A manganese titanate nanodisc@citric acid composite material and its preparation and application in the preparation of antitumor drugs

A technology of manganese titanate nanometer and composite material, which can be used in antitumor drugs, nanometer drugs, manganese compounds, etc., can solve the problems of unsatisfactory bioadaptive treatment effect, etc., and achieve improved biological piezoelectric catalytic performance and good biological applicability. , the effect of excellent biological piezoelectric catalytic activity

Active Publication Date: 2021-12-03
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problems of biological adaptability and unsatisfactory therapeutic effect in the existing piezoelectric catalytic therapy, the first purpose of the present invention is to provide a manganese titanate nanodisc@citric acid composite material (the present invention is also called manganese titanate Nanodisc@citric acid composite anti-tumor active material), aiming to provide a new structural material that can be administered intravenously, has excellent biocompatibility, biosafety, and excellent anti-tumor activity

Method used

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  • A manganese titanate nanodisc@citric acid composite material and its preparation and application in the preparation of antitumor drugs
  • A manganese titanate nanodisc@citric acid composite material and its preparation and application in the preparation of antitumor drugs
  • A manganese titanate nanodisc@citric acid composite material and its preparation and application in the preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1 (MTO+US group):

[0075] Step (1) MnTiO 3 Preparation of Nanodiscs:

[0076] MnTiO 3 Nanodiscs were synthesized by a simple one-step hydrothermal method. Isopropyl titanate (1.25 mmol) was gradually added to 16 mL of ethylene glycol at room temperature with vigorous stirring (solution A). Meanwhile, manganese chloride tetrahydrate (1.25 mmol) was dispersed in 4 mL of ethylenediamine with stirring (solution B). Pour solution B into solution A, and after uniform mixing, slowly drop 5 mL of deionized water into it under vigorous stirring. The solution was transferred to a 50mL stainless steel reaction kettle, and then the reaction kettle was put into an oven and heated at 200°C for 24h. Naturally cooled to room temperature, the product was collected by centrifugation, washed three times with 50% ethanol aqueous solution, and finally dispersed in absolute ethanol.

[0077] Depend on figure 1 (a) It can be seen that the MnTiO produced in step (1) 3 The n...

Embodiment 2

[0086] Compared with Example 1, the difference mainly lies in that the time of solvent heat is prolonged (36h), specifically:

[0087] Step (1) MnTiO 3 Preparation of Nanodiscs:

[0088] Isopropyl titanate (1.25 mmol) was gradually added to 16 mL of ethylene glycol at room temperature with vigorous stirring (solution A). Meanwhile, manganese chloride tetrahydrate (1.25 mmol) was dissolved in 4 mL of ethylenediamine with stirring (solution B). Pour solution B into solution A, and after uniform mixing, slowly drop 5 mL of deionized water into it under vigorous stirring. The solution was transferred to a 50mL stainless steel reaction kettle, and then the reaction kettle was put into an oven and heated at 200°C for 36h. Naturally cooled to room temperature, the product was collected by centrifugation, washed three times with 50% ethanol aqueous solution, and finally dispersed in absolute ethanol.

[0089] 5 mg of MnTiO 3 The ethanol solution was centrifuged and redispersed in...

Embodiment 3

[0091] The synthesis method and modification method are the same as in Example 1, but the hydrothermal reaction time is changed to 12h.

[0092] image 3 It is a picture of the manganese titanate nanodisc@citric acid composite material dispersion liquid in Examples 1-3. in, image 3 (a) It can be seen that even after modification, the water solubility of the manganese titanate nanodiscs synthesized by hydrothermal treatment for 12 h is still poor, and obvious coagulation occurred after standing. image 3 (b) is a picture of the manganese titanate nanodisc@citric acid composite material dispersion prepared in step 2 of Example 1, manganese titanate nanodisc@citric acid composite material is evenly dispersed in water without coagulation . image 3 (c) It can be seen that the solubility in water of the manganese titanate nanodiscs synthesized by hydrothermal treatment for 36 hours after modification with citric acid is slightly worse than that of Example 1. As can be seen fro...

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Abstract

The invention belongs to the technical field of anti-tumor materials, and specifically relates to a manganese titanate nano-disc@citric acid composite material, which includes a manganese titanate nano-disc and a citric acid compound layer coated on its surface. In addition, the present invention also relates to the preparation of the material and its application in the preparation of antitumor drugs. The research of the present invention found that based on the synergistic control of the composition and structure of the material, many differences such as difficulty in realizing biological application of manganese titanate, unsatisfactory piezoelectric biocatalytic performance, and insufficient antitumor activity can be solved unexpectedly.

Description

technical field [0001] The invention belongs to the technical field of anti-tumor drug development, and specifically relates to manganese titanate nano-disc@citric acid composite material. Background technique [0002] Cancer, that is, malignant tumors, has long been one of the major diseases that plague human beings due to its abnormal cell proliferation, uncontrollable growth ability and high lethality. At present, the treatment methods for cancer still focus on chemotherapy, radiotherapy, surgery and so on. However, these treatments have low treatment efficiency, lack of selectivity for normal cells and cancer cells, and their serious side effects lead to damage to the human immune system while treating cancer, and irreversible damage to normal cells , often causing great pain to cancer patients. Therefore, it is imminent to develop a treatment method that can specifically kill cancer cells and is relatively mild and less invasive. [0003] Piezoelectric catalytic ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00C01G45/00A61K47/69A61K47/54A61K9/08A61P35/00B82Y5/00B82Y30/00B82Y40/00
CPCA61K9/0019A61K9/08A61K41/0033A61K47/542A61K47/6923A61P35/00B82Y5/00B82Y30/00B82Y40/00C01G45/00
Inventor 徐倩倩高欣宇陈万松赵森峰刘又年邓留
Owner CENT SOUTH UNIV
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