Oral suspension preparation containing lopinavir and ritonavir

Abstract

The invention provides a compound oral suspension containing lopinavir and ritonavir and a preparation method thereof. The oral suspension comprises lopinavir and ritonavir active ingredients and pharmaceutically acceptable auxiliary materials. The lopinavir and ritonavir compound oral suspension provided by the invention is stable in quality, cannot be settled and caked after storing for a long period of time, can be quickly and evenly dispersed after shaking, and has good taste, and good patient compliance. The lopinavir and ritonavir compound oral suspension provided by the invention has high dissolution rate and improvement on bioavailability. The preparation provided by the invention is simple in preparation method and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound oral suspension containing lopinavir and ritonavir and a preparation method thereof. Background technique [0002] Human immunodeficiency virus (HIV) is a pathogenic retrovirus and the causative agent of acquired immunodeficiency syndrome (AIDS) and related disorders. In 2011, there were more than 34 million HIV-infected patients worldwide, of which 2.5 million were newly added, and 1.7 million died of related diseases. According to data from the Ministry of Health of my country, the number of AIDS cases in my country reached 20,450 in 2011, a year-on-year increase of 27.96%, and the number of deaths was 9,224, a year-on-year increase of 19.13%. [0003] At present, the design of anti-HIV drugs mainly targets three key enzymes in the HIV replication cycle, namely reverse transcriptase, protease, integrase, and HIV invasion process. According to the differen...

AI Technical Summary

Problems solved by technology

At present, the patents applied in China mainly involve solid preparations, and only the patent application number CN103655571A discloses a compound high-uniformity nano-co-dispersion containing lopinavir and ritonavir, but the process is relatively complicated and requires equipment. Higher, it is necessary to use a nano-dispersion grinder to grind the sample to the nanometer level, which is not conducive to industrial production

The present invention has developed an oral suspension with a simple preparation process. Compared with solid preparations, the oral suspension preparation has fast drug absorption, rapid onset of effect, and is convenient for patients to take. However, due to its complex drug components, each raw material There are interactions between materials and excipients, the stability of the drug is not good, and it will have a negative impact on the stability of the drug in the solution state

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