19results about How to "Improve biomimicry" patented technology

The invention relates to the technical field of biological tissue engineering, and discloses a nerve-blood brain barrier co-culture model, which comprises a culture chip, and nerves and blood brain barriers respectively constructed in upper culture micropores and lower culture micropores of the culture chip. Wherein a semi-permeable membrane is arranged between the lower-layer culture micropores and the upper-layer culture micropores of the culture chip; the nerves are obtained by inoculating neurons / brain organs obtained by stem cell differentiation into the upper culture micropores for co-culture, and the blood brain barrier is obtained by inoculating brain microvascular endothelial cells obtained by stem cell differentiation into one side of the semipermeable membrane in the lower culture micropores for co-culture. The co-culture model is higher in biomimetic property, and can better simulate the structure and function of the blood brain barrier, for example, the co-culture model has a barrier function closer to the physiological level, the selective permeability of a small molecule drug is matched with the in-vivo permeation condition, and the co-culture model has the function of a small molecule related transporter. The invention further discloses a construction method and application.

The invention discloses a bionic biped robot with variable rigidity joints and double-joint flexibility, which comprises a trunk, thighs, variable rigidity knee joints, shanks and feet, and the double-joint flexible part of each leg is driven by three elastic drivers connected in series; a front-side linear motor of the rigidity-variable knee joint is rotationally connected to a mounting frame at the lower end of the thigh, and an output shaft of the front-side linear motor is connected with one end of an L-shaped connecting piece; the rear-side linear motor is mounted on the mounting frame, an output shaft of the rear-side linear motor is sequentially sleeved with a rear-side shell, a rear-side spring and a front-side shell and then fixed to the output end connecting piece, and the two sides of the rear-side spring make contact with the rear-side shell and the output end connecting piece respectively; a rope is led out from the tail end of the front side shell, is wound on a rear side shaft and a knee joint shaft in sequence, penetrates through two pairs of rollers and is fixed on a knee joint output shaft; the rollers are installed at the other ends of the L-shaped connecting pieces, and the knee joint shaft is connected with the switching parts of the two L-shaped connecting pieces through bearings. The robot has good stability, flexibility and adaptability.

This invention belongs to the field of biomimetic robot technology, and specifically relates to a linkage-type shoulder motion mechanism. The technical solution is as follows: A linkage-type shoulder motion mechanism includes a torso fixation base, a shoulder fixation base fixed to the top of the torso fixation base, a shoulder structure rotatably connected to the shoulder fixation base, a forward tilting drive link rotatably connected to the shoulder structure, a forward tilting power source mounted on the torso fixation base, the outer ring of the output end of the forward tilting power source being rotatably connected to the forward tilting drive link, and the forward tilting power source being located on the rear side of the shoulder structure; a shoulder shrug power source mounted on the forward tilting drive link, the outer ring of the output end of the shoulder shrug power source being rotatably connected to a shoulder shrug drive link, and the other end of the shoulder shrug drive link being rotatably connected to the side of the torso fixation base. This invention provides a linkage-type shoulder motion mechanism capable of realizing forward tilting and up-and-down shoulder shrugs.

The invention provides a blood brain barrier bionic micro-fluidic chip device, and belongs to the technical field of bionic chips. The system comprises a concentration gradient generation module and a blood brain barrier bionic module. A concentration gradient generation module chip of the concentration gradient generation module is of a tree-shaped structure, and the concentration gradient of the medicine is generated through a multiple dilution method; according to the module, the uniform concentration gradient is formed at the outlet by accurately controlling the drug concentration, and the intervention effect of the drug on the disease can be researched according to the dose-effect relationship in one experiment. The blood-brain barrier bionic module comprises an upper-layer chip and a lower-layer chip which are separated by a porous film, and the upper-layer chip simulates a blood vessel end of a blood-brain barrier; and the lower-layer chip simulates a brain end. The design partially reproduces the cell structure and function of the blood-brain barrier, and allows researchers to establish a more effective blood-brain barrier model in vitro.

The invention discloses a high-simulation multifunctional artificial simulated sputum and a preparation method thereof. The artificial simulated sputum is characterized by comprising the following components: 6-8% (w / v) of pig mucin; 0.4% (w / v) of low molecular weight salmon sperm DNA; 0.0059% (w / v) of diethylene triamine pentaacetic acid; 5% (w / v) of sodium chloride; 2.2% (w / v) of potassium chloride; 1.81% (w / v) of tris (hydroxymethyl) aminomethane; 0.1% (w / v) of cystine; 5 ml of egg yolk emulsion; nutrition and growth factors; a microbial simulation component; and a stability and protective agent; the simulated sputum prepared by the method is close to real sputum in component, physicochemical property and biological activity, and has good stability and repeatability.

