14 results about "Lopinavir" patented technology

Provided herein are methods and compositions for treating and / or inhibiting the development or progression of conditions caused by, or associated with, Herpes Simplex Virus (HSV) infection. In particular, provided are compositions comprising lopinavir alone, or lopinavir and ritonavir, methods for their manufacture; and the use of said pharmaceutical compositions as a medicament. In particular, pharmaceutical compositions are provided for use in treating and / or inhibiting the progression of HSV related conditions.

The invention discloses an anti-HPV gel dressing and a preparation method thereof, belonging to the technical field of dressings. The invention comprises the following steps: dissolving lopinavir in methanol to obtain an organic phase, adding poloxamer 407 to deionized water to obtain an aqueous phase, dripping the organic phase into the aqueous phase at a uniform speed while stirring under room temperature, stirring in a fume hood to volatilize methanol after the dripping is completed, and subjecting the obtained solution to particle size treatment using a high-pressure homogenizer to obtain a lopinavir nanoparticle solution; and adding a chitosan-based functional component, poloxamer 407, and poloxamer 188 to the lopinavir nanoparticle solution, stirring at 4°C and 100-200 r / min for 2-4 hours, and placing the dressing in a 4°C refrigerator for treatment for 48 hours to obtain the anti-HPV gel dressing. The anti-HPV gel dressing has good drug sustained-release performance, mucosal adhesion, and viscosity permeability, and greatly improves the bioavailability of lopinavir.

The present invention relates to the use of lopinavir in preparing a drug for preventing gastric cancer metastasis. The lopinavir can inhibit the metastasis of gastric cancer cells and has good application prospects in the current clinical situation where there is a lack of effective means for preventing and treating gastric cancer metastasis.

The application discloses a preparation method of a lopinavir derivative, belongs to the field of compound preparation, and provides a novel drug molecule lopinavir derivative synthesis method which is reasonable in process design, high in yield, and convenient and controllable in operation process. The lopinavir derivative is synthesized through seven steps of reaction by taking an amine group protected epoxypropylamine and a carboxyl group protected L-valine as raw materials. The preparation method provided by the application is reasonable in process design, high in operability, relatively mild in reaction condition, and high in yield. The lopinavir derivative prepared by the application provides an important basis for scientific evaluation of quality, safety and efficiency of lopinavir. Meanwhile, compared with lopinavir, the lopinavir derivative synthesized by the application has better water solubility, overcomes the weakness of low water solubility and poor oral bioavailability of lopinavir, and can be developed into a substitute of lopinavir.

The utility model discloses a pressure tank device for producing lopinavir, which belongs to the technical field of chemical equipment and comprises a tank body, an injection unit and a crushing unit, the tank body is arranged for a pressure tank and used for reaction of mixed materials, the top of a connecting block is connected with a fixing block through a bolt, and the fixing block is connected with the injection unit through a bolt. Through holes are formed in the tops of the fixing block and the connecting block, the crushing unit comprises a feeding cylinder installed at the top of the fixing block, a feeding port is formed in the feeding cylinder, and the lower surface of the interior of the feeding port penetrates through the feeding cylinder and is connected with the guide pipe to be provided with a falling hole. An erecting mechanism is fixedly mounted at the top of the feeding cylinder, a driving motor is fixedly mounted at the top of the erecting mechanism, a rotating shaft is rotatably mounted at the bottom of the driving motor, and a crushing net is in threaded connection with the outer wall of the rotating shaft. And the influence on the subsequent reaction is reduced.

The utility model discloses a liquid storage bottle constant temperature and ventilation device for measuring lopinavir liquid chromatography, which belongs to the technical field of analysis and detection, and comprises a reaction unit, a temperature control unit and an exhaust unit, the reaction unit comprises a reaction box, a storage bottle is arranged in the reaction box, one side of the reaction box is provided with a door, and the other side of the reaction box is provided with an air inlet and an air outlet. The temperature control unit comprises a heating lamp arranged on the inner wall of the reaction box, an adjusting mechanism is arranged on the side face of the heating lamp, a power line penetrating through the reaction box is connected with the heating lamp, and the exhaust unit comprises an air guide pipe arranged at the top of the reaction box and penetrating through the interior of the reaction box. The top of the air guide pipe is provided with an air blowing mechanism, the top of the reaction box and the air guide pipe are provided with an exhaust pipe in a non-contact manner, and the device has the advantages that gas can be conveniently absorbed and subsequently treated, and the environment temperature is kept stable through the temperature control unit, so that the whole detection test is stably carried out.

The application belongs to the technical field of adsorbents for water treatment, and discloses an aluminum-based nanoflower adsorbent, a preparation method thereof and application of the aluminum-based nanoflower adsorbent in treating wastewater polluted by antiviral drugs. The preparation of the aluminum-based nanoflower adsorbent comprises the following steps: after water bath heating of aluminum material chemical polishing waste liquid and ammonia, post-treatment is performed to obtain the aluminum-based nanoflower adsorbent. The aluminum-based nanoflower adsorbent is prepared by using the aluminum material chemical polishing waste liquid, and the preparation process is simple, and the production cost is low, so that the purpose of "waste treatment by waste" is achieved. The obtained aluminum-based nanoflower adsorbent is easy to separate from the treated wastewater, has high treatment efficiency, and does not cause secondary pollution to the environment. The removal efficiency of the aluminum-based nanoflower adsorbent on lopinavir reaches 61.79-88.77%, and the removal efficiency of the aluminum-based nanoflower adsorbent on ciprofloxacin hydrochloride reaches 76.93-98.72%, so that the aluminum-based nanoflower adsorbent can be used as an adsorbent in wastewater polluted by antiviral drugs.

