Enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and injection, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of easy crystallization, etc., and achieve simple operation and good stability , Improve the effect of insoluble problems

Pending Publication Date: 2022-05-10
江西利德菲生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of enrofloxacin in alkaline aqueous sodium hydroxide solution still has limitations, and the preparation of higher concentration injections will easily precipitate crystals. In addition, alkaline injections cannot be used in large quantities in the body. The environment is weakly acidic. livestock and poultry

Method used

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  • Enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Weigh 3 kg of enrofloxacin, 3.42 kg of cationized hydroxyethyl cellulose, 19.5 g of sodium alginate, 1.38 kg of nicotinamide, 0.39 kg of disodium edetate, 2.2 liters of propylene glycol, polyethylene glycol 7.8 liters, some water for injection; mix 2.2 liters of propylene glycol, 7.8 liters of polyethylene glycol, and 5 liters of water for injection to obtain a mixed solution.

[0026] 2. Add 3 kg of enrofloxacin, 19.5 g of sodium alginate, 1.38 kg of nicotinamide and 0.855 kg of cationized hydroxyethyl cellulose to the mixture, heat up to 52°C and stir evenly, keep the temperature and let it stand for 0.7 hours to get treatment liquid.

[0027] 3. First add 0.39 kg of disodium ethylenediamine tetraacetate to the treatment solution, raise the temperature to 72°C and stir it magnetically; 0.1MPa, keep magnetic stirring until enrofloxacin is completely dissolved to obtain a reaction solution.

[0028] 4. After cooling the reaction solution to room temperature at a ra...

Embodiment 2

[0030] 1. Weigh 1.8 kg of enrofloxacin, 2.052 kg of cationized hydroxyethyl cellulose, 11.7 g of sodium alginate, 0.828 kg of nicotinamide, 0.234 kg of disodium edetate, 1.8 liters of propylene glycol, polyethylene glycol 6.2 liters, some water for injection; mix 1.8 liters of propylene glycol, 6.2 liters of polyethylene glycol, and 8 liters of water for injection to obtain a mixed solution.

[0031] 2. Add 1.8 kg of enrofloxacin, 11.7 g of sodium alginate, 0.828 kg of nicotinamide and 0.513 kg of cationized hydroxyethyl cellulose to the mixture, raise the temperature to 52°C and stir evenly, and keep it at a constant temperature for 0.6 hours to get treatment liquid.

[0032] 3. First add 0.234 kg of disodium edetate to the treatment liquid, raise the temperature to 72°C and stir it magnetically; 0.1MPa, keep magnetic stirring until enrofloxacin is completely dissolved to obtain a reaction solution.

[0033] 4. After cooling the reaction solution to room temperature at a ra...

Embodiment 3

[0035] 1. Weigh 4 kg of enrofloxacin, 4.56 kg of cationized hydroxyethyl cellulose, 26 g of sodium alginate, 1.84 kg of nicotinamide, 0.52 kg of disodium edetate, 2.5 liters of propylene glycol, polyethylene glycol 8.2 liters, some water for injection; mix 2.5 liters of propylene glycol, 8.2 liters of polyethylene glycol, and 3.2 liters of water for injection to obtain a mixed solution.

[0036] 2. Add 4 kg of enrofloxacin, 26 g of sodium alginate, 1.84 kg of nicotinamide and 1.14 kg of cationized hydroxyethyl cellulose to the mixture, heat up to 52°C and stir evenly, and keep it at a constant temperature for 0.8 hours for processing liquid.

[0037] 3. Add 0.52 kg of disodium ethylenediamine tetraacetate to the treatment liquid, raise the temperature to 72°C and stir it magnetically; 0.1MPa, keep magnetic stirring until enrofloxacin is completely dissolved to obtain a reaction solution.

[0038] 4. After cooling the reaction solution to room temperature at a rate of 20°C / ho...

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Abstract

The invention discloses an enrofloxacin injection and a preparation method thereof. The enrofloxacin injection comprises the following components: raw medicine enrofloxacin, auxiliary materials and a stock solution, the auxiliary materials comprise cationized hydroxyethyl cellulose, sodium alginate, nicotinamide and disodium ethylene diamine tetraacetate; the stock solution is formed by mixing water for injection, propylene glycol and polyethylene glycol. According to the invention, a mixed solvent of propylene glycol and polyethylene glycol is used for coordinating the components in the auxiliary material, the enrofloxacin mixed solution is sequentially treated step by step and component by component under different conditions, and finally the enrofloxacin injection with high stability is obtained by cooling and constant volume. The enrofloxacin injection prepared by the invention is weakly acidic, wherein the mass fraction of enrofloxacin can reach 20%; the injection is good in stability, effectively overcomes the defects of dissolvability and storage performance of the existing enrofloxacin injection, and has a good market prospect.

Description

technical field [0001] The invention relates to the technical field of preparation of medicine and veterinary medicine, in particular to an enrofloxacin injection and a preparation method thereof. Background technique [0002] Enrofloxacin, also known as ethyl ciprofloxacin, enrofloxacin, is a quinolone antibiotic. Enrofloxacin has a strong antibacterial effect on mycoplasma and belongs to a broad-spectrum bactericidal drug. Bacillus and many other bacteria have a certain bactericidal effect. Enrofloxacin is currently designated as an animal-specific drug by the state, and it has good tissue distribution; as a special antibacterial drug for aquatic products and livestock, enrofloxacin mainly acts on bacteria by blocking the replication of bacterial DNA. Bacterial nuclei inhibit bacterial DNA gyrase, leading to rapid death of bacteria, so it is not easy to develop drug resistance and has excellent antibacterial effect. [0003] In breeding prevention and control, enrofloxa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/18A61K47/22A61K47/36A61K47/38A61P31/04
CPCA61K31/496A61K9/0019A61K9/08A61K47/38A61K47/36A61K47/22A61K47/183A61P31/04
Inventor 石松明戴四发
Owner 江西利德菲生物药业有限公司
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