84results about How to "Moderation" patented technology

The invention relates to a health-care tea and relative technique, which uses hemp seed and sweet tea as basic materials, assisted with other natural Chinese medicine drug, to be used on various diseases. The inventive health-care tea combines the characters of food, health-care product and drug, with good taste, and treatment on hypertension, hyperlipemia, high cholesterol and constipation, without side effect.

The present invention relates to the field of functional food and particularly relates to a composite probiotic and prebiotic composition for improving constipation. The provided composite probiotic and prebiotic composition for improving the constipation comprises probiotics, lactitol, resistant dextrin, inulin, oligofructose, xylooligosaccharide, oligochitosan and oligoisomaltose. Prebiotics aredried using a dryer; the dried prebiotics are sterilized; the sterilized prebiotics are taken out to be placed in a sealed container for natural cooling; then the probiotics and prebiotics are weighed according to a weight ratio; and the weighed materials are mixed to obtain the composite probiotic and prebiotic composition. The probiotics and prebiotics are combined to stabilize the micro-organism colony environment in the intestines, also do not stimulate gastrointestinal nerves, do not produce drug dependence, and achieve the purpose of improving the constipation for a long time.

The invention relates to a Chinese medicinal preparation for treating cough, asthma, throat pain and its preparing process, wherein the preparation is prepared from Chinese ephedra, gypsum, bitter apricot seed, roor of sessile stemona, coltsfoot flower, thunberg fritillary bulb, mulberry bark, cordate houttuynia, mahonia stem, dried orange peel and licorice root.

The invention relates to the field of cosmetics, and particularly relates to an anti-allergic soothing composition and an anti-allergic soothing emulsion and a preparation method thereof. The anti-allergic soothing composition mainly comprises a first active component, stephania tetrandra extract, theanine and epigallocatechin gallate in weight ratio of 0.3-1.5:0.1-0.5:0.8-1.2:0.8-1.2. The first active component includes sophora japonica root extract, glycyrrhiza inflata root extract and scutellaria baicalensis root extract. The components of the anti-allergic soothing composition have a synergistic enhancement effect, and have effects of effectively reducing the adverse effect caused by stimulation, protecting the skin barrier, relieving itching and relieving pain, and soothing the skin;biological polysaccharide and active small molecules are in mutual synergy and slow release for longer lasting action to repair the sensitive skin.

The invention uses fructus cannabis and Guangxi sweet tea as basic raw materials, aided by another natural traditional Chinese medicine raw material of hawthorn to prepare the health protection tea which is both medicine and food; and the invention further discloses the process thereof on the basis of the disclosed health protection tea. The health protection tea has the integrated characteristicsof food, health products and medicine, has good taste and efficacies of eliminating diseases and prolonging life; and the health protection tea has good curative effects on hypertension, hyperlipaemia, high cholesterol and constipation, is suitable for wide groups of patients, and does not have any toxic side effect.

The invention discloses a dehydrating and embedding improvement method of human body or animal tissues. The method comprises the following steps of: fixing; dehydrating; transparence treatment; wax-dipping and embedding. The method comprises the following steps of: first, dehydrating fixed tissue by using ethanol with different concentrations from low concentration to high concentration in a gradient manner; then, placing the tissue dehydrated in the gradient manner into a mixed solution of absolute ethyl alcohol and butanol in a volume ratio of 1:1-1:5 for dehydrating, wherein the time for dehydrating by using the mixed liquid is 30-60 minutes, and then, further using butanol to dehydrate the tissue which is dehydrated by using the mixed liquid at 4-16 DEG C for 8-20 hours; at the end of dehydration, dipping the tissue in butanol for transparence treatment; and finally, wax-dipping and embedding the transparent tissue. The method provided by the invention is simple and convenient to operate, high in safety and reliability, remarkable in effect and wide in application.

The invention uses fructus cannabis and Guangxi sweet tea as basic raw materials, aided by other natural traditional Chinese medicines, including cassia seed, mulberry fruit, semen pruni, radish seed,Hangzhou white chrysanthemum and tea, to prepare the health protection tea which is both medicine and food; and the invention further discloses the process thereof on the basis of the disclosed health protection tea. The health protection tea has the integrated characteristics of food, health products and medicine, has good taste and efficacy of relaxing bowel; and the health protection tea can be used for treating constipation, is suitable for wide groups of patients, and does not have any toxic side effect.

