Application of balicatib in preparation of anti-filovirus infection drugs
A technology of balicatide and filovirus, which is applied in the field of medicine and can solve the problems such as the anti-filovirus of balicatide which has not been seen
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[0043] Example Balikati anti-filiovirus activity
[0044] 1. Principle of screening model
[0045] The entry of filovirus into host cells is the first step of virus infection, and inhibition of virus entry can effectively block virus infection. The glycoprotein (Glycoprotein, GP) on the surface of the filovirus envelope is the key protein in the entry process of the filovirus.
[0046] The present invention applies the envelope GP gene of the filovirus, including the envelope GP gene of the Mayinga strain of Zaire Ebola virus (EBOV-Mayinga GP, Gene Accession No. L11365), and the Makona strain of the Zaire Ebola virus Envelope GP gene (EBOV-Makona GP, Gene Accession No. KJ660346.2), Sudan Ebola virus envelope GP gene (EBOV-Sudan GP, Gene Accession No. FJ968794.1), Côte d’Ivoire Ebola virus Envelope GP gene (EBOV- Forest GP, Gene Accession No. FJ217162.1), Reston type Ebola virus envelope GP gene (EBOV-Reston GP, Gene Accession No. U23152.1), Bundi Buccio type Ebola virus envel...
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