Antibody for resisting to glucagon receptor and use thereof

A glucagon, antibody technology, applied in the direction of antibody, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, anti-animal/human immunoglobulin, etc., to reduce the level of intracellular cAMP

Inactive Publication Date: 2014-12-24
GMAX BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in some type 1 or type 2 diabetes, absolute or relative high glucagon results in hyperglycemia

Method used

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  • Antibody for resisting to glucagon receptor and use thereof
  • Antibody for resisting to glucagon receptor and use thereof
  • Antibody for resisting to glucagon receptor and use thereof

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Embodiment Construction

[0055] The technical solutions of the present invention will be further specifically described below through specific embodiments and in conjunction with the accompanying drawings.

[0056] In the present invention, unless otherwise specified, the raw materials and equipment used can be purchased from the market or commonly used in this field. The methods in the following examples, unless otherwise specified, are conventional methods in the art.

[0057] The present invention relates to antibodies such as antibodies that specifically bind to the human glucagon receptor (GCGR). These include antigen binding proteins that inhibit or block the binding of glucagon to human GCGR and reduce glucagon signaling through the receptor. In one embodiment there is provided a murine antibody that lowers blood sugar in an animal, including an antagonist antibody.

[0058] The present invention further provides antibody-related compositions, kits and methods that can specifically bind to th...

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Abstract

The invention discloses an antibody for resisting to a glucagon receptor and use thereof, and more particularly relates to a monoclonal antibody capable of being specifically combined with a human glucagon receptor as well as use of the antibody for treating or preventing Diabetes mellitus II and related diseases in mammals. The invention provides the novel antibody for resisting to a glucagon receptor capable of being specifically combined with a glucagon receptor. The cAMP level in a cell is reduced by means of inhibiting combination of glucagon and the receptor.

Description

technical field [0001] The present invention relates to an antibody, in particular to an anti-glucagon receptor antibody and its application. Background technique [0002] Human glucagon is an important hormone that acts together with insulin and participates in the regulation of glucose content in human blood. Glucagon and insulin are both peptide hormones. Glucagon is produced in the alpha islet cells of the pancreas and insulin is produced in the beta islet cells. When blood sugar levels fall, glucagon mainly releases glucose by stimulating some target cells (mainly liver cells). Glucagon and insulin regulate blood sugar in opposite ways. Insulin stimulates cells to take up and store glucose when blood sugar rises , lower blood sugar concentration. [0003] Natural human glucagon is composed of 29 amino acid residues: [0004] NH 2 -His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp -Leu-Met-Asn-Thr-COOH [0005] Glu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28C12N15/13C12N15/63A61K39/395A61P3/10
Inventor 张成汪笑峰景书谦
Owner GMAX BIOPHARM
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