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Compound recipe formula containing kurarinone prostaglandin E1 and aspirin, its preparation method and application

A technology of prostaglandin and aspirin, which is applied in the field of medicine and its preparation, can solve the problems of exacerbating the occurrence of cardiovascular and cerebrovascular diseases, the inability to directly resist hepatitis B virus, and application restrictions, so as to achieve the same physical and chemical properties and physiological effects, and enhance the synthetic function of the human body , a wide range of effects

Inactive Publication Date: 2003-05-07
蔡海德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also a good drug for cardiovascular and cerebrovascular diseases, and is recognized as a new generation of broad-spectrum endogenous drug, but it has side effects that cannot directly resist hepatitis B virus and injection pain, which limits its application
[0005] Aspirin is known to be a good pain reliever but inhibits PGI in humans 2 Synthetic, long-term use or a small amount of use will aggravate the occurrence of cardiovascular and cerebrovascular diseases or exacerbate symptoms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] formula:

[0033] Component Weight ratio Containing oxymatrine 99-102% matrine 500-700g Purity 99.5% prostaglandin E 1 100-250mg 6-0-maltosyl-β-cyclodextrin 2-2.5 times prostaglandin E 1 Mole number Aspirin with a purity of 98% 250-300g

[0034] Purity 98% or lysine 450-550g

[0035] Sterile water for injection 1500ml

[0036] Low Molecular Dextran-40 2-10%

[0037] Dissolve matrine in sterile water for injection to make a saturated solution, dissolve 6-0-maltosyl-β-cyclodextrin in sterile water for injection to make a saturated solution, and make the saturated solution of matrine under stirring Add dropwise to 6-0-maltosyl-β-cyclodextrin saturated solution until completely dissolved.

[0038] prostaglandin E 1 Dissolve in absolute ethanol to a saturated solution, dissolve 6-0-maltosyl-β-cyclodextrin in sterile water for injection to make a saturated solution, and mix the prostaglandin E 1 Add the saturated solution of absolute ethanol dropwise to the s...

Embodiment 2

[0041] Recipe: Component Weight Proportion

[0042] Oxymatrine 99-102% Matrine 800-1000g

[0043] 99.5% Purity Prostaglandin E 1 300-400mg

[0044] 6-0-maltosyl-β-cyclodextrin 5.5-6 times prostaglandin E 1 moles

[0045] 98% pure aspirin 400-500g

[0046] The purity is 98% or lysine 800-900g

[0047] Sterile water for injection 1500ml

[0048] Low Molecular Dextran-40 2-10%

[0049] Concrete preparation method is identical with embodiment 1.

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Abstract

A compound medicine containing kurarinol, prostaglandic E1 and aspirin is prepared through including the kurarinol and prostaglandin E1 by 6-0-malto-beta-cyclodextrin, mixing, adding others, and preparing the freeze dried powder injection. It can be used for treating cancers, cardiovascular and cerebrovascular diseases and hepatitis. Its advantages are sure curative effect, and no toxic by-effect.

Description

Technical field: [0001] The present invention relates to a kind of medicine and its preparation method and application, especially a kind of medicine containing matrine, prostaglandin E 1 The compound preparation of aspirin and aspirin and its preparation method and application. Background technique: [0002] It is known that matrine is a monomeric active ingredient extracted, purified and refined from Chinese herbal medicine Sophora flavescens or mountain bean root. Pharmacological and clinical experiments have proved that matrine has anti-cancer, white blood cell increase, anti-hepatitis B virus, and liver cell protection effects, but its anti-cancer mechanism is only to inhibit cancer cells, and this inhibitory effect is not significant only with cyclophosphine Amides are similar. Simultaneously, the patient feels pain when the currently used matrine injection is used, which is difficult to accept. [0003] It is known that prostaglandin E 1 It has the effect of inhib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5575A61K31/60A61P1/16A61P9/10A61P31/12A61P35/00
Inventor 蔡海德
Owner 蔡海德
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