The invention discloses sulphate-potassium magnesium and an application of a sulphate-potassium magnesium contained mixture as an animal feed additive. The sulphate-potassium magnesium is characterized in that 3-9kg / ton of sulphate-potassium magnesium into daily ration for pregnant sows or lactating sows. The application provided by the invention has the advantages that the defect of the traditional method for adding magnesium sulfate and replenishing magnesium and sulfur elements is changed, and the effective utilization rates of potassium, magnesium and sulfur elements are increased; potassium ions, magnesium ions and sulfate ions in a water solution are gradually absorbed; and meanwhile, the osmotic pressure in an intestinal canal can also be gradually raised, water in body fluid moves towards the enteric cavity, the volume of the enteric cavity is increased, the intestinal wall is expanded, and a function of treating astriction is achieved. By adopting slow solubility and slow release, the effect is mild, and the phenomena of secondary astriction, vomit, watery diarrhea, dyspnea and sow parturient prolonging and stillbirth cannot be caused if the sulphate-potassium magnesium is continuously used. The sulphate-potassium magnesium can be used for replenishing the three necessary constant mineral substances, namely the potassium, the magnesium and the sulfur at one step and improving the production property of animals.

The invention relates to a tanning method by using an improved-structure chromium-free retanning agent, belonging to the technical field of leather treatment. In order to overcome the defects of severe chromium pollution, low shrinkage temperature and low setting point in the retanning process, the invention provides a tanning method by using an improved-structure chromium-free retanning agent. The method comprises the following steps: adding shaving leather into a rotating drum, adding 100-150 wt% of water, regulating the temperature to 25-30 DEG C, adding 1.5-2.0 wt% of coordination polymerization inhibitor, and rotating for 10-30 minutes; regulating the pH value of the bath to at most 3.5, and rotating for 60-90 minutes; adding 1.0-2.0 wt% of tanning-assisting tannin, and rotating for 90-120 minutes; adding a non-chromium metal composite tanning agent and 0.2-0.4 wt% of alkali extractor to perform alkali extraction; and heating to 38-40 DEG C to perform treatment, and carrying out after-treatment to obtain the finished leather product. The tanning agent has the advantages of high setting point and high shrinkage temperature; and the method effectively controls the total chromium content in the wastewater and sludge.

The present invention discloses a tincture for remedying the dermatophytosis, which consists of components as follows: every 100ml 75 percent ethanol contains 8g to 15g of benzoic acid, 8g to 15g of camphor, 2g to 8g of salicylic acid, 20ml to 40ml of cortex pseudolaricis tincture, 1ml to 5ml of 10 percent iodine tincture and 10ml to 30ml of glycerin. The medicine is prepared by combining traditional Chinese medicines and western medicines, which overcomes the disadvantages of the existing medicine of high recurrence rate of remedying the dermatophytosis, great side effects after being used etc. The present invention medicates in a form of the tincture, which has very good curative effect for remedying the dermatophytosis.

The invention relates to a study method using capillary electrophoresis and UPLC-MS (ultra performance liquid chromatography - mass spectrometry) to analyze a regulating function of PQQ (pyrroloquinoline quinone) on catecholamine neurotransmitter, and belongs to the technical field of biological analysis. The method comprises the following steps of extracting brain tissues by anion solid-phase extraction, measuring the change of content of catecholamine in a mouse brain of a chronic stress induced depression model and the change of a reaction product of catecholamine, well separating PQQ, NE (noradrenaline), E (epinephrine) and products, and using UPLC-MS to identify the PQQ and the catecholamine reaction product. After proofing by results, the PQQ reacts with NE to generate the PQQNE, but does not react with E. The method has the advantages that the contents of NE in frontal lobe and hippocampus of the chronic stress induced depression model are obviously increased; by applying a certain amount of PQQ group, the content of NE is obviously decreased, and the contents of E in different groups are not obviously different; the PQQ is mainly used for regulating the catecholamine neurotransmitter through regulating the NE, but has no regulating function on E; the guidance meaning on the study of the depression disease mechanism and depression targeted medicine is realized.

