Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof

A mesoporous silicon and preparation technology, which is applied in the field of phase-change mesoporous silicon biomimetic preparations and its preparation, can solve the problems of inability to eliminate cell carriers, incapable of active controlled drug release, and narrow application range, and achieve flexible combination and powerful loading. Medicinal ability, the effect of easy surface modification

Active Publication Date: 2018-11-23
GUANGDONG NO 2 PROVINCIAL PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these solutions have several problems: one is that the drug cannot be actively controlled release, and the other is that the

Method used

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  • Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof
  • Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof
  • Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0041] Example 1 Preparation method of drug-loaded phase change mesoporous silicon biomimetic preparation

[0042] 1. Synthesis of drug-loaded phase-change mesoporous silicon biomimetic preparations

[0043] (1) Weigh 1.2027g of Cetrimonium Bromide (Cetrimonium Bromide, CTAB), add 20mL of deionized water and 10mL of absolute ethanol to form a 0.11mol / L CTAB solution, while stirring Gradually add silica solution, and then add 3mL ammonia. After 5 minutes of reaction, 3 mL of 1,4-bis(triethoxysilyl)benzene (BTEB) (1,4-bis(triethoxysilyl)benzene, BTEB) was added, and the mixture was stirred for another 6 hours. Centrifuge at 15000rpm / min for 15 minutes to collect the product, and disperse the precipitate in 0.6mol / L Na 2 CO 3 In the solution, and magnetically stirred in a water bath at 80°C for 30 min for etching. The product was collected by centrifugation at 15000 rpm / min for 15 minutes, washed with deionized water 3 times, and then freeze-dried and stored to obtain hollow mesopor...

Example Embodiment

[0055] Example 2 Drug-loaded phase-change mesoporous silicon preparations (Cell-DPHs) are used for the treatment of mice with breast cancer

[0056] 1. Construction of 4T1 breast cancer mouse model

[0057] (1) The inventors selected Balb / c nude mice as model mice. According to the ratio of 1 million 4T1 cells per mouse, 4T1 cells were subcutaneously injected into the right axillary fat pad of the mouse, and tumors were measured daily after 3 days volume.

[0058] (2) When the tumor volume reaches 150mm 3 At that time, the breast cancer model mice were grouped and Cell-DPHs treatment was started. The inventors randomly divided the tumors into 5 groups according to the size and shape of the tumor, with 6 animals in each group. The specific groups are as follows: control group (Control group), ultrasound group (US group), ultrasound phase change group (US+Cell-PHs group), drug-loaded phase change group (Cell-DPHs group) and ultrasound drug-loaded phase change group (US+Cell-DPHs gro...

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Abstract

The invention relates to a drug-loading phase-change mesoporous silicon bionic preparation. The preparation comprises a macrophage; the macrophage is used for swallowing with hollow mesoporous siliconloaded with a pharmaceutical active component and a perfluorinated compound. The perfluorinated compound is selected from perfluoropentane. The pharmaceutical active component is selected from an anti-inflammatory drug, an anti-tumor drug, a cardiovascular disease drug and a digestion system disease drug. The system provided by the invention has a wide application range and strong targeting performance. The drug-loading phase-change mesoporous silicon bionic preparation can be applied to tumors, autoimmunity diseases, inflammatory diseases and the like, lesion locations with inflammatory changes and diseases capable of attracting the macrophage to be gathered.

Description

technical field [0001] The invention relates to the field of drug targeted and controlled release preparations, in particular to a phase-change mesoporous silicon biomimetic preparation for targeted and controlled release of drugs, its preparation method and application. Background technique [0002] Commonly used clinical drug treatment methods include oral administration, intravenous injection, intravenous infusion, intramuscular injection, etc. However, since most of the drugs are not targeted, the drugs will accumulate in non-target sites and produce different degrees of toxic and side effects. At present, there are roughly the following solutions in the clinical and scientific circles: (1) Preparation of targeted biological agents: such as monoclonal antibodies; (2) Preparation of targeted drug-loaded nanoparticles: such as cisplatin liposomes, etc. ; (3) Preparation of cell-targeting vectors: such as neutrophils, etc. The currently adopted solutions all use passive an...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/46A61K47/04A61K47/06A61K45/00A61K31/704A61P35/00A61P29/00A61P9/00A61P1/00
CPCA61K9/5063A61K31/704A61K45/00A61K47/02A61K47/06A61P1/00A61P9/00A61P29/00A61P35/00
Inventor 刘红梅许智莉熊燃易文鸿
Owner GUANGDONG NO 2 PROVINCIAL PEOPLES HOSPITAL
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