78 results about "Group A - blood" patented technology

The invention discloses an intelligent intensive blood sampling management system based on a GPU, and belongs to the technical field of blood sampling management. The intelligent intensive blood sampling management system based on the GPU comprises a data acquisition unit and a data analysis unit. The problem that efficient management of the intensive blood sampling process is difficult to achieve in the prior art is solved, bar code and two-dimensional code information in the sample image can be rapidly and accurately recognized through the deep learning algorithm based on GPU acceleration, the sample information extraction speed and accuracy are improved, and the efficiency of blood sampling is improved. The trained deep learning model is used for analyzing the sample images, blood types and detection items can be automatically identified, errors caused by manual judgment are effectively avoided, samples are accurately classified according to the analysis result, the sample processing efficiency is improved, an automatic sorting device is accurately controlled according to the classification result, and the sorting efficiency is improved. And the sample test tubes are conveyed to designated positions, so that manual intervention is reduced, and meanwhile, the sorting accuracy and efficiency are improved.

This invention discloses a method for preparing A, B, and Lewis blood group antigens, wherein the A, B, and Lewis blood group antigens are specifically blood group A. tri Antigen, B tri Antigen, Le a Antigen and Le b Antigen. A one-pot photosensitive method was used to achieve blood group A. tri Antigen, B tri Antigen, Le a Antigen and Le b The method for obtaining large quantities of antigens, as described in this invention, features mild reaction conditions, shortened purification steps, simplicity, high efficiency, environmental friendliness, low cost, and high yield and purity of the target substance. This invention provides a practical and rapid chemical synthesis route for blood type A antigens. tri Antigen, B tri Antigen, Le a Antigen and Le b Antigens provide tools for the development of norovirus vaccines and related antibodies, and therefore have great application prospects.

The present application relates to the technical field of biomedical equipment, and particularly provides a blood type detector and a shaking and mixing device of the blood type detector, aiming to solve the problem that the mixing effect of blood samples and detection reagents of the existing blood type detector is poor, thereby affecting the detection result. To this end, the shaking and mixing device comprises a shaking and mixing mechanism and a cup loading component mounted on the shaking and mixing mechanism, the cup loading component is used for loading a reaction cup, and the shaking and mixing mechanism can vibrate with the cup loading component and the reaction cup in the cup loading component to mix the blood sample and the detection reagent in the reaction cup. By arranging the cup loading component on the shaking and mixing mechanism, the reaction cup can be directly fixed on the shaking and mixing mechanism, so that the vibration generated by the shaking and mixing mechanism can be better transmitted to the reaction cup, thereby improving the mixing effect of the blood sample and the detection reagent in the reaction cup, and further improving the accuracy of the detector.

The invention relates to the technical field of science popularization teaching aids, in particular to a blood type measuring science popularization teaching aid and a use method thereof, and the blood type measuring science popularization teaching aid comprises an operation table, a display screen, an A blood type typing resisting reagent area, a B blood type typing resisting reagent area and an extraction assembly; the extraction assembly comprises four blood simulation discs, four positioning bodies, a supporting driving mechanism, a rotating shaft, a rotating disc, four rebound mechanisms and four positioning mechanisms; the four blood simulation discs with the four positioning bodies are respectively inserted into the four slots and are respectively fixed by matching the positioning mechanisms with the positioning bodies; the support driving mechanism drives the rotating shaft to rotate and drives the turntable to rotate; after the rotating disc rotates for a plurality of circles, one blood simulation disc is randomly selected, the positioning mechanism of the blood simulation disc is loosened, the corresponding rebound mechanism pushes out a part of the blood simulation disc and the positioning body, and then the blood simulation disc and the positioning body are taken out together, so that the blood simulation disc can be randomly drawn, and the authenticity and challenge of an experiment are improved.

