The invention relates to the technical field of clinical medical treatment, and discloses a tissue biopsy needle. The tissue biopsy needle comprises a power mechanism, an outer sleeve needle and an inner core needle, wherein the inner core needle is embedded in the outer sleeve needle, a groove is formed in the side wall of the tail end of the outer sleeve needle, a semi-ring cutter correspondingto the groove is arranged on the inner core needle, and the power mechanism drives the semi-ring cutter to transversely rotate in the outer sleeve needle through a needle rod. The tissue biopsy needlehas the beneficial effects that in the process that a cutter opening of the inner core needle and a side cutter act together to cut tissue, the power mechanism drives the semi-ring cutter to rotate rapidly through the needle rod, rapid rotary cutting of the tissue to be detected is achieved to form a complete cylindrical sample, and the tissue is convenient to detect. In the cutting process, dueto the fact that rotary cutting is adopted, the outer sleeve needle and a needle tip are static, shaking cannot occur, damage to surrounding important organs is avoided, safety is greatly improved, and biopsy can be conveniently carried out on tissue such as large vascular gaps, dangerous organ sides, small nodules and lymph nodes.