The invention discloses medicine for treating liver-Yang hyperactivity, calming liver wind, and tonifying kidney yin and a preparation method. The medicine consists of Tuckahoe, scutellaria, uncaria, prunella, corn silk, cortex moutan, root of rehmannia, prepared rhizome of rehmannia, Chinese wolfberry, dogwood, radix cyathulae, Chinese yam, and medicated leaven. The preparation method comprises: firstly, soaking the Chinese yam in grain alcohol; secondly, soaking the prepared rhizome of rehmannia and the radix cyathulae in the grain alcohol; thirdly, drying and crushing the Tuckahoe, the scutellaria, the cortex moutan, chrysanthemum, the prunella, the uncaria, the corn silk, the Chinese yam, the root of rehmannia, the Chinese wolfberry, the dogwood, the medicated leaven, the prepared rhizome of rehmannia, and the radix cyathulae; and fourthly, putting fine powder into a sugar coating machine, adding 20 to 30 percent of dilute hydromel into the fine powder, stirring the mixture to prepare water-containing pills, and packaging the pills. The medicine has the advantages of reasonable formulation, remarkable medicine effect, full absorption, alleviation function, innocuousness, low cost, simple process, remarkable curative effect; in addition, the medicine can calm nerves, benefit kidney essence, fill encephalon, nourish Yin and calm wind. The preparation method has the advantages of simple process, remarkable curative effect, full absorption, alleviation function, innocuousness and low cost, and is suitable for industrialized production.

The invention relates to a paeoniflorin preparation for percutaneous administration and a preparation method. The paeoniflorin preparation percutaneous administration is prepared by mixing paeoniflorin, skeleton materials, polyacrylate and a percutaneous absorption enhancer in certain proportion. The preparation for percutaneous administration has high drug-loading rate, can effectively maintain blood concentration of a medicament in a body, can significantly improve the bioavailability of the paeoniflorin, is convenient to use, improves the adaptability of a patient, and has significant effect of preventing and treating cardiovascular and cerebrovascular diseases, particularly coronary heart disease.

The invention provides a method for preparing an enhanced and toughened L-polylactide composite membrane based on wool keratin cortex cells and belongs to the field of high polymer materials. The method comprises the following steps: firstly, dissolving polylactic acid into trichloromethane; secondly, mixing L-polylactide with wool keratin cortex cells, and putting into the polylactic acid solution; uniformly stirring the mixed solution at a normal temperature; finally, pouring the mixed solution into a film former, leaving to stand for 1-2 days at a vent hole at the room temperature, and filming naturally, thereby obtaining the cortex cell enhanced and toughened L-polylactide composite membrane. By adopting the simple method, the enhanced and toughened polylactic acid composite membrane is prepared and can be applied to fields such as packaging.

The invention provides an immunity enhancing marine collagen soybean peptide powder. The immunity enhancing marine collagen soybean peptide powder is prepared from the raw materials of, by weight part, 1-5 parts of marine fish skin collagen oligopeptide powder, 1-5 parts of soybean peptide powder, 1-5 parts of concentrated whey protein powder, 1-3 parts of xylitol, 0.1-0.2 part of citric acid and 0.001-0.003 part of vitamin C. Experiments prove that the immunity enhancing marine collagen soybean peptide powder can effectively improve immunity and reduce discomfort during taking and meanwhile is mild in effects and free from side effects.

The invention discloses a method for extracting adipose-derived stem cells, and belongs to the technical field of stem cell extraction. The method for extracting the adipose-derived stem cells comprises the steps of fat acquisition, washing, digestion, cleaning, lysis of red blood cells, termination of lysis, culture, re-inoculation, passage and identification. According to the method, adipose tissue is washed repeatedly with a cell washing liquid to effectively remove fat droplets; a digestive enzyme is utilized to digest collagenous fiber in an intercellular substance to release the cells, so that the damage to the cells is small, and the free cells maintain the activity of the cells in a mesenchymal basal culture medium; subculture is carried out on the cells not attached to walls in asupernatant of a cell culture bottle, thereby increasing the survival rate of the cells, and increasing the multiplication rate of the cells. The method for extracting the adipose-derived stem cells has the advantages that the method is simple and convenient; the enzymolysis of the adipose tissue is thorough, and each component cell is released maximumlly; the survival rate of the obtained adipose-derived stem cells is high.

