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Neuroprotective composition and uses thereof

a neuroprotective composition and antioxidant technology, applied in the field of amphiphilic antioxidant composition as neuroprotective agent, can solve the problems of reducing the effect of various toxicants and drugs, unable to disclose or suggest the use of triad as neuroprotective agent, and unable to protect neuronal cells from oxidant species, etc., to achieve the effect of preventing the loss of viability or function, stabilizing the cellular membrane, and facilitating normalization of neuronal cellular functions

Inactive Publication Date: 2004-11-25
PAQUIN JOANNE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0022] An advantage of the present invention is that it provides effective means for preventing the loss of viability or functions of neuronal cells in conditions of oxidative stress. It can also protect a neuronal cell from a toxic substance, stabilizes the cellular membrane of a neuronal cell and / or helps in the normalization of neuronal cellular functions.
[0023] Other objects and advantages of the present invention will be apparent upon reading the following non-restrictive description of several preferred embodiments made with reference to the accompanying drawings.
[0024] FIG. 1 is a graph showing the in vitro ROS production by peroxide-based prooxidant systems used with P19 neurons.
[0025] FIG. 2 is a graph showing the protection provided by TRIAD to P19 neurons exposed for different times to XA / XAO mediated oxidative stress.
[0026] FIG. 3 is a graph showing the protection provided by TRIAD components to P19 neurons exposed for different times to XA / XAO mediated oxidative stress.
[0027] FIG. 4 is a graph showing the protection provided by TRIAD to P19 neurons exposed to oxidative stress mediated by different concentrations of XAO.

Problems solved by technology

Until now, no ideal therapeutic agent is known to protect neuronal cells against oxidant species associated with various types of oxidative stress.
However, none of these patents discloses or suggests the use of TRIAD as neuroprotective agent.
Indeed, deleterious action of various toxicants and drugs is exerted via production of ROS.

Method used

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Neuroprotective Actions of TRIAD Against Oxidative Stress

Abstract

[0065] This work shows that TRIAD, a combination of sodium pyruvate, vitamin E and egg yolk fatty acids, has an antioxidant protective action on cultured P19 neurons exposed to oxidative stress. Oxidative stress was induced by incubation with prooxidant systems that generate major reactive oxygen species produced by ischemia-reperfusion of the brain in vivo, namely 1) xanthine / xanthine oxidase system to produce .O.sub.2.sup.- superoxide radicals and H.sub.2O.sub.2, 2) H.sub.2O.sub.2 it self, and 3) H.sub.2O.sub.2 in the presence of Fe.sup.2+ to produce .OH hydroxyl radicals. TRIAD-induced resistance to injury caused by oxidative stress was assessed by measurement of cell viability. TRIAD concentrations less than 3.times. permitted to achieve complete protection of neurons. Optimal concentrations of TRIAD with neurons exposed to peroxide-based systems were directly related to the oxidant power of the systems as measure...

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Abstract

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

Description

[0001] 1. Field of the Invention[0002] The present invention relates to the use of an amphiphilic antioxidant composition as a neuroprotective agent and to methods for using and preparing the same. More particularly, the present invention pertains to the use of a formulation of pyruvate, antioxidant, and lipid(s) such as fatty acids for protecting neurons against oxidative stress.[0003] 2. Description of the Prior Art[0004] Reactive oxygen species (ROS) have been implicated in the development of many heart and brain dysfunctions. Ischemia / reperfusion insults to these organs are among the leading causes of mortality in America. These insults are caused by complete or partial local occlusions of heart and brain vasculature, by heart stroke or attack, and by cerebral attacks and trauma to the brain. In addition, ROS are involved in artherosclerotic lesions, in the evolution of various neurodegenerative diseases, and are also produced in association to epileptic episodes, in inflammatio...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/19A61K31/23A61K31/355A61P9/00A61P25/00
CPCA61K31/19A61K31/23A61K31/355A61K31/07A61K31/015A61K2300/00A61P25/00A61P9/00
Inventor PAQUIN, JOANNEMATEESCU, MIRCEA-ALEXANDRUDE GRANDPRE, ERIC
Owner PAQUIN JOANNE
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