26 results about "Hypersensitivity reaction" patented technology

Tree pollen allergy is seasonal allergy caused by various tree pollen spread in air. The allergy affects a substantial proportion of populations, is particularly significant in European and North America areas, and is characterized by symptoms such as sneezing, nasal obstruction, rhinorrhea, eye itching and lacrimation, and throat irritation. The symptoms typically occur in spring, at which birch, alder, hazel and oak release pollen into the air. Tree pollen allergy is a type 1 hypersensitivity reaction mediated by an immunoglobulin E (IgE) antibody. The present invention relates to antibodies and antigen binding fragments thereof that bind to one or more of tree pollen allergens Bet v 1, Aln g 1, Cor a 1 and Quue a 1, resulting in inhibition of IgE-mediated anaphylaxis.

Tree pollen allergy is a seasonal allergy caused by various tree pollens suspended in the air. This allergy affects a significant proportion of the population, particularly in Europe and North America, and is characterized by symptoms such as sneezing, nasal congestion, runny nose, itchy or watery eyes, and throat inflammation. These symptoms typically occur in spring when trees such as birch, alder, hazel, and oak release pollen into the air. Tree pollen allergy is a type 1 hypersensitivity reaction mediated by immunoglobulin E (IgE) antibodies. This invention relates to antibodies and their antigen-binding fragments that bind to one or more tree pollen allergens, Bet v 1, Aln g 1, Cor a 1, and Que a 1, and inhibit the IgE-mediated allergic reaction.

In some embodiments, a composition comprising Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus plantarum, and Streptococcus thermophilus is provided. In some embodiments, provided is the use of a composition of any of the examples herein for preventing or alleviating anxiety and / or sensory hypersensitivity, preventing or treating autism spectrum disorder (ASD), anxiety disorder and / or gastrointestinal (GI) disorder or condition, enhancing attention and / or concentration, or stimulating a GABA receptor in a subject. In some embodiments, methods and kits are provided for preventing or alleviating anxiety and / or sensory hypersensitivity, preventing or treating autism spectrum disorders, anxiety disorders, and / or gastrointestinal disorders or conditions, enhancing attention and / or concentration, or stimulating GABA receptors in a subject. In certain embodiments, the compositions are safe to use and effective to prevent or alleviate anxiety and / or sensory hypersensitivity in subjects, particularly children subjects.

Provided are methods of biasing a response of a vaccine recipient's immune system toward protective sensitization. Methods include administering an agent or substance to the site of a subject of a temporally interacting cell-mediated allergic reaction to enhance the resulting level of protective sensitization.

The invention provides pediococcus acidilactici with functions of improving emotion and intestinal health and application of the pediococcus acidilactici. The pediococcus acidilactici A25-4 is preserved in Guangdong Microbial Culture Collection Center on May 23, 2025, and the preservation number of the pediococcus acidilactici A25-4 is GDMCC NO: 66384. The pediococcus acidilactici A25-4 has better cholate resistance and artificial gastrointestinal fluid resistance and can produce indole lactic acid ILA at high yield, and the optimal carbon source is fructo-oligosaccharide and galactooligosaccharide. The pediococcus acidilactici A25-4 in-vivo intervention can significantly improve the symptoms of an irritable bowel syndrome model mouse, specifically, the anxiety mood of a tested object is significantly improved; the viscera hypersensitivity of a tested object is obviously relieved; excessive activation of mast cells of a tested object is obviously inhibited; the ILA level in a tested object is obviously improved.

The invention belongs to the field of marker detection, and particularly relates to a marker for diagnosing or identifying potential causes of migraine, application, a kit, a device and an evaluation model. The invention provides a marker for diagnosing or identifying potential causes of migraine. The marker comprises indoleacrylic acid and / or hypersensitive C-reactive protein. The invention reveals that PFO is combined with migraine metabonomics maps, and branched chain amino acid metabolism, neurosteroid metabolism and tryptophan metabolism disorder are core pathological mechanisms for the first time. On the basis of plasma metabonomics characteristics of a PFO-combined migraine patient and a healthy control, 211 metabolites with significant difference are screened out, it is found that various metabolites are significantly related to the symptom severity of migraine, and two factors [indoleacrylic acid and hypersensitive C-reactive protein (hs-CRP)] significantly related to migraine related to patent foramen ovale are confirmed. In addition, the concentration of indolecrylic acid (IA) is found to have a relatively good prediction value on symptom relief after occlusion.

