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91 results about "Immuno suppression" patented technology

Immunosuppression: Suppression of the immune system and its ability to fight infection. Immunosuppression may result from certain diseases, such as AIDS or lymphoma, or from certain drugs, such as some of those used to treat cancer.

Method for generating t-cells compatible for allogenic transplantation

The present invention pertains to engineered T-cells, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered T-cells of the invention are characterized in that the expression of beta 2-microglobulin (B2M) and / or class II major histocompatibility complex transactivator (CIITA) is inhibited, e.g., by using rare-cutting endonucleases able to selectively inactivating by DNA cleavage the gene encoding B2M and / or CIITA, or by using nucleic acid molecules which inhibit the expression of B2M and / or CIITA. In order to further render the T-cell non-alloreactive, at least one gene encoding a component of the T-cell receptor is inactivated, e.g., by using a rare-cutting endonucleases able to selectively inactivating by DNA cleavage the gene encoding said TCR component. In addition, expression of immunosuppressive polypeptide can be performed on those modified T-cells in order to prolong the survival of these modified T cells in host organism. Such modified T-cell is particularly suitable for allogeneic transplantations, especially because it reduces both the risk of rejection by the host's immune system and the risk of developing graft versus host disease. The invention opens the way to standard and affordable adoptive immunotherapy strategies using T-Cells for treating cancer, infections and auto-immune diseases.
Owner:CELLECTIS SA

Extracorporeal Removal of Microvesicular Particles

ActiveUS20090304677A1Effective and relatively benign treatmentEffective and relatively benignDialysis systemsSolid sorbent liquid separationSpecific immunityWilms' tumor
The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with the goal of reversing antigen-specific and antigen-nonspecific immune suppression. Said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue, or the neoplastic tissue itself. Compositions of matter, medical devices, and novel utilities of existing medical devices are disclosed.
Owner:AETHLON MEDICAL INC

Extracorporeal removal of microvesicular particles

ActiveUS8288172B2Effective and relatively benignDialysis systemsSolid sorbent liquid separationAntigenNeoplastic tissue
The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with the goal of reversing antigen-specific and antigen-nonspecific immune suppression. Said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue, or the neoplastic tissue itself. Compositions of matter, medical devices, and novel utilities of existing medical devices are disclosed.
Owner:AETHLON MEDICAL INC

Methods for enhancing immune response

This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including; bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to H. Pylori infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.
Owner:AMINEX THERAPEUTICS

Prevention of nuclear, solar, and other radiation-induced tissue damage

InactiveUS20070293458A1Reduced cell attachmentHigh strengthBiocideAntinoxious agentsPhosphorylationPyrophosphate
Inositol hexaphosphate (IP-6) is a polyphosphorylated carbohydrate with potent antioxidant activity to prevent active oxygen species-mediated mutagenesis, cell injury and carcinogenesis. IP-6 also activates DNA repair mechanisms. Sublethal radiation causes DNA damage through the formation of free radicals, reactive oxygen species, and pyrimidine crosslinks leading to cellular proliferation, cell cycle arrest and apoptosis. In the skin it results in the induction of skin cancer, premature skin aging, immuno-suppression, inflammation, and cell death. Likewise sublethal exposure to ionizing radiation as in nuclear blasts (war-time, accidental, terrorist-induced etc), cosmic radiation, etc. also causes the same spectrum of damage to the cells and the organisms with acute symptoms and eventual high risk of many cancers. IP-6 and / or inositol and their pharmaceutically acceptable salts and derivatives, including pyrophosphates and citrate derivatives, significantly counteract the harmful effects of radiation, affecting cell cycle progression in a protective manner (more cells in the protective GI phase) as well as decreasing apoptosis and caspase-3 activation. Various salts of IP-6 are used with comparable efficacy and the combination of IP-6+inositol affords the best protection against radiation-induced cell injury. Thus IP-6 and inositol are effective agents for protection against nuclear, solar and other radiation injuries.
Owner:IP 6 RES

Prunella spike extract and its preparation method and use

An extract of prunella spike for treating rheumatoid arthritis and improving immune suppression contains phenolic acid (60-70%) and rosemaric acid (14-21%). Its preparing process is also disclosed.
Owner:JIANGSU KANION PHARMA CO LTD

Neutralizing factors as vaccine adjuvants

The present invention is a vaccine adjuvant composed of a vaccinia virus vector that encodes a polypeptides capable of neutralizing immune suppressive factors thereby enhancing or stimulating an immune response to a vaccine.
Owner:NEW JERSEY UNUIVERSITY OF MEDICINE & DENTISTRY OF

