Medical application of pregabalin

A technology of pregabalin and its use, which is applied in the field of pregabalin for treating cerebral ischemia or cerebral infarction, and achieves the effects of delaying transformation, improving quality of life and survival time, and treating and preventing definite effects.

Inactive Publication Date: 2013-11-13
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of pregabalin in the treatment of cerebral ischemia or cerebral infarction in the prior art or clinical practice

Method used

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  • Medical application of pregabalin
  • Medical application of pregabalin
  • Medical application of pregabalin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Pregabalin tablet preparation

[0019]

[0020] Preparation process: Weigh the prescribed amount of pregabalin, starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 2

[0021] Embodiment 2 pregabalin tablet preparation

[0022]

[0023] Preparation process: Weigh the prescription amount of pregabalin, microcrystalline cellulose and hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 8% starch slurry, add it to the mixed powder, mix well and make soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 3

[0024] Embodiment 3 pregabalin tablet preparation

[0025]

[0026]

[0027] Preparation process: Weigh the prescribed amount of pregabalin, starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The invention relates to an application of pregabalin in preparing a drug for treating and preventing ischemic cerebrovascular diseases, and belongs to the medicine field. Pregabalin is a conventional drug. According to the invention, a great many of experiments demonstrate that pregabalin can reduce NO and NOS level of an ischemic patient when the pregabalin is applied in the treatment of ischemic cerebrovascular diseases particularly cerebral ischemia or cerebral infarction, can reduce MDA content in serum, and has an obvious protect effect for brain hippocampus neurons. The medical application of gabapentin can provide a novel drug selection of patients suffering from the ischemic cerebrovascular diseases, and has wide medical application prospects.

Description

technical field [0001] The invention relates to a medical application of antiepileptic drug pregabalin, in particular to the application of pregabalin in treating cerebral ischemia or cerebral infarction, and belongs to the field of medicine. Background technique [0002] Ischemic cerebrovascular disease (ICVD) accounts for about 80% of all cerebrovascular diseases. It has the characteristics of high morbidity, disability and cure rate, and has become one of the diseases that seriously endanger human health. Ischemic cerebrovascular disease is a type of disease in which there is a sudden imbalance between the supply and demand of oxygen and other nutrients provided by local blood circulation and the metabolic needs of neurons, resulting in damage to neurons in the ischemic central area. Transient ischemic attack referred to as TIA, also known as transient ischemic attack or small stroke, it is due to the short-term insufficient blood supply of the arteries responsible for su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/197A61P9/10
Inventor 赵志全李斌
Owner LUNAN PHARMA GROUP CORPORATION
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