107 results about "Group A - blood" patented technology

The invention provides an SNP (Single Nucleotide Polymorphism) site of an ABO blood group variant, and a B subtype variant blood group identification kit and method, and relates to the technical field of biology. The SNP (Single Nucleotide Polymorphism) sites of the ABO blood group variant comprise the 842th c.842Cgt from an initiation codon of an ABO * B.01 allele coding region of an ABO gene; mutation of T. A substance for detecting the SNP site of the ABO blood group variant can be applied to preparation of a B subtype variant blood group identification method and product, so that the substance can be effectively applied to rapid detection of patients and blood donors, the B subtype variant blood group of an individual can be defined, and potential possible blood transfusion reaction can be prevented in time.

The invention discloses an intelligent intensive blood sampling management system based on a GPU, and belongs to the technical field of blood sampling management. The intelligent intensive blood sampling management system based on the GPU comprises a data acquisition unit and a data analysis unit. The problem that efficient management of the intensive blood sampling process is difficult to achieve in the prior art is solved, bar code and two-dimensional code information in the sample image can be rapidly and accurately recognized through the deep learning algorithm based on GPU acceleration, the sample information extraction speed and accuracy are improved, and the efficiency of blood sampling is improved. The trained deep learning model is used for analyzing the sample images, blood types and detection items can be automatically identified, errors caused by manual judgment are effectively avoided, samples are accurately classified according to the analysis result, the sample processing efficiency is improved, an automatic sorting device is accurately controlled according to the classification result, and the sorting efficiency is improved. And the sample test tubes are conveyed to designated positions, so that manual intervention is reduced, and meanwhile, the sorting accuracy and efficiency are improved.

This invention discloses a method for preparing A, B, and Lewis blood group antigens, wherein the A, B, and Lewis blood group antigens are specifically blood group A. tri Antigen, B tri Antigen, Le a Antigen and Le b Antigen. A one-pot photosensitive method was used to achieve blood group A. tri Antigen, B tri Antigen, Le a Antigen and Le b The method for obtaining large quantities of antigens, as described in this invention, features mild reaction conditions, shortened purification steps, simplicity, high efficiency, environmental friendliness, low cost, and high yield and purity of the target substance. This invention provides a practical and rapid chemical synthesis route for blood type A antigens. tri Antigen, B tri Antigen, Le a Antigen and Le b Antigens provide tools for the development of norovirus vaccines and related antibodies, and therefore have great application prospects.

1. The name of the product of this design: blood type analyzer. 2. Purpose of the product of this design: medical testing instrument used to analyze and detect blood type. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the key points of the design: main view.

The present application relates to the technical field of biomedical equipment, and particularly provides a blood type detector and a shaking and mixing device of the blood type detector, aiming to solve the problem that the mixing effect of blood samples and detection reagents of the existing blood type detector is poor, thereby affecting the detection result. To this end, the shaking and mixing device comprises a shaking and mixing mechanism and a cup loading component mounted on the shaking and mixing mechanism, the cup loading component is used for loading a reaction cup, and the shaking and mixing mechanism can vibrate with the cup loading component and the reaction cup in the cup loading component to mix the blood sample and the detection reagent in the reaction cup. By arranging the cup loading component on the shaking and mixing mechanism, the reaction cup can be directly fixed on the shaking and mixing mechanism, so that the vibration generated by the shaking and mixing mechanism can be better transmitted to the reaction cup, thereby improving the mixing effect of the blood sample and the detection reagent in the reaction cup, and further improving the accuracy of the detector.

The invention relates to the technical field of science popularization teaching aids, in particular to a blood type measuring science popularization teaching aid and a use method thereof, and the blood type measuring science popularization teaching aid comprises an operation table, a display screen, an A blood type typing resisting reagent area, a B blood type typing resisting reagent area and an extraction assembly; the extraction assembly comprises four blood simulation discs, four positioning bodies, a supporting driving mechanism, a rotating shaft, a rotating disc, four rebound mechanisms and four positioning mechanisms; the four blood simulation discs with the four positioning bodies are respectively inserted into the four slots and are respectively fixed by matching the positioning mechanisms with the positioning bodies; the support driving mechanism drives the rotating shaft to rotate and drives the turntable to rotate; after the rotating disc rotates for a plurality of circles, one blood simulation disc is randomly selected, the positioning mechanism of the blood simulation disc is loosened, the corresponding rebound mechanism pushes out a part of the blood simulation disc and the positioning body, and then the blood simulation disc and the positioning body are taken out together, so that the blood simulation disc can be randomly drawn, and the authenticity and challenge of an experiment are improved.