The invention belongs to the field of forensic detection, and particularly relates to a method for detecting allergens in drug-induced allergic shock. Based on a type I hypersensitivity reaction mechanism, carboxylated microspheres are used for cross-linking an anti-IgE antibody, an IgE-allergen compound in a sensitization stage of a detection sample is combined and captured, interference of residual components of the sample is removed through multiple times of cleaning, the antibody and drug binding protein are digested by enzyme to dissociate drug components, and the immunogenicity of the IgE-allergen compound in the sensitization stage of the detection sample is improved. And the LC-MS is used for qualitatively detecting medicine components so as to achieve the purpose of detecting the medicine allergen.

This invention belongs to the field of biopharmaceuticals, specifically relating to an endoplasmic reticulum-targeting antioxidant nanozyme, its preparation method, and its applications. The novel antioxidant nanozyme (Arg-Mnzyme) provided by this invention can effectively inhibit NOX1 expression, eliminate the accumulation of reactive oxygen species, and inhibit NOX1 activation and oxidative stress after temporomandibular joint arthritis-related pain, thus alleviating pain hypersensitivity. Compared to natural enzymes, nanozymes have stronger modifiability; this invention will construct an endoplasmic reticulum-precise antioxidant nanozyme to achieve precise regulation of oxidative stress.

The application provides a kind of low sensitization of penaeus vannamei and its preparation method and application, belong to food biotechnology field.The application uses fucoidan to treat penaeus vannamei by covalent modification, after treatment, protein spatial conformation has changed significantly, allergen epitope is hidden.After BALB / c mouse sensitization model and RBL-2H3 cell degranulation model test shows, the sensitization of covalent modification penaeus vannamei decreases by 72.88%, low sensitization penaeus vannamei can inhibit mast cell degranulation and increase the threshold of sensitization, but still has immunogenicity.Through the construction of BALB / c mouse oral tolerance model, it is found that low sensitization penaeus vannamei can significantly alleviate the multiple immunoglobulin-mediated hypersensitivity caused by mouse allergy, which proves that low sensitization penaeus vannamei has auxiliary effect on oral tolerance, can promote oral tolerance ability, can be used as an effective immune tolerance agent for shrimp allergy patients.

The present application relates to the use of substituted indazoles for treatment and / or prophylaxis of allergic and / or inflammatory diseases in animals, especially for treatment and / or prophylaxis of atopic dermatitis, Flea Allergy Dermatitis, inflammatory bowel disease, osteoarthritis and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, respiratory disease, mastitis and endometritis in animals.

Hypersensitive response eliciting peptides exhibiting improved solubility, stability, resistance to chemical degradation, or a combination of these properties are disclosed. Also disclosed are uses of these peptides or fusion polypeptides or DNA constructs encoding the same for modulating plant biochemical signaling, conferring disease resistance to a plant, enhancing plant growth, conferring tolerance to a plant to a biotic stress, conferring tolerance and resistance to a plant to an abiotic stress, conferring desiccation resistance to a cutting taken from an ornamental plant, conferring postharvest disease resistance or postharvest desiccation resistance to a fruit or vegetable, or enhancing the postharvest life of a fruit or vegetable.

The application discloses a pharmaceutical composition, an aprepitant injection and an aprepitant freeze-dried powder injection. The pharmaceutical composition comprises aprepitant, a primary stabilizer and a secondary stabilizer, wherein the primary stabilizer comprises sodium deoxycholate, and the secondary stabilizer comprises povidone. The aprepitant injection provided by the application can be injected for administration, the dosage of auxiliary materials is greatly reduced, the injection site is less irritating when used by patients, and the aprepitant injection is less likely to cause hypersensitivity reaction and is safer; the preparation has good stability, can be stored and transported at room temperature, and greatly reduces the production, storage and transportation costs.

