30results about How to "Excellent biocompatibility" patented technology

There is provided a drug carrier which has solved the problems of conventional drug carriers, which can encapsulate a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which has high dispersibility in an aqueous solution, and which is not problematical in safety. A drug carrier, which comprises injectable fine particles minimal in agglomeration between the particles, and which has excellent biocompatibility, is also provided. A hyaluronic acid modification product comprising hyaluronic acid or its derivative, and a polymer bonded together, the polymer being selected from polylactic acid, polyglycolic acid and lactic acid-glycolic acid copolymer, according to the present invention, provides a drug carrier which encapsulates a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which is well dispersible in an aqueous solution, and which is not problematical in safety. The hyaluronic acid modification product of the present invention also provides a drug carrier comprising injectable fine particles minimal in agglomeration between the particles, and having excellent biocompatibility.

The invention provides a production method of a bone tissue engineering scaffold material artificial tooth root. The method includes the six steps of: preparing a steel model, preparing an initial green body of the artificial tooth root, processing pores, filling the pores with a PLLA/nHA composite, spray-coating the green body with a PGA/nHA composite coating, and performing surface degradation.In the invention, the initial green body of the artificial tooth root is prepared with a PEEK and HA crystal whisker composite material as a bone tissue engineering scaffold material, wherein at corresponding positions on the green body, pores are processed and are filled with the degradable PLLA/nHA active composite material; finally, the green body is spray-coated with the PGA/nHA bioactive coating and then surface degradation is carried out to produce the bone tissue engineering scaffold material artificial tooth root capable of improving synostosis function. The artificial tooth root can be combined with bone through self-repairing on bones with bone induction cells, so that the elasticity modulus of the tooth root is matched with alveolar bone better, and bone absorption of the alveolar bone is not liable to be caused. The artificial tooth root is greatly better than a common artificial tooth root.

To provide an inhibitor for inhibiting protein adhesion capable of easily forming a coating layer which is excellent in water resistance, from which coating components are less likely to be eluted, on which protein is less likely to be adsorbed and which is excellent in biocompatibility; a coating solution; a medical device having a coating layer employing this inhibitor for inhibiting protein adhesion; a method for producing the same; and a fluoropolymer to be used in this inhibitor for inhibiting protein adhesion. A compound for inhibiting protein adhesion comprising a fluoropolymer that has units having a biocompatible group, a fluorine atom content of from 5 to 60 mass % and a proportion P represented by the following formula of from 0.1 to 4.5%. (Proportion P)=((proportion (mass %) of units having a biocompatible group to all units of the fluoropolymer))/(fluorine atom content (mass %) of the fluoropolymer))×100.

The invention provides a high-toughness super-wear-resistance artificial bone for repairing bone defects. The artificial bone has a structure of inner and outer layers, wherein the inner layer is an artificial bone rack made of PEEK resin, and is compounded with barium glass fibers and calcium carbonate whiskers; the outer layer the outer layer of the artificial bone rack is coated with a hardened compact layer which is sintered by bio-active glass ceramics; and a porous layer formed by bioactive glass ceramics is attached to the surface of the compact layer. The bonding performing of bioactive glass ceramics with bone is higher than that of hydroxyapatite, and the bonding performance of PEEK resin with bioactive glass ceramics is better than that of carbon fibers with hydroxyapatite, so that the artificial bone has enough mechanical performance and good biocompatibility, and has the mechanical performance, biocompatibility and bone bonding strength is superior than those of a conventional artificial bone product.

The invention relates to Ti-Zr-Nb-Fe-Al-Ce super elastic alloy and products thereof. Because of adding appropriate amount of Fe, Al and Ce elements, the super elastic alloy has high erosion resistance and oxidation resistance as well as excellent welding performance, cold workability, phase-changing super elasticity, shape memory property and biocompatibility. The welding performance, the cold workability and the biocompatibility of the alloy are better than those of TiNi shape memory alloy, while the super elasticity and the shape memory property are equivalent to those of the TiNi shape memory alloy. The Ti-Zr-Nb-Fe-Al-Ce super elastic alloy not only can be used as biomaterial capable of being implanted in a human body for a long time, but also can be used as industrial products made from the alloy such as spectacle frame, bra support, golf club head, pipe joint, spring and drive element; moreover, the alloy has the advantages of easy processing, low cost and wide application range.