Provided herein are methods and compositions for treating and / or inhibiting the development or progression of conditions caused by, or associated with, Herpes Simplex Virus (HSV) infection. In particular, provided are compositions comprising lopinavir alone, or lopinavir and ritonavir; methods for their manufacture; and the use of said pharmaceutical compositions as a medicament. In particular, pharmaceutical compositions are provided for use in treating and / or inhibiting the progression of HSV related conditions.

1. Name of the product of this design: Pharmaceutical packaging box (Lopinavir-Ritonavir Tablets). 2. Purpose of this design product: This design product is used for packaging of medicines. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view.

The utility model discloses a triphosgene solid feeding device in the production process of lopinavir intermediate TPA, and belongs to the technical field of feeding devices, the triphosgene solid feeding device comprises a feeding unit and an adjusting unit, the adjusting unit comprises a material guide cylinder, a table-shaped feeding cylinder is fixedly mounted at the top of the material guide cylinder, and a feeding port is formed in the top of the table-shaped feeding cylinder. The adjusting unit comprises a sealing groove formed in the inner wall of the material guiding barrel, an adjusting plate is fixedly installed on the outer wall of the material guiding barrel and is parallel to the sealing groove, the side face of the adjusting plate is open and penetrates through the material guiding barrel, and a circular sealing plate is slidably installed in the adjusting plate; the adjusting plate is fixedly installed on the inner wall of the sealing plate, a reset spring is fixedly installed on the inner wall of the adjusting plate, the other end of the reset spring is fixedly connected with the inner wall of the sealing plate, an inserting groove penetrating through the adjusting plate is formed in the end, away from the sealing plate, of the adjusting plate, and a positioning groove is formed in the outer wall of the inserting groove. And the channel is changed along with the change of the material state.

The utility model discloses lopinavir intermediate 2, 6-dimethyl phenoxy acetic acid waste liquid and waste residue treatment equipment, which belongs to the technical field of chemical equipment and comprises a rack, a filtering unit, a driving mechanism and a separating unit. Wherein the liquid flows downwards to a filter box to be guided, discharged and collected, at the moment, a driving motor drives a scraping mechanism to conduct circumferential rotation through a first transmission shaft, scraping plates move upwards from gaps between intercepting plates to fish up waste residues, and when the scraping plates reach the position close to a material containing box, an air spraying pipe sprays air to a guide plate to spray the waste residues downwards into the material containing box; then a second transmission shaft drives a spiral pushing rod to operate, waste residues are pushed to a discharging pipe and discharged and collected, waste liquid, waste residues and the like collected at a filter box can be repeatedly fed from a feeding pipe so as to better filter and separate the waste liquid and waste residues, and the device has the advantages of being good in filtering effect, high in separation efficiency and higher in practicability.

The utility model discloses a lopinavir intermediate drying device, which belongs to the technical field of drying devices and comprises a drying box, an outward rotating motor arranged on the inner wall of the drying box, a rotating shaft extending out of the drying box and located in the drying box, and a storage unit connected with the center of the rotating shaft. The impact unit is arranged on the lower surface of the interior of the drying box and is vertical to the storage unit, the storage unit comprises a main storage box, the center position of the outer wall of the main storage box is connected with the rotating shaft, an auxiliary storage box is inserted into the main storage box, a sealing ring is fixedly installed on the outer wall of the auxiliary storage box, and the impact unit comprises a positioning cylinder; the lopinavir intermediate drying device comprises a positioning cylinder, a sliding groove is formed in the top of the positioning cylinder, a sliding block is installed in the sliding groove in a sliding mode, and the inner wall of the sliding block is fixedly connected with an impact block arranged in the positioning cylinder. The lopinavir intermediate drying device has the advantages that lopinavir intermediates can be fully dried, and the situation of uneven drying caused by accumulation is prevented.

The utility model discloses a lopinavir centrifugal device, which belongs to the technical field of raw material separation, and comprises a centrifugal unit, a scraping unit and a material storage unit, the centrifugal unit comprises a rotating motor, the rotating motor is arranged on a support seat, the top of the rotating motor is provided with a rotating shaft, and the rotating shaft is arranged on the support seat. A connecting rod is fixedly connected to the top of the rotating shaft, a centrifugal cylinder is arranged on the connecting rod, a threaded hole is formed in the bottom of the centrifugal cylinder, the connecting rod is connected with the centrifugal cylinder through the threaded hole, and a plurality of discharging holes are formed in the inner wall of the centrifugal cylinder; the scraping unit comprises a connecting pipe extending into the centrifugal barrel, a scraping plate is fixedly installed on the outer wall of the connecting pipe, a discharging groove is formed in the side face of the scraping plate, and the top of the connecting pipe is connected with a driving shaft of a driving motor. And the condition of insufficient material accumulation and separation is reduced.

This invention provides methods for treating acute respiratory distress syndrome (ARDS), including ARDS associated with respiratory viral infections. [Solution] Administer plasma kallikrein (pKal) inhibitors such as anti-pKal antibodies as inhibitors of the contact activation pathway. Immunomodulators such as IL-6R inhibitors, antiviral agents such as lopinavir, ritonavir, interferon beta, umfenovir, and remdesivir, antimalarial agents such as chloroquine, and / or inhibitors of the contact activation pathway such as C1 inhibitors, pKal inhibitors, and bradykinin receptor antagonists may be administered to the patient as additional therapeutic agents.