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Injection-type compound bone repairing material containing more biological factors and using animal fibrin as carrier

A technology of biological factors and animal fibers, applied in the field of bone repair materials, can solve the problems of complex operation, limited scope of application, high cost, etc., and achieve the effects of good biological activity, wide range of clinical use, and low cost

Inactive Publication Date: 2002-10-30
孙明林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing method of using bone growth factor is to compound it on a solid material and implant it into the wound site through surgery. The operation is complicated, the cost is high, and the scope of application is limited, especially for closed fractures and other cases that do not require surgical treatment. Difficult to apply

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: According to the technical scheme of the present invention, the injection-type multiple biological factor composite bone repair material with animal fibrin as the carrier is prepared according to the following method:

[0017] 1) Aseptically take anticoagulant blood from pigs, cattle and other mammals, separate the plasma and extract fibrinogen by low-temperature centrifugation, freeze-dry to make spongy fibrinogen, which is the first part of the system;

[0018] 2) A certain dose of recombinant human bone morphogenetic protein, fibroblast growth factor and transforming growth factor β is added to thrombin to form the second part of the system.

[0019] 3) The first part uses double distilled water as a solvent, and prepares a suspension before use; wherein the concentration of fibrin is 70mg / ml;

[0020] 4) The second part uses 40mM / L calcium chloride as a solvent, the concentration of thrombin is 500IU / ml, and the concentrations of recombinant human bone...

Embodiment 2

[0022] Embodiment 2: According to the technical scheme of the present invention, the injection-type multiple biological factor composite bone repair material with animal fibrin as the carrier is prepared according to the following method:

[0023] 1) Aseptically take anticoagulant blood from pigs, cattle and other mammals, separate the plasma and extract fibrinogen by low-temperature centrifugation, freeze-dry to make spongy fibrinogen, which is the first part of the system;

[0024] 2) A certain dose of recombinant human bone morphogenetic protein, fibroblast growth factor and transforming growth factor β is added to thrombin to form the second part of the system.

[0025] 3) The first part uses double distilled water as a solvent, and prepares a suspension before use; wherein the concentration of fibrin is 110mg / ml;

[0026] 4) The second part uses 40mM / L calcium chloride as a solvent, the concentration of thrombin is 500IU / ml, and the concentrations of recombinant human bon...

Embodiment 3

[0028] Embodiment 3: According to the technical scheme of the present invention, the injection-type multiple biological factor composite bone repair material with animal fibrin as the carrier is prepared according to the following method:

[0029] 1) Aseptically take anticoagulant blood from pigs, cattle and other mammals, separate the plasma and extract fibrinogen by low-temperature centrifugation, freeze-dry to make spongy fibrinogen, which is the first part of the system;

[0030] 2) A certain dose of recombinant human bone morphogenetic protein, fibroblast growth factor and transforming growth factor β is added to thrombin to form the second part of the system.

[0031] 3) The first part uses double distilled water as a solvent, and prepares a suspension before use; wherein the concentration of fibrin is 90mg / ml;

[0032] 4) The second part uses 40mM / L calcium chloride as solvent, the concentration of thrombin is 500IU / ml, and the concentrations of recombinant human bone m...

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Abstract

An injection-type composite bone repair material for treating bone fracture, nonunion, dysostosis and osteoporosis contains the fibrin in mammal's blood as carrier, genetically recombinant bone morphogenetic protein, fibroblast growth factor and beta-converting growth factor. Its advantages are sure curative effect, wide application range and high safety.

Description

[0001] 1. Field [0002] The present invention relates to a bone repair material for medical clinical application, in particular to an injection-type material with animal fibrin as carrier which is used for clinical fracture, nonunion, bone defect, osteoporosis and other diseases and can be used in veterinary medicine A variety of biological factors composite bone repair material. 2. Background technology [0003] The existing method of using bone growth factor is to compound it on a solid material and implant it into the wound site through surgery. The operation is complicated, the cost is high, and the scope of application is limited, especially for closed fractures and other cases that do not require surgical treatment. Difficult to apply. 3. Contents of the invention [0004] According to the partial defects or deficiencies in the above-mentioned prior art, the object of the present invention is to provide a kind of animal fibrin-based fiber protein that is used for dis...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K47/42A61P19/08
Inventor 孙明林
Owner 孙明林
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