A kind of lopinavir and ritonavir compound high homogeneity nano co-dispersion and preparation method thereof

Abstract

The invention provides a lopinavir and ritonavir compound high-uniformity nano co-dispersion body. The lopinavir and ritonavir compound high-uniformity nano co-dispersion body consists of lopinavir and ritonavir which are taken as active ingredients, a dispersing aid, an anti-agglormeration material, a dispersing stabilizer, a dispersion supporter and a lubricant. The lopinavir and ritonavir which are taken as active ingredients account for 25%-60%. The lopinavir and ritonavir compound high-uniformity nano co-dispersion body prepared by the preparation method disclosed by the invention can be prepared into a single-dose preparation according to a normal method. According to a dissolution rate experiment, the preparation disclosed by the invention has release amount of 40%-80% within 30 minutes. The preparation prepared by the dispersion body disclosed by the invention is high in dissolution rate, and can be used for improving the bioavailability. The lopinavir and ritonavir compound high-uniformity nano co-dispersion body prepared by the preparation method disclosed by the invention satisfies and is superior to mixing uniformity standards. The preparation method disclosed by the invention is simple and easy to implement, can be used for popularizing application of a nano mechanical grinding technology on the pharmaceutical industry and promoting the development of the technology, and is suitable for industrial production and greater in application value.

Description

technical field

[0001] The invention relates to pharmaceutical preparations, in particular to a high-uniformity nanometer co-dispersion, in particular to a compound high-uniformity nanometer co-dispersion of lopinavir and ritonavir and a preparation method thereof. Background technique

[0002] According to reports, about 40% of the active substances that play the main pharmacological activity in drugs are insoluble in water. Poorly water-soluble drug (poorly water-soluble drug) is difficult to be absorbed by the body due to its low solubility in water, and the elimination speed in the body is relatively fast, and the bioavailability is poor. At present, it is more and more difficult to find drugs with new chemical structures, and even if new candidate drugs are found, about 40% of the candidate drugs cannot be marketed due to the defect of poor water solubility. According to reports, it is estimated that about 65 billion US dollars of drugs are produced globally every year...

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