The invention discloses a method for improving neuropathic pain, and relates to the technical field of medical treatment. According to the present invention, the number of M2 type macrophages in the SCN is increased by using the low intensity pulse ultrasound (LIPUS) treatment, such that the inflammatory factors of the peripheral nerve and the central nervous system induced by the partial sciatic nerve ligation (PSL) are reduced, and the hypersensitivity reaction down-regulation shows that the neuropathic pain induced by the PSL is effectively improved by using the LIPUS. All data show that LIPUS may be an effective method for treating neuropathic pain.

The invention provides application of soybean rust fungus elicitor PpE1 protein in inducing plant immune response and / or improving plant resistance, and belongs to the technical field of elicitor protein application. The amino acid sequence of the soybean rust fungus elicitor PpE1 protein is as shown in SEQ ID NO. 2. The invention discovers the application of the soybean rust fungus protein elicitor PpE1 in inducing plant immune response and improving plant resistance for the first time. The PpE1 can cause the hypersensitive reaction of the nicotiana benthamiana and induce active oxygen in the nicotiana benthamiana to burst out; the protein can induce immune response of soybeans, including burst of active oxygen, activation of MAPK and expression of immune genes, and promote resistance of the soybeans to rust fungi; the heterologous expression of the PpE1 can also improve the resistance of the soybean to rust fungi. The invention provides a new way for improving the disease resistance of plants, and has a wide application prospect in agricultural production.

The present invention relates to SNPs for diagnosing drug hypersensitivity reactions and diagnostic methods using the same. The present inventors analyzed protein coding sites in genomic DNA of patients with drug hypersensitivity reactions and found that specific SNPs including rs35372932 are closely related to the onset of drug hypersensitivity reactions. The SNPs can be used to develop genetic diagnostic reagents for diagnosing or predicting the onset of drug hypersensitivity reactions.

The current invention relates to mesenchymal stem cells (MSCs) or a pharmaceutical composition comprising an effective amount of MSCs for use in the treatment of insect-bite hypersensitivity (IBH) in equines.

Development of biomarkers for the diagnosis of the condition, severity, disease type of severe drug eruptions such as drug hypersensitivity syndrome and Stevens-Johnson syndrome / toxic epidermal necrolysis. A method for detecting severe drug eruptions, comprising the steps of: measuring the expression of at least one protein selected from the group consisting of a stratified protein, TNF receptor superfamily member 8 (CD30 / TNFRSF8), interleukin-1 receptor antagonist (IL-1Ra), and TNF receptor superfamily member 6B (DcR3 / TNFRSF6B) in a sample derived from a subject.

The application relates to the technical field of plant genetic engineering, and discloses a salt-tolerant sorghum gene and application. The nucleotide sequence of the salt-tolerant sorghum SbDFRs01 gene is shown in SEQ ID NO:1, and the amino acid sequence encoded by the nucleotide sequence is shown in SEQ ID NO:2. Gene expression level analysis results show that the SbDFRs01 gene has a high expression level in the root system of sorghum, and the expression level in the root system after salt and alkali stress is further significantly increased. When the SbDFRs01 gene is overexpressed in Arabidopsis, a cell hypersensitive reaction can be triggered, and the expression level of an anti-stress related gene is obviously increased. Therefore, the salt-tolerant sorghum SbDFRs01 gene improves the salt tolerance of plants, and provides a theoretical basis for cultivating salt-tolerant plant varieties.

