Biomarker for forecasting severe drug-induced cutaneous adverse reaction of child patient and application

Abstract

The invention discloses a biomarker for forecasting severe drug-induced cutaneous adverse reaction of a child patient and an application. The biomarker is capable of forecasting the risk of severe cutaneous adverse reaction of the child patient using beta-lactam antibiotics such as penicillin, cephalosporin, carbamazepine, lamotrigine, oxcarbazepine, phenytoin, allopurinol, nevirapine, abacavir, methazolamide and dapsone.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to biomarkers and applications for predicting severe drug-induced skin adverse reactions in children. Background technique [0002] Adverse cutaneous drug reaction (ACDRs) refers to the general term for skin pathological changes caused by a variety of drugs, herbal medicines or other chemicals, and its clinical manifestations are similar to other skin diseases, among which maculopapular rash accounts for 90% of CARs. %, urticaria and severe cutaneous adverse drug reactions (severe cutaneous adverse drug reactions, SCARs) accounted for 2% of all ACDRs. ACDRs are the most common adverse drug reactions, accounting for 18%-20% of adverse drug reactions. ACDRs can be divided into type A drug skin adverse reactions and type B drug skin adverse reactions. The former is related to the mechanism of action of the drug and is usually dose-dependent and predictable; the latter is gener...

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Problems solved by technology

However, most of these studies are carried out in adults, and adults are affected by factors such as dietary habits (such as smoking, drinking, high-fat diet, etc.), comorbidities (such as diabetes, etc.), making the prediction of genetic polymorphisms on adult SCARs limited ability

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