1. The name of this design product: Blood type test card. 2. Purpose of this design product: This design product is a test card used to detect the blood type of humans or animals. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The blood type detection card comprises a main body, limiting clamping grooves are formed in the two sides of the front end of the upper surface of the main body, a plurality of detection blocks are fixedly connected to the middle of the upper surface of the main body, an inlet is formed in the center of the upper surface of each detection block, and the limiting clamping grooves are communicated with the limiting clamping grooves. The rear end of the upper surface of the main body is fixedly connected with a plurality of detection strips, and the outer wall of the rear end of the main body is fixedly connected with a flexible connecting strip. Compared with the prior art, the blood type detection card provided by the utility model is small in size and simple in structure, the blood type detection card is convenient to use due to the arranged specification card, so that a worker can carry the blood type detection card conveniently, and can carry out a test conveniently as required; therefore, the use convenience and the application range of the blood type detection card are improved.

The utility model relates to a simple and easy device for detecting human blood type, including flushing liquid containing container, detection subassembly and liquid suction piece, flushing liquid containing container has the containing cavity that contains flushing liquid, and containing cavity has top opening to allow detection subassembly inserts containing cavity, and containing cavity inboard wall is provided with first limit piece, the antibody for blood type detection is fixed in detection subassembly, the antibody can be combined with blood type antigen specificity, detection subassembly has first end and second end, liquid suction piece detachably fixed in second end of detection subassembly, detection subassembly outside wall is provided with second limit piece, wherein, when first end of detection subassembly inserts containing cavity, first limit piece and second limit piece cooperate and form longitudinal limit to fix detection subassembly in containing cavity, the utility model has the characteristics of simple operation, high accuracy, fast detection.

The invention discloses a risk assessment system for difficulty in cross matching of blood, and relates to the technical field of clinical medical examination and blood transfusion management. The system comprises a data input module, a risk calculation module, a risk layering module and a result output and suggestion module. The data input module obtains key information of a patient, wherein the key information comprises an erythrocyte irregular antibody screening result, multiple myeloma diagnosis, hematology department medical history, age of more than or equal to 60 years, pregnancy-related disease state and blood type identification difficulty; the risk calculation module adopts a preset scoring algorithm to endow each factor with a weight and calculates a total risk score; the risk layering module divides the patients into three levels of low risk, medium risk and high risk; and the result output module provides differentiated clinical management paths corresponding to the risk levels. According to the method, early warning of difficulty in cross matching of blood is achieved through quantitative evaluation, blood transfusion process efficiency can be optimized, clinical risks can be reduced, and the method has good prediction performance (AUC = 0.819) and a high negative prediction value (93.7%).

The invention provides a freeze-dried universal platelet rich plasma (PRP) preparation and a preparation process thereof, aiming at solving the problems that the existing PRP is limited in blood type matching, difficult in biological activity preservation, short in validity period and the like. According to the preparation, 18-19% of the type A, 7-8% of the type B and 73-74% of the type AB are mixed with PRP of different blood types and freeze-dried. Tests show that agglutination does not exist in cross blood matching, the titers of the anti-A antibody and the anti-B antibody are both lower than 1: 2, and blood group reaction is effectively avoided. Freeze-drying causes little damage to growth factors, still has biological activity within 24 months, and has a good cell proliferation test effect. Animal experiments show that wound healing can be remarkably promoted. In addition, the culture medium is good in stability in the environment of 4 DEG C, and the moisture, growth factors and the sterile state all meet the requirements. The preparation disclosed by the invention has the advantages of obvious universal advantages, good biological activity preservation and strong stability, and provides a better choice for clinical treatment.

The invention aims to provide a gene identification method for an A-type variant blood group in an ABO blood group system, namely, a screening method for the A-type variant blood group is established on the basis that an SNP site which can cause wrong typing of the ABO blood group is obtained through screening. The SNP sites are located at 188-190 sites of an A subtype gene with a nucleotide sequence of SEQ ID NO: 1, and are A deletion. The invention provides a new application of ABO blood type A variant gene detection, thereby providing a gene diagnosis, prenatal gene screening and genetic counseling approach for effectively avoiding blood type error typing and acute hemolytic transfusion reaction. The application effect shows that the SNP site of the gene and the detection primer provided by the invention can be effectively used for rapid detection of the ABO blood type A variant gene mutation site in peripheral blood of a clinical patient.

