The invention relates to traditional Chinese medicine powder for treating parasite infection of swamp eel and a preparation method thereof; the traditional Chinese medicine powder is prepared by the following raw materials by weight: 4% of quispualis indica, 10% of radix stemonae, 20% of cyrtomium fortune, 15% of semen torreya, and 51% of starch. The preparation method comprises the following steps: drying three raw material herbs of quispualis indica, radix stemonae, and cyrtomium fortune by electric heating to reduce the water content to be below 5%, crushing the dried herbs by a hammer crusher, sieving by a 60-mesh steel sieve, proportionally adding raw auxiliary materials of 4% of quispualis indica, 10% of radix stemonae, 20% of cyrtomium fortune, 15% of semen torreya, and 51% of starch, well mixing by a mixer, and packaging into bags to obtain the preparation. The traditional Chinese medicine powder of the invention is an anthelmintic agent special for swamp eel, and has the effects of improving appetite and invigorating spleen. The medicine of the invention is traditional Chinese medicine powder refined by traditional Chinese medicine, has no toxic or side effect on swamp eel, and is convenient for use; the preparation method is simple in operation, stable and feasible in process, and suitable for industrial production; the product can effectively prevent and treat parasitic diseases; and the project has good development meaning and market prospects.