that the implanted electrode is severely curved or deformed, the center coordinates of the electrode contact area can still be accurately positioned. In the case that imaging is relatively fuzzy and adjacent contacts are difficult to distinguish, the application still has accurate distinguishing ability. In addition, the application can automatically segment different electrodes, independently determine the spatial axis and target point direction of each electrode, and calculate the marking path of the electrode contact. The position and direction of the electrode do not need to be manually marked by a person, and the operation process is convenient. Therefore, the application has the ability to completely, accurately, comprehensively and efficiently complete the electrode calibration work which needs to be manually or semi-automatically completed by a large number of manual interventions in the past, and the application further embodies the characteristics of full automation, high precision and strong flexibility.

The application provides a multi-conducting elastic implant electrode and a preparation method thereof. The multi-conducting elastic implant electrode comprises an electrode body, the electrode body comprises a plurality of electrode segments, each electrode segment comprises an electrode ring, a clamping column and a connecting column, the electrode ring is sleeved outside the connecting column, the plurality of electrode segments are arranged, the clamping column and the connecting column are sequentially and alternately arranged and fixedly connected, two adjacent clamping columns clamp the electrode ring, and the electrode ring and the clamping column are in sealed arrangement; the clamping column is provided with a through hole penetrating through two end surfaces; each electrode ring is electrically connected with a wire, free ends of the wires pass through the through hole and are located on the same side of the electrode body. The application can improve the flexibility of the implant electrode as a whole and can effectively improve the adaptability of the product implanted in the body.

The invention discloses a device for acquiring a bio-electricity signal and equipment for acquiring the bio-electricity signal, which are used for implanting an electrode under an epidermal layer to acquire the bio-electricity signal. According to the technical scheme, the device for obtaining the bio-electricity signals comprises an implanted electrode, a power supply, a data output unit and a control circuit, the implanted electrode comprises a first electrode and a second electrode which can collect the bio-electricity signals, the first electrode and the second electrode are connected in an insulated mode, and the power supply is connected with the data output unit. The power supply can provide electric energy for the first electrode, the second electrode, the data output unit and the control circuit, the control circuit is suitable for processing bio-electricity signals collected by the first electrode and the second electrode, and the data output unit is suitable for wirelessly transmitting the processed bio-electricity signals to the outside.

The present disclosure relates to a system for assisting in implanting an electrode wire, comprising: an electrode wire fixing apparatus; a guide needle fixing apparatus; a movement mechanism; a first camera, arranged on a first side of a plane and towards a metal part, the first camera having a first optical path; a second camera, arranged on the first side of the plane and towards the metal part, the second camera having a second optical path at an angle to the first optical path; and a processing apparatus, configured to identify a relative position of the end of a guide needle to a through hole based on images shot by the first camera and the second camera, and control the movement mechanism to drive the electrode wire fixing apparatus and / or the guide needle fixing apparatus to move, so that the end of the guide needle is aligned with the through hole. The present disclosure further relates to a method for guiding an electrode wire.

The present invention discloses a pseudo-neural electrode for precise stimulation of the cochlear nucleus. It is made of a flexible material and includes at least one implanted electrode wire, which is provided with a number of electrode points. Each electrode point at least includes: an outer ring electrode and a central electrode. The outer ring electrode is arranged around the periphery of the central electrode to form a concentric circle structure, and the central electrode is electrically insulated from the outer ring electrode. The present invention uses a flexible material to fabricate micron-level electrodes, whose size and material are close to the target neurons, can penetrate deep into the cochlear nucleus, and can achieve precise stimulation of the target neurons, reducing the stimulation of non-target neurons. Moreover, the present invention also designs a micro Laplace concentric circle electrode structure, and any two or more of the electrode arrays can form a current loop, which can effectively inhibit the diffusion of the stimulation current, making the stimulation more efficient, achieving more precise and efficient stimulation of the neurons in the deep part of the cochlear nucleus that respond to different frequencies of sound, and at the same time improving the auditory reconstruction effect.

The invention discloses a flexible implantable electrode and a preparation method thereof, and a detection system. The flexible implantable electrode comprises a flexible substrate; the graphitization-like carbon film is located on the flexible substrate, the graphitization-like carbon film is provided with a working electrode pattern, a reference electrode pattern and a counter electrode pattern, and the graphitization-like carbon film is formed by pre-mixing graphene oxide and a polymer precursor and then coating the mixture on the first substrate for carbonization reaction; the catalyst layer is positioned on the working electrode pattern; the enzyme recognition layer is positioned on the catalytic layer; the selective membrane is positioned on the enzyme recognition layer; the ink layer is positioned on the reference electrode pattern; and the salt bridge film layer is positioned on the ink layer. The flexible implantable electrode disclosed by the invention has good biocompatibility, long-term stability, mechanical flexibility and implantation adaptability; the thickness and the structure uniformity are good, and large-scale preparation is facilitated.

The present invention relates to an electrode, which is an in vivo insertable electrode, including a substrate, an electrically conductive layer formed on the substrate, a platinum black layer formed on the electrically conductive layer, a self-assembled monolayer (SAM) formed on the platinum black layer, and a lubricant layer formed on the SAM, a method of manufacturing the electrode, and a medical device including the electrode. The in vivo insertable electrode according to the present invention provides excellent electrical properties such as low impedance. Further, it shows that friction with tissue occurring when the electrode is inserted is reduced, and trauma during insertion and an immune rejection response after insertion is suppressed. Further, in the long term, it is possible to detect signals with high sensitivity throughout the entire period by preventing bioadhesion of in vivo cells, such as immune cells, and other proteins.