623results about How to "Reduce occurrence" patented technology

Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements.

The present invention provides a flowable composition suitable for use as a controlled release implant. The flowable composition can be administered into the ocular region of a mammal. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides methods of medical treatment that include administering the flowable composition into the ocular region of a mammal.

Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit / hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.

A method and apparatus for reducing the longitudinal aspect of the catheter to stent force comprises at least one grip member for use with a stent delivery system. The grip engages a stent in the unexpanded state prior to delivery of the stent by retracting a stent retaining sheath. The grip comprises a body region having an outer diameter, a first end and a second end. The outer diameter of the first end is greater than the outer diameter of the second end. The grip is at least partially constructed from a polymeric material.

The invention provides a multi-sensor system that uses an algorithm based on adaptive filtering to monitor a patient's respiratory rate. The system features a first sensor selected from the following group: i) an impedance pneumography sensor featuring at least two electrodes and a processing circuit configured to measure an impedance pneumography signal; ii) an ECG sensor featuring at least two electrodes and an ECG processing circuit configured to measure an ECG signal; and iii) a PPG sensor featuring a light source, photodetector, and PPG processing circuit configured to measure a PPG signal. Each of these sensors measures a time-dependent signal which is sensitive to respiratory rate and, during operation, is processed to determine an initial respiratory rate value. An adaptive digital filter is determined from the initial respiratory rate. The system features a second sensor (e.g. a digital 3-axis accelerometer) that attaches to the patient's torso and measures an ACC signal indicating movement of the chest or abdomen that is also sensitive to respiratory rate. This second signal is processed with the adaptive filter to determine a final value for respiratory rate.

Compositions comprising omega-3 fatty acids are provided, where the compositions are useful for treating cardiovascular disease in patients suffering from chronic kidney disease (CKD), preventing its further progression, and treating underlying risk factors such as hypertension, dyslipidemia, obesity and / or diabetes. Also provided are methods of using the compositions to reduce the occurrence of or prevent major coronary events, including myocardial infarctions, in patients with CKD.

The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and / or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and / or other conditions that cause such lesions. The invention also relates to kits for treatment and / or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

The invention provides a system for measuring respiratory rate (RR) from a patient. The system includes an impedance pneumography (IP) sensor, connected to at least two electrodes, and a processing system that receives and processes signals from the electrodes to measure an IP signal. A motion sensor (e.g. an accelerometer) measures at least one motion signal (e.g. an ACC waveform) describing movement of a portion of the patient's body to which it is attached. The processing system receives the IP and motion signals, and processes them to determine, respectfully, frequency-domain IP and motion spectra. Both spectra are then collectively processed to remove motion components from the IP spectrum and determine RR. For example, during the processing, an algorithm determines motion frequency components from the frequency-domain motion spectrum, and then using a digital filter removes these, or parameters calculated therefrom, from the IP spectrum.

A vascular access device may include a body and a layer of the body that communicates with a pathogenic environment to discourage adhesion of a pathogen to the layer and thus repress pathogenic activity. A method of repressing pathogenic activity in a vascular access device includes providing the device with a body, and coating the body with a layer that discourages adhesion of a pathogen to the layer.

An optical zone for a lens has a center optical axis. A first region of the optical zone includes a first optical curve having a first optical axis that is collinear with the center optical axis. A plurality of secondary regions is formed within the first region. Each of the secondary regions has a respective secondary optical curve with a corresponding secondary optical axis. Each secondary optical axis is collinear with the first optical axis. Each of the secondary optical curves is decentered relative to the first optical curve.

The magnetic tape has a magnetic layer containing ferromagnetic powder and binder on the surface on one side of a nonmagnetic support and has a backcoat layer containing nonmagnetic powder and binder on the surface on the other side of the nonmagnetic support, wherein the backcoat layer is less than or equal to 0.30 μm in thickness; and the logarithmic decrement as determined by a pendulum viscoelasticity test on the surface on the backcoat layer side of the magnetic tape is less than or equal to 0.060.

An invention to reduce the occurrence and severity of rear-end vehicle collisions, where two or more sensors are located on (i) the front of or forward facing of the “lead” vehicle and on (ii) the rear of or rearward facing of the “lead” vehicle so as to provide data and information to a controller that processes the sensor information and generates signals to one or more light emitting mechanisms mounted on or facing rearward of the “lead vehicle” that emit caution light to warn the driver of the “following vehicle” about the speed, distance, presence, approach, or other characteristics of nearby vehicles located behind, in front of, and including the lead vehicle.