The invention discloses a heme ligand mimic and a synthesis method thereof. A compound name of the heme ligand mimic provided by the invention is 5,10,15,20-tetra-(5-phenyl phosphate)-5,10-15,20-dibundled porphyrin, and a structural formula of the heme ligand mimic is as shown in a formula (1)(the formula is shown in the description). The synthesis method of the heme ligand mimic mainly comprisesthe following steps of dialdehyde bridging, namely the synthesis of an intermediate product bridged bromodialdehyde; ring formation, namely the synthesis of an intermediate product tetrabromo dibundled porphyrin; C-P bond formation, namely the synthesis of an intermediate product tetraphosphate dibundled porphyrin, and hydrolysis of phosphate, namely the synthesis of a target product tetraphosphoric acid dibundled porphyrin. Porphyrin provided by the invention has a saddle-type nonplanar feature, further, is excellent in water solubility, and is a better model compound for simulating a structure and a function of a heme ligand; further, the synthesis method of the heme ligand mimic is mild in condition and less in synthesis steps; raw materials are easily obtained; a product is easily purified; a yield in each step is relatively high, and due to the introduction of a phosphate radical, the heme ligand mimic is not only enabled to become good in water solubility and be widened in pH (potential of hydrogen) value scope of application, but also has better biological applicability.

The present invention relates to a medical device or implant made at least in part of a high-strength, low-modulus metal alloy comprising niobium, tantalum, and at least one element selected from the group consisting of zirconium, tungsten, and molybdenum. The medical devices according to the present invention provide superior characteristics with regard to biocompatibility, radio-opacity and MRI compatibility.

The invention discloses external nano-hydroxyapatite/polydopamine wet adhesion type styptic powder and a preparation method thereof. The styptic powder is nano-hydroxyapatite loaded with polydopamine.The preparation method comprises the following steps: adding nano-hydroxyapatite and dopamine into a weakly alkaline solution, and reacting at room temperature; and carrying out freeze drying on theproduct to obtain the nano-hydroxyapatite/polydopamine needle-like composite styptic powder. The material has a multifunctional hydroxyapatite and polydopamine structure, and can be further modified with many substrates. The material can be applied to hemostasis in different forms in different dosage forms, can be prepared into emergency lifesaving powder, hemostasis hydrogel, self-adhesive dressing, hemostasis antibacterial sponge and the like by being integrated with other medical materials and medical instruments, and the novel drug delivery carrier can be prepared by doping or crosslinkingantibacterial, wound healing promoting and pain relieving drugs and nano-hydroxyapatite or reacting the drugs with polydopamine, and multifunctional integration of the hemostatic material is realized.

Present invention is a stent apparatus in which a stent to scaffold a vessel from the inside is held by a stent covering member comprising: a tubular cartridge expandable and contractible in radial direction, the expansion of which in axial direction orthogonal to the radial direction being restricted; a stent formed of a biodegradable polymer as a tubular shape, shape memorized to an expanded size larger than an inner diameter of a target blood vessel in which the stent is to be implanted, and mounted to the tubular cartridge in contracted state; and a stent covering member formed of a biodegradable polymer having elasticity as a cylindrical shape having an inner diameter to keep the stent in contracted state by holding an outer surface of the stent and, when the stent is expanded to the shape memorized shape, plastically deformed to release the holding of the stent.

The invention relates to an araneus ventricosus wrapped fibroin full-length gene and a preparation method thereof. The sequence of the gene is as shown in SEQ ID NO.1. The preparation method comprisesthe following steps: amplifying an NT sequence partially wrapping a fibroin protin by using a degenerate PCR (Polymerase Chain Reaction) method, complementing the NT sequence through anchoring PCR, designing a pair of primers according to the NT sequence obtained through sequencing and a CT sequence obtained from the NCBI (National Center of Biotechnology Information), performing PCR amplification on a full-length AcSp gene, performing blunt end cloning on a segment obtained through amplification, extracting plasmid of a positive cloning bacterium with the full-length AcSp gene, and performing full-length sequencing, so as to obtain the gene. The gene is an araneus ventricosus wrapped fibroin full-length gene with a complete NT end, a repeating area and a complete CT end, and has potential application values in the field of artificial spider thread fiber preparation.

The invention relates to the field of sponge, in particular to environment-friendly degradable water-absorbing sponge with excellent mechanical performance. Preparation raw materials of the degradablewater-absorbing sponge include the following substances in parts by weight: 100 parts by weight of bacterial cellulose hydrogel block, 4-8 parts by weight of A additive, 3-6 parts by weight of B additive, 0.2-0.6 part by weight of formaldehyde, 0.35-0.75 part by weight of zinc oxide, 1.95-2.85 parts by weight of sodium fluorosilicate, 2.15-3.5 parts by weight of A accelerant, 0.35-0.55 part by weight of B accelerant and 5.5-8.5 parts by weight of additive. The substrate material (bacterial cellulose hydrogel block) used for the degradable water-absorbing sponge and the large numbers of components in the degradable water-absorbing sponge are all environment-friendly degradable materials, so that a prepared product is more environment-friendly.

