52 results about "Parasite Infections" patented technology

This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable alpha-helix and has the following structure comprising at least 12 amino acidsA=an amino acid selected from the basic amino acids Lys,Arg or HisB=an amino acid selected from the aromatic amino acids Phe, Trp or TyrC=an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, Val or Ala, andsaid peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-m of the repetitive sequence motifs (A2-B2-C1-A3) have the retro orientation and the remaining repetitive motifs (A2-B2-C1-A3) have the orientation as presented in the formula and wherein,R1-R2- and R3 are a number of amino acids, and whereinm=1-10, preferably 2-8, more preferably 2-5 andn=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or diagnosis related to i.a. parasite infection topical and systemic tumors and septic shock.

This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

The present invention relates generally to a method of eliciting or otherwise inducing an immune response to a microorganism and compositions for use therein. More particularly, the present invention relates to a method of inducing an immune response to a parasite utilising an immunogenic composition comprising a glycosylphosphatidylinositol (referred to herein as “GPI”) inositolglycan domain or its derivative or equivalent. The present invention is useful, inter alia, as a prophylactic and / or therapeutic treatment for microorganism infections of mammals such as, for example, parasite infections and in particular infection by Plasmodium species. In another aspect the invention provides a method of diagnosing, monitoring, screening for or otherwise qualitatively or quantitatively assessing an immune response to a microorganism and, in particular, a parasite. More particularly, this aspect of the present invention is directed to assessing said immune response utilising a GPI inositoglycan domain or its derivative or equivalent. The development of this aspect of the present invention facilitates, inter alia, the qualitative and / or quantitative analysis of anti-GPI antibodies in a biological sample, the identification and / or isolation of unique specificities of antibodies (such as those which bind a parasite derived toxin or the parasite itself), epitope specific screening or the rational design of immunogenic molecules and the generation, thereby, of functionally effective immunointeractive molecules.

The present invention provides a bodily fluid-testing composition for the determination and quantification of a specific ion concentration exceeding a pre-set threshold in a tested fluid, in which an ion oppositely charged to the ion in the bodily fluid is used to compete with an indicator reagent in order to compensate for variability in specific binding of the bodily fluid ions. The present invention further provides an article for monitoring of bodily fluids comprising a substrate and an absorbent material for absorbing the bodily fluid. The substrate includes a composition suitable for identification of a specific ion concentration in a tested fluid. The article can be used to indicate the presence of abnormal ammonium concentration in human urine, amniotic fluid leakage, or biogenic secretions associated with bacterial vaginosis, parasite infections, or deficiency of lactobacillus population, without giving a false positive result.

The insect inoculation system and method optimizes the conditions wherein host insect cadavers are infected by a selected parasite. Host insect cadavers are exposed to the selected parasite within the inoculation chamber. The inoculation chamber is configured to optimize the parasite infection and reproduction process. The insect parasites produce multiple offspring which remain in the infected insect cadavers. At the end of the inoculation process, the infected cadavers are removed from the chamber and the insect parasites are harvested and used in bio-pest control processes.

The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant.

Non-allergic hypersensitivity reactions can be observed in a sample of cells from a subject in response to anaphylatoxins. Accordingly, methods are provided for detecting clinical conditions such as cellular hyper-reactivity, non-allergic hypersensitivity, asthma, inflammation, chronic or acute infection, bacterial infection, viral infection, parasite infection, adverse drug reaction, organ rejection, vasculitis, mastocytosis, eosinophilia, basophilia, leukemia, and / or C3a or C5a receptor defects in a subject. Also provided are kits for detecting such clinical conditions in a subject.

The present invention discloses the cultivating technology of aseptic cavy and the feed formula. The cultivating technology includes abdominal incision to take out cavy embryo, raising and propagating in aseptic isolating apparatus, and providing delicious feed comprising protein, carbohydrate, fat, vitamins and minerals and Co-60 ray irradiated. The cavy thus raised has high survival rate and no microbe and parasite infection, and makes it possible to obtain correct and reliable experiment result. The present invention may be used widely in various research and production fields.