1. The name of this design product: Blood type test card. 2. Purpose of this design product: This design product is a test card used to detect the blood type of humans or animals. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The utility model relates to a simple and easy device for detecting human blood type, including flushing liquid containing container, detection subassembly and liquid suction piece, flushing liquid containing container has the containing cavity that contains flushing liquid, and containing cavity has top opening to allow detection subassembly inserts containing cavity, and containing cavity inboard wall is provided with first limit piece, the antibody for blood type detection is fixed in detection subassembly, the antibody can be combined with blood type antigen specificity, detection subassembly has first end and second end, liquid suction piece detachably fixed in second end of detection subassembly, detection subassembly outside wall is provided with second limit piece, wherein, when first end of detection subassembly inserts containing cavity, first limit piece and second limit piece cooperate and form longitudinal limit to fix detection subassembly in containing cavity, the utility model has the characteristics of simple operation, high accuracy, fast detection.

The invention discloses a risk assessment system for difficulty in cross matching of blood, and relates to the technical field of clinical medical examination and blood transfusion management. The system comprises a data input module, a risk calculation module, a risk layering module and a result output and suggestion module. The data input module obtains key information of a patient, wherein the key information comprises an erythrocyte irregular antibody screening result, multiple myeloma diagnosis, hematology department medical history, age of more than or equal to 60 years, pregnancy-related disease state and blood type identification difficulty; the risk calculation module adopts a preset scoring algorithm to endow each factor with a weight and calculates a total risk score; the risk layering module divides the patients into three levels of low risk, medium risk and high risk; and the result output module provides differentiated clinical management paths corresponding to the risk levels. According to the method, early warning of difficulty in cross matching of blood is achieved through quantitative evaluation, blood transfusion process efficiency can be optimized, clinical risks can be reduced, and the method has good prediction performance (AUC = 0.819) and a high negative prediction value (93.7%).

The invention provides a freeze-dried universal platelet rich plasma (PRP) preparation and a preparation process thereof, aiming at solving the problems that the existing PRP is limited in blood type matching, difficult in biological activity preservation, short in validity period and the like. According to the preparation, 18-19% of the type A, 7-8% of the type B and 73-74% of the type AB are mixed with PRP of different blood types and freeze-dried. Tests show that agglutination does not exist in cross blood matching, the titers of the anti-A antibody and the anti-B antibody are both lower than 1: 2, and blood group reaction is effectively avoided. Freeze-drying causes little damage to growth factors, still has biological activity within 24 months, and has a good cell proliferation test effect. Animal experiments show that wound healing can be remarkably promoted. In addition, the culture medium is good in stability in the environment of 4 DEG C, and the moisture, growth factors and the sterile state all meet the requirements. The preparation disclosed by the invention has the advantages of obvious universal advantages, good biological activity preservation and strong stability, and provides a better choice for clinical treatment.

The invention aims to provide a gene identification method for an A-type variant blood group in an ABO blood group system, namely, a screening method for the A-type variant blood group is established on the basis that an SNP site which can cause wrong typing of the ABO blood group is obtained through screening. The SNP sites are located at 188-190 sites of an A subtype gene with a nucleotide sequence of SEQ ID NO: 1, and are A deletion. The invention provides a new application of ABO blood type A variant gene detection, thereby providing a gene diagnosis, prenatal gene screening and genetic counseling approach for effectively avoiding blood type error typing and acute hemolytic transfusion reaction. The application effect shows that the SNP site of the gene and the detection primer provided by the invention can be effectively used for rapid detection of the ABO blood type A variant gene mutation site in peripheral blood of a clinical patient.

The present invention discloses a neutralizing anti-idiotypic antibody of an anti-D antibody, comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises at least one of HCDR1, HCDR2, and HCDR3 sequences, wherein: the amino acid sequence of the HCDR1 is shown in SEQ ID No. 1; the amino acid sequence of the HCDR2 is shown in SEQ ID No. 2; and the amino acid sequence of the HCDR3 is shown in SEQ ID No. 3. This neutralizing anti-idiotypic antibody has the ability to neutralize anti-D-mediated hemagglutination of red blood cells and can be used to detect mixed samples containing multiple blood type antibodies unexpectedly containing anti-D. It can also be used for risk assessment and clinical diagnosis and treatment of Rh-HDFN.

