Ivermectin in-vivo gel injection and preparation method thereof
A body gel injection, ivermectin technology, applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of no long-term effect, unable to meet the demand, etc. , to achieve the exact clinical effect, reduce the chance of secondary infection, and achieve obvious effects
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preparation example Construction
[0066] The preparation method of described injection is as follows:
[0067] Step 1), take 20% organic solvent, add ivermectin and stir to dissolve it, as No. I solvent
[0068] liquid spare,
[0069] Step 2), take another remaining amount of organic solvent, add the prescribed amount of PLGA, stir to dissolve, and then
[0070] Add the prescribed amount of carbomer-941, stir and dissolve as II solution for later use,
[0071] Step 3), mix I solution and II solution, add the prescribed amount of Tween-80 and stir evenly,
[0072] Step 4), filter with a 0.22um filter terminal, potting, and sterilize at 100°C for 30 minutes.
[0073] The organic solvents are respectively one of N-methylpyrrolidone and N,N-dimethylformamide.
[0074] The operations are all carried out at room temperature, and water pollution is avoided during the entire preparation process of the preparation.
Embodiment 1
[0075] Embodiment 1: a kind of ivermectin in vivo gel injection its raw and auxiliary material components are as follows:
[0076] Active ingredient: Ivermectin 5g
[0078] Carbomer-941 1g
[0079] Tween-80 0.1g
[0080] N-Methylpyrrolidone 90ml
[0081] The preparation steps of this injection are as follows: the ivermectin of prescription quantity is added 20ml N-methylpyrrolidone
[0082] in, stir to dissolve. --I solution
[0083] Take the remaining amount of N-methylpyrrolidone, add PLGA and Carbomer-941 respectively, and stir to dissolve. --II solution (spare)
[0084] Mix liquid III and liquid II, add the prescribed amount of Tween-80, and stir well.
[0085] 0.22um filter terminal filter, the measured pH is 8.5. Potting. Sterilize at 100°C for 30 minutes.
Embodiment 2
[0086] Embodiment 2: a kind of ivermectin in vivo gel injection its raw and auxiliary material components are as follows:
[0087] Active ingredient: Ivermectin 5g
[0088] Excipient: PLGA 10g
[0089] Carbomer-941 1g
[0090] Tween-80 0.2g
[0091] N-Methylpyrrolidone 85ml
[0092] The preparation method is the same as in Example 1.
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