A separator for a lithium secondary battery includes a high molecular porous film with a shut-down function and a heat-resistant porous layer integrally formed on each side of the high molecular porous film. The heat-resistant porous layers contain a heat-resistant high-molecular material and a ceramic filler. By using the separator, the occurrence of a short-circuit due to the melting and shrinkage of the high molecular porous film is prevented. Also, in the event of a short-circuit and the generation of heat higher than the melting point of the material of the high molecular porous film, the expansion of the short-circuit is prevented, so that the safety of the lithium secondary battery is improved.

A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and / or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

The invention provides a multi-sensor system that uses an algorithm based on adaptive filtering to monitor a patient's respiratory rate. The system features a first sensor selected from the following group: i) an impedance pneumography sensor featuring at least two electrodes and a processing circuit configured to measure an impedance pneumography signal; ii) an ECG sensor featuring at least two electrodes and an ECG processing circuit configured to measure an ECG signal; and iii) a PPG sensor featuring a light source, photodetector, and PPG processing circuit configured to measure a PPG signal. Each of these sensors measures a time-dependent signal which is sensitive to respiratory rate and, during operation, is processed to determine an initial respiratory rate value. An adaptive digital filter is determined from the initial respiratory rate. The system features a second sensor (e.g. a digital 3-axis accelerometer) that attaches to the patient's torso and measures an ACC signal indicating movement of the chest or abdomen that is also sensitive to respiratory rate. This second signal is processed with the adaptive filter to determine a final value for respiratory rate.

The invention provides compounds of the general formula (I)which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and / or disorders or diseases that are mediated by 11β-hydroxylase (CYP11B1) with these compounds.

This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route.

A learning apparatus performs a learning process for a feed-forward multilayer neural network with supervised learning. The network includes an input layer, an output layer, and at least one hidden layer having at least one probing neuron that does not transfer an output to an uppermost layer side of the network. The learning apparatus includes a learning unit and a layer quantity adjusting unit. The learning unit performs a learning process by calculation of a cost derived by a cost function defined in the multilayer neural network using a training data set for supervised learning. The layer quantity adjusting unit removes at least one uppermost layer from the network based on the cost derived by the output from the probing neuron, and sets, as the output layer, the probing neuron in the uppermost layer of the remaining layers.

Provided are a method of manufacturing a group-III nitride semiconductor light-emitting device in which a light-emitting device excellent in the internal quantum efficiency and the light extraction efficiency can be obtained, a group-III nitride semiconductor light-emitting device and a lamp. Included are an epitaxial step of forming a semiconductor layer (30) so as to a main surface (20) of a substrate (2), a masking step of forming a protective film on the semiconductor layer (30), a semiconductor layer removal step of removing the protective film and the semiconductor layer (30) by laser irradiation to expose the substrate (2), a grinding step of reducing the thickness of the substrate (2), a polishing step of polishing the substrate (2), a laser processing step of providing processing marks to the inside of the substrate (2), a division step of creating a plurality of light-emitting devices (1) while forming a division surface of the substrate (2) to have a rough surface.

The invention provides a multi-sensor system that uses an algorithm based on adaptive filtering to monitor a patient's respiratory rate. The system features a first sensor selected from the following group: i) an impedance pneumography sensor featuring at least two electrodes and a processing circuit configured to measure an impedance pneumography signal; ii) an ECG sensor featuring at least two electrodes and an ECG processing circuit configured to measure an ECG signal; and iii) a PPG sensor featuring a light source, photodetector, and PPG processing circuit configured to measure a PPG signal. Each of these sensors measures a time-dependent signal which is sensitive to respiratory rate and, during operation, is processed to determine an initial respiratory rate value. An adaptive digital filter is determined from the initial respiratory rate. The system features a second sensor (e.g. a digital 3-axis accelerometer) that attaches to the patient's torso and measures an ACC signal indicating movement of the chest or abdomen that is also sensitive to respiratory rate. This second signal is processed with the adaptive filter to determine a final value for respiratory rate.

A method and apparatus for controlling a self-refreshing display device coupled to a graphics controller are disclosed. A self-refreshing display device has a capability to drive the display based on video signals generated from a local frame buffer in the display device. A graphics controller coupled to the display device may optimally be placed in one or more power saving states when the display device is operating in a panel self-refresh mode. The graphics controller detects one or more progressive levels of idleness in the graphics controller and the pixel data stored in a frame buffer. Based on the detected idleness, the graphics controller signals the display device to enter or exit the panel self-refresh mode and enters a power saving state. When exiting the panel self-refresh mode, the display device and / or graphics controller ensure that the video signals generated by the local controller and the graphics controller are aligned.