The invention discloses a blood type and microbiological detection data correlation analysis method based on a statistical model, and belongs to the technical field of medical treatment. Through data preprocessing and feature fusion, standardized processing and dimensionality reduction expression of blood type information and microbiological detection high-dimensional features are realized, and a joint feature matrix is constructed; an integrated Gaussian mixture network is adopted to carry out multi-level distribution modeling, and high-resolution clustering of microbial spectrums of different blood group populations is realized in combination with a category cascade discrimination mechanism. Further, a complex nonlinear relation between the blood type and the microorganism data is dynamically analyzed in a multi-scale space by utilizing a self-adaptive multi-scale correlation mining algorithm. Then, screening and analyzing key causal variable pairs of the blood type-microbiome through sparse regression and causal inference by adopting an interpretable correlation modeling and variable screening method; the accuracy and generalization ability of correlation analysis are improved, and accurate prediction and high-reliability risk judgment are realized.

The utility model discloses a blood scraping spoon for a blood type detection experiment, and belongs to the technical field of medical experiment equipment. The spoon comprises a rod body, a spoon body a and a spoon body b, the rod body is a long-strip-shaped cylinder, the spoon body a is fixed to one end of the rod body, the spoon body b is fixed to the other end of the rod body, and the rod body, the spoon body a and the spoon body b are of an integrated structure and are made of straw regeneration degradable materials; the spoon body a and the spoon body b are in small spoon shapes with thin-walled edges and are the same in structure, one ends, far away from the rod body, of the spoon body a and the spoon body b are linear, and openings of the spoon body a and the spoon body b face the same direction; the length of the rod body is 7 cm, the diameter of the rod body is 3-4 mm, and the inner diameter of the spoon body a and the inner diameter of the spoon body b are 4-5 mm. The rod body is divided into two identical parts, one part of the rod body and the spoon body a are light blue, and the other part of the rod body and the spoon body b are light yellow. According to the utility model, peripheral blood can be fully scraped, two antibodies can be effectively ensured not to be confused in the process of uniformly mixing the antibodies and the blood, and the correctness of a result is ensured.

1. The name of the design product: full-automatic blood type analyzer. 2. The use of the design product: using column agglutination method, together with the matching detection reagent, for ABO system blood type typing, Rh system blood type typing, irregular antibody screening, cross matching and direct anti-human globulin test on human blood samples in clinical application. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

To provide pluripotent cells including induced pluripotent stem cell, embryonic stem cells and hypo-immune pluripotent cells that are ABO blood type O Rhesus Factor negative and evade rejection resulting from blood type antigen mismatch.SOLUTION: Provided is a modified pluripotent cell or a cell derived therefrom where the cell is ABO blood type O Rhesus Factor negative (Rh-), and the cell has: (a) reduced or eliminated ABO blood type antigen selected from the group consisting of A1, A2 and B; and / or (b) reduced or eliminated expression of Rh protein antigen selected from the group consisting of Rh C antigen, Rh E antigen, Kell K antigen (KEL), Duffy (FY) Fya antigen, Duffy Fy3 antigen, Kidd(JK), Jkb antigen, MNS antigen U and MNS antigen S.SELECTED DRAWING: None

The application discloses a risk assessment system for cross matching difficulty, and relates to the technical field of clinical medical examination and blood transfusion management. The system comprises a data input module, a risk calculation module, a risk stratification module and a result output and suggestion module. The data input module obtains key information of a patient, including irregular red blood cell antibody screening results, multiple myeloma diagnosis, hematology department medical history, age of 60 years or older, pregnancy-related disease state and blood type identification difficulty; the risk calculation module adopts a preset scoring algorithm to assign weights to each factor and calculate a total risk score; the risk stratification module divides the patient into three grades of low risk, medium risk and high risk; and the result output module provides a differentiated clinical management path corresponding to the risk grade. The application realizes early warning of cross matching difficulty through quantitative assessment, can optimize the efficiency of the blood transfusion process and reduce clinical risk, has good prediction performance (AUC=0.819) and a high negative predictive value (93.7%).

