90results about How to "Uniform dosing" patented technology

A charged particle beam irradiation system includes measurement means 15 for measuring an accumulated beam charge amount Qm0, the ion beams orbiting in a synchrotron 13, immediately before an extraction control period in an operating cycle of the synchrotron 13; and beam extraction control means 20, 24, 28, 29 for controlling extraction of the ion beams so that extraction of a total of the ion beams is to be completed in time with expiration of an extraction control time Tex which is set in advance based on the measurement Qm0 of the accumulated beam charge amount. When an irradiation apparatus includes an RMW 32, an amplitude of an extraction radiofrequency voltage is controlled according to a ratio Qm0 / Qs0 of the measurement to a reference value of the accumulated beam charge amount and a ratio Tb / Ta of an actual beam extraction time to the extraction control time Tex.

An expandable stent is fabricated from a plurality of circumferential rings, each pair of adjacent circumferential rings being interconnected by a multiplicity of links, each link contacting a portion of a strut in one ring along one longitudinal axis and a portion a strut in a directly adjacent ring along a different longitudinal axis. Each link is circumferentially S-shaped and adjacent links are mirror images of each other. The resulting stent is both flexible and strong when expanded thereby providing good scaffolding. In one embodiment, the strut material is fabricated of shape memory alloy such that when the strut is compressed so as to be insertable into a vessel, the strut will automatically expand to its previous dimension upon rising to the temperature of the vessel in which it is placed, thereby to expand and hold open the vessel without need for a balloon catheter.

A therapy apparatus for producing thermal neutrons at a tumor site in a patient has a plurality of fast neutron sources surrounding a moderator, a fast neutron reflecting media around the fast neutron sources, a gamma-ray and neutron shielding media surrounding the fast neutron reflecting media, and a patient chamber positioned inside the moderator. The fast neutron sources are positioned around the moderator to maximize and direct the neutron flux to said tumor site.

Methods and apparatuses for coating surface of medical devices using coating heads are disclosed. In one embodiment, the invention includes a coating method using a coating head, wherein the coating head comprises at least one outlet orifice from which flows a coating material, to deposit at least one layer of coating material dispelled through the outlet orifice onto the surface of the medical device. In another embodiment, a slide coating head is used to deposit multiple layers of superposed coating materials. These methods are used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats.

A therapy apparatus for producing thermal neutrons at a tumor site in a patient has a plurality of fast neutron sources surrounding a moderator, a fast neutron reflecting media around the fast neutron sources, a gamma-ray and neutron shielding media surrounding the fast neutron reflecting media, and a patient chamber positioned inside the moderator. The fast neutron sources are positioned around the moderator to maximize and direct the neutron flux to said tumor site.

The invention discloses a gynecology administration device. The gynecology administration device comprises a drug pushing tube, an outer sleeve and a drug distributing tube, wherein the drug pushing tube is provided with a drug inlet and outlet hole in the front end face, and a first O-type ring is fixed to the outer side wall of the front end of the drug pushing tube; the outer sleeve is arranged outside the drug pushing tube in a sleeving mode, and a second O-type ring is fixed to the inner side of the front end of the outer sleeve; the drug distributing tube is arranged outside the drug pushing tube in a sleeving mode, the rear end of the drug distributing tube is connected with the outer sleeve in a sealed mode, administration holes are formed in the bottom and the side wall of the drug distributing tube, a communicating groove is formed in the inner tube wall of the drug distributing tube, and when the front end of the drug pushing tube abuts against a limiting protrusion, interlayer spaces before and after the first O-type ring are communicated. The administration device discharges a drug through the multiple holes, administrates the drug evenly, is large in acting surface, prevents the drug from accumulating locally, and ensures that the drug fast takes effect on the focus portion in time, and therefore the use efficiency and the treatment effect of the drug are improved; the drug distributing tube is disposable, so that the gynecology administration device is safe and sanitary, the drug pushing tube and the outer sleeve are convenient to clean and can be recycled, and therefore the cost of treating gynecological disease is reduced; excessive drug residue can be avoided, drug waste is reduced, and the gynecology administration device can be operated coherently, smoothly and easily.