The invention provides a red rice yeast bitter gourd composite peptide tablet for preventing hypertension, hyperlipidemia and hyperglycemia. The tablet comprises the following components: wheat oligopeptide powder, soybean peptide powder, collage peptide powder, albumin peptide powder, polydextrose, isomalto-oligosaccharide, inulin, red rice yeast, a bitter gourd extract, gingko powder and tea polyphenol. The red rice yeast bitter gourd composite peptide tablet is not only good in palatability, but also relatively remarkable in effect of relieving symptoms of patients suffering from hypertension, hyperlipidemia and hyperglycemia.

The invention discloses a pharmaceutical composition for treating osteoporosis, a liposome preparation of the pharmaceutical composition, and a preparation method thereof. The pharmaceutical composition comprises the following components in mass part: 1-5 parts of icaritin, 1-5 parts of chiratin, 1-5 parts of loganin and an optional pharmaceutically acceptable carrier. According to the technical scheme of the invention, icaritin, chiratin and loganin are adopted as active pharmaceutical ingredients to be combined for the first time. It has been proved that, the pharmaceutical composition has an outstanding curative effects in treating osteoporosis. Meanwhile, based on the characteristics of traditional Chinese medicine, the pharmaceutical composition has the obvious advantages of moderate effect and little side effects. The pharmaceutical composition is prepared in the form of a liposome preparation, thus being good in targeting and obvious in sustained-release effect. The liposome preparation well reduces the toxic effect of the pharmaceutical composition and improves the stability of the pharmaceutical composition.

The invention discloses shellfish heparin with a mild anti-coagulation effect as well as a preparation method and the application thereof. The preparation method comprises the following steps: raw material treatment; self-dissolution; enzymolysis: adding NaOH to regulate the pH value to 7.8-8.2, adding trypsin, performing enzymolysis for 3.5-6.5 hours at a temperature of 32-42 DEG C, then adding HCl to regulate the pH value to be 6.8-7.2, adding papain and performing enzymolysis for 4.5-5.5 hours at a temperature of 62-68 DEG C to obtain an hydrolysate; enzyme inactivation and centrifugation;concentration and alcohol precipitation; re-dissolution and protein removal; de-salting and drying. The shellfish heparin as well as the preparation method and the application thereof disclosed by theinvention has the benefits that The shellfish heparin with the anti-coagulation effect is prepared by taking celomactra antiquata, panopea abrupta, tapes dorsatus, tegillarca granosa and meretrix assources for the first time; the heparin comes from marine shellfishes and is high in safety and mild in effect; not only are the sources of the heparin widened, but also the preparation method is simple, the product quality is stable, and application values are good in the preparation of the heparin with low side effects or other products with mild anti-coagulation effects.

The invention discloses a traditional Chinese medicinal composition with effects of loosening the bowel to relieve constipation, which is prepared from the following raw materials in parts by weight: 10-30 parts of Cistanche deserticola, 20-40 parts of black sesame seed, 5-18 parts of Cannabis sativa seeds, 5-15 parts of Prunus japonica and / or Prunus humilis seeds, 5-15 parts of dried tangerine peel, and 8-20 parts of malt rootlets. The invention also discloses application of the traditional Chinese medicinal composition in preparing medicaments or health products with effects of loosening the bowel to relieve constipation. The invention also discloses an ointment containing the traditional Chinese medicinal composition. The traditional Chinese medicinal composition disclosed by the invention has reasonable formulation, in which Cistanche deserticola can enter the blood aspect of the kidney channel, has the effects of warming and recuperating the kidney-yang, enriching the blood and moistening dryness, reinforcing vital function, and nourishing yin, and is a monarch drug; Prunus japonica and / or Prunus humilis seed has the effects of loosening the bowel and relieving constipation, and promoting urination; Cannabis sativa seed has the effects of nourishing and moistening, and the action is mild; Prunus japonica and / or Prunus humilis seed and Cannabis sativa seed are together ministerial drugs; black sesame seed has the effects of nourishing yin and blood, nourishing the liver and the kidney; dried tangerine peel has the effects of regulating the flow of qi, and strengthening the spleen; malt rootlets have the effect of promoting digestion; and black sesame seed, dried tangerine peel and malt rootlets are together adjuvant drugs. The six traditional Chinese medicinal materials interact to enhance the effects of loosening the bowel to relieve constipation.

