Injection-type compound bone repairing material containing more biological factors and using animal fibrin as carrier
A technology of biological factors and animal fibers, applied in the field of bone repair materials, can solve the problems of complex operation, limited scope of application, high cost, etc., and achieve the effects of good biological activity, wide range of clinical use, and low cost
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[0016] Example 1: According to the technical scheme of the present invention, an injectable multiple biological factor composite bone repair material with animal fibrin as a carrier is prepared according to the following method:
[0017] 1) Aseptically take the anticoagulant blood of mammals such as pigs and cattle, separate the plasma and extract the fibrinogen by low-temperature centrifugation, freeze-drying to make spongy fibrinogen as the first part of the system;
[0018] 2) A certain dose of recombinant human bone morphogenetic protein, fibroblast growth factor and beta transforming growth factor are added to thrombin to form the second part of the system.
[0019] 3) The first part uses double-distilled water as the solvent to prepare a suspension before use; the concentration of fibrin is 70mg / ml;
[0020] 4) The second part uses 40mM / L calcium chloride as solvent, the concentration of thrombin is 500IU / ml, and the concentrations of recombinant human bone morphogenetic pro...
Example Embodiment
[0022] Example 2: According to the technical scheme of the present invention, an injectable multiple biological factor composite bone repair material with animal fibrin as a carrier is prepared according to the following method:
[0023] 1) Aseptically take the anticoagulant blood of mammals such as pigs and cattle, separate the plasma and extract the fibrinogen by low-temperature centrifugation, freeze-drying to make spongy fibrinogen as the first part of the system;
[0024] 2) A certain dose of recombinant human bone morphogenetic protein, fibroblast growth factor and beta transforming growth factor are added to thrombin to form the second part of the system.
[0025] 3) The first part uses double-distilled water as the solvent to prepare a suspension before use; the concentration of fibrin is 110mg / ml;
[0026] 4) The second part uses 40mM / L calcium chloride as solvent, the concentration of thrombin is 500IU / ml, and the concentrations of recombinant human bone morphogenetic pr...
Example Embodiment
[0028] Example 3: According to the technical scheme of the present invention, an injectable multiple biological factor composite bone repair material with animal fibrin as a carrier is prepared according to the following method:
[0029] 1) Aseptically take the anticoagulant blood of mammals such as pigs and cattle, separate the plasma and extract the fibrinogen by low-temperature centrifugation, freeze-drying to make spongy fibrinogen as the first part of the system;
[0030] 2) A certain dose of recombinant human bone morphogenetic protein, fibroblast growth factor and beta transforming growth factor are added to thrombin to form the second part of the system.
[0031] 3) The first part uses double-distilled water as the solvent to prepare a suspension before use; the concentration of fibrin is 90mg / ml;
[0032] 4) The second part uses 40mM / L calcium chloride as solvent, the concentration of thrombin is 500IU / ml, and the concentrations of recombinant human bone morphogenetic pro...
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