The invention belongs to the technical field of data storage, and particularly discloses a full-automatic blood type analyzer data storage safety management method, which comprises the following steps of: classifying blood type detection data generated by a full-automatic blood type analyzer to construct blocks, and calculating an original hash value of each block to form a data chain; complete relevance storage of the blood type detection data is realized, the integrity of each data block is ensured, and any data tampering can cause the change of the hash value, so that the data change can be found in time, and the detection efficiency is improved. In addition, when it is recognized that the data chain changes, local locking operation or all locking operation is intelligently selected by combining the system performance monitoring data at the change moment and the proportion condition of the change blocks, and the flexibility of the locking operation after data changes is displayed. According to the method, system performance reduction caused by forced execution of all locking is avoided, and data locking is ensured on the premise that the system stability is maximized.

The present invention discloses a neutralizing anti-idiotypic antibody of an anti-D antibody, comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises at least one of HCDR1, HCDR2, and HCDR3 sequences, wherein: the amino acid sequence of the HCDR1 is shown in SEQ ID No. 1; the amino acid sequence of the HCDR2 is shown in SEQ ID No. 2; and the amino acid sequence of the HCDR3 is shown in SEQ ID No. 3. This neutralizing anti-idiotypic antibody has the ability to neutralize anti-D-mediated hemagglutination of red blood cells and can be used to detect mixed samples containing multiple blood type antibodies unexpectedly containing anti-D. It can also be used for risk assessment and clinical diagnosis and treatment of Rh-HDFN.

The invention discloses a blood type and microbiological detection data correlation analysis method based on a statistical model, and belongs to the technical field of medical treatment. Through data preprocessing and feature fusion, standardized processing and dimensionality reduction expression of blood type information and microbiological detection high-dimensional features are realized, and a joint feature matrix is constructed; an integrated Gaussian mixture network is adopted to carry out multi-level distribution modeling, and high-resolution clustering of microbial spectrums of different blood group populations is realized in combination with a category cascade discrimination mechanism. Further, a complex nonlinear relation between the blood type and the microorganism data is dynamically analyzed in a multi-scale space by utilizing a self-adaptive multi-scale correlation mining algorithm. Then, screening and analyzing key causal variable pairs of the blood type-microbiome through sparse regression and causal inference by adopting an interpretable correlation modeling and variable screening method; the accuracy and generalization ability of correlation analysis are improved, and accurate prediction and high-reliability risk judgment are realized.

The utility model discloses a blood scraping spoon for a blood type detection experiment, and belongs to the technical field of medical experiment equipment. The spoon comprises a rod body, a spoon body a and a spoon body b, the rod body is a long-strip-shaped cylinder, the spoon body a is fixed to one end of the rod body, the spoon body b is fixed to the other end of the rod body, and the rod body, the spoon body a and the spoon body b are of an integrated structure and are made of straw regeneration degradable materials; the spoon body a and the spoon body b are in small spoon shapes with thin-walled edges and are the same in structure, one ends, far away from the rod body, of the spoon body a and the spoon body b are linear, and openings of the spoon body a and the spoon body b face the same direction; the length of the rod body is 7 cm, the diameter of the rod body is 3-4 mm, and the inner diameter of the spoon body a and the inner diameter of the spoon body b are 4-5 mm. The rod body is divided into two identical parts, one part of the rod body and the spoon body a are light blue, and the other part of the rod body and the spoon body b are light yellow. According to the utility model, peripheral blood can be fully scraped, two antibodies can be effectively ensured not to be confused in the process of uniformly mixing the antibodies and the blood, and the correctness of a result is ensured.

1. The name of the design product: full-automatic blood type analyzer. 2. The use of the design product: using column agglutination method, together with the matching detection reagent, for ABO system blood type typing, Rh system blood type typing, irregular antibody screening, cross matching and direct anti-human globulin test on human blood samples in clinical application. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

To provide pluripotent cells including induced pluripotent stem cell, embryonic stem cells and hypo-immune pluripotent cells that are ABO blood type O Rhesus Factor negative and evade rejection resulting from blood type antigen mismatch.SOLUTION: Provided is a modified pluripotent cell or a cell derived therefrom where the cell is ABO blood type O Rhesus Factor negative (Rh-), and the cell has: (a) reduced or eliminated ABO blood type antigen selected from the group consisting of A1, A2 and B; and / or (b) reduced or eliminated expression of Rh protein antigen selected from the group consisting of Rh C antigen, Rh E antigen, Kell K antigen (KEL), Duffy (FY) Fya antigen, Duffy Fy3 antigen, Kidd(JK), Jkb antigen, MNS antigen U and MNS antigen S.SELECTED DRAWING: None

1. Name of the Design Product: Blood Type Detection Plate (Capsule Type). 2. Use of the Design Product: For detecting blood types. 3. Design Key Points of the Design Product: The combination of shape and pattern. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective view.

