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Functional nanodiamond medicine carrying system with targeting performance and preparation method thereof

A nano-diamond and nano-drug-loading technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problem of low solubility of anticancer drugs, passive targeting, and poor therapeutic effects, etc. problem, to achieve the effect of simple and easy preparation method and easy to degrade solution

Inactive Publication Date: 2019-01-29
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present invention, hydrophobic anticancer drugs and photothermal materials (ICG) are encapsulated in protein protamine by molecular self-assembly method, and the outer layer is encapsulated with hyaluronic acid so as to realize the targeted delivery of drugs. Thermal therapy addresses low solubility and poor passive targeting and therapeutic efficacy of anticancer drugs

Method used

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  • Functional nanodiamond medicine carrying system with targeting performance and preparation method thereof
  • Functional nanodiamond medicine carrying system with targeting performance and preparation method thereof
  • Functional nanodiamond medicine carrying system with targeting performance and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Proceed as follows:

[0045] (1) 2 mg of curcumin was dissolved in 1 mL of methanol, 2 mg of ICG was dissolved in 1 mL of deionized water, and 100 microliters of each was added to a 1 mg / ml nanodiamond dispersion to obtain a first mixed solution.

[0046] (2) 10 mg of protamine (protamine sulfate PS, purchased from Sigma) was dissolved in 1 mL of deionized water to obtain the second solution

[0047] (3) Add the first mixed solution to the second solution, vortex for 1 minute, centrifuge and add deionized water to redissolve. Then centrifuge and add water to redissolve, and repeat the above operation 3 times. The obtained stable dispersion is the first dispersion.

[0048] (4) 20 mg of hyaluronic acid was dissolved in 1 ml of deionized water to obtain a third solution. The first dispersion liquid was mixed with the third solution, stirred for 30 minutes, centrifuged and precipitates were collected to obtain stable nanoparticles.

[0049] Test results:

[0050]Accor...

Embodiment 3

[0061] In this example, the nanomedicine composition was prepared according to the same method as in Example 1, except that 50 microliters of curcumin was added.

[0062] According to the same measurement method as in Example 1, the particle size of the nanomedicine composition obtained in this example is measured by a laser particle size analyzer to be 108.6nm; the degree of dispersion is 0.142, the surface potential recorded is -11.3mV, and the encapsulation efficiency 95%

Embodiment 4

[0064] In this example, the nanomedicine composition was prepared in the same manner as in Example 1, except that 200 microliters of curcumin was added.

[0065] According to the same measurement method as in Example 1, the particle diameter of the nano-medicine composition obtained in the present embodiment is 165.3nm using a laser particle size analyzer; %

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Abstract

The invention relates to a functional nanodiamond medicine carrying system with targeting performance and a preparation method thereof. The characteristics of large specific surface area and high adsorbability of nanodiamond are used, so that hydrophobic anticancer medicine and photothermal materials are adsorbed onto the surface of the nanodiamond; proteins with antitumor activity are adsorbed onto the surface of the nanodiamond by using the physical action of mutual attraction of positive and negative charges, so that the dispersibility of nanometer particles in water is improved; and a targeting material coats the outer layer, and the photothermal materials are added into the inner layer, so that the effects of improving the medicine carrying capacity, delivering hydrophobic anticancermedicine to tumor positions in a targeted way and reinforcing the treatment effect of the medicine on the tumor by combining photothermal therapy are achieved. By using a simple and feasible method, the problem of burst release of the hydrophobic anticancer medicine is solved; and the active targeting problem of the nanometer particles is also solved.

Description

technical field [0001] The invention relates to the field of nano-drug carrier materials, and specifically relates to a targeted nano-drug carrier and a preparation method thereof. Background technique [0002] Curcumin is a chemical component extracted from the rhizomes of some plants in Zingiberaceae and Araceae. Among them, turmeric contains about 3% to 6%, which is a rare pigment with diketones in the plant kingdom, which is diketones compound. Medicine has shown that curcumin exerts its anti-cancer effect by inducing the differentiation of malignant tumor cells, inducing tumor cell apoptosis and inhibiting the various stages of tumor growth. It is widely used in clinical practice. However, the hydrophobic effect and poor stability of curcumin limit its application in medicine. [0003] Indocyanine green (indocyanine green, ICG) is a typical cyanine near-infrared dye, and it is also a photothermal material approved by the US FDA for clinical use. The emission waveleng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/42A61K47/36A61K47/04A61K41/00A61K31/12A61P35/00
CPCA61K9/5115A61K9/5161A61K9/5169A61K31/12A61K41/0052A61P35/00A61K2300/00
Inventor 盛望崔馨月邓雄威
Owner BEIJING UNIV OF TECH
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