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Tension-free hernia patch and preparation method thereof

A tension-free, patch technology, applied in the fields of medical science, prosthesis, coating, etc., can solve the problems of infection and skin sinus, rough surface of the patch, damage to surrounding tissues, etc., to reduce abdominal adhesion and intestinal fistula, The effect of good mechanical properties matching and improved service life

Active Publication Date: 2013-04-10
王明刚 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also some problems in the application of polypropylene mesh. First, the surface of the mesh is relatively rough. When it is used to repair the full-thickness defect of the abdominal wall, it will directly contact with the abdominal organs, which will not only cause serious abdominal adhesions, And it may erode the intestinal wall, leading to intestinal fistula; secondly, if a large abdominal wall defect is repaired, the later scar contraction will cause the mesh to twist, and its irregular surface will stimulate and damage the surrounding tissue, causing infection and skin sinus formation

Method used

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  • Tension-free hernia patch and preparation method thereof
  • Tension-free hernia patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Step 1: Put the polypropylene wire with a diameter of 50 μm in absolute ethanol to remove oil for 5 minutes, then rinse the polypropylene wire with distilled water, and put it in a stannous chloride hydrochloric acid solution with a temperature of 10 and a pH value of 1 for treatment 3min; Rinse the processed polypropylene filament with distilled water and set aside;

[0065] Wherein: tin protochloride hydrochloric acid solution is: tin protochloride is dissolved in the hydrochloric acid that molar concentration is 5mol / L, is then diluted to pH value 1 with distilled water, and the concentration of stannous chloride in the solution is 10g / L;

[0066] Step 2: Add the silicon methylation reagent to the reaction container until it is full, soak for 24 hours, pour out the reagent, rinse the reaction container with distilled water, and set aside;

[0067] Wherein: the silylating reagent is a mixture of dichloromethane and trimethylchlorosilane, and the volume percentage is d...

Embodiment 2

[0075] Step 1: Put the polypropylene wire with a diameter of 65 μm in absolute ethanol to remove oil for 5 minutes, then rinse the polypropylene wire with distilled water, and put it in a stannous chloride hydrochloric acid solution with a temperature of 15°C and a pH value of 1.5 Treat for 2 minutes; rinse the treated polypropylene silk with distilled water and set aside;

[0076] Wherein: stannous chloride hydrochloric acid solution is: tin protochloride is dissolved in the hydrochloric acid that molar concentration is 7mol / L, is then diluted with distilled water to pH value 1.5, and the concentration of stannous chloride in the solution is 15g / L;

[0077] Step 2: Add the silicon methylation reagent to the reaction container until it is full, soak for 24 hours, pour out the reagent, rinse the reaction container with distilled water, and set aside;

[0078] Wherein: the silylating reagent is a mixture of dichloromethane and trimethylchlorosilane, and the volume percentage is ...

Embodiment 3

[0086] Step 1: Put the polypropylene wire with a diameter of 80 μm in absolute ethanol to remove oil for 5 minutes, then rinse the polypropylene wire with distilled water, and put it in a stannous chloride hydrochloric acid solution with a temperature of 20°C and a pH value of 2 Treat for 5 minutes; rinse the treated polypropylene silk with distilled water and set aside;

[0087] Wherein: stannous chloride hydrochloric acid solution is: tin protochloride is dissolved in the hydrochloric acid that molar concentration is 9mol / L, is then diluted to pH value 2 with distilled water, and the concentration of stannous chloride in the solution is 20g / L;

[0088] Step 2: Add the silicon methylation reagent to the reaction container until it is full, soak for 24 hours, pour out the reagent, rinse the reaction container with distilled water, and set aside;

[0089] Wherein: the silylating reagent is a mixture of dichloromethane and trimethylchlorosilane, and the volume percentage is dich...

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Abstract

Belonging to the field of organic polymer compound preparation or chemical processing, the invention provides a tension-free hernia patch and a preparation method thereof. The patch provided in the invention has good toughness and strength match, no adverse reaction in the human body, and excellent biocompatibility, and is free of inflammation and foreign body reaction. When the patch is implanted into organisms, abdominal adhesions and intestinal fistulas are greatly reduced, so that the patch is a good material for incisional hernias, abdominal hernias, stomal hernias, umbilical hernias and other herniorrhaphies. The patch includes a basal layer made of a non-absorbable material and a surface coating made of an absorbable material. The surface coating is softer, and can be completely absorbed by the human body in 60 days, thus providing time for combination of the basal layer and surrounding tissues. The patch provided in the invention has a simple preparation process and a low manufacturing cost. As a medical tension-free hernia patch, it has excellent comprehensive performance, and is a safe and reliable patch, thus having great social and economic value.

Description

technical field [0001] The invention belongs to the field of organic polymer compound preparation or chemical processing, and specifically relates to a tension-free hernia patch and a preparation method thereof. Background technique [0002] A hernia is when a part of a body tissue or organ leaves its original location and enters another location through a gap, defect or weak part of the body. Hernia is a common disease and frequently-occurring disease in general surgery. Because hernia can cause many diseases, it poses a serious threat to people's health and life. If the hernia is not treated, there may be a risk of incarceration at any time. If there is pain, hard texture, difficulty in massaging and kneading, accompanied by abdominal pain, abdominal distension, and gradually nausea and vomiting, long-term intestinal ischemia and necrosis can be life-threatening. Generally, adults cannot repair their hernia by themselves, and must rely on external means for treatment. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/16A61L27/50A61F2/02
Inventor 王明刚陈杰
Owner 王明刚
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