Methods and apparatuses for coating surfaces of medical devices by electroplating are disclosed. In one embodiment, the invention includes a coating method in which a mixture of a therapeutic agent, and a plating material are electroplated onto the surface of the medical device. The electroplating method may be performed at a relatively low temperature to avoid destruction of the therapeutic agent. In another embodiment, a coating method is disclosed in which the coating is formed by suspending a therapeutic agent in an electrolytic solution and electroplating a plating material onto the medical device wherein the plating material carries the suspended therapeutic agent. Thus, the coating of plating material contains the suspended therapeutic agent. These methods and apparatuses are used to apply one or more coating materials, simultaneously or in sequence by varying the electroplating voltage. In certain embodiments of the invention, the coating materials include therapeutic agents and cationic drugs.

The invention belongs to the field of medical instruments and relates to cavitary mucosal drug delivery devices, in particular to an intelligent cavitary mucosal drug delivery device. The device comprises a display control operation platform, a heating sleeve, a peristaltic pump, a controllable liquid medicine valve and a micro wireless camera. The device is also provided with a wireless signal processor, the micro wireless camera transmits an observed image to the display control operation platform through the wireless signal processor, and the display control operation platform is connected with other equipment through a wire communication circuit to control the equipment. Through the combination of wire communication and wireless arrangement, the operability and data signal transmission effect of the device can be improved to a large extent, the device is convenient to operate, good in drug feeding effect, uniform in drug delivery, high in automation degree and capable of saving more labor, and the device is more intelligent compared with the prior art.

An apparatus and methods to form a tissue scaffolding are provided. The apparatus may include a catheter shaft extending from a proximal end to a distal tip, a distal balloon positioned on the catheter shaft proximal to the distal tip, and a proximal balloon positioned on the catheter shaft proximal to the distal balloon. The apparatus may further include an intermediate balloon positioned on a distal segment of the catheter shaft proximal to the distal balloon and distal to the proximal balloon. The intermediate balloon and the distal segment each include a translucent material. A light fiber may extend through the distal segment. A first lumen and a second lumen may be arranged in the catheter shaft, the first lumen comprising a first port located between the distal balloon and the intermediate balloon, and the second lumen comprising a second port located between the intermediate balloon and the proximal balloon.

A method is taught that provides for transmucosal delivery of a biological cargo and optical molecular imaging probes to a subject animal or human. At least one biological cargo-laden nanoparticle imaging probe is provided in a form that will be absorbed via mucosal tissue. The biological cargo-laden nanoparticle imaging probe is delivered to the mucosal tissue of the animal or human. The method further may include steps of providing a support member adapted to receive the subject in an immobilized state; positioning the subject on the support member; and after the delivering of the imaging probe, imaging the immobilized subject using a multimodal imaging system.

A charged particle beam irradiation system includes a synchrotron which accelerates an ion beam, an irradiation apparatus for irradiating an object with the ion beam introduced from the synchrotron, detection means for measuring an amount of accumulated charge of the ion beam that orbits in the synchrotron immediately before an extraction control period in an operating cycle of the synchrotron, and beam extraction control means for controlling extraction of the ion beam based on the measurement result of the accumulated beam charge amount so that extraction of a total amount of the ion beam is to be completed with an expiration of an extraction control time, the extraction control time representing a length of the extraction control period of the synchrotron and being set in advance.

An extended release composition of Pramipexole or a pharmaceutical acceptable salt thereof, wherein the active agent is coated on a non pareil inert core, the drug loaded core is further coated with a polymeric layer which enables the release of the active agent over an extended period and optionally the extended release pellets being further blended with suitable excipients and compressed into a multi unit tablet and processes for the preparation of the said composition.

The invention belongs to the technical field of pharmaceutic preparation, and discloses a wettability solid dispersing powder of florfenicol composition and a preparation method thereof. The wettability solid dispersing powder of florfenicol composition is prepared from the following raw materials in parts by weight: 2-21 parts of florfenicol, 21-39 parts of hydroxypropyl-beta-cyclodextrin, 2.6-10 parts of tween-60, 27.5-57.4 parts of anhydrous dextrose, 10-18 parts of sodium dihydrogen phosphate and 0.0004-0.0042 part of pharmaceutically accepted antioxidant. The wettability solid dispersing powder of florfenicol composition remarkably improves the dispersity of florfenicol in water, can be prepared into injection and dry suspension, and is convenient to use, even in administration, low in side effect and more beneficial to popularization and application of florfenicol in animal husbandry and aquaculture industry. The preparation method of the wettability solid dispersing powder of florfenicol composition is simple in process, low in production cost and suitable for industrial production.