The invention discloses a composite material based on a hollow mesoporous carbon sphere loaded ABO blood group monoclonal antibody, which comprises a hollow mesoporous carbon sphere and an ABO blood group monoclonal antibody loaded on the hollow mesoporous carbon sphere, and the ABO blood group monoclonal antibody is selected from at least one of an A-type antibody and a B-type antibody. The invention also discloses a preparation method of the composite material. The preparation method comprises the following steps: carrying out surface amino modification on the hollow mesoporous carbon spheres; dispersing in an ABO blood group monoclonal antibody solution, and stirring to react; the ABO blood group monoclonal antibody is fixed on the surface of the hollow mesoporous carbon sphere, so that the stability, the specificity and the sensitivity of the antibody are improved, and rapid and accurate ABO blood group identification is realized. The invention also discloses a kit comprising the composite material, and application of the composite material in detection of the ABO blood type.

A disposable blood typing device is provided for determining ABO and RhD blood types using binary logic-based interpretation. The device includes a sample application area, test zones containing dried anti-A, anti-B, and optionally anti-D reagents, and a result output mechanism configured to display a binary outcome for each antigen. Binary values are assigned based on visible agglutination reactions, which are processed through a logical mapping structure—such as a printed chart, mechanical indicator, or electronic logic circuit—to determine the corresponding blood type. The device may incorporate visual indicators, control regions, waste containment, and optional digital components for electronic display or wireless data transmission. Designed for single use, the system facilitates self-administered or point-of-care testing without requiring clinical expertise, and may be integrated with mobile applications or health records systems. The invention enhances test accuracy, usability, and data interoperability while minimizing contamination risk and interpretation error.

The present application relates to the technical field of biomedical equipment, and particularly provides a blood type detector, aiming to solve the problem of low automation degree of the existing blood type detector, resulting in poor user experience. To this end, the blood type detector comprises a shell, a feeding device and a sample filling device installed in the shell, the feeding device comprises a feeding mechanism and a fixing mechanism for carrying a blood collection tube, the feeding mechanism can move with the fixing mechanism and the blood collection tube fixed on the fixing mechanism to make the blood collection tube communicate with the sample filling device, the sample filling device can fill the blood sample in the blood collection tube into a reaction cup, and the feeding mechanism can also cooperate with the sample filling device to unload the blood collection tube on the fixing mechanism from the fixing mechanism. Through such a setting, the detector of the present application can automatically complete the feeding and unloading of the blood collection tube, thereby improving the automation degree of the detector.

The invention relates to a blood type auxiliary study and judgment method, which comprises the following steps: performing mixing, centrifugation and reaction treatment on a weak agglutination classified blood sample in blood type detection operation, performing precipitation on the sample, and analyzing the light transmittance to obtain the light transmittance variance of the sample and the reactivity and reaction acceleration of the reaction sample. And performing threshold comparison and judgment by combining a light transmission change rate upper limit calibration threshold, a light transmission change acceleration upper limit calibration threshold and a local turbidity gradient variance upper limit calibration threshold under dynamic adjustment of a temperature adjustment factor reflected by the real-time temperature, so as to determine the optimal precipitation time of the sample, effectively control the precipitation time to be too large, and simultaneously ensure the precipitation accuracy of the sample. It is guaranteed that the sample can fully react under the optimal precipitation duration, then the blood detection process is accurately controlled, blood type study and judgment are assisted, and the method has wide application prospects in practical application.

1. The material of the article to which this design relates is synthetic resin. 2. The article to which this design relates is a set of teaching tools that can be used to learn about ABO blood types and RhD blood types. 3. Teaching tool A represents red blood cells, teaching tool B represents type A antigens, teaching tool C represents type B antigens, teaching tool D represents RhD antigens, teaching tool E represents anti-type A antibodies, teaching tool F represents anti-type B antibodies, and teaching tool G represents anti-RhD antibodies. 4. The article to which this design relates is designed to easily explain the phenomenon of red blood cells and the antigens present on their surfaces reacting with antibodies in serum. 5. Reference Figures 1 to 3 show the product in use. Reference Figure 1 shows that when type B red blood cells are reacted with a type A person, the anti-B antibodies in the type A serum and the type B red blood cells agglutinate. Reference Figure 2 shows that when type A red blood cells are reacted with a type B person, the anti-A antibodies in the type B serum and the type A red blood cells agglutinate. Reference Figure 3 shows the RhD phenomenon, where red blood cells with RhD antigens on their surface agglutinate with anti-RhD antibodies.

