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New application of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and 2-borneol composition

A technology of pyrazoline and composition, applied in the new application field of 3-methyl-1-phenyl-2-pyrazoline-5-one and 2-camphenol composition, can solve the problem of undisclosed Eda The application of lavone and borneol composition in the treatment of cardiovascular diseases, etc., to achieve the effect of reducing the infarct size and improving the therapeutic effect

Active Publication Date: 2012-07-18
NANJING SIMCERE DONGYUAN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN101524352 discloses the composition of Edaravone and Borneolum and the application of said composition in the treatment of ischemic cerebrovascular disease, but this document does not disclose the application of Edaravone and Borneol composition in the treatment of cardiovascular diseases

Method used

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  • New application of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and 2-borneol composition
  • New application of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and 2-borneol composition
  • New application of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and 2-borneol composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 injection preparation

[0023] Take by weighing 1.111g edaravone and 139mg (+)-2-borneol, be dissolved in 80ml 1,2-propanediol, add water for injection and dilute to 1L, obtain the edaravone borneol compound that concentration is 1.25mg / ml Injection A1.

[0024] Take by weighing 889mg edaravone and 111mg (+)-2-camphor, dissolve in 80ml 1,2-propanediol, add water for injection and dilute to 1L, obtain the edaravone-borneol compound injection that concentration is 1mg / ml A2.

[0025] Weigh 889mg of edaravone and 111mg (+)-2-camphor, dissolve in 80ml of 1,2-propanediol, add water for injection and dilute to 0.5L, and obtain the Edaravone-borneol compound injection with a concentration of 2mg / ml Solution A3.

[0026] Take by weighing 1.094g edaravone and 156mg (+)-2-borneol, be dissolved in 80ml 1,2-propanediol, add water for injection and dilute to 1L, obtain the edaravone-borneol compound that concentration is 1.25mg / ml Injection B1.

[0027] Take by wei...

Embodiment 2

[0050] Example 2 Myocardial ischemia-reperfusion experiment in rats

[0051] 2.1 Preparation of rat myocardial ischemia-reperfusion model

[0052] SD rats (Shanghai Slack Experimental Animal Co., Ltd.) were quarantined in a normal-level environment, weighing 280g-300g, anesthetized with pentobarbital intraperitoneally (30mg / kg), fixed in the supine position, and monitored the animal's ECG with standard II leads ; Incision of the trachea, insertion of a tracheal intubation, artificial respiration (90 breaths / min, breathing ratio (115:1)) by artificial respiration. The thoracotomy was performed at the 4th to 5th intercostal space on the left side, the pericardium was broken, and the pericardium was exposed. The heart, except group 1, was threaded at the root of the anterior descending coronary artery (3 / 8 curved needle suture, 0 / 3 nylon thread) for ligation; after threading for 10 minutes, two thin plastic rings were threaded Insert the two ends of the ligature (parallel to the...

Embodiment 3

[0066] Example 3 Rabbit myocardial ischemia-reperfusion experiment

[0067] 3.1 Preparation of rabbit myocardial ischemia-reperfusion model

[0068] Rabbits (Shanghai Slack Experimental Animal Co., Ltd.) were quarantined in a normal-grade environment, weighing 2.2-3.0 kg, both male and female, anesthetized with 1.5% pentobarbital sodium ear vein injection (30 mg / kg), fixed in the supine position, Monitor the animal's ECG with standard II leads; cut the trachea, insert a tracheal intubation, and connect the animal artificial respirator for artificial respiration (90 times / min, breathing ratio (115:1). Open the 4th to 5th intercostal space on the left side. Chest, the pericardium was broken, and the heart was exposed. All groups except group 1 were threaded at the root of the anterior descending coronary artery (3 / 8 curved needle suture, 0 / 3 nylon thread) for ligation; stabilized after threading 10 minutes, put two thin plastic rings into the two ends of the ligature (parallel ...

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Abstract

The invention relates to application of an edaravone and borneol medicinal composition to preparation of a medicament for preventing and / or treating myocardial ischemia-reperfusion injury.

Description

technical field [0001] The invention relates to the application of a composition of 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol in the preparation of a drug for preventing and / or treating myocardial ischemia-reperfusion injury. Background technique [0002] The maintenance of normal metabolism and function of body tissues and organs depends on good blood circulation. Ischemia of local tissues and organs caused by various reasons often causes ischemic damage to tissue cells. It has also been found in animal experiments and clinical observations that after blood reperfusion is restored under certain conditions, cellular dysfunction and structural damage in some animals or patients are not alleviated but aggravated, thus further ischemic injury after blood reperfusion The aggravated phenomenon is called ischemia-reperfusion injury (IRI). IRI will be a major clinical problem, which has attracted extensive attention and research from scholars all over the world. [0003] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4152A61K31/045A61P9/10
Inventor 杨士豹张安元周娟
Owner NANJING SIMCERE DONGYUAN PHARM CO LTD
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