101results about How to "Achieve targeted delivery" patented technology

The invention provides an embolism material composition as well as preparation method and use thereof, the embolism material composition is prepared from reactant raw materials, wherein the reactant raw materials comprise a biocompatibility material, a roentgenopaque substance and a magnetic resonance imaging substance, the roentgenopaque substance and the magnetic resonance imaging (MRI) substance are covered by the biocompatibility material. The embolism material composition not only can be directly detected by an X-ray image device, but also can be directly detected by the MRI, so that a doctor can select a detection method according to self condition of a patient and the medical device condition.

The invention discloses an adriamycin-loaded aptamer-modified DNA nanocage and a preparation method thereof, and belongs to the field of medicine science and technology. Oligonucleotide sequences of MUC1 mucoprotein aptamers are modified onto four oligonucleotide sequences of a DNA regular tetrahedron structure through nucleotide sequence synthesis; and on the basis of a base complementation pairing rule, the stable DNA regular tetrahedron structure is formed through self-assembling under certain conditions, so that the DNA nanocage which is modified with different numbers of the MUC1 mucoprotein aptamers at various vertexes, and adriamycin is loaded through physical trapping so as to achieve a purpose of conducting targeting therapy of tumors. Experiments prove that the drug-loaded DNA nanocage can be formed through self-assembling of a nanocage nucleic acid skeleton, without the participation of complex preparation steps; efficient targeted intake of human breast cancer MCF-7 cells is achieved on the basis of a targeting effect of the MUC1 mucoprotein aptamers and a transmembrane transport property of the DNA nanocage; and meanwhile, the aptamers are protected from being degraded by nuclease in vivo; therefore, a novel drug-delivery system is provided for tumor-targeted delivery of chemotherapeutics.

The invention discloses a method for up-conversion energy feeding of a tuned mass of a magnetorheological damper and the damper. The damper mainly comprises a piston rod, a piston and a cylinder block; a main vibrating structure and the piston are connected through the piston rod; an induction coil is arranged on the piston; and the cylinder block is filled with magnetorheological elastomers. A controllable electromagnetic field is produced through control on the current of the induction coil, so that the rigidity and the damping of the damper are adjusted. The cylinder block used as the tunedmass produce the inertia force reacting on the main vibrating structure, so that the purpose of reducing and even eliminating vibration of the main vibrating structure is achieved. An impact head isarranged at the tail end of the piston rod, an annular elastic membrane is fixed to the cylinder block, a piezoelectric material sheet is arranged on the elastic membrane, when the piston rod moves relative to the cylinder block, the impact head collides with the elastic membrane to produce high-frequency self-excited vibration, the piezoelectric material is subjected to high-frequency pulling andcompression, and efficient conversion of vibration energy is realized. The method and the damper have the advantages as follows: 1, targeted delivery of energy is realized; 2, the structure is compact and reliable; 3, the energy feeding efficiency is relatively high.

The invention relates to a multi-purpose cerium dioxide nanometer drug-loading system realizing the targeted stimulation responsiveness. According to the multi-purpose cerium dioxide nanometer drug-loading system, cerium dioxide with cytotoxicity is taken as a drug-loading main body, sugar is taken as a targeting group, the pillar [5] arene realizing sugar functionalization is taken as a host molecule, pyridinium salt modified on the surface of the cerium dioxide drug-loading main body and containing disulfide bonds is taken as a guest molecule, through the host-guest interaction, the pillar [5] arene realizing sugar functionalization is bonded to the surface of cerium dioxide adsorbing anti-cancer drug, and thus the anti-cancer drug is encapsulated to the surface of the drug-loading main body. Since the pillar arene containing galactosyls is connected to the surface, the biocompatibility of the system can be obviously improved; meanwhile, the galactosyls can act with specific galactose binding protein excessively expressed on the surfaces of cancer cells, so that the targeted selective entering into the cancel cells is realized, further, GSH with high concentration in the cancer cells is utilized for promoting disulfide bonds in the system to rapidly fracture, then the anti-cancer drug is released, the cerium dioxide nanometer particles with cytotoxicity are exposed out, and the synergy in resisting caner of the cerium dioxide nanometer particles and drug is realized.

The invention provides a targeted delivery system based on functionalized macrophages/monocytes, and construction and application of the targeted delivery system. According to the invention, bioactiveprotein or polypeptide which can undergo transmembrane expression is adopted to modify macrophages/monocytes so as to realize functionalization of the macrophages/monocytes, a functionally modified cell membrane is used as a shell to coat nanoparticles so as to construct the targeted delivery system, so a bionic nanometer material slowly releases a drug at a tumor part and is endowed with a tumor-specific targeting function; and tumor-specific targeting and deep tumor delivery are realized by combining the sustained drug releasing function of the nanometer material with a functionalized macrophage membrane, and the tumor enrichment amount of the nanometer material and the tumor treatment effect of the drug-loaded nanometer material are further enhanced.