This invention provides a simple, rapid, low-cost, high-throughput, and accurate integrated solution that eliminates the need for nucleic acid extraction and purification. It enables targeted capture, amplification, and first-generation sequencing analysis of all key regions of the ABO gene directly from various clinical samples, including whole blood, saliva, oral swabs, and dried blood spots. The operation is simple and low-cost, thus achieving accurate ABO blood typing, subtype analysis, and the discovery of new variants. The method described in this invention can be applied to the identification of difficult blood types, and can discover new ABO alleles, blood group gene chimeras, and rare blood types such as subtype-related intron mutations.

The invention discloses a preparation method of a neonatal ABO hemolytic disease detection simulation specimen in blood transfusion medicine teaching, which comprises the following steps: a, collecting blood plasma or serum of healthy people, and absorbing IgM anti-A, anti-B and anti-AB; b, separating the absorbed plasma or serum, and taking the upper-layer plasma or serum for later use; c, sensitizing corresponding blood type red blood cells, namely absorbing IgG anti-A or anti-B by the A type or B type red blood cells, and preparing a simulation specimen; and d, preserving the specimen. The method disclosed by the invention is simple to operate, and the prepared specimen is a simulated specimen and is used for detecting the neonatal ABO hemolytic disease as an experimental content in blood transfusion medical experiment teaching. The use of the simulation specimen is convenient for students to learn and understand the experiment operation technology in blood transfusion medical experiment teaching, solves the problem that the newborn ABO hemolytic disease detection specimen is not easy to obtain, and meets the requirements of blood transfusion medical experiment teaching.

The invention provides a multi-hospital red blood cell transport decision-making method fused with a blood type substitution rule, and relates to the technical field of red blood cell transport decision-making. The method comprises the following steps: firstly, establishing a real-time inventory database of all hospitals in a target area; secondly, erythrocyte shortage hospitals are detected, and candidate erythrocyte transport hospitals and candidate transport blood types thereof are screened; taking blood type substitution, library age, transfer cost and shortage punishment as comprehensive optimization objectives to construct a multi-hospital transfer decision model; and finally, solving the multi-hospital transport decision model, and determining a final erythrocyte transport hospital, a transport blood type thereof and an erythrocyte transport amount. Transfer cooperation among multiple hospitals in a region is enhanced, idle red blood cells are transferred across hospitals, and red blood cell bank age and blood type substitution rules are brought into a transfer decision, so that the range of red blood cells capable of participating in transfer is enlarged, the red blood cell shortage phenomenon is effectively inhibited, red blood cell resources are fully utilized, and particularly, the use amount of red blood cells with relatively large bank age is greatly increased; and resource waste is reduced.

The invention relates to the technical field of inventory management, in particular to a blood inventory intelligent management system which comprises a blood type compatibility screening module, an inventory replacement judgment module, a blocking path recognition module, a reservoir migration triggering module and a unit regulation and control sequencing module. According to the method, through linkage screening of compatible blood types and remaining storage duration, preferential aggregation distribution of immediate blood in a stock is realized, the use timeliness control capability is enhanced, an alternative allocation path identification mechanism between the blood types is established in combination with a stock difference value and a tolerance threshold value, the allocation flexibility and adaptability are improved, allocation path blocking judgment is introduced, and the allocation efficiency is improved. A high-risk path boundary is defined, the resource mismatching risk is reduced, migration units are screened based on double conditions of storage duration and reservoir capacity proportion, the space utilization rate and the recognition precision of immediate units are improved, the migration process is controlled through warehousing time sorting, and the reservoir reconstruction rhythm is optimized. Accurate identification of inventory distribution, reasonable screening of path combination and efficient updating of the reservoir are realized.

This invention relates to the field of biological detection, and in particular to an IgM antibody for preventing erythrocyte agglutination, its preparation method, and its uses. The IgM antibody for preventing erythrocyte agglutination is obtained by mixing and incubating a natural IgM antibody with DTT. The IgM antibody can be used to prepare products for detecting ABO blood types and products for detecting the expression levels of type A antigen and / or type B antigen. The prepared products can be used for quantitative detection of ABO antigen expression, studying changes in ABO antigen expression levels among different genotypes, and studying diseases related to ABO antigen expression levels.