The invention discloses a double-balloon precise quantitative drug injection catheter. The catheter comprises a guide wire, a main catheter body and a balloon, the balloon is composed of an inner balloon body and an outer balloon body, the main catheter body is arranged in the middle of the outer balloon body and the inner balloon body, the guide wire is arranged in the main catheter body, the guide wire penetrates through a guide wire inlet formed in the main catheter body and penetrates out from a guide wire outlet, the main catheter body is internally provided with a pressure catheter bodyand a drug injection catheter body, the outlet end of the drug injection catheter body penetrates through the catheter and placed in a gap between the inner balloon body and the outer balloon body, the other end of the drug injection catheter body is connected with a drug injection pump, ad a control valve is arranged on the drug injection catheter body. The outlet end of the pressure catheter body penetrates through the main catheter body to be communicated with the inner balloon body, and the other end of the pressure catheter body is connected with a pressure pump. Accordingly, precise control over the dosage of applied drugs can be achieved, the drug injection amount and pressure size are controlled through a drug injection pipe and a pressure pipe respectively, drugs are injected intothe endovascular wall, dosing is uniform, the drugs are not wasted, the drugs can be fully utilized, drug injection can be conducted repeatedly, and the type of drug injection can be changed.

A precise transfusion apparatus for antalgic purpose is composed of a protective casing with a three-way supporter in it, an elastic medicine bag, flow regulator, dripping hopper, guide tube, filter, needle jointer and needle. Its advantages are simple structure, uniform transfusion speed, and high antalgic effect.

A filling unit and a method for filling a confectionery mass into a container or a mold includes a fill housing with a filling nozzle (2) and at least two dosing pistons in a cylinder which is connected to the fill housing. In the fill housing, a valve is arranged for each cylinder. A mixing block with internal ducts connects each of the outlets with a respective internal duct in the filling nozzle. The confectionery mass is conducted from a filling nozzle into at least one of the cylinders after which the confectionery mass is dosed down into the mold or container by actuating the dosing pistons. The speeds of the pistons are controlled independently of each other, providing varying patterns in longitudinal direction of the ice-cream / confectionery product. The movement of the filling unit relative to the container or mold can be varied providing additional options for variation in patterns.

The invention relates to an invermectin in-vivo gel injection and a preparation method thereof, aiming at providing a long-acting injection for preventing and treating livestock parasite infections, and a preparation method thereof. Raw materials required by every 100 mL of the invermectin in-vivo gel injection comprise 5 g-10 g of injection grade invermectin, 10 g-20 g of poly(lactic-co-glycolicacid) (PLGA), 1 g -2 g of carbomer-941, 0.1 g -0.2 g of tween-80 and 85 mL-90 mL of an organic solvent. The injection is an in-vivo gel prepared from invermectin, and is used for preventing and treating gastrointestinal parasites of cattle, pigs and sheep, lungworm and externally parasitic diseases such as lice, and mites and fly larvae. The injection has an obvious effect; and the preparation method of the injection is simple and easily operational, and is suitable for large-scale production.

A laser interference lithography system with flat-top intensity profile comprises a laser source for emitting a coherent laser beam, a first beam expander for adjusting the coherent laser beam size, a refractive beam shaper for converting a Gaussian intensity profile inherent to the coherent laser beam into a flat-top one and outputting a first collimated laser beam, a second beam expander for receiving the first collimated laser beam and outputting a second collimated laser beam, a sample holder for holding a substrate, and at least one reflector for reflecting the second collimated laser beam to generate a third collimated laser beam. The second and third collimated laser beams are transmitted to the substrate at a predetermined angle to create an interference pattern exposed onto the substrate.

The invention discloses a novel urethra dosing device for urinary surgery, and belongs to the field of a medical treatment device. The device comprises a dosing body, a cylindrical pollution absorber, a pusher and a spring; the pollution absorber is a hollow structure and formed to be a holding cavity; the front end of the pollution absorber is provided with a spherical pollution absorbing head. Specific to problems that stains in the urethra can pollute drug fluid, and the drug dosing device causes discomfort sense to patients and the drug dosing is uneven when the urethra is applied with drugs in the prior art, the dosing device can gradually enter the urethra through the spherical pollution absorber, and reduce the discomfort sense; the pollution absorbing hole can absorb stains in the urethra before dosing, and the stains are completely isolated from the drug fluid and thus no pollution forms; the drug dosing ball can reduce the friction between the dosing device and the urethra, thus the discomfort sense is further reduced while the dosing is gradually carried out; besides, the drug dosing is uniform.