The invention discloses a method for preparing bean flour and functional soybean protein rich in glyceollin by adopting a solid fermentation method. The method comprises the following steps: inoculating an aspergillus oryzae spore suspension into peeled and damaged soybeans which are soaked for 6-12 hours to obtain contaminated soybeans; putting the contaminated soybeans into a culture dish, and sealing with a sealing film; carrying out solid fermentation in a dark box at 20-30 DEG C for 3-5 days, and carrying out freeze-drying and crushing to obtain the bean flour rich in glyceollin; degreasing the obtained bean flour rich in the glyceollin with normal hexane; and carrying out alkali-solution and acid-isolation on the obtained degreased bean flour, thus obtaining the functional soybean protein rich in the glyceollin. According to the method disclosed by the invention, the bean flour and the protein reach the effect of gathering isoflavone aglycones and Glyceollins; the protein is relatively high in yield; and the bean flour and the functional soybean protein are suitable for industrial production, and can be applied to flour products, dairy products and vegetable protein drinks for menopause women as special protein ingredients.

The invention discloses a carbonic ester polymer vesicle for a micromolecule-carrying medicine, and a preparation method and application of the carbonic ester polymer vesicle. The medicine is a hydrophilic negatively-charged micromolecule medicine; a reversible crosslinking biodegradable polymer vesicle with an asymmetric membrane structure is obtained in a way that a polymer is subjected to crosslinking after the polymer is self-assembled; the molecular chain of the polymer includes a hydrophilic chain segment and a hydrophobic chain segment, which are connected in sequence; the hydrophobic chain segment comprises a polycarbonate chain segment and/ or polyester chain segment; the vesicle loads the medicine through the compounding of intracavity calcium acetate and medicine, i.e., pemetrexed in an alkaline buffer solution; a membrane is reversible crosslinking biodegradable polycarbonate with good biocompatibility; the dithiolane of a side chain is similar to a human body natural antioxidant, i.e., thioctic acid; and a shell takes PEG (polyethylene glycol) as a background and simultaneously contains a targeting molecule capable of carrying out targeting on cancer cells. The carbonic ester polymer is expected to become a nanometer medicine system which combines the advantages of being simple, stable and multifunctional with the advantage that the hydrophilic micromolecule medicine can be favorably subjected to entrapment into a whole. Under the method, the nanometer medicine system can be used for effectively coating a great quantity of negatively-charged micromolecule medicines.

The invention provides a curcumin Pickering emulsion with colon targeted transmission function, a preparation method and application thereof. The method includes: firstly mixing ovalbumin with carboxymethyl konjac glucomannan to form polyelectrolyte compound soft gel, then conducting high-speed homogeneous dispersion to form microgel, then taking soft solid particles formed by crosslinking of dihydromyricetin as an emulsifier, and taking a medium-chain triglyceride solution of curcumin as the oil phase to prepare the curcumin Pickering emulsion. According to the invention, the curcumin Pickering emulsion with colon targeted transmission function can be prepared by changing the soft gel, the microgel and the dihydromyricetin crosslinking conditions. The curcumin Pickering emulsion preparedby the preparation method disclosed by the invention not only reserves the colon targeted transmission properties of carboxymethyl konjac glucomannan, but also can avoid the adverse effects of the environment on curcumin, and the bioavailability of curcumin is greatly improved.

Disclosed is a method for preparing a cell growth scaffold having a structural memory feature, comprising a step of preparing a micro-fibrous or flocculent acellular tissue matrix material; a step of preparing an acidification-treated hydrogel-like acellular tissue matrix particles; proportionally mixing the micro-fibrous or flocculent acellular tissue matrix material with the acidification-treated hydrogel-like acellular tissue matrix particles, followed by injection-molding, freezing treatment, radiation treatment, and ultimately preparing a porous cell growth scaffold that can be stored at room temperature. The prepared cell growth scaffold is a porous cell growth scaffold that has no chemical crosslinking, and has a biological activity, a stable three-dimensional structure and a structural memory feature. The cell growth scaffold has an excellent biocompatibility and complete biodegradability, and supports the growth of cells and the growth of tissues and organs in vitro and in vivo, thereby being suitable for repair of human soft tissue traumas and defects.