The invention provides a feed additive with a mould-proof, anti-oxidization and detoxifying function. The feed additive comprises the following ingredients in parts by weight: 4 to 7 parts of glucose oxidase, 4 to 7 parts of edible tannin, 4 to 7 parts of glucuronic acid lactone, 2 to 5 parts of tert-butylhydroquinone, 5 to 8 parts of beta-carotene, 3 to 5 parts of methionine, 3 to 5 parts of vitamin E, 3 to 5 parts of vitamin D, 3 to 5 parts of vitamin A, 3 to 5 parts of selenium and 40 to 50 parts of sepiolite clay. The feed additive is added to the feed, so that not only can mildew and oxidization of the feed be prevented, but also the feed which is slightly mildewed can be continuously fed because the feed additive has a function of eliminating the mycotoxin of a body, and the waste of the feed can be reduced.

The invention discloses a novel use of schizandrin. The schizandrin can be used for preparing a drug for treating the high blood pressure and can be made into an oral liquid preparation or an injection preparation, so that the blood pressure of a high blood pressure patient can be effectively lowered, the occurrence of the high blood pressure complication can be prevented, and the living quality of the patient can be improved.

The invention discloses a traditional Chinese medicine composition for treating osteoarthritis. The traditional Chinese medicine composition is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-30 parts of suberect spatholobus stems, 10-30 parts of honeysuckle stems, 10-30 parts of herba aristolochiae, 5-15 parts of radix stephaniae tetrandrae, 10-20 parts of cocculus orbiculatus, 10-20 parts of radix rehmanniae, 50-80 parts of fructus cannabis, 50-80 parts of radix angelicae pubescentis, 50-80 parts of bunge cherry seeds, 50-80 parts of fructus aurantii, 50-80 parts of semen plantaginis, 50-80 parts of semen cuscutae, 50-80 parts of Chinese yam, 50-80 parts of radix achyranthis bidentatae, 50-80 parts of dogwoods and 20-40 parts of notopterygium roots. The traditional Chinese medicine composition is reasonable in formula, wide in raw material sources of traditional Chinese medicines used in the formula, low in cost, suitable for patients suffering from chronic diseases such as osteoarthritis and also convenient to carry and take.

The invention belongs to the technical field of medicine, and particularly relates to a Zhuang medicine for treating gout and a preparation method thereof. The Zhuang medicine is prepared from, by weight, 25-50 parts of herb of glabrous sarcandra, 15-40 parts of polygonum cuspidatum, 15-40 parts of honeysuckle stems, 15-40 parts of fenbixie, 15-40 parts of plantain herb, 10-30 parts of cynanchum paniculatum, 10-30 parts of garden balsam stems and 3-12 parts of liquorice roots. According to the Zhuang medicine preparation for treating gout, the accessories meeting the medicine standard are added, and medical solid particles or a liquid preparation is prepared. The Zhuang medicine preparation for treating gout is scientific and reasonable in formula, and has the functions of clearing heat and promoting dieresis and dispelling wind and removing obstruction in the meridians, and the clinical application result shows that the Zhuang medicine preparation for treating gout has the effects ofclearing heat and toxins, removing damp toxins, removing wind toxins, relieving swelling, adjusting the water channel and dredging the dragon channel and the fire channel, and has a good effect of treating gout caused by rheumatic fever and damp toxins, wherein gout comprises the symptoms of arthralgia, swelling, scorching hot, inhibited bending and stretching, increasing blood uric acid, uratomaand the like.

The invention discloses a traditional Chinese medicine polysaccharide facial mask capable of replenishing water and dispelling freckle. The traditional Chinese medicine polysaccharide facial mask capable of replenishing water and dispelling freckle comprises a rhizoma anemarrhenae polysaccharide extract, a purslane herb polysaccharide extract and a plantain seed polysaccharide extract, wherein thepurslane herb polysaccharide extract and the plantain seed polysaccharide extract both contain hyaluronic acid which is not less than 10%, and the weight ratio of the rhizoma anemarrhenae polysaccharide extract to the purslane herb polysaccharide extract to the plantain seed polysaccharide extract is 1:(0.5-2):(0.7-3). The invention also discloses a preparation method of the traditional Chinese medicine polysaccharide facial mask capable of replenishing water and dispelling freckle. The inventor of the invention finds that heat removing medicines of rhizoma anemarrhenae polysaccharide, purslane herb polysaccharide and plantain seed polysaccharide can enable skin to be tender, fine and smooth and particularly can lock up skin moisture. Three traditional Chinese medicine polysaccharides arehigh in content in medicinal materials, an extraction method is simple, materials are economic, medicinal material sources are extensive, the polysaccharides are sticky in property, and the traditional Chinese medicine polysaccharides are suitable for preparing facial mask products which have multiple efficacy from combined measures.