This disclosure provides improved derivatives of artemisinin; pharamaceutical compositions containing these compounds; methods for preparing these compounds and compositions; methods of using these compounds and compositions for preventing, controlling or treating infectious diseases including but not limited to parasitic infectious diseases such as T. gondii infection, trypanosome parasite infection, plasmodia parasite infection, and cryptosporidium parasite infection; methods for preventing, controlling or treating toxoplasma infection; and methods for treating psychiatric disorders associated with toxoplasma infection including but not limited to schizophrenia using the disclosed compounds and compositions alone or in combination with one or more antipsychotic drugs.

This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

A method of detecting parasite infection, particularly malaria, includes mixing a blood sample with a lytic reagent system to lyse red blood cells, and to form a sample mixture; performing a differential analysis of white blood cells of the sample mixture on a blood analyzer, and obtaining a cell volume distribution of a white blood cell subpopulation from a cell volume measurement used in the differential analysis; obtaining a cell volume parameter from the cell volume distribution of the white blood cell subpopulation; evaluating the cell volume parameter against a predetermined criterion, and reporting an indication of the parasite infection if the cell volume parameter meets the predetermined criterion. The method also uses a discriminant obtained from cell volume parameters of two different white blood cell subpopulations against a predetermined criterion. The method further use a cell distribution parameter of a cell distribution obtained using a RF impedance measurement.

The invention relates to traditional Chinese medicine powder for treating parasite infection of swamp eel and a preparation method thereof; the traditional Chinese medicine powder is prepared by the following raw materials by weight: 4% of quispualis indica, 10% of radix stemonae, 20% of cyrtomium fortune, 15% of semen torreya, and 51% of starch. The preparation method comprises the following steps: drying three raw material herbs of quispualis indica, radix stemonae, and cyrtomium fortune by electric heating to reduce the water content to be below 5%, crushing the dried herbs by a hammer crusher, sieving by a 60-mesh steel sieve, proportionally adding raw auxiliary materials of 4% of quispualis indica, 10% of radix stemonae, 20% of cyrtomium fortune, 15% of semen torreya, and 51% of starch, well mixing by a mixer, and packaging into bags to obtain the preparation. The traditional Chinese medicine powder of the invention is an anthelmintic agent special for swamp eel, and has the effects of improving appetite and invigorating spleen. The medicine of the invention is traditional Chinese medicine powder refined by traditional Chinese medicine, has no toxic or side effect on swamp eel, and is convenient for use; the preparation method is simple in operation, stable and feasible in process, and suitable for industrial production; the product can effectively prevent and treat parasitic diseases; and the project has good development meaning and market prospects.

A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable alpha-helix and has the following structure comprising at least 12 amino acids R1-R2-A1-B1-(A2-B2-C1-A3)m-(C2)n-R3, wherein A=an amino acid selected from the basic amino acids Lys,Arg or His B=an amino acid selected from the aromatic amino acids Phe, Trp or Tyr C=an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, Val or Ala, and said peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-n of the repetitive sequence motifs (A2-B2-C1-A3) have the retro orientation and the remaining repetitive motifs (A2-B2-C1-A3) have the orientation as presented in the formula and wherein, R1-R2- and R3 are a number of amino acids, and wherein m=1-10, preferably 2-8, more preferably 2-5 and n=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or diagnosis related to i.a. parasite infection topical and systemic tumors and septic shock.

This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

This invention relates to long-acting injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a poloxamer, and a co-solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the long-acting injectable formulations of the invention to the animal in need thereof.

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

The invention discloses a method for producing feed additive for preventing and curing pig anemia and comprises the following technique steps: 1. preparing traditional Chinese medicine extract; 2. absorbing the traditional Chinese medicine extract with an absorbent; 3. mixing the absorbed semi-finished product with porphyrin iron, copper lysine, zinc glycinate and auxiliary materials to obtain the finished product. The invention has the advantages that porphyrin iron can be directly absorbed by an organism and can be synthesized with haptoglobin (Hp) into hemoglobin with low energy consumption, high efficiency and fast blood enrichment speed so as to effectively prevent and cure piglet anemia; the traditional Chinese medicine extract can effectively kill pig endoparasite; the product has good efficacy both for pig anemia and parasite infection; the product accelerates synthesis of in vivo hemoglobin and increases hemoglobin quantity to promote in vivo blood circulation, eliminate striving for nutrients from parasite, eliminate anemia symptom, improve metabolic rate of pig organism, and cause the skin of pig to show healthy pink color.

