Inhalant used for inhibiting coronavirus, and preparation method and application of inhalant

A coronavirus and inhalant technology, applied in the field of coronavirus-inhibiting inhalants and their preparation, can solve the problems of low target organ selectivity and narrow therapeutic window for systemic drug administration
CN113350323APending Publication Date: 2021-09-07深圳瑞思普利生物制药有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
深圳瑞思普利生物制药有限公司
Publication Date
2021-09-07

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Abstract

The invention relates to an inhalant used for inhibiting coronavirus, and a preparation method and application of the inhalant, and belongs to the technical field of pharmaceutical preparations. The inhalant comprises Remdesivir and / or a pharmaceutically acceptable salt thereof. According to the inhalant used for inhibiting the coronavirus, due to adoption of small-dose pulmonary administration,effective pulmonary administration concentration can be achieved when micronized or aerosolized Remdesivir is inhaled, the coronavirus, especially the novel coronavirus, can be effectively inhibited, the defects of a narrow treatment window and poor safety in the prior art are overcome, a small dosage is given for multiple times, so that the inhalant can be accumulated in the lung so as to form an effective virus inhibition effect, a curative effect can be improved or the dosage of the Remdesivir is reduced, and potential side effects are reduced.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an inhalant for inhibiting coronavirus, its preparation method and application. Background technique

[0002] Coronaviruses are enveloped, non-segmented, positive-sense, single-stranded RNA viruses with genome sizes ranging from 26 to 32 kb, the largest known RNA virus genomes. The virion has a genomic RNA and a phosphorylated nucleocapsid (N) protein wrapped in a phospholipid bilayer and covered by two different types of spike proteins: the spike glycoprotein trimer (S ) and hemagglutinin esterase (HE) present in some CoVs. The membrane (M) protein, a type III transmembrane glycoprotein, and the envelope (E) protein are located between the S protein in the viral envelope.

[0003] In recent years, coronaviruses have periodically emerged around the world. The unexpected emergence of the coronavirus, its ease of transmission, and its catastrophic consequence...

Claims

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