Biomarker for forecasting severe drug-induced cutaneous adverse reaction of child patient and application

A biomarker and adverse reaction technology, applied in the field of biomarkers to predict severe drug-induced skin adverse reactions in children, can solve the problems of limited predictive ability of adult SCARs

Inactive Publication Date: 2016-12-07
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Abstract
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Problems solved by technology

However, most of these studies are carried out in adults, and adults are affected by factors such as dietary habits (such as smoking, drink...

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  • Biomarker for forecasting severe drug-induced cutaneous adverse reaction of child patient and application

Examples

Experimental program
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Effect test

Embodiment Construction

[0015] 1. Collect peripheral venous blood samples or oral exfoliated cells.

[0016] 2. Genomic DNA extraction.

[0017] 3. For different drugs β-lactam antibiotics (penicillin, cephalosporin), carbamazepine, lamotrigine, oxcarbazepine, phenytoin, allopurinol, nevirapine, abacavir, methazolamide, Dapsone selects different genetic testing kits.

[0018] (1) β-lactam antibiotics (penicillins, cephalosporins): including IL-13R130Q, IL-4RA I50V, IL-4RA S478P, IL-4RA Q551R, IL-13 1055C>T, IL-13 1055C>T , IL-4RA Q551R, IL-4RαIle75Val, IL-10-819C>T, IL-10-592C>A, IL-4RαQ576R AA, IL-4RαI75V AA, IL-4RαQ576 / I75, IL-18-607A / C, A genetic detection kit for one or more combinations or haplotypes in IL-18-137G / C polymorphism.

[0019] (2) Carbamazepine: a genetic detection kit containing one or more combinations or haplotypes of HLA-B*15:02, HLA-B*15:11, and HLA-A*31:01 polymorphisms .

[0020] (3) Lamotrigine: including HLA-B*4403, HLA-B*15:02, HLA-A*6801, HLA-B*5801, HLA-C*0718, HLA-D...

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Abstract

The invention discloses a biomarker for forecasting severe drug-induced cutaneous adverse reaction of a child patient and an application. The biomarker is capable of forecasting the risk of severe cutaneous adverse reaction of the child patient using beta-lactam antibiotics such as penicillin, cephalosporin, carbamazepine, lamotrigine, oxcarbazepine, phenytoin, allopurinol, nevirapine, abacavir, methazolamide and dapsone.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to biomarkers and applications for predicting severe drug-induced skin adverse reactions in children. Background technique [0002] Adverse cutaneous drug reaction (ACDRs) refers to the general term for skin pathological changes caused by a variety of drugs, herbal medicines or other chemicals, and its clinical manifestations are similar to other skin diseases, among which maculopapular rash accounts for 90% of CARs. %, urticaria and severe cutaneous adverse drug reactions (severe cutaneous adverse drug reactions, SCARs) accounted for 2% of all ACDRs. ACDRs are the most common adverse drug reactions, accounting for 18%-20% of adverse drug reactions. ACDRs can be divided into type A drug skin adverse reactions and type B drug skin adverse reactions. The former is related to the mechanism of action of the drug and is usually dose-dependent and predictable; the latter is gener...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/156C12Q2600/172
Inventor 阳国平马婉乐郭成贤项玉霞黄洁袁洪
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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