Apparatus and methods for controlling and applying flash lamp radiation

Apparatus and methods are disclosed for treating allergic rhinitis (seasonal and perennial hay fever), by application of flash lamp radiation. The nasal cavity can be illuminated in a safe and effective manner, with non-coherent light from a flash-lamp or other suitable source. This illumination can be accomplished in any suitable manner, including by use of a handheld device. Such handheld embodiments may contain a power source (battery or AC), control circuitry, light source (flash-lamp or diode laser), lens (focusing or non-focusing), light filter, and / or fiber-optic for delivering light to the nasal cavity. Embodiments include using any suitable light energy, such as visible light in the red wavelengths with a power output of 1 to 10 Joules per cm2. The device can be pre-programmed to deliver a specified amount of light in a specified amount of time using multiple pulses (in the case of a flash lamp) or a continuous wave (in the case of a diode laser). In many useful embodiments, a rigid fiber-optic extends from the lens / light filter a length of 10 to 20 mm, although it can be any convenient and useful size and shape. Contact sensors can be arrayed on the device for various purposes, such as to restrict illumination to times when the fiber optic is inserted into the nasal cavity. This and / or other safety features can prevent the high-intensity light from being fired into open space, a person's eyes, and / or otherwise causing a potential vision or other hazard. Preferably, the device can be easily and comfortably inserted into a nostril. The fiber-optic can be angled (either in its own shape or by the user manipulating it to a convenient angle / position) so as to allow the user to easily grip the device and insert the fiber-optic without having to use a mirror or other aid. Light from the device can be emitted at a specified light frequency that causes a desired immunosuppressive response in the cellular system.
Owner:ALLERGIA INC

Construction and application of recombinant Chicken Marek's Disease Virus SC9-1 strain and SC9-2 strain

The invention relates to a construction and an application of recombinant Chicken Marek's Disease Virus SC9-1 strain and SC9-2 strain. The recombinant virus construction method solves the technical problem that kanr gene cannot be knocked out again by a present method after kanr gene containing flp recognition sites at two ends is continuously used twice to knock out two specific functional genes on the same virus genome. The obtained recombinant virus MDV SC 9-1 strain and MDV SC 9-2 strain are used as production strains of Marek's Disease live vaccine. The prepared vaccine prevents the very virulent or emerging very virulent plus MDV induced chicken Marek's disease. The protective immunity effect of the vaccine is superior to CVI988 / Rispens strain vaccine which is mostly widely used in foreign and domestic markets at present. The antigenicity of the recombinant virus is more similar to that of Chinese epidemic strain than the antigenicity of the similar virus rMd5deltameq which has been published in the United State. The strains provided by the invention will not induce tumor and has no immune suppression effect. Therefore, the strains are more applicable to China.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Apparatus and methods for controlling and applying flash lamp radiation

Apparatus and methods are disclosed for treating allergic rhinitis (seasonal and perennial hay fever), by application of flash lamp radiation. The nasal cavity can be illuminated in a safe and effective manner, with non-coherent light from a flash-lamp or other suitable source. This illumination can be accomplished in any suitable manner, including by use of a handheld device. Such handheld embodiments may contain a power source (battery or AC), control circuitry, light source (flash-lamp or diode laser), lens (focusing or non-focusing), light filter, and / or fiber-optic for delivering light to the nasal cavity. Embodiments include using any suitable light energy, such as visible light in the red wavelengths with a power output of 1 to 10 Joules per cm2. The device can be pre-programmed to deliver a specified amount of light in a specified amount of time using multiple pulses (in the case of a flash lamp) or a continuous wave (in the case of a diode laser). In many useful embodiments, a rigid fiber-optic extends from the lens / light filter a length of 10 to 20 mm, although it can be any convenient and useful size and shape. Contact sensors can be arrayed on the device for various purposes, such as to restrict illumination to times when the fiber optic is inserted into the nasal cavity. This and / or other safety features can prevent the high-intensity light from being fired into open space, a person's eyes, and / or otherwise causing a potential vision or other hazard. Preferably, the device can be easily and comfortably inserted into a nostril. The fiber-optic can be angled (either in its own shape or by the user manipulating it to a convenient angle / position) so as to allow the user to easily grip the device and insert the fiber-optic without having to use a mirror or other aid. Light from the device can be emitted at a specified light frequency that causes a desired immunosuppressive response in the cellular system.
Owner:ALLERGIA INC

Methods of screening for B cell activity modulators

The invention provides for the identification of all genes, whether known or novel, which are differentially expressed within and among B cells, making possible the characterization of their temporal regulation and function in the B cell response and / or in B cell mediated disorders. Expression profiles, nucleic acids and proteins are provided for differing states of B cells, including resting, naive, activated, tolerant and immunosuppressed B cells. The present invention makes possible the identification and characterization of targets useful in prognosis, diagnosis, monitoring, rational drug design, and / or therapeutic intervention of immune system disorders.
Owner:AFFYMETRIX INC +1

