39results about How to "Mild side effects" patented technology

This invention provides methods for alleviating seizure disorders in an animal, particularly epilepsy, by regulating the flux through the gluconeogenic enzyme PEPCK in brain cells.

This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.

This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.

This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.

The present invention relates to the new use of high solubility berberine in preparing medicine. The high solubility berberine may be dissolved in 500 times of water and is easy to be absorbed by human body to make best use and raise curative effect. It may be used in treating and preventing hypertension, hyperlipemia, arrhythmia, heart disease, hepatitis, etc.

A compound medicine containing kurarinol, prostaglandic E1 and aspirin is prepared through including the kurarinol and prostaglandin E1 by 6-0-malto-beta-cyclodextrin, mixing, adding others, and preparing the freeze dried powder injection. It can be used for treating cancers, cardiovascular and cerebrovascular diseases and hepatitis. Its advantages are sure curative effect, and no toxic by-effect.

The invention discloses angstrom silver oral liquid and a preparation method and application in gastric cancer treatment thereof. The angstrom silver oral liquid is prepared from angstrom silver element powder, medicinal sugar and high-purity distilled water. The preparation method comprises the steps that the angstrom silver element powder is added to the high-purity distilled water to obtain anangstrom silver solution; dispersing treatment is conducted on the angstrom silver solution; the medicinal sugar is added to the dispersed angstrom silver solution, and dispersing treatment is conducted again; the dispersed angstrom silver solution is heated and sterilized, and the angstrom silver oral liquid is obtained after natural cooling is conducted. Angstrom silver injection has significantgastric cancer cell proliferation and migration inhibition capability. The appearance and weight of primary organs are not significantly changed after oral consecutive application of angstrom silveris conducted for 15 days, and H&E dyeing and immunohistochemical analysis prove that the expression amount of tissues structures and activated Caspase-3 of the primary organs after angstrom silver application is conducted is not significantly changed.

The invention relates to the technical field of drugs and provides an application of nicotinamide to preparation of drugs or health products for healing diabetic wounds. Nicotinamide is a type of vitamin B3. Animal experiments prove that nicotinamide can effectively promote diabetic wound healing, has great significance in treating diabetic gangrene, and has high safety and wide therapeutic window as a drug.

A process for synthesizing aryltretinoin and aryltretinoin ethylester, used for preparing capsules to treat psoriasis, includes such steps as reaction between [1-(5,6,7,,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-ethyl]-phosphine triphenylbromide and p-ethoxycarbonyl benzaldehyde in isopropanol to obtain P-[(E)-2 -(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl]-ethyl benzoate, that is, aryltretinoin ethylester, and adding it to alcohol to synthesize P-[(E)-2 -(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl]-benzoate, that is, aryltretinoin.

A compound for inducing male sterility of plant (paddy rice, wheat, cotton, etc) is disclosed, which is just the 3-carboxyl-4-pyranone. Its advantages are high efficiency (98% or more), high fruit bearing rate for hybridized seeds, and high selection index (more than 30).

The invention relates to the technical field of medicine, in particular to application of incarvillateine compounds in preparation of anti-breast cancer drugs. Two kinds of methods, namely an operative treatment method and a drug treatment method, can be used for treating breast cancer at present, however, breasts are usually needed to be excised in the operative treatment method, which does serious harm to bodies and minds of women, while the side effect of the drug treatment method is large. Incarvillateine compounds can inhibit the activity of a breast cancer cell MCF-7 and RhoGTOs family target cells, so that after the incarvillateine compounds are applied to the preparation of anti-breast cancer drugs, the growth speed of tumors can be effectively reduced, the lifetime of a patient can be prolonged and the side effect is slight.

The invention relates to a forward osmotic membrane preparation method. The forward osmotic membrane preparation method is used for solving the problem that an existing forward osmotic membrane preparation method is complicated and high in cost. The forward osmotic membrane preparation method comprises the steps of preparing a polyacrylonitrile solution, preparing a polyacrylonitrile basal membrane, preparing a treated polyacrylonitrile basal membrane, preparing an ultra-filtration basal membrane containing aniline, preparing a composite crude nano-filtration membrane crude product, soaking the product in an ethanol water solution, then soaking the product in TRIS, then adding polyethyleneimine and gallic acid, performing crosslinking coating to obtain a forward osmotic membrane. The polyethyleneimine and the gallic acid adopted in the preparation method are low in price and cost, polymerization reaction between the polyethyleneimine and the gallic acid easily occurs, side reaction is controllable, conditions are moderate, the obtained composite forward osmotic membrane has good separating performance, and the forward osmotic membrane preparation method is applied to the fields of antibiotic separation, fruit juice concentration and seawater desalination.