The invention relates to an invermectin in-vivo gel injection and a preparation method thereof, aiming at providing a long-acting injection for preventing and treating livestock parasite infections, and a preparation method thereof. Raw materials required by every 100 mL of the invermectin in-vivo gel injection comprise 5 g-10 g of injection grade invermectin, 10 g-20 g of poly(lactic-co-glycolicacid) (PLGA), 1 g -2 g of carbomer-941, 0.1 g -0.2 g of tween-80 and 85 mL-90 mL of an organic solvent. The injection is an in-vivo gel prepared from invermectin, and is used for preventing and treating gastrointestinal parasites of cattle, pigs and sheep, lungworm and externally parasitic diseases such as lice, and mites and fly larvae. The injection has an obvious effect; and the preparation method of the injection is simple and easily operational, and is suitable for large-scale production.

Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and include a reporter of virus or parasite infection. Methods of making and using the cell cultures are also provided.

The invention relates to the field of aquaculture, in particular to a method for low-salinity circulating aquaculture of scortum barcoo. According to the method, fish fries are immersed in high-salinity water to be sterilized, freshwater bacteria and parasites can be effectively killed or the number of freshwater bacteria and parasites can be effectively reduced through salinity change, and then bacterium and parasite infection rate of fish fries is reduced. In the culturing process, the content of bacteria and parasites in circulating water is low, the growth environment of scortum barcoo is relatively clean, and therefore no drug is needed during culture so that the quality of aquatic products can be improved greatly.

The invention relates to an antigen used for the early diagnosis of haemonchus contortus infection, and application thereof. The invention authenticates an antigen used for parasite infection, and theamino acid sequence of the antigen is disclosed in SEQ ID NO.1. The antigen can be used for carrying out specific recognition on an antibody in the serum of a host infected with the haemonchus contortus for 14 days, a definite diagnosis is made before 4-6 days of ovum ovulation, and the pollution of the ovum for the environment and a pasture can be avoided so as to perform an important meaning for the prevention and control of the haemonchus contortus disease. By use of the antigen disclosed by the invention, the antigen is used for establishing an indirect ELISA (Enzyme Linked ImmunosorbentAssay) detection method, and therefore, the antigen has the advantages of being high in sensitivity, good in specificity, simple in operation, high in diagnosis speed, economic, convenient and the like during large-scale detection, and has a good application prospect in the diagnosis, the prevention and the curing of the haemonchus contortus disease of ruminants, including cows, goats, deer, camels and the like.

Disclosed herein are conjugates of a therapeutic compound and polypeptides, such as a conjugate of niclosamide and an elastin-like polypeptide. These conjugates may form nanoparticles through self-assembly, which improve the solubility, bioavailability, and pharmacokinetic profiles of the therapeutic compound. Also disclosed are methods for treating cancer, parasite infection, bacterial infection, viral infection, metabolic diseases, Type II diabetes, NASH, NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis.

This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and / or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.

The present disclosure relates to methods of preventing or treating parasite infection in a plurality of fish in need thereof, comprising administering to the fish an effective amount of a medicated fish feed. The medicated fish feed comprises fish feed granules or pellets coated with a composition comprising a neonicotinoid such as imidacloprid and a carrier having a high apparent digestibility coefficient such as a processed / cooked corn protein concentrate.

Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and include a reporter of virus or parasite infection. Methods of making and using the cell cultures are also provided.

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, X, W, m and n are as defined hereinabove. The compounds are useful for the treatment and / or prophylaxis of diseases which are associated with 2,3-oxidosqualane-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and / or hyperproliferative disorders, and treatment and / or prophylaxis of impaired glucose tolerance and diabetes.