The invention discloses a multilevel targeted hyaluronic acid nanoparticle loaded with methotrexate and a preparing method thereof, and belongs to the technical field of medicine. The multilevel targeted hyaluronic acid nanoparticle is characterized by being formed by wrapping a polyamido-amine dendrimer with a small particle size (about 5 nm) in a hyaluronic acid nanoparticle with a large particle size (about 200 nm), and methotrexate is used as an anti-tumor drug (encapsulation efficiency and drug loading capacity are 71.62+/-3.159% and 6.46+/-0.518% respectively), so that the multilevel targeted hyaluronic acid nanoparticle intravenous injection administration preparation loaded with methotrexate is prepared. After the multilevel targeted hyaluronic acid nanoparticle enters systemic circulation, passive targeting and concentration of the nanoparticle in tumor tissue can be achieved through the hypertonicity effect of tumor tissue blood vessels, meanwhile, the hyaluronic acid nanoparticle can be degraded through high-expression hyaluronidase of tumor tissue, so that the wrapped polyamido-amine dendrimer can be released, and deep permeation of tumor tissue and trans-tumor cell drug delivery can be achieved by means of the small particle size and the positively charged surface of the polyamido-amine dendrimer.

The invention belongs to the field of medical embolization devices, relates to a sodium alginate microsphere targeted vascular embolization agent containing an antineoplastic drug and a preparation method thereof. Alginic acid is taken as a pharmaceutical carrier, the antineoplastic drug etoposide is a pharmaceutical active ingredient, divalent metal cation or calcium ion solution is taken as a solidifying agent, and the sodium alginate encapsulates the etoposide to prepare ideal particle size-controllable sodium alginate microspheres comprising the etoposide, thus avoiding toxic side effect of traditional etoposide administration such as anaphylaxis and inconvenience. The vascular embolization agent changes the dosage form and route of administration way of the antineoplastic drug etoposide, has high efficacy and low toxicity, and is safely and effectively applied to clinical application. The vascular embolization agent has the advantages of mild preparation condition and simple and convenient operation, and is fit for large-scale production. The vascular embolization agent can be used for vascular embolization, local targeted tumor treatment, and treating small-cell carcinoma of the lung, oophoroma, carcinoma of testis, gastric cancer and liver cancer by administering the vascular embolization agent during operations.

The invention discloses a tumor-targeted photodynamic medicine carrying nanoparticle as well as a preparation method and an application thereof, belonging to a medical preparation containing porphyrin or a medical preparation prepared by a method which utilizes wave energy to process materials. According to the invention, porphyrin or derivates of porphyrin of a functional group and polyethylene glycol and polypropylene glycol of a polyether chain segment are connected through chemical bonds or ester bonds or amido bonds of perssads, and then polymerized into a nanoparticle aqueous dispersion of porphyrin or derivates, loaded with a chemotherapy drug with a conjugated structure and dialyzed to obtain the tumor-targeted photodynamic medicine carrying nanoparticle. The nano material prepared by the method is high in yield, regular in shape, uniform in distribution and good in biosecurity, can be effectively loaded with an antitumor drug with a conjugated structure; a water-soluble photosensitizer can effectively reverse drug tolerance of a chemotherapy drug after being irradiated by near-infrared light; the nanoparticle can efficiently target and position tumors, has good anelasticity, effectively inhibits tumor growth, and has a wide application prospect in preparing breast cancer tumor-targeted drugs.

The invention relates to a hyaluronic acid-modified amide hectorite nanoparticle and a preparation and an application of the hyaluronic acid modified hectorite amide nanoparticle. The hyaluronic acid modified hectorite amide nanoparticle is (3-amino propyl) ethoxydimethylsilane modified hectorite; and the mass fraction of the hyaluronic acid in the nanoparticle is 17.17%-19.09%. The preparation method comprises the following steps: modifying a hectorite surface with (3-amino propyl) ethoxydimethylsilane on to obtain hectorite amide; and through covalent action of amino and carboxyl, grafting the hectorite amide surface with hyaluronic acid, thus obtaining the hyaluronic acid modified hectorite amide nanoparticle. The stability and the biocompatibility of the nanoparticle are improved; meanwhile, the hyaluronic acid-modified hectorite amide nanoparticle has specific targeting action on cancer cells with high expression for a CD44 receptor, and can be applied to targeted delivery of anti-cancer drugs; and the hyaluronic acid-modified hectorite amide nanoparticle is simple in preparation method, mild in reaction condition and easy to operate, and has an industrial implementation prospect.