The present invention discloses a compound injection in absolut ethyl alcohol or compound powdered injection preparation of prostaglandin E1, prostaglandin E1 potassium salt, prostaglandin E1 sodium salt or prostaglandin A1 and prostaglandin B1. The compound preparation is used in preventing and treating AIDS and abstaining from drugs. It has unique recipe, complementary components, determined curative effect and less toxic side effect.

The invention relates to an inhalant used for inhibiting coronavirus, and a preparation method and application of the inhalant, and belongs to the technical field of pharmaceutical preparations. The inhalant comprises Remdesivir and / or a pharmaceutically acceptable salt thereof. According to the inhalant used for inhibiting the coronavirus, due to adoption of small-dose pulmonary administration,effective pulmonary administration concentration can be achieved when micronized or aerosolized Remdesivir is inhaled, the coronavirus, especially the novel coronavirus, can be effectively inhibited, the defects of a narrow treatment window and poor safety in the prior art are overcome, a small dosage is given for multiple times, so that the inhalant can be accumulated in the lung so as to form an effective virus inhibition effect, a curative effect can be improved or the dosage of the Remdesivir is reduced, and potential side effects are reduced.

The invention relates to an antipyretic traditional Chinese medicine of the Zhuang medicine type and relates to the field of traditional Chinese medicines, in particular, it is a traditional Chinese medicine suitable for antipyretic. The effect of western medicine on reducing fever is fast, but many people have lingering fears about its side effects. The object of the present invention is to provide a traditional Chinese medicine of Zhuang medicine and Zhuang medicine type for reducing fever. , its weight proportions are: Forsythia 9—24%, Gynostemma 11—26%, Burdock root 9—22%, Citrus aurantium 8—11%, Licorice 4—8%, Morus alba 6— -9%, Anemarrhena 5-21%, Bupleurum 20-45%, the preparation method is to boil the juice and take it to effectively reduce fever. The present invention has the advantage of relatively mild side effects.

The present invention relates to a Chinese medicine for external application for curing ankylosing spondylitis. It is made up by mixing the following 8 Chinese medicinal materials: eucommia bark 40-50g. aconite main tuber 20-30g. turmeric 20-30g, dried ginger 20-30g, orient vine 20-30g, speranskia / balsam 20-30g, arisaema root 10-20g and dragon's blood 0.5-1g.

The invention discloses vaccine and a combination medicine for preventing tuberculosis, a method for preparing the vaccine and application, and belongs to the field of medicines for treating tuberculosis latent infection. By the aid of the vaccine with mycobacterium microbial compound adjuvants for preventing the tuberculosis, the problems of ineffectiveness or poor effects of existing subunit vaccine for treating tubercle bacillus latent infected population, diversified adjuvants, hypersensitivity and Koch reaction risks can be pertinently solved. The vaccine with mycobacterium microbial compound adjuvants for preventing the tuberculosis comprises Ag85b proteins, ESAT6-CFP10 proteins and mycobacterium vaccae thallus extract. The vaccine, the combination medicine, the method and the application have the advantages that the vaccine with the mycobacterium microbial compound adjuvants for preventing the tuberculosis is used for treating latent tuberculosis infection, and obvious effects can be realized; the vaccine only comprises a single type of adjuvants, and accordingly hypersensitivity and Koch reaction risks can be prevented.

The invention discloses a traditional Chinese medicine with drug treatment function and a preparation technique thereof. The medicine is prepared by the following material medicines according to weight proportion: 15 to 18 portions of Rhizoma Corydalis, 4 to 7.5 portions of root of herbaceous peony, 4 to 6 portions of ordate houttuynia, 4 to 6 portions of myrobalam, 1 to 3 portions of cynanchum paniculatum, 1 to 3 portions of fructus alpiniae oxyphyllae and 2 to 4.5 portions of bile arisaema. The invention also provides a preferable preparation technique for preparing the traditional Chinese medicine. The invention is a drug treatment traditional Chinese medicine which can effectively remove poison and addiction and has the functions of clearing away heat and removing phlegm as well as invigorating blood circulation and stopping pain.

The invention relates to a method for administrating preparations containing oseltamivir guanidyl carboxylate analogues and / or ethyl esters thereof. Administration is carried out through inhalation. The method can be used for treating cold caused by influenza viruses. By adopting the administration method provided by the invention, not only can dependence on the single variety of drugs such as oseltamivir, zanamivir and peramivir be reduced and new drug resistant virus strains generated by using the single variety in quantity be avoided but also the method which is favorable for greatly improving the bioavailability compared with oral administration or intravenous drip is provided for oseltamivir guanidyl carboxylate analogues or ethyl esters thereof; more importantly, the method which has the advantages of small drug dose, less side effects and high effect taking speed is provided.

