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Medical function of cnidium monnieri lactone

A technology of cnidolide and medicine, which is applied in the field of medicine and achieves the effect of less side effects

Inactive Publication Date: 2007-09-19
海南盛科天然药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the anti-cardiocerebral ischemia activity of cnidone

Method used

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  • Medical function of cnidium monnieri lactone

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0016] Take the dried rhizome of Angelica glauca Edgew., an Umbelliferae plant, and grind it into a coarse powder, and perform supercritical extraction with CO2 at an extraction pressure of 25MPa, an extraction temperature of 40°C, and an extraction time of 6 hours. 2 The flow rate is 2L / Kg angelica·h, the extract is filtered, the filtrate is allowed to stand, and the oil layer is taken to obtain the gray-green leaf angelica essential oil. The essential oil yield averaged about 1.5%.

[0017] Silica gel column chromatography separates cnidactone, the ratio of essential oil to column chromatography silica gel is 1:10, petroleum ether (30-60°C) diethyl ether gradient eluent is used to collect cnidactone components, and the solvent is recovered to obtain .

preparation example 2

[0019] Take the dried rhizome of Conioselinum vaginatum Thell, a Umbelliferae plant, crush it into a coarse powder, and perform supercritical extraction with CO2 at an extraction pressure of 25 MPa, an extraction temperature of 40°C, and an extraction time of 6 hours. 2 The flow rate is 2L / Kg angelica·h, the extract is filtered, the filtrate is allowed to stand, and the oil layer is taken to obtain Ligusticum edulis essential oil. The essential oil yield averaged about 1.5%.

[0020] Silica gel chromatography to separate cnidactone, the ratio of essential oil to column chromatography silica gel is 1:10, petroleum ether (30-60°C) diethyl ether gradient eluent is used to collect cnidactone components, and the solvent is recovered to obtain .

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Abstract

Application of cnidiumlactone for preparing a drug for treating ischemic heart disease and ischemic cerebrovascular disease.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the medical application of cnidilide. Background technique [0002] Cnidilide, also known as cnidilide, is also known as cnidilide, and its chemical name is n-butyltetrahydrophthalide. Cnidactone is a 3-alkylphthalide compound extracted from Ligusticum edulis, Chuanxiong, celery seed and other plants. [0003] [0004] Molecular structure of cnidone [0005] In recent years, domestic and foreign studies on several representative 3-hydrocarbylphthalides such as ligustilide have been focused on, but there are few studies on the pharmacological activity of cnidone. Pharmacological activity has the following aspects: reduce blood viscosity [Naito Takashi, Kubota Kiyoshi, Shimoda Yumi, et al. Effects of constituents of a Chinese crude drug, Ligustici Chuanxiong Rhizoma, on vasoconstriction and bloodviscosity. Nat Med, 49(3): 288-92], muscle relaxation [Ozaki Yukihiro, Se...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P9/10
Inventor 吴巍邵萌滕厚雷刘军锋翟大伟
Owner 海南盛科天然药物研究院有限公司
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