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Novel use of schizandrin

A kind of schisandrin methyl, new-purpose technology, applied in the field of biomedicine, to achieve the effect of mild effect, less adverse reaction, stable blood pressure

Inactive Publication Date: 2018-10-12
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no literature that mentions that Schisandrin A can be used in the treatment of hypertension

Method used

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  • Novel use of schizandrin
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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0016] (1) Pharmacological experiment

[0017] 1. Materials

[0018] 1.1 Experimental animals

[0019] Sprague-Dawley (SD) rats, SPF grade, male, weighing about 200g-250g, were purchased from the Experimental Animal Center of Xi'an Jiaotong University (permit number: SCXK (Shaanxi) 2008-008).

[0020] 1.2 Instruments

[0021] Microvascular tensiometer, Danish DMT company; Physiological recorder, Australia Adinstruments company; Stereo microscope, Japan Olympus company; Multifunctional circulating constant temperature water bath, Haichangji Geological Instrument Co., Ltd.

[0022] 1.3 Reagent

[0023] Phenylephrine [(R)-(-)-phenylephrine, PE], acetylcholine [Acetylclohe chloride, Ach], American Sigma Company; physiological nutrient solution (PSS) composition (mM): NaCl 119, KCl 4.6, NaH 2 PO 4 2H 2 O 1.2, MgCl 2 ·5H 2 O 1.2, N...

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PUM

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Abstract

The invention discloses a novel use of schizandrin. The schizandrin can be used for preparing a drug for treating the high blood pressure and can be made into an oral liquid preparation or an injection preparation, so that the blood pressure of a high blood pressure patient can be effectively lowered, the occurrence of the high blood pressure complication can be prevented, and the living quality of the patient can be improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a new application of schisandrin A. Background technique [0002] Hypertension refers to an increase in systemic arterial blood pressure (systolic or diastolic blood pressure) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney and other organ functions or organs. Clinical syndrome of qualitative impairment. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. Hypertension has a high morbidity rate, a high disability rate, and a high mortality rate. Good blood pressure management can improve the quality of life of patients. A retrospective study showed that reducing systolic blood pressure by 10mmHg and diastolic blood pressure by 5mmHg can reduce the incidence of coronary atherosclerotic heart disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61P9/12
CPCA61K31/09A61P9/12
Inventor 申旭霁陈玉龙郑蕾刘欢欢
Owner XIAN MEDICAL UNIV
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