A method for treating a restless limb disorder such as restless legs syndrome in a subject comprises administering, transmucosally in the oronasopharyngeal chamber of the subject, one or more doses of rotigotine or a pharmaceutically acceptable salt, prodrug or metabolite thereof, wherein each such dose comprises an amount effective to reduce occurrence and / or severity of one or more symptoms of the disorder, but wherein the total of all such doses in a 24-hour period does not exceed about 450μg rotigotine free base equivalent.

The present invention relates to a system and methods for noninvasively providing therapy for movement disorder symptoms. The present invention provides such a therapy system which provides trans-cranial direct current stimulation (tDCS) in order to treat those symptoms and the disorders. The present invention further provides such tDCS therapy while the subject sleeps in order to minimize the time required and impact of the therapy on the subject's waking life. The system, methods, and devices of the present invention are intended to provide a low-dose electrical current, trans-cranially, to a specific area of the subject's brain while he or she sleeps in order to decrease the occurrence, severity, and duration of the symptoms of movement disorders. The present invention aims to reduce the amount of medication necessary, counteract the effects of medication wearing off during sleep, and to overall improve the quality of life of subjects suffering from movement disorders.

The invention relates methods of reducing the risk or preventing the occurrence of an adverse event (AE) or a serious adverse event (SAE) associated with a medical treatment comprising inhalation of nitric oxide.

A reduction-drive device has a first and a second reduction mechanism and distribution device. The first reduction mechanism has a planetary carrier, a planetary gear rotatably supported by the planetary carrier, an internal gear in mesh with the planetary gear and a sun gear. The first reduction mechanism is supported by the housing so as to reduce driving force of the electric motor. The second reduction mechanism is positioned between the electric motor and the first reduction mechanism so as to reduce an output of the first reduction mechanism. The differential device is supported by the housing so as to distribute the output of the second reduction mechanism to a wheel side.

A linear-motion telescopic mechanism according to the present invention includes a plurality of block members (22) by which an arbitrary arm length is achieved in such a manner that the plurality of block member (22) are rigidly connected to each other so as to elongate a linear-motion telescopic joint (J3). On the other hand, by separating the plurality of block members (22) one by one from a rigid alignment of the plurality of block members (22), the linear-motion telescopic joint (J3) is contracted. The block members (22) unfixed from the rigid alignment are still serially connected but not in a rigid manner. That is, the block members (22) thus unfixed can be flexed in any directions, and therefore can be housed inside a support member (1) in a compact manner. This arrangement can provide a linear-motion telescopic mechanism (i) which enhances safety by eliminating such a risk, inevitable for a typical robot arm having an elbow joint, that an object around the robot arm gets caught between arm sections when the elbow joint is closed, and (ii) which can reduce a space to be occupied by the robot arm.

An electronic apparatus (1) for control or training of an animal includes a housing (2) supported by a strap against the animal's skin, first and second stimulus probes (5) connected to a surface (9) of the housing, and control circuitry in the housing including output terminals selectively producing aversive stimulus. A stabilizing member (7) is connected to a location of the surface (9) of the housing that is offset from a straight line between the first and second stimulus electrodes (5) so that conductive tips of the first and second stimulus electrodes and a tip of the stabilizing post define a triangle, whereby the conductive tips of the first and second stimulus electrodes and the tip of the stabilizing member are pressed against the skin of the animal and prevent rocking of the conductive tips of the first and second stimulus electrodes against the skin of the animal to reduce the occurrence and / or severity of skin sores.

An electroplating solution contains a wetting agent in addition to a suppressor and an accelerator. In some embodiments, the solution has a cloud point temperature greater than 35° C. to avoid precipitation of wetting agent or other solute out of the plating solution. In some embodiments, the wetting agent decreases the air-liquid surface tension of the electroplating solution to 60 dyne / cm2 or less to increase the wetting ability of the solution with a substrate surface. In some embodiments of a method for plating metal onto substrate surface, the electroplating solution has a measured contact angle with the substrate surface less than 60 degrees.

An optical device that includes an optical element, an imager, and a prism bracket. The optical element includes an optical element having first and second prisms coupled together. The imager is arranged adjacent to the first prism and configured to receive light from or to transmit light to the optical element, wherein the first prism is spaced between the second prism and the first imager. The prism bracket is coupled between the second prism and the first imager to hold the first imager in a desired positional alignment relative to the optical element. The optical device may further include additional sets of an optical element, imager, and prism bracket, wherein all of the sets are coupled to a color light combiner.