Preparation method of medicine for treating pelada

A technology of medicine and alopecia areata, applied in the field of medicine preparation, can solve problems such as skin thinning and Cushing's sign, and achieve obvious curative effect, benign economic benefits and social benefits

Inactive Publication Date: 2006-08-30
罗洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the treatment of alopecia areata, hormones are mostly applied systemically or locally, but long-term use of hormones will produce a series of obvious side effects such as: Cushing's sign, skin thinning, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0050] Drug preparation: each bottle of lyophilized powder was dissolved with 3ml of normal saline (to restore the original concentration before lyophilization). Biosafety Examples of Drugs

[0051] 1). Acute toxicity test in mice: We selected Kunming mice aged 7-9 weeks and weighing 18-22 g. According to the pre-test common ratio of 0.8, 5 dosage groups of 50.0ml / kg, 40.0ml / kg, 32.0ml / kg, 25.6ml / kg, and 20.5ml / kg were established, with 10 mice in each group, half male and half male. After a single intraperitoneal injection, observe and record the poisoning reaction, death situation and time of the animal immediately after the drug, and observe continuously for 14 days.

[0052] 2). Rabbit pyrogen test: Select 3 Japanese white-eared rabbits with a body weight of 1.8-2.4 kg. Administration is given by 10ml / kg ear vein injection. Measure the body temperature of the anus of the rabbit at a depth of 6 cm, and then measure the body temperature once every 1 hour, a total of 3 tim...

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PUM

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Abstract

A process for preparing the medicine to treating alopecia areata includes such steps as preparing the basic culture medium from human AB-type serum, low-sugar culture medium (DMEM), Hepes, sodium bicarbonate and L-glutamine proportionally, culturing the low-passage human hair papilla cells, taking the supernatant and freeze-drying to obtain powder.

Description

technical field [0001] The invention relates to a preparation method of a medicine, in particular to a preparation method of a medicine for treating alopecia areata. technical background [0002] Alopecia areata is one of the common clinical diseases in dermatology, accounting for 10 to 15% of outpatient visits in dermatology. Due to the accelerated pace of life, this number has a further upward trend. Further development of alopecia areata can evolve into general alopecia and total alopecia. This puts a serious burden on the patient's body and mind. In the treatment of alopecia areata, corticosteroids are mostly applied systemically or locally, but long-term use of corticosteroids will produce a series of obvious side effects such as: Cushing's sign, skin thinning and so on. How to reduce or treat alopecia areata without hormones is an urgent problem to be solved at present. [0003] It is generally believed that human dermal papilla cells (DPC) play an important role in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K35/16A61K9/19A61P17/14C12N5/08A61K35/36
Inventor 罗洋
Owner 罗洋
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