Neuroprotective composition and uses thereof
a neuroprotective composition and antioxidant technology, applied in the field of amphiphilic antioxidant composition as neuroprotective agent, can solve the problems of reducing the effect of various toxicants and drugs, unable to disclose or suggest the use of triad as neuroprotective agent, and unable to protect neuronal cells from oxidant species, etc., to achieve the effect of preventing the loss of viability or function, stabilizing the cellular membrane, and facilitating normalization of neuronal cellular functions
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Neuroprotective Actions of TRIAD Against Oxidative Stress
Abstract
[0065] This work shows that TRIAD, a combination of sodium pyruvate, vitamin E and egg yolk fatty acids, has an antioxidant protective action on cultured P19 neurons exposed to oxidative stress. Oxidative stress was induced by incubation with prooxidant systems that generate major reactive oxygen species produced by ischemia-reperfusion of the brain in vivo, namely 1) xanthine / xanthine oxidase system to produce .O.sub.2.sup.- superoxide radicals and H.sub.2O.sub.2, 2) H.sub.2O.sub.2 it self, and 3) H.sub.2O.sub.2 in the presence of Fe.sup.2+ to produce .OH hydroxyl radicals. TRIAD-induced resistance to injury caused by oxidative stress was assessed by measurement of cell viability. TRIAD concentrations less than 3.times. permitted to achieve complete protection of neurons. Optimal concentrations of TRIAD with neurons exposed to peroxide-based systems were directly related to the oxidant power of the systems as measure...
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