8 results about "Lopinavir" patented technology

The application discloses a preparation method of a lopinavir derivative, belongs to the field of compound preparation, and provides a novel drug molecule lopinavir derivative synthesis method which is reasonable in process design, high in yield, and convenient and controllable in operation process. The lopinavir derivative is synthesized through seven steps of reaction by taking an amine group protected epoxypropylamine and a carboxyl group protected L-valine as raw materials. The preparation method provided by the application is reasonable in process design, high in operability, relatively mild in reaction condition, and high in yield. The lopinavir derivative prepared by the application provides an important basis for scientific evaluation of quality, safety and efficiency of lopinavir. Meanwhile, compared with lopinavir, the lopinavir derivative synthesized by the application has better water solubility, overcomes the weakness of low water solubility and poor oral bioavailability of lopinavir, and can be developed into a substitute of lopinavir.

The utility model discloses a pressure tank device for producing lopinavir, which belongs to the technical field of chemical equipment and comprises a tank body, an injection unit and a crushing unit, the tank body is arranged for a pressure tank and used for reaction of mixed materials, the top of a connecting block is connected with a fixing block through a bolt, and the fixing block is connected with the injection unit through a bolt. Through holes are formed in the tops of the fixing block and the connecting block, the crushing unit comprises a feeding cylinder installed at the top of the fixing block, a feeding port is formed in the feeding cylinder, and the lower surface of the interior of the feeding port penetrates through the feeding cylinder and is connected with the guide pipe to be provided with a falling hole. An erecting mechanism is fixedly mounted at the top of the feeding cylinder, a driving motor is fixedly mounted at the top of the erecting mechanism, a rotating shaft is rotatably mounted at the bottom of the driving motor, and a crushing net is in threaded connection with the outer wall of the rotating shaft. And the influence on the subsequent reaction is reduced.

The utility model discloses a liquid storage bottle constant temperature and ventilation device for measuring lopinavir liquid chromatography, which belongs to the technical field of analysis and detection, and comprises a reaction unit, a temperature control unit and an exhaust unit, the reaction unit comprises a reaction box, a storage bottle is arranged in the reaction box, one side of the reaction box is provided with a door, and the other side of the reaction box is provided with an air inlet and an air outlet. The temperature control unit comprises a heating lamp arranged on the inner wall of the reaction box, an adjusting mechanism is arranged on the side face of the heating lamp, a power line penetrating through the reaction box is connected with the heating lamp, and the exhaust unit comprises an air guide pipe arranged at the top of the reaction box and penetrating through the interior of the reaction box. The top of the air guide pipe is provided with an air blowing mechanism, the top of the reaction box and the air guide pipe are provided with an exhaust pipe in a non-contact manner, and the device has the advantages that gas can be conveniently absorbed and subsequently treated, and the environment temperature is kept stable through the temperature control unit, so that the whole detection test is stably carried out.

Provided herein are methods and compositions for treating and / or inhibiting the development or progression of conditions caused by, or associated with, Herpes Simplex Virus (HSV) infection. In particular, provided are compositions comprising lopinavir alone, or lopinavir and ritonavir; methods for their manufacture; and the use of said pharmaceutical compositions as a medicament. In particular, pharmaceutical compositions are provided for use in treating and / or inhibiting the progression of HSV related conditions.

The utility model discloses a triphosgene solid feeding device in the production process of lopinavir intermediate TPA, and belongs to the technical field of feeding devices, the triphosgene solid feeding device comprises a feeding unit and an adjusting unit, the adjusting unit comprises a material guide cylinder, a table-shaped feeding cylinder is fixedly mounted at the top of the material guide cylinder, and a feeding port is formed in the top of the table-shaped feeding cylinder. The adjusting unit comprises a sealing groove formed in the inner wall of the material guiding barrel, an adjusting plate is fixedly installed on the outer wall of the material guiding barrel and is parallel to the sealing groove, the side face of the adjusting plate is open and penetrates through the material guiding barrel, and a circular sealing plate is slidably installed in the adjusting plate; the adjusting plate is fixedly installed on the inner wall of the sealing plate, a reset spring is fixedly installed on the inner wall of the adjusting plate, the other end of the reset spring is fixedly connected with the inner wall of the sealing plate, an inserting groove penetrating through the adjusting plate is formed in the end, away from the sealing plate, of the adjusting plate, and a positioning groove is formed in the outer wall of the inserting groove. And the channel is changed along with the change of the material state.

The utility model discloses a lopinavir intermediate drying device, which belongs to the technical field of drying devices and comprises a drying box, an outward rotating motor arranged on the inner wall of the drying box, a rotating shaft extending out of the drying box and located in the drying box, and a storage unit connected with the center of the rotating shaft. The impact unit is arranged on the lower surface of the interior of the drying box and is vertical to the storage unit, the storage unit comprises a main storage box, the center position of the outer wall of the main storage box is connected with the rotating shaft, an auxiliary storage box is inserted into the main storage box, a sealing ring is fixedly installed on the outer wall of the auxiliary storage box, and the impact unit comprises a positioning cylinder; the lopinavir intermediate drying device comprises a positioning cylinder, a sliding groove is formed in the top of the positioning cylinder, a sliding block is installed in the sliding groove in a sliding mode, and the inner wall of the sliding block is fixedly connected with an impact block arranged in the positioning cylinder. The lopinavir intermediate drying device has the advantages that lopinavir intermediates can be fully dried, and the situation of uneven drying caused by accumulation is prevented.

The utility model discloses a lopinavir centrifugal device, which belongs to the technical field of raw material separation, and comprises a centrifugal unit, a scraping unit and a material storage unit, the centrifugal unit comprises a rotating motor, the rotating motor is arranged on a support seat, the top of the rotating motor is provided with a rotating shaft, and the rotating shaft is arranged on the support seat. A connecting rod is fixedly connected to the top of the rotating shaft, a centrifugal cylinder is arranged on the connecting rod, a threaded hole is formed in the bottom of the centrifugal cylinder, the connecting rod is connected with the centrifugal cylinder through the threaded hole, and a plurality of discharging holes are formed in the inner wall of the centrifugal cylinder; the scraping unit comprises a connecting pipe extending into the centrifugal barrel, a scraping plate is fixedly installed on the outer wall of the connecting pipe, a discharging groove is formed in the side face of the scraping plate, and the top of the connecting pipe is connected with a driving shaft of a driving motor. And the condition of insufficient material accumulation and separation is reduced.

This invention provides methods for treating acute respiratory distress syndrome (ARDS), including ARDS associated with respiratory viral infections. [Solution] Administer plasma kallikrein (pKal) inhibitors such as anti-pKal antibodies as inhibitors of the contact activation pathway. Immunomodulators such as IL-6R inhibitors, antiviral agents such as lopinavir, ritonavir, interferon beta, umfenovir, and remdesivir, antimalarial agents such as chloroquine, and / or inhibitors of the contact activation pathway such as C1 inhibitors, pKal inhibitors, and bradykinin receptor antagonists may be administered to the patient as additional therapeutic agents.