The invention discloses an application of a composition in the preparation of bowel relaxing and intestine clearing products. The composition includes a seaweed substance and an enzyme inhibitor. The composition can promote the intestinal peristalsis of normal mice and increase the stool volume of the normal mice and constipation mice; the seaweed substance has wide source and low price; and the bowel relaxing and intestine clearing products prepared by using the composition have intestine moistening, bowel relaxing and intestine clearing functions, can be used for treating and relieving various types of constipations and abdominal distension and pain caused by the constipations, have the advantages of fast acting, mild effect, obvious dose effect relationship, and no abdominal distension and pains or other untoward effects, can be processed to prepare various oral forms convenient for patients to use, and are safe and effective to the patients.

The invention relates to the technical field of leather manufacturing, in particular to a leather manufacturing method with the hair saving and hair removing functions. The leather manufacturing method comprises the following steps: pre-soaking in water; flesh removing; main soaking in water; unhairing and liming; and flesh removing on limed skin and splitting. According to the leather manufacturing method provided by the invention, a sulfydryl urea compound LM and an expanding agent LS, namely an organic chelate alkali, are utilized in the hair saving and liming process, so that the sulfide consumption in the lime-soda liming process can be reduced by 66.6%, the lime consumption can be reduced by 74.3%, and the COD emission in the liming process can be reduced by 80%. However, the properties of finished leather are still good.

The invention discloses a complex probiotic composition with an anti-aging effect, and a preparation method and an application of the complex probiotic composition. The composition can keep an intestinal function, tonify qi, nourish blood and resist aging. The composition comprises 1-10 parts of bifidobacteria, 1-10 parts of lactobacillus bulgaricus, 1-10 parts of streptococcus thermophilus, 1-10parts of lactobacillus acidophilus and one or more of the following medicines: 5-30 parts of Chinese angelica roots, 10-40 parts of astragalus mongholicus, 10-40 parts of poria cocos, 5-20 parts of barbary wolfberry fruits, 5-20 parts of siberian solomonseal rhizome, 5-20 parts of tangerine peel and 1-15 parts of licorice roots. The composition has effects of improving intelligence, enhancing physical capability, alleviating constipation, presbyopia, allergic rhinitis and alopecia, enhancing body immunity, improving sleeping and alleviating gastroenteritis. According to the composition, probiotics are creatively matched with the traditional Chinese medicines, and the composition has a definite effect.

The invention provides a pulping process method for synchronously quenching and bleaching rice straws. A pulping method for quenching a rice straw raw material in a room temperature environment for at least four hours by using a mixed chemical liquid medicine prepared by dissolving caustic soda, sulfonate and hydrogen peroxide in water is adopted, wherein the chemical liquid medicine is prepared from the components by total weight percentage of the mixed liquid medicine: 5-10 percent of caustic soda, 1-2 percent of sulfonate, and 10-12 percent of hydrogen peroxide, and the water dose is 10-12 times of the dry weight part. By adopting the technical scheme, the pulping process flow is greatly shortened, the constraint of lignin to fibers can be eliminated in the quenching process, so that the fibers can be sufficiently softened into pulp in the quenching process, and the pulping process is high in yield, high in quality, low in cost and friendly to environment.

The invention relates to a paeoniflorin preparation for percutaneous administration and a preparation method. The paeoniflorin preparation percutaneous administration is prepared by mixing paeoniflorin, skeleton materials, polyacrylate and a percutaneous absorption enhancer in certain proportion. The preparation for percutaneous administration has high drug-loading rate, can effectively maintain blood concentration of a medicament in a body, can significantly improve the bioavailability of the paeoniflorin, is convenient to use, improves the adaptability of a patient, and has significant effect of preventing and treating cardiovascular and cerebrovascular diseases, particularly coronary heart disease.