A compound for inducing male sterility of plant (paddy rice, wheat, cotton, etc) is disclosed, which is just the 3-carboxyl-4-pyranone. Its advantages are high efficiency (98% or more), high fruit bearing rate for hybridized seeds, and high selection index (more than 30).

The invention discloses a traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts of the outer shell of the fruit of the fruit of the lotus seed, and 1-5 parts of the flower of the seed of the lotus seed. The method is to take the husk of the lobster nut kernel and the lobster flower in the corresponding weight ratio, dry them and pulverize them, add an appropriate amount of pure water, stir, and boil for 3-10 minutes to obtain the product. The traditional Chinese medicine composition of the present invention has the effects of clearing away heat and detoxifying, strengthening the body and eliminating pathogenic factors, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, simmering pus and growing flesh, removing putrefaction and promoting muscle growth. Clinically, the traditional Chinese medicine composition of the invention can be used for the treatment of fungal infection diseases, and has definite curative effect and mild side effects.

The invention discloses a traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 1-10 parts of shells of tamarind nuts and 1-5 parts of tamarind flowers. The preparation method includes the steps that the shells of the tamarind nuts and the tamarind flowers in a corresponding weight ratioare obtained, air-dried and smashed, a proper amount of purified water is added and stirred, the mixture is boiled for 3-10 min, and the composition is obtained. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, strengthening the body resistance to eliminate pathogenic factors, promoting blood circulation to remove blood stasis, relieving swelling and pain, expelling pus and promoting granulation, removing slough and promoting tissue regeneration. Clinically, the traditional Chinese medicine composition can be used for treating fungal infection diseases; the traditional Chinese medicine composition is exact in curative effect and small in side effect.

The invention relates to a combination drug for treating cervical cancer, which is a preparation processed by mixing 85 to 95 percent of sodium valproate and 5 to 15 percent of all-trans retinoic acid, comprising an oral preparation, or external preparation, or vaginal suppository allowed by pharmacy. External cyto-inhibition experiment shows that the inhibition ratio of the combination drug is 56 percent which is higher than that of a cis-platinum group of 41 percent, an ATRA group of 30 percent and a VPA group of 1 percent. Animal experiments show that the effect of the combination drug for inhibiting tumor growth is obviously superior than the effect of monotherapy the VPA and the oral cis-platinum.

A Chinese medicine in the form of decoction or capsule for treating depression is prepared from Hyperici sampsonii and borneol.

The invention relates to a combination drug for treating cervical cancer, which is a preparation processed by mixing 85 to 95 percent of sodium valproate and 5 to 15 percent of all-trans retinoic acid, comprising an oral preparation, or external preparation, or vaginal suppository allowed by pharmacy. External cyto-inhibition experiment shows that the inhibition ratio of the combination drug is 56 percent which is higher than that of a cis-platinum group of 41 percent, an ATRA group of 30 percent and a VPA group of 1 percent. Animal experiments show that the effect of the combination drug for inhibiting tumor growth is obviously superior than the effect of monotherapy the VPA and the oral cis-platinum.

The invention relates to the technical field of medicine, in particular to application of incarvillateine compounds in preparation of anti-breast cancer drugs. Two kinds of methods, namely an operative treatment method and a drug treatment method, can be used for treating breast cancer at present, however, breasts are usually needed to be excised in the operative treatment method, which does serious harm to bodies and minds of women, while the side effect of the drug treatment method is large. Incarvillateine compounds can inhibit the activity of a breast cancer cell MCF-7 and RhoGTOs family target cells, so that after the incarvillateine compounds are applied to the preparation of anti-breast cancer drugs, the growth speed of tumors can be effectively reduced, the lifetime of a patient can be prolonged and the side effect is slight.

The present invention relates to a Chinese medicine for external application for curing ankylosing spondylitis. It is made up by mixing the following 8 Chinese medicinal materials: eucommia bark 40-50g. aconite main tuber 20-30g. turmeric 20-30g, dried ginger 20-30g, orient vine 20-30g, speranskia / balsam 20-30g, arisaema root 10-20g and dragon's blood 0.5-1g.

The invention discloses a traditional Chinese medicine with drug treatment function and a preparation technique thereof. The medicine is prepared by the following material medicines according to weight proportion: 15 to 18 portions of Rhizoma Corydalis, 4 to 7.5 portions of root of herbaceous peony, 4 to 6 portions of ordate houttuynia, 4 to 6 portions of myrobalam, 1 to 3 portions of cynanchum paniculatum, 1 to 3 portions of fructus alpiniae oxyphyllae and 2 to 4.5 portions of bile arisaema. The invention also provides a preferable preparation technique for preparing the traditional Chinese medicine. The invention is a drug treatment traditional Chinese medicine which can effectively remove poison and addiction and has the functions of clearing away heat and removing phlegm as well as invigorating blood circulation and stopping pain.