The invention discloses a preparation method of linear diblock polymeric prodrugs with pH simulative responsibility and in-vitro activity of the prodrugs with pH simulative responsibility. The preparation method is characterized in that with an RAFT (reversible addition and fragmentation chain transfer) polymerization reaction as a main reaction, different polymeric prodrugs are synthesized by changing the proportion of a hydrophilic block and a hydrophobic block, and folic acid is further used to partially modify and synthesize a drug delivery system with pH simulative responsibility and targeting performance. An experiment proves that the system has high drug load capacity, good water solubility and low toxic and side effects and has accurate and efficient cancer treatment potential, and the utilization rate of the drugs is effectively increased.

The invention discloses a tumor-targeting cell drug carrier and an application thereof. The drug carrier is prepared from a cytomembrane-embedded drug bonding material and a carrier cell, the cytomembrane-embedded drug bonding material is prepared from hydrophilia polypeptide, an alkyl chain and a bonding drug, and embedded into the cytomembrane of the carrier cell, and drug delivery is achieved through the tropism of the carrier cell for tumor. The tumor-targeting cell drug carrier can simultaneously deliver any two bonding drugs of a photodynamics treatment photosensitizer, a chemotherapy drug and a fluorescent molecular to tumor; enrichment of drugs at the tumor region is achieved, the treatment effect of drugs is improved, and the side effect of drugs is reduced. A preparing method of the cytomembrane-embedded drug bonding material is simple, practicable, high in yield and easy to purify. The cell drug carrier is of great significance in promoting accurate treatment of tumor and achieving personalized treatment.

The invention discloses a metal polymer, a metal polymer nano-micelle as well as a preparation method and application of the metal polymer nano-micelle. The metal polymer or pharmaceutically acceptable salt or solvate of the metal polymer is shown as a formula I or a formula II; alkynyl is introduced into metal iridium and ruthenium complexes and reacts with water-soluble monoazide polyethylene glycol through a click reaction to synthesize the metal polymer, and the metal polymer can be self-assembled into a nano-micelle with a core-shell structure in an aqueous solution. The preparation method is simple and convenient, the reproducibility is good, the quality is controllable, in addition, the nano-micelle can greatly improve the biocompatibility of metal drugs, can be applied to optical treatment, and has potential anti-tumor application prospects.

The invention provides a multifunctional nano-carrier with drug resistance and hypoxia/glutathione dual responsiveness and a preparation method and application thereof, and belongs to the technical field of biomedical polymer materials. A nano delivery system carrier is an amphiphilic block copolymer, and can encapsulate hydrophobic chemotherapeutic drugs through intermolecular force to form nano-micelles. In hypoxia and GSH high-expression tumor tissues, nitro groups on the nano-carrier can be reduced, so that coupling between nitroimidazole and O6-thienylmethylguanine (O6-TMG) is broken, and at the same time, disulfide bonds are reduced by glutathione and also broken, thereby causing the nano-micelles to be broken. After the micelles are broken, an internally encapsulated alkylating agent and O6-TMG capable of inhibiting AGT activity are released, thereby exerting a targeted anti-tumor effect, and at the same time, the sensitivity of tumor cells to the alkylating agent is specifically improved.

The invention relates to a folate-receptor-mediated pH-sensitive Decoy-ODN (Decoy-oligodeoxynucleotide) nanoparticle preparation and a preparation method thereof. A nanoparticle suspension is prepared from 5-200 mu g/ml of the Decoy-ODN used as a generic medicament, 0.01-6.0 mg/ml of folate-conjugated trimethyl chitosan used as a medicament carrier and 10-500 mu g/ml of pH-sensitive material by a complex coacervation method, wherein the folate conjugation rate of the folate-conjugated trimethyl chitosan is 5-30%, and the ratio of the total volume of the Decoy-ODN solution and the pH-sensitive material solution to the volume of the folate-conjugated trimethyl chitosan solution is 1:(1-4). The folate-receptor-mediated pH-sensitive Decoy-ODN nanoparticle preparation provided by the invention has the advantages of good shaping property, uniform particle size distribution, high DNA (deoxyribonucleic acid) binding rate, better stability, low cytotoxicity and high in-vitro transfection efficiency.

