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Application of composition in preparation of bowel relaxing and intestine clearing products

A composition and product technology, applied in application, food preparation, drug combination, etc., can solve the problems of damage to the enteric nervous system of patients, chemical components have liver toxicity, and easy to produce drug dependence, etc., to achieve moderate effect and onset of effect Fast, Inexpensive Results

Inactive Publication Date: 2014-12-17
SUZHOU SCISCAPE BIO PHARMA TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of these drugs will cause harm to the human body. For example, the chemical components contained in some drugs have liver toxicity; Once this kind of constipation is formed, it is very stubborn, and some need to take medicine for many years, even life-long medication; some medicines can cause diarrhea, which may lead to electrolyte depletion and serious metabolic disorders, especially when potassium ion disturbances even cause heart rhythm disorders. Disorders and other hazards; long-term use of stimulant laxatives represented by phenolphthalein and castor oil can damage the patient's enteric nervous system, and this damage is likely to be irreversible

Method used

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  • Application of composition in preparation of bowel relaxing and intestine clearing products
  • Application of composition in preparation of bowel relaxing and intestine clearing products
  • Application of composition in preparation of bowel relaxing and intestine clearing products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Combination of the composition of the present invention

[0032] Weigh the corresponding raw materials according to the weight ratio of the seaweed substances and enzyme inhibitors in Table 1, and directly mix them to form a powder composition, or mix and then dissolve in water to form a composition solution. The effective mycin of the embodiment can be a mixture of one or more of effective mycin AH (the use of different isomers has no difference in the inhibitory effect of the enzyme), mainly effective mycin A; trehalose is trehalose (α , Α), isotrehalose (β, β) and new trehalose (α, β) mixture.

[0033] Table 1 Combination of the composition of the present invention

[0034]

[0035] Further, the solid composition or the composition solution can be used to prepare a preparation using a conventional method, not to list them all.

experiment example

[0036] Experimental example: Absorption of the composition of the present invention in the body

[0037] 1. Laboratory animals and materials

[0038] Male ICR mice, 8 weeks old, weighing 20±2g, purchased from Beijing Huafukang Experimental Animal Company;

[0039] Composition of this experimental example:

[0040] Composition 1 solution: Take 15 g of trehalose and 3 mg of effective mycin, use 100 mL of medical sterile water to prepare a composition 1 solution, and set aside.

[0041] 2. Experimental method

[0042] After 3 days of normal feeding, the mice were fasted for 12 hours and could not help but water. They were randomly divided into 4 groups according to their blood sugar levels, the blank control group, the administration group and the negative control group 1-2. The administration group was intragastrically administered with 13.3 mL / kg of the mouse body weight of the composition 1 solution of this experimental example; the blank control group was intragastrically administered ...

Embodiment 2

[0047] Example 2. Effect of the composition on intestinal peristalsis of normal mice

[0048] 1. Laboratory animals and materials

[0049] Male ICR mice, 8 weeks old, weighing 20±2g, purchased from Beijing Huafukang Experimental Animal Company;

[0050] The composition solution of this example:

[0051] Composition 1 solution: take 15g of trehalose and 3mg of effective mycin, use 100mL of medical sterile water to prepare a composition 1 solution, and set aside;

[0052] Composition 2 solution: Take 300 g of trehalose and 3 mg of effective mycin, use 100 mL of sterile medical water to prepare a composition 2 solution, and set aside;

[0053] Composition 3 solution: Take 600 g of trehalose and 3 mg of effective mycin, and use 100 mL of medical sterile water to prepare a composition 3 solution, and set aside;

[0054] Composition 4 solution: take 15g trehalose and 3mg hexaconazole, use 100mL medical sterile water to prepare a composition 4 solution, set aside;

[0055] Composition 5 solution:...

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Abstract

The invention discloses an application of a composition in the preparation of bowel relaxing and intestine clearing products. The composition includes a seaweed substance and an enzyme inhibitor. The composition can promote the intestinal peristalsis of normal mice and increase the stool volume of the normal mice and constipation mice; the seaweed substance has wide source and low price; and the bowel relaxing and intestine clearing products prepared by using the composition have intestine moistening, bowel relaxing and intestine clearing functions, can be used for treating and relieving various types of constipations and abdominal distension and pain caused by the constipations, have the advantages of fast acting, mild effect, obvious dose effect relationship, and no abdominal distension and pains or other untoward effects, can be processed to prepare various oral forms convenient for patients to use, and are safe and effective to the patients.

Description

Technical field [0001] The invention relates to the field of medicine and health care, in particular to the application of a composition in preparing a laxative and intestinal cleansing product. Background technique [0002] With the improvement of people's living conditions and the improvement of living standards, the human body has been ingesting high-fat foods for many years, coupled with residual pesticides in the food, water pollution, and toxins in cigarettes, alcohol, and medicines, which are easily in the human body Toxins and stools are formed. The most important detoxification system in the human body is the intestine. Under normal physiological conditions, most of the garbage produced in the body can be excreted through the intestine. However, when the body is in fatigue, improper diet, lack of sleep, etc. When this kind of illness or medication is unreasonable, the elimination of garbage from the body will be blocked and stool will be formed. Stool, that is, the fece...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A23L1/09A23L2/39A23L2/38A61P1/10A61P29/00A61K31/715A61K31/7016A23L33/125
Inventor 张成岗李志慧李雨
Owner SUZHOU SCISCAPE BIO PHARMA TECH
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