The present invention belongs to the field of biological detection technology, and provides a CD38 monoclonal antibody-MOFs composite biomaterial. The CD38 monoclonal antibody-MOFs composite biomaterial includes a core and a coating layer, wherein the core is a MOFs composite biomaterial, and the coating layer is a CD38 monoclonal antibody or an irregular blood type antibody. In the CD38 monoclonal antibody-MOFs composite biomaterial provided by the present invention, Zu-MOF as a host not only does not affect the antibody's ability to detect its corresponding antigen, but also can be stored for a long time, avoiding high temperature and biological damage. The use of the CD38 monoclonal antibody-MOFs composite biomaterial provided by the present invention helps to dissipate the agglutination caused by the interference of the CD38 monoclonal antibody and improve the accuracy of the blood matching results.

Provided are a primer and probe composition for cat blood type detection, a detection method, and use. The primer and probe composition for detecting the wild-types and the mutants of the above four sites is designed according to the single nucleotide polymorphism (SNP) mutation of genotyping of 179G>T, 268T>A, 364C>T and 1322delT four sites of a cat cytidine monophospho-N-acetylneuraminic acid (CMAH) gene; an amplification curve is plotted by utilizing a real-time fluorescence polymerase chain reaction (PCR) technology, and the recognition of bases of four SNP sites is achieved by analysis of the amplification curve, so as to determine cat blood types. The detection method of the present disclosure is carried out entirely in a closed space, thereby avoiding the problem of environmental aerosol pollution.

The application discloses a risk assessment system for cross matching difficulty, and relates to the technical field of clinical medical examination and blood transfusion management. The system comprises a data input module, a risk calculation module, a risk stratification module and a result output and suggestion module. The data input module obtains key information of a patient, including irregular red blood cell antibody screening results, multiple myeloma diagnosis, hematology department medical history, age of 60 years or older, pregnancy-related disease state and blood type identification difficulty; the risk calculation module adopts a preset scoring algorithm to assign weights to each factor and calculate a total risk score; the risk stratification module divides the patient into three grades of low risk, medium risk and high risk; and the result output module provides a differentiated clinical management path corresponding to the risk grade. The application realizes early warning of cross matching difficulty through quantitative assessment, can optimize the efficiency of the blood transfusion process and reduce clinical risk, has good prediction performance (AUC=0.819) and a high negative predictive value (93.7%).

The invention discloses a composite material based on a hollow mesoporous carbon sphere loaded ABO blood group monoclonal antibody, which comprises a hollow mesoporous carbon sphere and an ABO blood group monoclonal antibody loaded on the hollow mesoporous carbon sphere, and the ABO blood group monoclonal antibody is selected from at least one of an A-type antibody and a B-type antibody. The invention also discloses a preparation method of the composite material. The preparation method comprises the following steps: carrying out surface amino modification on the hollow mesoporous carbon spheres; dispersing in an ABO blood group monoclonal antibody solution, and stirring to react; the ABO blood group monoclonal antibody is fixed on the surface of the hollow mesoporous carbon sphere, so that the stability, the specificity and the sensitivity of the antibody are improved, and rapid and accurate ABO blood group identification is realized. The invention also discloses a kit comprising the composite material, and application of the composite material in detection of the ABO blood type.

A disposable blood typing device is provided for determining ABO and RhD blood types using binary logic-based interpretation. The device includes a sample application area, test zones containing dried anti-A, anti-B, and optionally anti-D reagents, and a result output mechanism configured to display a binary outcome for each antigen. Binary values are assigned based on visible agglutination reactions, which are processed through a logical mapping structure—such as a printed chart, mechanical indicator, or electronic logic circuit—to determine the corresponding blood type. The device may incorporate visual indicators, control regions, waste containment, and optional digital components for electronic display or wireless data transmission. Designed for single use, the system facilitates self-administered or point-of-care testing without requiring clinical expertise, and may be integrated with mobile applications or health records systems. The invention enhances test accuracy, usability, and data interoperability while minimizing contamination risk and interpretation error.

The present invention relates to a blood type auxiliary judgment method based on machine learning. The method analyzes the strong and weak agglutination areas of blood during the blood type detection process. The initial strong agglutination area upper limit, weak agglutination area interval, and non-agglutination area lower limit of the area enclosed by the blood strong agglutination standard circle, the blood weak agglutination standard circle, and the reaction hole boundary circle are used to analyze each blood sample to be detected in sequence. The complementary processing mode of area comparison and machine learning is executed. While continuously optimizing the agglutination detection model, the blanks between different types of agglutination area intervals are continuously filled and improved. Through the continuous mutual promotion between the two, the accuracy of blood type auxiliary judgment by the two methods of area comparison and machine learning is improved at the same time, the shortcomings of the prior art are overcome, and the working efficiency of blood type auxiliary judgment is effectively improved.