The invention belongs to the technical field of biological materials, and discloses an apatite microcarrier and a preparation method and application thereof. The heat-resistant temperature of the apatite microcarrier is 1000-1350 DEG C, the apatite microcarrier is mainly prepared from at least one of hydroxyapatite, halogen apatite, tricalcium phosphate, tetracalcium phosphate and apatite subjected to ion replacement. The invention also provides a preparation method of the apatite microcarrier. The apatite microcarrier still has good thermal stability at a high temperature of 1150 DEG C or above, and can be fully sterilized.The apatite microcarrier has no residual organic solvent, has no toxicity to cells, has good biocompatibility, and is beneficial to the application of the apatite microcarrier in the medical field.

The invention discloses an emergency rescue-oriented wound repair intelligent pistol and a use method thereof. The emergency rescue-oriented wound repair intelligent pistol comprises a drug delivery module, a high-voltage electrostatic generation module and a control module. The drug delivery module realizes drug delivery through an electrically controlled stepping motor, and drug delivery processes such as electrostatic spinning, biological material extrusion, material spraying and the like are combined, so that the effectiveness of the in-situ prepared material on the wound surface is improved; most importantly, through the optimal design of the structure, plug-and-play is achieved, the trauma wound surface can be quickly treated by the device, and emergency rescue scenes can be conveniently and quickly coped with.

The invention belongs to the technical field of cosmetics, and particularly relates to inorganic microspheres for cosmetic scrubbing exfoliation. A core-shell structure is composed of two parts including an inorganic particulate basal body and soybean protein powder adhered to the surface of the basal body, a core of the core-shell structure adopts the inorganic particulate basal body, and a shell layer of the core-shell structure adopts the soybean protein powder. The inorganic particulate basal body is preferably selected from at least one of zeolite powder, diatomite and barium sulfate; by adhering soybean protein coarse powder to holes or defect parts, the inorganic microspheres for cosmetic scrubbing exfoliation are obtained after grinding. The soybean protein coarse powder is inlaid in surface micropores or defect parts of inorganic particulates, which is similar to countless tiny fiber brushes for scrubbing and stripping fine horns of a face during washing. The inorganic microspheres have a micro scrubbing exfoliation function, can be used in facial washing milk and the like for everyday use, and cannot cause damages to skins.

The invention discloses a double-layer asymmetric dressing for promoting skin wound repair and a preparation method thereof, and belongs to the technical field of biomedical materials. According to the invention, a symmetric membrane prepared by adopting electrostatic spinning and 3D biological printing technologies is used as a skin wound dressing, a compact electrostatic spinning nanofiber membrane is prepared from 8-12 wt% of polycaprolactone and 2-6 wt% of polylactic acid blended spinning liquid to simulate an epidermal layer of skin so as to simulate the compactness and waterproof capacity of the epidermal layer, and the top layer of the membrane can be used as a protection barrier so as to prevent permeation of bacteria and microorganisms; a 3D printing hydrogel is prepared from 5 wt% of sodium alginate, 2-8 wt% of polyvinyl alcohol and 1 wt% of chitosan quaternary ammonium salt; and the bottom layer can absorb a large amount of exudate, a proper structure and environment are provided for cell migration and proliferation, and the healing effect of skin wounds is improved.

The invention discloses a high-expansion degradable nasal cavity filling hemostasis material and a preparation method thereof. The hemostasis material is a product prepared by taking carboxymethyl chitosan, bacterial cellulose, water, an activating agent and a degradation regulating agent as raw materials. According to the hemostasis material, the implantation size is small, the hemostasis material not only can be integrally implanted into the nasal cavity, but also can be implanted after being trimmed as needed, and clinic use is flexible and convenient; the liquid absorbing speed is high, the hemostasis material can absorb liquid to be completely expanded within 20 seconds, and the expanding size reaches 10 times that of the self size; the material is low in weight, flexible, rich in elasticity, high in plasticity, full and uniform in oppression to the mucosa, good in patient comfort, great in market application and popularization potential and wide in social benefit prospect.

The invention relates to a drug-loading phase-change mesoporous silicon bionic preparation. The preparation comprises a macrophage; the macrophage is used for swallowing with hollow mesoporous siliconloaded with a pharmaceutical active component and a perfluorinated compound. The perfluorinated compound is selected from perfluoropentane. The pharmaceutical active component is selected from an anti-inflammatory drug, an anti-tumor drug, a cardiovascular disease drug and a digestion system disease drug. The system provided by the invention has a wide application range and strong targeting performance. The drug-loading phase-change mesoporous silicon bionic preparation can be applied to tumors, autoimmunity diseases, inflammatory diseases and the like, lesion locations with inflammatory changes and diseases capable of attracting the macrophage to be gathered.