The invention belongs to the technical field of molecular plant pathology, and particularly relates to a peanut bacterial wilt resistant gene AhPR10-54 and application thereof. According to the invention, through whole genome identification and bioinformatics analysis, 883 PR family genes (AhPR) are totally identified in peanuts, and the genes are distributed in 16 different subfamilies; further gene expression analysis shows that most AhPR genes can respond to induction of biological stress and abiotic stress; then 15 candidate genes are screened out for bacterial wilt inoculation treatment and plant hormone induction, and results show that AhPR10-54 and the like have significant up-regulation expression characteristics in disease-resistant peanut varieties. The AhPR10-54 gene is used for disease resistance identification, and the result shows that transient overexpression of AhPR-54 can induce hypersensitivity of plants and significantly improve the resistance of tobacco to ralstonia solanacearum. The invention provides an important basis for the cultivation of broad-spectrum disease-resistant varieties of plants.

The present invention relates to an immediate-release oral pharmaceutical composition comprising Amlodipine and Ubiquinone (coenzyme Q10) for enhanced immunomodulatory activity. The formulation includes Amlodipine besylate (5 mg), Ubiquinone (coenzyme Q10) (50 mg), and pharmaceutically acceptable excipients to form a 500 mg tablet capable of rapid disintegration and drug release. The composition demonstrates superior cell-mediated and innate immune enhancement compared to standard immunostimulants, as evidenced by delayed-type hypersensitivity and carbon clearance assays. The synergistic combination not only restores immune competence in post-viral immune suppression syndrome (PVISS) and immune fatigue but also improves macrophage activation and lymphocyte response. The formulation is stable, effective, and suitable for once-daily oral administration.

Described herein are compositions and methods for mitigating or preventing hypersensitivity reactions in a subject. In particular, described are compositions and methods for mitigating or prophylactically preventing hypersensitivity reactions in a subject that would otherwise arise in response to a PEG moiety in a PEGylated compound and substrate, including PEGylated drugs and vaccines.

This invention provides a physiological age prediction model that predicts the physiological age of a subject by detecting physical examination indicators. These indicators include measurements of blood cells, glucose metabolism, tumor markers, urine components, anthropometric measurements, lipids, blood components, and tissue function. Preferably, these indicators include one or more selected from the following: glomerular filtration rate (eGFR), cystatin C, serum creatinine (SCr), blood urea nitrogen (BUN), timed up and go, light reaction time, fasting blood glucose (FBG), insulin-like growth factor (IGF), superoxide dismutase (SOD), insulin (INS), albumin (Alb), alkaline phosphatase (ALP), folic acid, lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and high-sensitivity C-reactive protein (hs-CRP). More preferably, all of the aforementioned physical examination indicators are included. This invention also provides a physiological age prediction device applying the above-mentioned physiological age prediction model and a computer storage medium.

The present application relates to a kind of target extraction process of inducing mesenchymal stem cell secretion TGF-β and IL-10 anti-inflammatory factor combination and its application in pain treatment preparation, the process is activated mesenchymal stem cell by VEGF-A-link-TNF-α fusion protein as shown in SEQ ID NO:4 Specific, significantly improve its TGF-β and IL-10 secretion level;The fusion protein is targeted with TNF-α inflammatory signal by VEGF receptor cooperation, realize the efficient induction of anti-inflammatory factor expression;Mesenchymal stem cell pretreated by VEGF-A-link-TNF-α fusion protein as shown in SEQ ID NO:4 can significantly relieve the hyperalgesia of neuropathic pain model, with significant clinical application prospect.

The present invention relates to a 5-aminolevulinic acid derivative having improved storage stability and bioavailability, and a pharmaceutical composition comprising the same, the present invention exhibits a pharmacokinetic profile in which 5-aminolevulinic acid is more effectively exposed to blood in vivo, and reduces side effects after treatment, such as pain, erythema, swelling, edema, burning sensation, pruritus, spalling, hyperpigmentation and long-term stimulation and hypersensitivity. Further, the present invention relates to a 5-aminolevulinic acid derivative and a composition comprising the same, in which 5-aminolevulinic acid exhibits high efficiency while reducing the severity of side effects, and the 5-aminolevulinic acid derivative and the composition comprising the same are useful for photodynamic diagnosis and therapy.