2 results about "Abacavir" patented technology

The application discloses a preparation method of an abacavir metabolite, and belongs to the field of drug metabolite synthesis. The whole process is reasonable in design, strong in operability, and has high implementation value and social and economic benefits. The method uses compound I as a starting material, and synthesizes the abacavir metabolite through two-step reactions. The optimal synthesis step and reaction condition are screened through experiments. The abacavir metabolite synthesized by the method has a liquid-phase purity of 98.2% or above and a chiral purity of 99.9% or above, provides a test sample for abacavir research, and has important research reference value in clinical pharmacokinetic research and new drug research and development.

The application discloses an abacavir degrading bacterium. The degrading bacterium is obtained from activated sludge in an aerobic tank of a sewage treatment plant in Guangzhou, Guangdong, and is obtained through artificial domestication culture and separation and purification. The name of the bacterium is Pseudomonas sp. abacavir-1, and the bacterium is preserved in the Guangdong Microbial Culture Collection Center of the Guangdong Institute of Microbiology, located at No. 59, Building 5, Guangzhou Martyrs' Road, Guangzhou, on September 23, 2022, and the preservation number is GDMCC NO: 62829. The strain of the application has the ability to degrade single abacavir under oligotrophic conditions, can be used for degrading abacavir in the environment or a sewage treatment plant, and provides a new germplasm resource for abacavir treatment.