The present application relates to the technical field of biomedical equipment, and particularly provides a blood type detector, aiming to solve the problem of low automation degree of the existing blood type detector, resulting in poor user experience. To this end, the blood type detector comprises a shell, a feeding device and a sample filling device installed in the shell, the feeding device comprises a feeding mechanism and a fixing mechanism for carrying a blood collection tube, the feeding mechanism can move with the fixing mechanism and the blood collection tube fixed on the fixing mechanism to make the blood collection tube communicate with the sample filling device, the sample filling device can fill the blood sample in the blood collection tube into a reaction cup, and the feeding mechanism can also cooperate with the sample filling device to unload the blood collection tube on the fixing mechanism from the fixing mechanism. Through such a setting, the detector of the present application can automatically complete the feeding and unloading of the blood collection tube, thereby improving the automation degree of the detector.

The invention relates to a blood type auxiliary study and judgment method, which comprises the following steps: performing mixing, centrifugation and reaction treatment on a weak agglutination classified blood sample in blood type detection operation, performing precipitation on the sample, and analyzing the light transmittance to obtain the light transmittance variance of the sample and the reactivity and reaction acceleration of the reaction sample. And performing threshold comparison and judgment by combining a light transmission change rate upper limit calibration threshold, a light transmission change acceleration upper limit calibration threshold and a local turbidity gradient variance upper limit calibration threshold under dynamic adjustment of a temperature adjustment factor reflected by the real-time temperature, so as to determine the optimal precipitation time of the sample, effectively control the precipitation time to be too large, and simultaneously ensure the precipitation accuracy of the sample. It is guaranteed that the sample can fully react under the optimal precipitation duration, then the blood detection process is accurately controlled, blood type study and judgment are assisted, and the method has wide application prospects in practical application.

1. The material of the article to which this design relates is synthetic resin. 2. The article to which this design relates is a set of teaching tools that can be used to learn about ABO blood types and RhD blood types. 3. Teaching tool A represents red blood cells, teaching tool B represents type A antigens, teaching tool C represents type B antigens, teaching tool D represents RhD antigens, teaching tool E represents anti-type A antibodies, teaching tool F represents anti-type B antibodies, and teaching tool G represents anti-RhD antibodies. 4. The article to which this design relates is designed to easily explain the phenomenon of red blood cells and the antigens present on their surfaces reacting with antibodies in serum. 5. Reference Figures 1 to 3 show the product in use. Reference Figure 1 shows that when type B red blood cells are reacted with a type A person, the anti-B antibodies in the type A serum and the type B red blood cells agglutinate. Reference Figure 2 shows that when type A red blood cells are reacted with a type B person, the anti-A antibodies in the type B serum and the type A red blood cells agglutinate. Reference Figure 3 shows the RhD phenomenon, where red blood cells with RhD antigens on their surface agglutinate with anti-RhD antibodies.

The invention relates to a Sanger sequencing method primer group and a kit for human RHD blood group genotyping detection, and belongs to the field of biomedicine clinical molecular detection. The Sanger sequencing method primer group for human RHD blood type genotyping detection comprises a specific PCR (Polymerase Chain Reaction) amplification primer group, and the specific PCR amplification primer group comprises 9 pairs of amplification primers designed according to an RHD gene specific sequence; and the primer group also comprises 10 RHD specific sequencing primers corresponding to the amplification products. The RHD gene specific amplification primer has the following technical effects that the RHD gene specific amplification primer designed by adopting an ARMS combined homologous sequence specific base method is higher in specificity and accuracy; in cooperation with the RHD specific sequencing primer, the gene sequence of a sample to be detected is detected through a Sanger sequencing method, the RHD genotype is interpreted, and a new mutation point can be found. According to the kit disclosed by the invention, the identification results of the exons from the RHD blood group genes 1 to 10 can be obtained, so that the RHD genetic typing of an experimental sample can be accurately judged.

This invention provides a simple, rapid, low-cost, high-throughput, and accurate integrated solution that eliminates the need for nucleic acid extraction and purification. It enables targeted capture, amplification, and first-generation sequencing analysis of all key regions of the ABO gene directly from various clinical samples, including whole blood, saliva, oral swabs, and dried blood spots. The operation is simple and low-cost, thus achieving accurate ABO blood typing, subtype analysis, and the discovery of new variants. The method described in this invention can be applied to the identification of difficult blood types, and can discover new ABO alleles, blood group gene chimeras, and rare blood types such as subtype-related intron mutations.