3results about How to "Novel preparation method" patented technology

The invention discloses an efficient preparation method of mivacurium chloride, which comprises the following steps: (1) reacting (E)-octyl-4-ene-1, 8-diacid, 3-chloro-1-bromopropane, alkali, cesium chloride and a reaction solvent at the temperature of 30-100 DEG C for 6-15 hours; cooling after the reaction is completed, adding water and an organic solvent for extraction, and separating liquid; washing an organic phase with water, and concentrating under reduced pressure to obtain (E)-octyl-4-ene-1, 8-diacid di-(3-chloropropyl) ester; and (2) carrying out a reaction on the (E)-octyl-4-ene-1, 8-diacid di-(3-chloropropyl) ester, the (R)-(+)-5 '-methoxylaudanin, sodium iodide, potassium carbonate and the reaction solvent at the temperature of 50-85 DEG C for 18-40 hours, and carrying out post-treatment to obtain mivacurium chloride. The method disclosed by the invention is novel, avoids the use of thionyl chloride and a condensing agent, is more environment-friendly, is friendly to the environment and an operator, and is mild in reaction condition, high in reaction efficiency, high in yield, low in equipment requirement and simple to operate; the method has the advantages of cheap and easily available reaction raw materials and reagents, few by-products, simple purification and easy operation, and is suitable for preparation of human bulk drugs with high purity and safety requirements, and the purity of the obtained mivacurium chloride is higher than 99.5%.

The application discloses a kind of buried copper block circuit board and its manufacturing method, the manufacturing method includes: the two outer layers of core plate are copper foil layer, and window position A is provided on the non-line area of one outer layer;Core plate is double-sided inner layer pattern production, to make inner layer circuit pattern and pad on the two outer layers of core plate respectively, and make a plurality of flow blockings on one outer layer of core plate, which are surrounded outside window position A;The insulating layer is covered on the two outer layers of core plate, and window position B is provided on the insulating layer adjacent to flow blocking, which is opposite to window position A;Based on window position, insulating layer and core plate are windowed;After the copper block gap with rough surface is placed in window, it is compressed and handled, and in the process of compression, the flow of colloid in window is controlled by flow blocking, so that copper block is firmly combined with insulating layer and core plate together.The manufacturing method is simple and reasonable, easy to implement, the reliability and stability of the obtained circuit board product are high, and the market demand is met.

The application belongs to the field of polymer preparation, and particularly relates to a preparation method of polyurea with a stimulating fluorescent response. H ), the fluorescent functional monomer (ON H ) is constructed by the reaction of epoxy resin and amino, and the phthalic acid group is suspended on the main chain by the reaction of ON and diisocyanate, so that the phthalic acid polymer is formed in the material, the structure or state of the phthalic acid polymer changes under different environments due to the different states of the carboxyl group under different pH values and the characteristic that the carboxyl group can form a coordination action with metal ions, the fluorescent characteristics change, and the fluorescent color changes from yellow-green to blue with the increase of the pH value. The preparation method of the polyurea with the stimulating fluorescent response is novel, the prepared polyurea has the stimulating fluorescent response characteristics, and has a wide market prospect. The steps are simple, the operation is convenient, and the practicability is high.