A filling unit and a method for filling a confectionery mass into a container or a mold includes a fill housing with a filling nozzle (2) and at least two dosing pistons in a cylinder which is connected to the fill housing. In the fill housing, a valve is arranged for each cylinder. A mixing block with internal ducts connects each of the outlets with a respective internal duct in the filling nozzle. The confectionery mass is conducted from a filling nozzle into at least one of the cylinders after which the confectionery mass is dosed down into the mold or container by actuating the dosing pistons. The speeds of the pistons are controlled independently of each other, providing varying patterns in longitudinal direction of the ice-cream / confectionery product. The movement of the filling unit relative to the container or mold can be varied providing additional options for variation in patterns.

A method and a device are disclosed for transdermal delivery to an animal or human of biological cargo-laden nanoparticles. The particles may include multimodal optical molecular imaging probes. The particles may be delivered by providing them in a form that can be absorbed through the skin and applying them to the skin of an animal or human. The application may be accomplished using biological cargo-laden nanoparticles in a device attachable to the skin. The device may be attached directly to the skin by a device containing a vasodilating agent or agents, or micro needles, or multi-layer time release material. The biological cargo-laden nanoparticles may comprise drugs, vaccines, bio-pharmaceuticals, imaging contrast agents, multimodal imaging contrast agents, biomolecules, or anti-infectives. The device may include a first plurality of different types of biological cargo-laden nanoparticles located in a corresponding second plurality of separate time release layers.

The invention relates to an environment protective type casting system of aerosol, which comprises one or several propellants, by employing the environment-friendly type propellant separately, or using the environment-friendly type propellant system consisting of several propellants, the compatibility of the feed liquid can be improved substantially.

A spraying drug delivery device comprises a sleeve, wherein an internal cavity is formed in the sleeve and can accommodate a needle cylinder of a syringe; and at least one spray nozzle, wherein the spray nozzles are arranged at the front end of the sleeve and communicate with the internal cavity of the sleeve. An axial direction of each spray nozzle forms an angle with an axial direction of the sleeve. A finger-pressure pinch plate may also be formed at or adjacent to the rear end of the sleeve. Two spray nozzles can also be arranged at the front end of the sleeve. The spraying drug delivery device can achieve full spraying of medicated liquid, uniform drug delivery and leakage prevention. The invention further relates to a spraying drug delivery system comprising the device.

The present invention relates to the field of mechanical technology, in particular to a visualized anorectal drug delivery device, which includes a drug delivery tube, one end of the drug delivery tube is provided with a flexible end, a camera is embedded in the outer wall of the flexible end, a fixing ring is arranged on the outer surface of one end of the drug delivery tube away from the flexible end, a telescopic device is connected to one end of that drug delivery tube away from the flexible end, the surface of the drug delivery tube is provided with a plurality of sustained-release tabletplacing grooves, a sustained-release tablet is arranged inside the sustained-release tablet placing groove, a fixing paste is arranged on the top of the sustained-release tablet placing groove, the surface of the drug delivery tube is also provided with a lubricant placing groove, the lubricant placing groove is internally provided with a fixing column, The outer side of the fixed column is wrapped with vaseline. The invention has simple structure and convenient use. The drug administration tube can ensure uniform administration to the inside of the patient's anus and intestine, and can adjust the drug administration depth and improve the drug administration effect. The vaseline can further lubricate the outer wall of the drug administration tube and avoid the friction between the drug administration tube and the inside wall of the patient's anus and intestine from causing discomfort to the patient.

