The invention provides a medicinal preparation for treating epidemic keratoconjunctivitis. The preparation comprises crude medicines such as saposhnikovia divaricata, senecio scandens ham, mint, centipeda minima, concha haliotidis, stigma croci, white mulberry root bark, isatis roots, semen cuscutae, ash bark, eclipta, liriope spicata, honeysuckle, buddleja officinalis, plantain herbs, schizonepeta, glossy privet fruits, coptis chinensis, flatstem milkvetch seeds, Chinese yams, polygonum aviculare, selfheal spike, fructus broussonetiae, feather cockscomb seeds, raspberries, pipewort, caryopteris incana and bidens bipinnata. The medicinal preparation is low in side effect occurrence rate, stable in treatment effect, reliable, high in safety and higher in clinical application value.