Gene-deleted attenuated African swine fever virus strain and application thereof

The invention belongs to the technical field of bioengineering, and particularly relates to a gene-deleted attenuated African swine fever virus strain with innate immune suppression and application. The invention finds that the ASFV MGF-505-7R can inhibit generation of interferon; an ASFV MGF-505-7R gene is deleted in an African swine fever original virulent strain to obtain the attenuated Africanswine fever virus strain with higher safety, thus providing a theoretical basis and practical reference for successful preparation of an African swine fever vaccine in the future. Further, a researchworker can finally prepare safe and effective African swine fever vaccine candidate strains by knocking out the ASFV MGF-505-7R and one or more disclosed virulence genes (such as CD2V, MGF360-12L, MGF360-13L, MGF360-14L, MGF360-505R and the like) simultaneously.
Owner:LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI

Adjuvant immunotherapy for the treatment cancer, of clinical manifestations associated with the diseases like cachexia and correction of adverse effects of drugs such as immunosuppression, secundary cachexia, neutropenia and lymphopenia, comprising the association or combination of a biological response modifier specially selected and other substances with antineoplastic action and/or other treatments

A compound for use in a method of treatment of cancer, including precancerous lesions, and adverse events caused by the disease or anti-cancer agents and treatments, such as cancer cachexia, lymphopenia, neutropenia, febrile neutropenia includes in combination an immunomodulatory and at least one anti-cancer agent or treatment suitable for treating the disease. The immunomodulator is a proteic aggregate of ammonium and magnesium phospholinoleate-palmitoleate anhydride. The anti-cancer agent or treatment suitable for treating the disease provides synergistic effects without additional toxicity when used with the immunomodulatory. The anti-cancer treatment is selected from the following group: surgical procedures, transplantation of bone marrow cells, systemic and localized radiotherapy, and combinations thereof.
Owner:NUNES LSEU SILVA

GMCSF and Truncated CCL2 Conjugates and Methods and Uses Thereof

A conjugate protein comprising a GM-CSF or a fragment thereof and a truncated CCL2 is described. The conjugate protein has unexpected immune suppressive, anti-obesity and tumoricidal properties and is useful in a variety of therapeutic applications.
Owner:GALIPEAU JACQUES +1

Anti-CII chimeric antigen receptor coding gene, slow virus plasmid, Treg immune cell, and applications thereof

ActiveCN109694875AExert immunosuppressive functionTo achieve the effect of treating rheumatoid arthritisAntipyreticAntibody mimetics/scaffoldsSingle-Chain AntibodiesAntigen receptors
The invention discloses an anti-CII chimeric antigen receptor coding gene, which comprises a Linker nucleic acid artificial sequence, a CII single chain antibody nucleic acid artificial sequence, a CD8 hinge region nucleic acid artificial sequence, a CD8 trans-membrane domain nucleic acid artificial sequence, a 2B4 co-stimulation area nucleic acid artificial sequence, a CD3 zeta signal transduction area nucleic acid artificial sequence, a T2A self-cleavable region nucleic acid artificial sequence, a CTLA4 nucleic acid artificial sequence, and a RQR8 molecular switch area nucleic acid artificial sequence. The invention also discloses a slow virus plasmid containing the anti-CII chimeric antigen receptor coding gene, a Treg immune cell, and applications thereof. On the premise that the curative effect is guaranteed, the immuno-suppression activity of CAR-Tregs cells is enhanced, and at the same time, the safety of CAR-Tregs cells is guaranteed.
Owner:上海兴瑞一达生物科技有限公司

Drug product, a method of administrating a vaccine using the drug product, and an apparatus for iontophoresis

It is an object of the present invention to provide a method and an apparatus capable of noninvasively administrating vaccine through the skin, and thereby making the immune response activate. A drug product according to the present invention is characterized in that the drug product has a support medium, an electrode formed on the support medium and protected partly by an insulating material for avoiding a direct cutaneous contact, a vaccine containing layer for containing a vaccine, wherein the vaccine is an antigen for inducing an immune suppression protein. A method of administrating a vaccine according to the present invention is characterized in that the vaccine is administrated by the iontophoresis using the drug product according to the drug product of the present invention as an electrode. An apparatus for the iontophoresis according to the present invention is characterized in that the drug product according to the present invention is used as an electrode.
Owner:JOSAI UNIV CORP