The invention relates to the technical field of gynaecology and obstetrics, and discloses a gynecological pudendum dosing device capable of reducing waste and uniformly dosing. The gynecological pudendum dosing device comprises a handheld handle. Through the cooperative use of air bags, channels and a shell, the air bags can be driven to bulge during dosing, then the inner wall of a vagina is supported, wrinkles of the inner wall are expanded, and medicine can be uniformly sprayed on the surface of the inner wall when being applied, so that medicine application incapability at the wrinkles isavoided; through the cooperative use of a first conveying pipe, a second conveying pipe and the channels, the liquid medicine and compressed gas are evenly mixed to form dense fine mist to be sprayedout, so that spraying is more uniform; it is guaranteed that the liquid medicine is adsorbed to the surface of the inner wall through air pressure, so that medicine application is more uniform; and through cooperative use of a first positioning rib and a second positioning rib, residual liquid medicine in the conveying pipes is brought out through air pressure when medicine application is finishedso that the residue of the liquid medicine can be reduced to the maximum extent, and then waste of the liquid medicine is reduced.

The invention discloses a medication nursing device for patients in the cardiology department, including a drug delivery plate, wherein the top end of the drug feeding plate is connected with a mounting plate, and the two sides of the mounting plate are provided with drug feeding cartridges, one side of the drug cartridge is connected with a second fixing plate, and a rubber plug is slidably connected with the inner wall of the medicine feeding cartridge, one side wall of the rubber plug is connected with a movable rod, and a first fixing plate is connected to an end of the movable bar extending away from the rubber plug to the exterior of the drug cartridge, a side of the second fixing plate close to the first fixing plate is hinged with two first hinge bars arranged symmetrically, and asecond hinge bar is hinged between the first hinge bar and the first fixing plate. A guide groove arranged in an arc structure is arranged on the side of the top end of the drug feeding plate far fromthe mounting plate. The invention can be fixed on the patients with different neck thickness, and can uniformly administer medicine to the patients, thereby avoiding the waste of medicinal materialsand reducing the pain degree of the patients when taking medicine, and is suitable for popularization.

The invention discloses a compound medicine containing letrozole and a preparation method of the compound medicine. The medicine contains the letrozole, copovidone, mannitol, cellulose, crosslinked povidone, magnesium stearate, polyethylene glycol, lactose and starch. The formula of the medicine consists of 8-20 parts of the letrozole, 80-150 parts of the copovidone, 1-3 parts of the mannitol, 4-6 parts of the cellulose, 1-2 parts of the crosslinked povidone, 1-2 parts of the magnesium stearate, 1-3 parts of the polyethylene glycol, 0.5-1 part of the lactose and 1-2 parts of the starch. The compound medicine provided by the invention can significantly improve a letrozole dissolution rate and can further improve bioavailability and clinical treatment effect of medicinal active ingredients; and in addition, a release speed can be reduced, so that the purpose of uniform administration is achieved; therefore, drug tolerance is enhanced.

The invention discloses an outer mixing double fluid fan-shaped spray nozzle which comprises a nozzle body, a nozzle, a supporting pipe, a seal cover and a central pipe, wherein a through hole is formed in the central position of the seal cover; one end of the central pipe is inserted into the supporting pipe through the through hole and the inner part of the nozzle is hermetically connected to the seal cover; and an annular cavity where water circulates is formed between the outer side wall of the central pipe and the inner side walls of the supporting pipe and the nozzle. According to the nozzle structure, a biological pesticide and water are sprayed out through the central pipe and the annular cavity, separately, solid particles such as biological living bodies and auxiliary agents in apesticide are prevented from being in contact with and colliding with the nozzle under protection of water, the erosive wear of the nozzle is reduced, and the damage of microbial cells at the nozzleis also reduced, so that a pest control purpose is achieved.

Methods and apparatuses for coating surface of medical devices using coating heads are disclosed. In one embodiment, the invention includes a coating method using a coating head, wherein the coating head comprises at least one outlet orifice from which flows a coating material, to deposit at least one layer of coating material dispelled through the outlet orifice onto the surface of the medical device. In another embodiment, a slide coating head is used to deposit multiple layers of superposed coating materials. These methods are used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats.

The invention discloses a preparation method of tissue engineering skin, belongs to the technical field of tissue engineering and aims to solve the problem that defects exist in current making methodsof tissue engineering skin support materials and interaction mode of cells and the support materials. The preparation method includes following steps: (1), preparing a nano electrostatic spinning material; (2), culturing human body skin cells; (3), culturing the cells onto a nanofiber material. The preparation method is simple in building method and few in operation step, and good animal in-vivoexperiment effect can be acquired.