Ivermectin in-vivo gel injection and preparation method thereof

A body gel injection, ivermectin technology, applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of no long-term effect, unable to meet the demand, etc. , to achieve the exact clinical effect, reduce the chance of secondary infection, and achieve obvious effects

Active Publication Date: 2014-06-04
HENAN HEIMA ANIMAL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these patented preparations do not have long-acting effects and cannot meet the current veterinary clinical needs for long-acting ivermectin preparations

Method used

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  • Ivermectin in-vivo gel injection and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0066] The preparation method of described injection is as follows:

[0067] Step 1), take 20% organic solvent, add ivermectin and stir to dissolve it, as No. I solvent

[0068] liquid spare,

[0069] Step 2), take another remaining amount of organic solvent, add the prescribed amount of PLGA, stir to dissolve, and then

[0070] Add the prescribed amount of carbomer-941, stir and dissolve as II solution for later use,

[0071] Step 3), mix I solution and II solution, add the prescribed amount of Tween-80 and stir evenly,

[0072] Step 4), filter with a 0.22um filter terminal, potting, and sterilize at 100°C for 30 minutes.

[0073] The organic solvents are respectively one of N-methylpyrrolidone and N,N-dimethylformamide.

[0074] The operations are all carried out at room temperature, and water pollution is avoided during the entire preparation process of the preparation.

Embodiment 1

[0075] Embodiment 1: a kind of ivermectin in vivo gel injection its raw and auxiliary material components are as follows:

[0076] Active ingredient: Ivermectin 5g

[0077] Excipient: PLGA 10g

[0078] Carbomer-941 1g

[0079] Tween-80 0.1g

[0080] N-Methylpyrrolidone 90ml

[0081] The preparation steps of this injection are as follows: the ivermectin of prescription quantity is added 20ml N-methylpyrrolidone

[0082] in, stir to dissolve. --I solution

[0083] Take the remaining amount of N-methylpyrrolidone, add PLGA and Carbomer-941 respectively, and stir to dissolve. --II solution (spare)

[0084] Mix liquid III and liquid II, add the prescribed amount of Tween-80, and stir well.

[0085] 0.22um filter terminal filter, the measured pH is 8.5. Potting. Sterilize at 100°C for 30 minutes.

Embodiment 2

[0086] Embodiment 2: a kind of ivermectin in vivo gel injection its raw and auxiliary material components are as follows:

[0087] Active ingredient: Ivermectin 5g

[0088] Excipient: PLGA 10g

[0089] Carbomer-941 1g

[0090] Tween-80 0.2g

[0091] N-Methylpyrrolidone 85ml

[0092] The preparation method is the same as in Example 1.

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Abstract

The invention relates to an invermectin in-vivo gel injection and a preparation method thereof, aiming at providing a long-acting injection for preventing and treating livestock parasite infections, and a preparation method thereof. Raw materials required by every 100 mL of the invermectin in-vivo gel injection comprise 5 g-10 g of injection grade invermectin, 10 g-20 g of poly(lactic-co-glycolicacid) (PLGA), 1 g -2 g of carbomer-941, 0.1 g -0.2 g of tween-80 and 85 mL-90 mL of an organic solvent. The injection is an in-vivo gel prepared from invermectin, and is used for preventing and treating gastrointestinal parasites of cattle, pigs and sheep, lungworm and externally parasitic diseases such as lice, and mites and fly larvae. The injection has an obvious effect; and the preparation method of the injection is simple and easily operational, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of veterinary antiparasitic drugs, in particular to an ivermectin in-vivo gel injection and a preparation method thereof, and aims to provide a long-acting injection for preventing and treating domestic animal parasitic infections and the same Preparation. Background technique [0002] Ivermectin is Avi Multicomponent semisynthetic macrolides produced by fermentation of Streptomyces avermitilis antibiotic , is a new broad-spectrum, high-efficiency, low-toxicity antibiotic parasite Medicines, especially for internal and external parasites nematodes And arthropods have a good killing effect. Ivermectin is widely used in gastrointestinal nematodes, lung nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes in dogs, ear mites , scabies mite , heartworms and microfilariae, and poultry gastrointestinal nematodes and External parasites . [0003] Ivermectin is a hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61K47/34A61P33/02A61P33/10A61P33/14
Inventor 罗振军吴小萍保广春吴营王天柱
Owner HENAN HEIMA ANIMAL PHARM CO LTD
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