Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Manganese titanate nanoplate @ citric acid composite material, preparation thereof and application of composite material in preparation of antitumor drugs

A technology of manganese titanate nanometer and composite material, which can be used in nanomedicine, antitumor drug, manganese compound, etc., can solve the problem of unsatisfactory biological adaptive treatment effect and so on.

Active Publication Date: 2021-03-09
CENT SOUTH UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of biological adaptability and unsatisfactory therapeutic effect in the existing piezoelectric catalytic therapy, the first purpose of the present invention is to provide a manganese titanate nanodisc@citric acid composite material (the present invention is also called manganese titanate Nanodisc@citric acid composite anti-tumor active material), aiming to provide a new structural material that can be administered intravenously, has excellent biocompatibility, biosafety, and excellent anti-tumor activity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Manganese titanate nanoplate @ citric acid composite material, preparation thereof and application of composite material in preparation of antitumor drugs
  • Manganese titanate nanoplate @ citric acid composite material, preparation thereof and application of composite material in preparation of antitumor drugs
  • Manganese titanate nanoplate @ citric acid composite material, preparation thereof and application of composite material in preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1 (MTO+US group):

[0075] Step (1) MnTiO 3 Preparation of Nanodiscs:

[0076] MnTiO 3 Nanodiscs were synthesized by a simple one-step hydrothermal method. Isopropyl titanate (1.25 mmol) was gradually added to 16 mL of ethylene glycol at room temperature with vigorous stirring (solution A). Meanwhile, manganese chloride tetrahydrate (1.25 mmol) was dispersed in 4 mL of ethylenediamine with stirring (solution B). Pour solution B into solution A, and after uniform mixing, slowly drop 5 mL of deionized water into it under vigorous stirring. The solution was transferred to a 50mL stainless steel reaction kettle, and then the reaction kettle was put into an oven and heated at 200°C for 24h. Naturally cooled to room temperature, the product was collected by centrifugation, washed three times with 50% ethanol aqueous solution, and finally dispersed in absolute ethanol.

[0077] Depend on figure 1 (a) It can be seen that the MnTiO prepared in step (1) 3 The n...

Embodiment 2

[0086] Compared with Example 1, the difference mainly lies in that the time of solvent heat is prolonged (36h), specifically:

[0087] Step (1) MnTiO 3 Preparation of Nanodiscs:

[0088] Isopropyl titanate (1.25 mmol) was gradually added to 16 mL of ethylene glycol at room temperature with vigorous stirring (solution A). Meanwhile, manganese chloride tetrahydrate (1.25 mmol) was dissolved in 4 mL of ethylenediamine with stirring (solution B). Pour solution B into solution A, and after uniform mixing, slowly drop 5 mL of deionized water into it under vigorous stirring. The solution was transferred to a 50mL stainless steel reaction kettle, and then the reaction kettle was put into an oven and heated at 200°C for 36h. Naturally cooled to room temperature, the product was collected by centrifugation, washed three times with 50% ethanol aqueous solution, and finally dispersed in absolute ethanol.

[0089] 5 mg of MnTiO 3 The ethanol solution was centrifuged and redispersed in...

Embodiment 3

[0091] The synthesis method and modification method are the same as in Example 1, but the hydrothermal reaction time is changed to 12h.

[0092] image 3 It is a picture of the manganese titanate nanodisc@citric acid composite material dispersion liquid in Examples 1-3. in, image 3 (a) It can be seen that even after modification, the water solubility of the manganese titanate nanodiscs synthesized by hydrothermal treatment for 12 h is still poor, and obvious coagulation occurred after standing. image 3 (b) is a picture of the manganese titanate nanodisc@citric acid composite material dispersion prepared in step 2 of Example 1, manganese titanate nanodisc@citric acid composite material is evenly dispersed in water without coagulation . image 3 (c) It can be seen that the solubility in water of the manganese titanate nanodiscs synthesized by hydrothermal treatment for 36 hours after modification with citric acid is slightly worse than that of Example 1. As can be seen fro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of antitumor materials, and particularly relates to a manganese titanate nanoplate @ citric acid composite material. The composite material comprises a manganese titanate nanoplate and a citric acid compound layer coating the surface of the manganese titanate nanoplate. In addition, the invention further relates to preparation of the material and application of the material in preparation of antitumor drugs. Research shows that based on cooperative control over components and structure of the material, the problems that manganese titanate is difficult to biologically apply, piezoelectric biological catalytic performance is not ideal, and antitumor activity is insufficient can be solved accidentally.

Description

technical field [0001] The invention belongs to the technical field of anti-tumor drug development, and specifically relates to manganese titanate nano-disc@citric acid composite material. Background technique [0002] Cancer, that is, malignant tumors, has long been one of the major diseases that plague human beings due to its abnormal cell proliferation, uncontrollable growth ability and high lethality. At present, the treatment methods for cancer still focus on chemotherapy, radiotherapy, surgery and so on. However, these treatments have low treatment efficiency, lack of selectivity for normal cells and cancer cells, and their serious side effects lead to damage to the human immune system while treating cancer, and irreversible damage to normal cells , often causing great pain to cancer patients. Therefore, it is imminent to develop a treatment method that can specifically kill cancer cells and is relatively mild and less invasive. [0003] Piezoelectric catalytic ther...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K41/00C01G45/00A61K47/69A61K47/54A61K9/08A61P35/00B82Y5/00B82Y30/00B82Y40/00
CPCA61K9/0019A61K9/08A61K41/0033A61K47/542A61K47/6923A61P35/00B82Y5/00B82Y30/00B82Y40/00C01G45/00
Inventor 徐倩倩高欣宇陈万松赵森峰刘又年邓留
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com