New application of composition of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and borneol

A composition and pyrazoline technology, applied in the directions of active ingredients of hydroxy compounds, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of inability to prevent recurrence, affecting the quality of life of patients, and difficult to cure.

Active Publication Date: 2012-08-29
NANJING SIMCERE DONGYUAN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical treatment of this disease is aimed at temporary relief, it is difficult to cure it, and it cannot stop the recurrence, which seriously affects the quality of life of the patient.

Method used

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  • New application of composition of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and borneol
  • New application of composition of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and borneol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 Medicine preparation

[0023] Take by weighing 1.111g edaravone and 139mg (+)-2-camphor, dissolve in 80ml 1,2-propylene glycol, add water for injection and dilute to 1L, obtain the compound recipe edaravone injection that concentration is 1.25mg / ml A1.

[0024] Take by weighing 1.111g edaravone and 139mg (+)-2-camphor, dissolve in 80ml 1,2-propanediol, add water for injection and dilute to 0.5L, obtain the compound recipe edaravone injection that concentration is 2.5mg / ml Solution A2.

[0025] Take by weighing 1.094g edaravone and 156mg (+)-2-camphor, dissolve in 80ml 1,2-propanediol, add water for injection and dilute to 1L, obtain the compound recipe edaravone injection that concentration is 1.25mg / ml B1.

[0026] Take by weighing 1.094g edaravone and 156mg (+)-2-camphor, dissolve in 80ml 1,2-propanediol, add water for injection and dilute to 0.5L, obtain the compound recipe edaravone injection that concentration is 2.5mg / ml Liquid B2.

[0027] Take ...

Embodiment 2

[0041] Example 2 Animal model evaluation of the therapeutic effect of edaravone and borneol composition on psoriasis

[0042] Forty-four guinea pigs with a body weight of 300-400 g, half male and half male, were randomly divided into a blank group of 10 and a model group of 34 guinea pigs. Each animal in the model group was coated with 5% propranolol hydrochloride emulsion liniment on the left auricle skin (0.3g / cm2) with a glass rod, twice a day for 2 consecutive weeks. After the last administration, 4 guinea pigs in the normal group and 4 guinea pigs in the model group were killed to take skin samples of the left auricle, fixed in formaldehyde, stained with HE, and observed with a light microscope to evaluate the quality of the model.

[0043] The remaining 30 guinea pigs in the model group were randomly divided into 5 groups, i.e. the model group, the positive drug control group of methotrexate (1 mg / kg), and the high and low doses of compound edaravone (1.5, 0.75, 0.375 mg...

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Abstract

The invention relates to a new application of composition of 3-methyl-1-phenyl-2-pyrazoline-5-ketone and borneol, namely the application in preparation of medicine for preventing and/or treating psoriasis.

Description

technical field [0001] The invention relates to the application of a composition of 3-methyl-1-phenyl-2-pyrazolin-5-one and borneol in the preparation of drugs for preventing and / or treating psoriasis. Background technique [0002] Psoriasis (psoriasis) is a relatively common chronic inflammatory skin disease with genetic predisposition. It is currently considered to be an immune inflammatory disease controlled by polygenes and closely related to environmental factors. The clinical symptoms are mainly characterized by silvery white scales covering the rash, film phenomenon and spotting bleeding after peeling off, and some patients are accompanied by joint lesions. Its histopathology mainly manifests as hyperplasia of keratinocytes, accumulation of inflammatory cells, proliferation and expansion of blood vessels in the dermal papilla, etc., and the expression of various cytokines in the skin lesions increases, and about 1 / 3 of the affected patients are accompanied by progress...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4152A61K31/045A61P17/06
Inventor 杨士豹华垚
Owner NANJING SIMCERE DONGYUAN PHARM CO LTD
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