Application of nicotinamide to preparation of drugs for healing diabetic wounds

A technology for wound healing and diabetes, which is applied in the field of medicine, can solve the problems that there are no literature reports on nicotinamide wound healing, and achieve the effect of promoting wound healing, wide therapeutic window and high safety

Inactive Publication Date: 2013-10-09
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There are no relevant literature reports on the

Method used

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  • Application of nicotinamide to preparation of drugs for healing diabetic wounds
  • Application of nicotinamide to preparation of drugs for healing diabetic wounds
  • Application of nicotinamide to preparation of drugs for healing diabetic wounds

Examples

Experimental program
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Effect test

Example Embodiment

[0022] Example 1: Nicotinamide can promote wound healing in diabetic mice

[0023] To prepare a diabetic mouse incision injury model, the process is as follows: After an 8-week-old diabetic model mouse (db / db mouse, Nanjing Model Animal Center) is anesthetized, the skin is incised in the left groin to form a 1 cm long The incision is then sutured.

[0024] The drug group was given nicotinamide (purchased from Sigma-Aldrich, 20 mg / kg / day, orally administered).

[0025] The control group was given saline.

[0026] Two weeks after the administration, the healing of the local incision was observed visually. The formula for calculating the healing rate: healing rate = healing / (healing + unhealing) × 100%. The results show that nicotinamide can significantly promote the wound healing rate (Table 1); the detailed picture can be seen figure 1 , Niacinamide can significantly promote the wound healing rate.

[0027] Table 1. Nicotinamide promotes wound healing rate in diabetic mice

[0028]

[...

Example Embodiment

[0030] Example 2: Nicotinamide promotes blood circulation reconstruction in the limbs of a diabetic mouse ischemia model

[0031] To prepare the lower limb ischemia model of diabetic mice, the process is as follows: After anesthetizing an 8-week-old diabetic model mouse (db / db mouse, Nanjing Model Animal Center), the skin is incised in the left groin to separate the femoral artery, After the femoral vein, the blood flow of the femoral artery is blocked with a hemostat, and then the femoral artery is cut with scissors.

[0032] The administration group was given nicotinamide (purchased from Sigma-Aldrich, 20 mg / kg / day, orally administered).

[0033] The control group was given saline.

[0034] Two weeks after the administration, the laser Doppler blood flow meter of British Perimed was used to detect the blood circulation reconstruction of the limbs after the ischemia model in real time. The results show that nicotinamide can promote the blood circulation reconstruction of the limbs a...

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Abstract

The invention relates to the technical field of drugs and provides an application of nicotinamide to preparation of drugs or health products for healing diabetic wounds. Nicotinamide is a type of vitamin B3. Animal experiments prove that nicotinamide can effectively promote diabetic wound healing, has great significance in treating diabetic gangrene, and has high safety and wide therapeutic window as a drug.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of nicotinamide in the preparation of wound healing medicine for treating diabetes. Background technique [0002] The pathogenesis of diabetes is complex, seriously endangers human health, and usually brings serious complications. Difficulty in healing the wounds of diabetic patients is a difficult point in the treatment of diabetes. The main reason is that high blood sugar damages the microcirculatory vessels and causes poor blood circulation in the extremities, especially the lower extremities. The consequence is that the limb wounds will not heal for a long time, leading to gangrene or even amputation, which brings huge physical and mental harm to the patient. This disease is often referred to as "diabetic foot". Therefore, seeking therapeutic drugs that can promote wound healing in diabetes has always been one of the hotspots in the field of diabetes resear...

Claims

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Application Information

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IPC IPC(8): A61K31/455A23L1/29A61P3/10A61P17/02A23L33/00
Inventor 缪朝玉王培赵衍宋捷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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