The invention discloses a blood group reagent quality control kit and application thereof, the blood group reagent quality control kit comprises a plurality of independently subpackaged composite quality control products, and each quality control product simultaneously comprises quality control red blood cells with known antigen spectra and quality control plasma with known antibody spectra; the quality control red blood cells are human red blood cells with known ABO blood type, RhD blood type and Rh haplotype; the quality control plasma contains blood group antibodies with known specificity and immune globulin types, and the blood group antibodies comprise IgM antibodies and / or IgG antibodies. The invention also discloses application of the blood group reagent quality control kit in indoor quality control of blood group serology detection and an indoor quality control method of blood group serology detection. The kit provided by the invention can realize integrated and efficient detection, and synchronously complete indoor quality control of a plurality of core items such as blood type identification, antibody screening, cross matching of blood and the like.

The present invention relates to bacteria and metabolites thereof that are capable of binding to A, B and / or O blood type antigens or which are acid and / or bile tolerant, their use in probiotic compositions and food products, and methods for their selection. The invention also relates to the use of said bacteria and metabolites for the prevention and / or treatment of gastrointestinal disorders.

The invention relates to the technical field of blood collection devices, and particularly discloses a blood collection device for blood type detection, which comprises a box body, an automatic blood collection device, a power supply module and a tablet computer. The automatic blood collection device is arranged on the lower portion of the box body, an opening is formed in the middle of the box body, the bottom face of the box body is inclined upwards, the power supply module is arranged on the upper portion of the box body, and the tablet computer is assembled on the top face of the box body. And the working part of the circulating jacking mechanism is vertical to the bottom surface of the opening and faces the bottom surface. The bottom surface of the opening is provided with a collecting hole for the capillary needle tube to penetrate through, the two supplementing units are arranged corresponding to the circulating jacking mechanism and respectively push the capillary needle tube and the liquid collecting cup to the working part, and the circulating jacking mechanism is matched with the two supplementing units, can jack the liquid collecting cup and is assembled with the liquid collecting cup in a clamping manner, and drives the assembly body to move towards the collecting hole, so that the collecting end of the capillary needle tube penetrates through the collecting hole. The purposes of reducing the manual labor intensity of blood type detection and improving the blood sample collection efficiency are achieved.

The invention discloses a big data processing-based non-repayment blood donation recruitment method and system, and the method comprises the steps: obtaining blood station blood type inventory data, clinical blood use prediction data and regional blood type distribution data, and generating target blood donation amount sets of different blood types; collecting historical blood donor data; on the basis of the target blood donation amount set and historical blood donor data, an adaptive value of each blood donor is calculated through a blood donor priority scoring model, and the adaptive values are used for screening a target blood donor group; screening out a target blood donation point set based on a traffic time minimization principle according to the residential address distribution information of the target blood donor group and the plurality of candidate blood donation points; and generating a blood donation recruitment scheme based on the target blood donation point set and the historical recruitment mode response data of the target blood donor group. According to the invention, the problems of low blood donor screening efficiency, unreasonable blood donation point layout, homogenization of recruitment modes and the like in a traditional system are effectively solved, and the intelligent level and resource matching precision of blood recruitment are remarkably improved.

The invention relates to a primer group for MNS blood type genotyping detection, a kit and application, and belongs to the field of biomedicine clinical molecular detection. The primer group comprises one pair of amplification primers designed according to a GYPA gene specific sequence and five sequencing primers, and one pair of amplification primers designed according to a GYPB gene specific sequence and five sequencing primers. The specific amplification primer can be used for accurately and specifically amplifying the GYPA and the GYPB respectively, and the specific sequencing primer can be used for carrying out high-resolution sequencing reaction on the GYPA and GYPB gene subtypes. The invention has the following technical effects: the specificity of the GYPA and GYPB gene specific amplification primers designed by adopting a mismatch and double specific base combination method is high, and the GYPA and GYPB gene subtypes can be accurately distinguished by matching with the specific sequencing primers provided by the invention. The kit provided by the invention can be used for accurately judging the MNS blood type genetic typing of an experimental sample. The method is quick and simple to operate and low in cost, and has wide application prospect and clinical reference value.