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Application of high-solubility berberine in preparing medicine

A high-solubility, berberine technology, used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems that hinder research and development in the technical field and do not consider the possibility of animal drugs to treat human diseases.

Inactive Publication Date: 2006-05-17
吴开敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the technical prejudice formed by humans not being able to take veterinary medicines has lasted for decades, causing people not to consider the possibility of animal medicines being used to treat human diseases, and hindering people's research and development in this technical field for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]Chen XX, female, 60 years old, was admitted to the hospital on February 21, 2003 due to an accidental fall and was found to have a fracture of the left upper arm and type 2 diabetes (fasting blood sugar up to 23mmol / L), as well as fundus hemorrhage, cataract, and retinal detachment in the left eye. , severe hypertension and other complications, immediately inject insulin to control blood sugar, and treat other injuries and diseases symptomatically. The patient repeatedly requested the use of oral drugs to treat diabetes, and on July 24, 2003, he started to take traditional Chinese medicines such as berberine sulfate daily while maintaining the dosage of proinsulin. When the fasting blood glucose and 2h postprandial blood glucose are stable in the good or normal range (the blood glucose evaluation standard refers to the diabetes control goals in the Asia-Pacific region: ①Good: fasting ≤6.1mmol / L, 2h postprandial ≤8mmol / L; ②Normal: Fasting>6.1≤7mmol / L, 2h after meal>8≤10mm...

Embodiment 2

[0033] Oral drugs for type 1 diabetes are ineffective, and only insulin therapy can be used for life. It has always been the conclusion of the medical community at home and abroad. Patients generally feel the trouble and pain of injection, and hope to control blood sugar with oral drugs. The highly soluble berberine (referred to as medicine A) is taken in combination with a traditional Chinese medicine glycosidase inhibitor (referred to as medicine B, see Note 1) and a compound traditional Chinese medicine (referred to as medicine C, see Note 2) that can regulate the functions of the viscera and restore the body's balance. The results showed that patients with type 1 diabetes and those whose pancreas had been partially removed could experience hypoglycemia after taking the above-mentioned drugs while maintaining the original insulin dosage, indicating that oral drugs also have hypoglycemic effects on type 1 diabetes.

[0034] Guangxi Huang ××, female, 24 years old, suffering f...

Embodiment 3

[0039] Hua ××, male, 63 years old, with type 2 diabetes mellitus, with chronic nephritis and mild coronary heart disease. After examination, fasting blood glucose was 10.5mmol / L, 2h postprandial blood glucose was 13.8mmol / L, urine glucose++, and urine protein++. After 3 months of oral administration of berberine sulfate, the blood glucose dropped to the normal range, and the urine glucose and urine protein were negative. In addition, Hua You complained that the chest tightness, palpitations, angina pectoris and DE phenomenon (male erectile miasma often seen in diabetics and the elderly) that appeared from time to time were significantly improved. According to the analysis, it may be due to the effect of berberine directly dilating blood vessels and promoting blood circulation.

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Abstract

The present invention relates to the new use of high solubility berberine in preparing medicine. The high solubility berberine may be dissolved in 500 times of water and is easy to be absorbed by human body to make best use and raise curative effect. It may be used in treating and preventing hypertension, hyperlipemia, arrhythmia, heart disease, hepatitis, etc.

Description

technical field [0001] The invention relates to a new use of high-solubility berberine in pharmacy. Background technique [0002] Since the 1950s, some experts, scholars and medical staff have conducted a large number of animal experiments and clinical trials on the widely used berberine hydrochloride, and proposed that berberine can also treat diabetes and its complications in addition to antibacterial. It can treat certain heart and cerebrovascular diseases such as cancer and hypertension (see Table 1). Although they fully affirmed and highly appraised the effect of berberine in the treatment of the above-mentioned diseases, but because the solubility of berberine hydrochloride is very low, the curative effect is not very satisfactory, and it has not been popularized and applied. [0003] Berberine, also known as berberine, is an isoquinoline alkaloid. The total alkaloids extracted from Chinese medicines such as Coptis chinensis are further separated, and the salts forme...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K9/14A61K9/16A61K9/20A61K9/48A61P3/06A61P9/06A61P9/10A61P9/12
Inventor 吴开敏
Owner 吴开敏
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