The invention discloses a nano therapeutic agent and a preparation method and an application thereof. The nano therapeutic agent includes glucose oxidase and a hydrophobic chemotherapy drug located ina hydrophobic cavity of the glucose oxidase. The nano therapeutic agent is a compound of glucose oxidase and the hydrophobic chemotherapy drugs, wherein the glucose oxidase and the hydrophobic chemotherapy drugs are combined by hydrophobic effect; and the nano therapeutic agent can realize targeted delivery of tumor, chemotherapy and hunger-like combined therapy at the same time.

The invention provides an exosome nano drug loading system modified by superparamagnetic nano-iron. The exosome nano drug loading system comprises an exosome for loading an insulin secretion-promotingdrug and superparamagnetic nano-iron, wherein the superparamagnetic nano-iron is distributed on the surface of the exosome and is connected to the exosome through the combination of transferrin and atransferrin receptor on the surface of the exosome, and the superparamagnetic nano-iron enables the exosome carrier to have targeting ability and blood glucose responsiveness under the action of an external magnetic field. According to the invention, the exosome loads a diabetes medicine, an exosome nano-carrier is prepared, superparamagnetic nano-iron SPION is adopted as an exosome target head to achieve targeted delivery, pancreatic tissue is targeted through an external magnetic field, the drug carrier is endowed with blood glucose responsiveness, and a nano drug delivery system capable ofeffectively prolonging the in-vivo half-life period of diabetes drugs and having blood glucose response is obtained.

The invention relates to a functional nanodiamond medicine carrying system with targeting performance and a preparation method thereof. The characteristics of large specific surface area and high adsorbability of nanodiamond are used, so that hydrophobic anticancer medicine and photothermal materials are adsorbed onto the surface of the nanodiamond; proteins with antitumor activity are adsorbed onto the surface of the nanodiamond by using the physical action of mutual attraction of positive and negative charges, so that the dispersibility of nanometer particles in water is improved; and a targeting material coats the outer layer, and the photothermal materials are added into the inner layer, so that the effects of improving the medicine carrying capacity, delivering hydrophobic anticancermedicine to tumor positions in a targeted way and reinforcing the treatment effect of the medicine on the tumor by combining photothermal therapy are achieved. By using a simple and feasible method, the problem of burst release of the hydrophobic anticancer medicine is solved; and the active targeting problem of the nanometer particles is also solved.

The embodiment of the invention discloses a fullerene phthalocyanine derivative as well as a preparation method and application thereof. The fullerene phthalocyanine derivative has the advantages of novel structure, small possibility of generating photobleaching, light degradation and aggregation, high phototoxicity and low dark toxicity and is more stable under an illumination condition.

The invention discloses a folic acid-modified starch microcapsule with reduction responsiveness and a preparation method thereof, and belongs to the technical field of biomedical materials. The folic acid-modified starch microcapsule is a medicine-loaded microcapsule which uses a disulfide bond-crosslinked and folic acid-modified amino starch crosslinked membrane as a capsule wall and a hydrophobic medicine-loaded oil phase as a core material through ultrasonic radiation on the hydrophobic medicine-loaded oil phase and an aqueous amino starch solution which is modified by folic acid and a sulfhydryl-containing compound. The folic acid is directly loaded onto the capsule wall of the microcapsule, and the targeting property of the folic acid and the reduction responsiveness of disulfide bonds are combined with the biocompatibility of amino starch, so that the targeted delivery and the controllable release of a hydrophobic medicine are achieved; a product is pure, non-toxic, large in medicine loading capacity, and is widely applicable to coating of the hydrophobic medicine; the targeted delivery of the medicine is achieved by the targeting property of the folic acid, and the controllable release of the medicine is achieved by the reduction responsiveness of the disulfide bonds; and by the preparation method, operation is simple, efficient and fast, and the possibility of introduction of impurities is low.

The invention relates to a method for massively preparing midkine antisense oligodeoxynucleotide nano-liposomes for injection. The method comprises the following steps: dissolving a mixture of cationic liposomes and lecithoid liposomes in an organic solvent to obtain a liposome liquor; then, initially dispersing the liposomes by an ultrasonic instrument, and ultrafiltering to remove the organic solvent, and finally squeezing by a squeezer at a high pressure to uniform grain size to obtain blank nano-liposomes; and then, mixing with an MK-ASODN liquor to obtain MK-ASODN nano-liposomes. The grain size of the midkine antisense oligodeoxynucleotide nano-liposomes for injection produced by the method is within 100-500nm, and the midkine antisense oligodeoxynucleotide nano-liposomes for injection is stable in property and the anti-hepatoma effect of the midkine antisense oligodeoxynucleotide nano-liposomes for injection is remarkably enhanced. The method is simple in process, easy to realize, very easy to amplify, and suitable for industrial production.