Traditional Chinese medicine composition as well as preparation method and use thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and preparation thereof, can solve the problems of lack of heart failure prevention and treatment drugs, high toxicity of drugs, unsatisfactory curative effect, etc., and achieve the enhancement of myocardial cell autophagy activity, simple composition, and overcoming serious problems. Effects of adverse reactions

Inactive Publication Date: 2013-04-17
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is still a lack of effective prevention and treatment drugs for heart failure, and there are problems such as high drug toxicity and unsatisfactory curative effect

Method used

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  • Traditional Chinese medicine composition as well as preparation method and use thereof
  • Traditional Chinese medicine composition as well as preparation method and use thereof
  • Traditional Chinese medicine composition as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 capsule of the present invention

[0023] 200g red ginseng, 400g salvia miltiorrhiza, 200g crocus;

[0024] Grind red ginseng, salvia miltiorrhiza, and scrophulariaceae into coarse powder, reflux extract 6 times the amount of red ginseng and scrophulariaceae with 60% ethanol for 3 times, each time for 2 hours, filter, recover ethanol from the filtrate, and measure the relative density when it is concentrated to 60°C. For the extract of 1.30, 6 times the amount of Danshen ginseng was refluxed and extracted with 80% ethanol for 3 times, each time for 2 hours, filtered, the filtrate recovered ethanol, and when concentrated to 60°C, the extract with a relative density of 1.30 was measured. The slag was extracted three times with 6 times the amount of water, each time for 1 hour, filtered, and when the filtrate was concentrated to 60°C, the extract with a relative density of 1.30 was measured, the above extracts were combined, dried under redu...

Embodiment 2

[0025] The preparation of embodiment 2 granules of the present invention

[0026] 160g red ginseng, 350g salvia miltiorrhiza, 160g crocus;

[0027] Grind red ginseng, salvia miltiorrhiza, and scrophulariaceae into coarse powder, extract 7 times the amount of red ginseng and scrophulariaceae under reflux with 70% ethanol for 3 times, each time for 1 hour, filter, recover ethanol from the filtrate, and measure the relative density when concentrated to 60°C. For the extract of 1.25, 7 times the amount of danseng and 90% ethanol were refluxed and extracted 3 times, each time for 1 hour, filtered, the filtrate recovered ethanol, and when concentrated to 60 ° C, the relative density of the extract was 1.25. The slag was extracted with 7 times the amount of water for 3 times, each time for 1.5 hours, filtered, and when the filtrate was concentrated to 60°C, the extract with a relative density of 1.25 was measured, the above extracts were combined, dried under reduced pressure, crush...

Embodiment 3

[0028] The preparation of embodiment 3 tablet of the present invention

[0029] 240g red ginseng, 450g red ginseng, 240g crocus

[0030] Grind red ginseng, salvia miltiorrhiza, and scrophulariaceae into coarse powder, reflux extract 5 times the amount of red ginseng and scrophulariae with 50% ethanol for 3 times, each time for 3 hours, filter, recover ethanol from the filtrate, and measure the relative density when concentrated to 60°C. For the extract of 1.28, 5 times the amount of red ginseng and 70% ethanol were refluxed and extracted 3 times, each time for 3 hours, filtered, the filtrate recovered ethanol, and when concentrated to 60 ° C, the relative density of the extract was 1.28. The slag was extracted three times with 5 times the amount of water, each time for 2 hours, and filtered. When the filtrate was concentrated to 60 ° C, the extract with a relative density of 1.28 was measured. The above extracts were combined, dried under reduced pressure, crushed, and then an...

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Abstract

The invention relates to a traditional Chinese medicine composition as well as a preparation method and a use thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following bulk pharmaceutical chemicals in parts by weight: 160-240 parts of red ginsengs, 350-450 parts of roots of red rooted salvia and 160-240 parts of radix scrophulariae. The traditional Chinese medicine composition is compounded under the guide of the theories of traditional Chinese medicine, has the functions of invigorating qi for relieving desertion, promoting blood circulation to remove blood stasis and clearing heat and promoting dieresis, are used for treating angina pectoris, palpitate, chest pain, shortness of breath and fatigue. Moreover, the traditional Chinese medicine composition has a good curative effect for preventing and treating the first-grade cardiac failure and the second-grade cardiac failure, and can be used for realizing cardiac function protection by strengthening autophagy activities of the myocardial cells and reducing apoptosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for enhancing cardiomyocyte autophagy and a preparation method thereof. Background technique [0002] Cardiovascular disease is a kind of disease with great harm, high morbidity and mortality in today's human beings. The heart is the source of blood circulation. Various heart diseases, especially myocardial ischemic diseases, often lead to a decrease or loss of myocardial contractility, low cardiac function, insufficient cardiac output, and insufficient blood supply to tissues and organs, resulting in a series of symptoms. And signs, and finally turned into heart failure. [0003] At present, there is still a lack of effective prevention and treatment drugs for heart failure, and there are problems such as high drug toxicity and unsatisfactory curative effect. Chinese patent CN101584805A dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61P9/10A61P9/06A61P9/04A61P9/00
Inventor 孙连坤刘永强苏静杨晓春李洪岩康劲松
Owner JILIN UNIV
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