A medical macromolecular microsphere adsorbent for a blood perfusion apparatus and a preparation method thereof are provided. The polystyrene-divinylbenzene microspheres are graded by different pore sizes and specific surface areas, medically purified, and grafted by a bioactivity-controlled grafting technology. In the microsphere adsorbent, the volume ratio of microspheres with pore sizes of 1-10 μm, 10-100 μm and 100 μm is 1:(1-10):(1-20), the content of residual monomers in the microsphere has O.D_{190-400 nm}≤0.03. The microsphere adsorbent not only can adsorb harmful micromolecules in blood but also can effectively adsorb harmful medium-molecules and macromolecules in blood, thereby meeting clinical application demands.

The invention discloses a bone replacement complex and a preparation method and application thereof, and the bone replacement complex comprises a support which is used for filling a bone defect part and is constructed to be of a porous structure; the functional colloid is used for filling the porous structure of the stent and has flowability; wherein the stent comprises tricalcium phosphate; the functional colloid comprises hyaluronic acid hydrogel. The method comprises the steps of preparing a stent and enabling functional colloid to immerse the stent. The bone replacement complex is used for repairing alveolar bones. The bone replacement complex and the preparation method and application thereof have the beneficial effects that the bone replacement complex which is excellent in biological adaptability and beneficial to tissue growth and the preparation method and application of the bone replacement complex are provided.

The invention discloses a high-hardness and high-wear-resistance titanium alloy as well as a preparation method and application thereof. The chemical composition of the high-hardness and high-wear-resistance titanium alloy is TiaPtbMc, wherein M is at least one of Pd, Au, Ag and Rh, a is more than or equal to 70 at.% and less than or equal to 75 at.%, b is more than or equal to 24 at.% and less than or equal to 30 at.%, c is more than or equal to 1 at.% and less than or equal to 5 at.%, and a+b+c=100 at.%. The high-hardness and high-wear-resistance titanium chooses Ti and Pt binary alloys as the basis, and elements such as Pd, Au, Ag and Rh are further alloyed, so that the hardness of the alloy is remarkably improved; due to the fact that the selected alloying elements have relatively highchemical stability, the corrosion resistance and the biocompatibility of the alloy can be improved; the main crystal phase is a Ti3Pt intermetallic compound, the microhardness value of the Ti3Pt intermetallic compound is greater than 700HV, which is far higher than pure titanium and traditional medical titanium alloy, and can effectively alleviate the problem of poor wear resistance; and in addition, Pt, Pd, Au, Ag, Rh and the like are precious metal elements, have relatively high chemical stability and high corrosion resistance in a physiological environment, and can effectively reduce ion precipitation and reduce biotoxicity.

The invention discloses an enrofloxacin injection and a preparation method thereof. The enrofloxacin injection comprises the following components: raw medicine enrofloxacin, auxiliary materials and a stock solution, the auxiliary materials comprise cationized hydroxyethyl cellulose, sodium alginate, nicotinamide and disodium ethylene diamine tetraacetate; the stock solution is formed by mixing water for injection, propylene glycol and polyethylene glycol. According to the invention, a mixed solvent of propylene glycol and polyethylene glycol is used for coordinating the components in the auxiliary material, the enrofloxacin mixed solution is sequentially treated step by step and component by component under different conditions, and finally the enrofloxacin injection with high stability is obtained by cooling and constant volume. The enrofloxacin injection prepared by the invention is weakly acidic, wherein the mass fraction of enrofloxacin can reach 20%; the injection is good in stability, effectively overcomes the defects of dissolvability and storage performance of the existing enrofloxacin injection, and has a good market prospect.

The invention belongs to the technical field of antitumor materials, and particularly relates to a manganese titanate nanoplate @ citric acid composite material. The composite material comprises a manganese titanate nanoplate and a citric acid compound layer coating the surface of the manganese titanate nanoplate. In addition, the invention further relates to preparation of the material and application of the material in preparation of antitumor drugs. Research shows that based on cooperative control over components and structure of the material, the problems that manganese titanate is difficult to biologically apply, piezoelectric biological catalytic performance is not ideal, and antitumor activity is insufficient can be solved accidentally.