Asymmetric cyclobutane derivatives, preparation method and applications thereof

The invention discloses asymmetric cyclobutane derivatives (synthetic derivatives G of rabdosia scoparia lactones), which are named as scopariusicide derivatives, a pharmaceutical composition taking the asymmetric cyclobutane derivatives as the active component, a preparation method of asymmetric cyclobutane derivatives, and an application of asymmetric cyclobutane derivatives in preparation of immuno-suppressive drugs. According to the preparation, scopariusicides, which is derived from pharmaceutical plants, is taken as the template; a precursor compound ent-clerodane diterpene A is taken as the initial raw material, a series of artificial analogues are obtained through six steps of chemical synthesis; the basic structure of the derivatives has a characteristic that ent-clerodane hetero-diterpene has an asymmetric cyclobutane segment, the side chain and aromatic ring of the derivatives may have different substituents, and thus there are many kinds of derivatives. The compounds are synthesized for the first time, the synthesis route is novel, and the derivatives have potential bioactivity, can be used as the lead compounds of immuno-suppressive drugs, and have a very important research value and application prospect.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI

Fully human anti-RANKL antibody

The present invention relates to fully humanized antibodies, specifically to a fully human anti-RANKL antibody, a nucleic acid molecule encoding the antibody, and a composition containing the antibody. The present invention further relates to uses of the antibody in preparation of drugs for prevention and treatment of bone loss related diseases, especially osteoporosis, arthritis osteolysis damage or tumor bone metastasis and other diseases. According to the present invention, the antibody is specifically bound with human RANKL and blocks the activity of the human RANKL while the potential immunesuppression of the human RANKL on human body is reduced, the antibody has good stability, and the defect of the non-uniformity (heterogeneity) of the IgG2 antibody production on the batch quality identification is avoided.
Owner:SHANGHAI JMT BIO INC

Recombinant human mannan-binding lectin

InactiveCN1715296APeptide/protein ingredientsAntiviralsDiseaseMannan binding
The invention relates to treatment on immune system diseases which includes the treatment on the defect in the immune system. The invention includes the preparation of a novel expressing construction body for coding the MBL of human, a novel preparation of recomposing the MBL of human with a high similarity to a natural MBL of human and also includes the application of the compound in combinations, drugs and treatment on the state correlative with an immune restraining state and / or the MBL defect state (including a latent state). An MBL defect state is correlative with the susceptibility increase of infection. More concretely, the invention relates to the treatment on the state (including the latent state, namely the state needs not to be treated currently). The treatment aims at human beings and animals the immune systems of which are similar to human beings.
Owner:斯蒂芬·蒂尔 +2

Composition and method for reducing chemotherapy-induced neutropenia via the administration of plinabulin and a g-csf agent

Plinabulin and one or more G-CSF drugs are used for treating a chemotherapy induced neutropenia, stimulating neutrophil survival, reducing bone pain induced by the G-CSF drug and alleviating immune suppression effect induced by the G-CSF drug. For example, docetaxel-induced neutropenia can be reduced by-co-administering plinabulin and one or more G-CSF compounds.
Owner:BEYONDSPRING PHARMA INC

miRNA FOR TREATING CANCER AND FOR USE WITH ADOPTIVE IMMUNOTHERAPIES

In some aspects, miRNA for the treatment of cancer are provided. In some embodiments, a miRNA (e.g., miR-124, miR-142, and / or miR-138) may be used to promote or enhance immune destruction of a cancer, or reduce the immune suppression of the cancer, in a subject. In other aspects, the miRNA may be used in, or in combination with, an adoptive immunotherapy.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Compositions and methods for treating toll-like receptor-driven inflammatory diseases

Many disorders wherein inflammation is a hallmark such as rheumatoid arthritis, sepsis, or cancer, are chronic and impose a significant burden on family and society due to their high morbidity and mortality. Each year the United States government spends $2.6T to treat chronic Inflammatory diseases, which are linked to 70% of the deaths every year. Protein therapeutics, such as anti-TNFα antibodies that selectively block the TNFα cascade, have become the mainstay therapy for the management of chronic inflammatory diseases. Despite the promise of these early studies, concerns about the side effects of these protein drugs, including induction of auto-antibodies and immuno-suppression, may limit the applications to disease treatments. Thus, there is a need to develop new drugs and delivery systems for the prevention and treatment of inflammatory diseases. The present invention relates to extracellular vesicle composition, system, and methods for treating Toll-like receptor-driven inflammatory disease.
Owner:SOUVIE BIODELIVERY LLC

Altering inflammatory states of immune cells in vivo by modulating cellular activation states

PendingUS20210046156A1Induce killingReduce and prevent growth and developmentPowder deliveryOrganic active ingredientsImmuno suppressionCell biology
Systems and methods to modulate the activation state of immune cells in vivo are described. The systems and methods can be used to transform immunosuppressive macrophages that support cancer growth and metastasis into highly activated tumoricidal macrophages.
Owner:FRED HUTCHINSON CANCER CENT

Methods and compositions to enhance the immunogenicity of tumors

Methods and compositions for enhancing the immunogenicity of a tumor of interest by modulating / altering the expression of specific complement proteins and complement protein receptors associated withthe immune suppression of a tumor / tumor cell are described herein.
Owner:INSIDEOUTBIO INC
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