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Safflower lyochrome rich in carthamin A, its preparing process, its preparation and its medical usage

A technology of safflower yellow and safflower, which is applied in the field of safflower yellow and its preparation, can solve the problem of low content of safflower A, and achieve the effects of improving drug efficacy, strong industrial applicability, and simple steps

Inactive Publication Date: 2002-09-11
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although CN1272500A also discloses a kind of safflower yellow and its extraction method and its application for treating or preventing various cardiovascular and cerebrovascular diseases, we found that the safflower yellow prepared by the extraction method described in this invention is The content of safflower glycoside A in the

Method used

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  • Safflower lyochrome rich in carthamin A, its preparing process, its preparation and its medical usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take red peanut medicine, add water 10-15 times its weight, boil for 90 minutes, filter, concentrate the filtrate under reduced pressure to a relative density of 1.12, add ethanol to 80% alcohol content, precipitate at 4°C for 24 hours, filter, filtrate filtrate Concentrate to a relative density of 1.15, add 10 times the amount of water, precipitate at 4°C for 12 hours, centrifuge, take the supernatant, absorb it with 30% by weight D101 macroporous adsorption resin, eluate 2 columns with deionized water Volume, and then continue to elute with deionized water for 4 column volumes, collect the eluate, absorb it with 5% by weight of polyamide, first wash with deionized water until colorless, and then wash with 95% ethanol for 8 column volumes , Collect the eluate, concentrate on a rotary evaporator to remove ethanol, freeze-dry to obtain safflower yellow, and measure the content of safflower glycoside A in 85%.

Embodiment 2

[0023] Take red peanut medicine, add water 10-15 times its weight, boil for 70 minutes, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.20, add ethanol to 80% alcohol content, precipitate at 4°C for 24 hours, filter, and filtrate filtrate Concentrate to a relative density of 1.10, add 10 times the amount of water, precipitate at 4°C for 24 hours, centrifuge, take the supernatant, absorb it with 40% by weight D101 macroporous adsorption resin, eluate 3 columns with deionized water Volume, and then continue to elute with deionized water for 5 column volumes, collect the eluate, absorb it with 10% by weight of polyamide, first wash with deionized water until colorless, and then wash with 95% ethanol for 8 column volumes , Collect the eluate, concentrate on a rotary evaporator to remove ethanol, freeze-dry to obtain safflower yellow, and the content of safflower glycoside A is determined to be 90%.

Embodiment 3

[0025] Take red peanut medicine, add water 10-15 times its weight, boil for 50 minutes, filter, concentrate the filtrate under reduced pressure to a relative density of 1.25, add ethanol to 80% alcohol content, precipitate at 4°C for 24 hours, filter, filtrate filtrate Concentrate to a relative density of 1.20, add 10 times the amount of water, precipitate at 4°C for 24 hours, centrifuge, take the supernatant, absorb it with 40% by weight D101 macroporous adsorption resin, and eluate 3 columns with deionized water Volume, and then continue to elute with deionized water for 5 column volumes, collect the eluate, absorb it with 10% by weight of polyamide, first wash with deionized water until colorless, and then wash with 95% ethanol for 8 column volumes , Collect the eluate, concentrate on a rotary evaporator to remove the ethanol, freeze-dry to obtain safflower yellow, and the content of safflower glycoside A is determined to be 98%.

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Abstract

A safflower lyochrome rich is carthamin A (80-100%) and its preparing process and application to preparation of medicines to prevent and cure cardiovascular and cerebrovascular ischemia, and its medicines and preparing process are also disclosed.

Description

Technical field [0001] The present invention relates to a safflower yellow pigment rich in safflower glycoside A and a preparation method thereof. The present invention also relates to the use of the safflower yellow pigment as an effective ingredient to prepare a medicine for treating cardiac and cerebral ischemia diseases. In addition, the present invention also It relates to pharmaceutical preparations containing the safflower yellow pigment and their preparation methods. Background technique [0002] Carthamus tinctorius is the dried flower of Carthamus tinctorius L., a common Chinese medicine for activating blood and removing blood stasis. Carthamus yellow is a water-soluble flavonoid compound in safflower that has the effect of activating blood and removing blood stasis. There are different reports on the preparation and chemical composition of safflower yellow pigment. The earliest reports in the literature used cellulose column chromatography to chromatograph the aqueous ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K9/20A61K9/48A61K31/7048A61P9/10C07H1/08C07H11/04
Inventor 刘珂傅风华马成俊徐本明张达磊刘培利李桂生刘志峰朱海波
Owner SHANDONG LUYE PHARMA CO LTD
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