The invention relates to a
nanoparticle and a preparation method thereof. Poly(
lactide-glycolide acid) (
PLGA) is in the center to serve as a core,
phospholipid surrounds the surface of the
PLGA core in
monolayer and distearoyl
phosphatidylethanolamine-polyethyleneglycol-carboxyl (DSPE-PEG-COOH) penetrates the
monolayer phospholipid to serve as the shell. The
phospholipid, the DSPE-PEG-COOH and the
PLGA have good
biocompatibility, can entrap hydrophobic drugs and control the drugs to release slowly in the human bodies. The phospholipid surrounds the surface of the PLGA, thus ensuring that the particle can avoid
immune system recognition so that the circulating
half life of the particle is lengthened. The PEG shell ensures the particle to have
spatial stability, static stability, long circulation and other characteristics and to be not easily agglomerated. Meanwhile, carboxyl is easily crosslinked with such ligands as antibodies,
peptide, probes and the like, thus ensuring the particle to have targeting characteristic. The preparation method of the
nanoparticle is simple, convenient practical and is easy to operate and popularize.