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Garlic oil enteric pellet capsule and preparation method thereof
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A technology of enteric-coated pellets and garlic oil, which is applied in capsule delivery, pharmaceutical formulations, oil/fat/wax non-active ingredients, etc., can solve the problems of poor stability, easy degradation, and long residence time of the main drug, so as to ensure effective properties and stability, high bioavailability, and the effect of improving water solubility
Active Publication Date: 2010-08-18
HAINAN PULIN PHARMA
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Problems solved by technology
[0003] 1. Ordinary tablets, capsules, and soft capsules are disintegrated in the stomach, and the main drug has poor stability and easy degradation under acidic conditions, making it difficult to play its due role;
[0004] 2. Although enteric-coated tablets can avoid gastric acid damage, the retention time in the stomach is called micro-pills, and the release in the intestine is not as uniform as micro-pills; enteric-coated capsules are easy to open in the stomach, and thus partially destroyed
[0005] 3. Enteric-coated capsules may also be broken due to food extrusion. Even if they are opened in the intestine, the drug distribution concentration is much more concentrated than that of micropills, which is not conducive to the absorption of drugs, so there is no drug effect of micropill preparations at the same dose
[0006] Publication No. CN101006994 Chinese patent application for allicin enteric-coated capsules and its preparation method discloses a kind of allicin enteric-coated capsules and its preparation method, the patent application is to coat garlic oil with β-cyclodextrin, and then Then make granules or micropills, and finally cover the capsule shell to get it. After the micropills of this enteric-coated capsule are dissolved in the intestine, the cost of using β-cyclodextrin and garlic oil is relatively high, and the cost of β-cyclodextrin packaging is relatively high. Poor packaging and compatibility lead to easy degradation of allicin and poor stability
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Embodiment 1
[0028] Example 1: In this example, garlic oil enteric-coated pellet capsules were prepared, and the following prescription was adopted:
[0032] Shellac 149.2g, add 1500ml 95% ethanol, stir overnight to dissolve completely, set aside;
[0033] Isolation gown: 20g PVP, 6.7g talcum powder, add 500ml 95% ethanol to dissolve, suspend, set aside.
[0034] Concrete preparation process steps are as follows:
[0035] a. Take the prescription amount of vegetarian pill auxiliary materials, add 95% ethanol to fully suspend, add garlic oil, stir for 30 minutes, add TW-80 and continue stirring for more than 30 minutes, set aside;
[0036] b. Take the pellet core and place it in the pill making machine, feed the pellets and make pellets, and the parameters are controlled as follows:
[0037] Speed 350rpm. The temperature is 24dec, the spraying is 25, and the air volume is high;
[0038] C. Take the pel...
Embodiment 2
[0043] Embodiment 2: the present embodiment adopts following prescription:
[0054] Shellac 149.2g, add 1500ml 95% ethanol, stir overnight to dissolve completely, set aside;
[0055] Isolation gown: 20g PVP, 6.7g talcum powder, add 500ml 95% ethanol to dissolve, suspend, set aside.
[0056] Process is identical with embodiment 1.
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Abstract
The invention relates to the field of antibacterial agent, in particular to a garlic oil enteric pellet capsule and a preparation method thereof. Wherein the garlic oil pellet capsule is composed of a coated pellets and a coating layer, the coated pellets comprises pharmaceutically active ingredients of garlic oil and coated pellet minor ingredient; wherein the coated pellet minor ingredient comprises pellet core, bonding agent, absorbing agent, disintegrating agent, antioxygen agent and antiplastering aid while the coating layer comprises an enteric coating and an isolated layer; the coated pellet comprises the following components according to weight percentage: 5-40% of garlic oil, 10-60% of pellet core, 2-10% of binding agent, 20-50% of absorbing agent, 0.5-5% of antioxygen agent, 0.5-10% of disintegrating agent and 2-20% of antiplastering aid.Compared with the existing allicindosage form, the garlic oil enteric pellet capsule of the invention enjoys more advanced dosage form, thus ensuring effectiveness and stability of the capsule and high bioavailability; in addition, with the enteric pellet capsule of the invention, harm done to gastric mucosa as the capsule is dissolved inside the stomach is avoided and the allicin is not damaged by gastric acid so that drug effect of the capsule is not affected.
Description
technical field [0001] The invention relates to the field of antibacterial drug preparations, in particular to a garlic oil enteric-coated pellet capsule and a preparation method thereof. Background technique [0002] Allicin (Allicin), also known as allicin, chemical name diallyl trisulfide (CH2=CH2CH22S2S2S2CH22CH=CH2), is a volatile oily substance extracted from the spherical bulb of garlic, and is the main active ingredient of garlic. In addition to garlic's traditional antibacterial, antiviral, and antiprotozoal effects, allicin has been proven by modern medicine to have antitumor, lower blood lipids, and improve body immunity. It is known as "natural broad-spectrum antibiotics". Pure allicin The bactericidal effect of garlic is 100 times that of penicillin. In today's situation where antibiotics are abused and antibacterial properties are continuously enhanced, garlic oil is considered to be an ideal and safe alternative. In recent years, scholars at home and abroad h...
Claims
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