The utility model discloses a jellyfish lamp which comprises a lamp shell, tentacles, a motor, a first gear set, a circuit board and lamp beads. The multiple whiskers are arranged at the bottom of the lamp shell. The motor is arranged in the lamp shell; the first gear set is connected with the output end of the motor; a plurality of connecting holes are formed in the bottom of the lamp shell, and the top ends of the whiskers penetrate through the connecting holes to be connected with the first gear set. The circuit board is arranged in the lamp shell and electrically connected with the motor. The lamp bead is arranged in the lamp shell and electrically connected with the circuit board. The jellyfish lamp is good in bionic effect, and the tentacles can rotate.

The invention discloses a multi-drug combined screening chip and a design method and application thereof.The chip is of a multi-layer structure and sequentially comprises a single drug concentration gradient generating plate, a cell culture plate and a plurality of drug mixing plates from top to bottom, the single drug concentration gradient generating plate comprises a drug adding hole and a concentration gradient drug generating hole, and the drug adding hole is communicated with the cell culture plate; the medicine adding hole is communicated with the concentration gradient medicine generating hole through a mixing flow channel; a plurality of cell culture chambers are arranged on the cell culture plate, and each cell culture chamber is communicated with a drug mixing hole; each medicine mixing plate is provided with a concentration gradient medicine transition hole and a medicine mixing hole; the concentration gradient drug transition holes and the concentration gradient drug generation holes are in one-to-one correspondence and are communicated; the concentration gradient medicine transition hole is communicated with the medicine mixing hole through a distribution runner; and the medicine mixing holes are communicated with a cell culture chamber of the cell culture plate.

The invention discloses a constant-temperature cyclic heating and efficient stir-frying integrated cooker structure, which aims to solve the problems of non-uniform heating and single stir-frying action of the existing cooker, and comprises a machine table, a stir-frying pan mounted in a groove of the machine table, and a thermal insulation layer covering the outer part of the bottom end of the stir-frying pan and forming a hot air channel with the outer wall of the stir-frying pan. A heating bin is arranged in the machine table, an electric heating plate is arranged in the heating bin, the electric heating plate and the hot air channel form a closed circulating air channel through an air inlet pipe and an air outlet pipe, and a stir-frying assembly is arranged over the stir-frying pan and comprises an elastic rubber column driven by a push rod motor to ascend and descend and driven by a rotating motor to rotate and a stir-frying frame fixed to the tail end of the elastic rubber column. Uniform constant-temperature heating is achieved through closed hot air circulation, meanwhile, the stir-frying frame which can be lifted and rotated and has the elastic tail end is used for simulating complex stir-frying actions, closed-loop cooperative control over the heating and stir-frying processes is achieved in combination with the temperature sensor and the controller, and the cooking uniformity, the finished dish quality and the automation degree are effectively improved.

The invention discloses a mechanical arm which comprises a plurality of arm parts connected in sequence, and every two adjacent arm parts are connected through an electric transmission assembly so that every two adjacent arm parts can rotate relatively. And the control assembly is used for controlling the electric transmission assembly to rotate, the control assembly is connected with the electric transmission assembly through a wire harness, and the control assembly is arranged outside the electric transmission assembly and installed on the arm part rotationally connected with the electric transmission assembly. According to the mechanical arm, the multiple arm parts connected in sequence are arranged, every two adjacent arm parts are rotationally connected through the corresponding electric transmission assembly, and the control assembly is installed in one arm part, so that the mechanical arm can better simulate a human arm structure, the integration and the bionic property of the mechanical arm are improved, and the mechanical arm is compact in overall structure and convenient to use. And the miniaturization design requirement can be met.

The utility model provides a pelvis structure and a robot, and relates to the technical field of robots. The pelvis structure comprises a first driving part, a second driving part and a third driving part, the first driving part is used for being connected with a leg structure of the robot, and the first driving part can drive the leg structure to rotate around a first reference axis; the second driving piece is connected with the first driving piece, and the second driving piece can drive the first driving piece to rotate around a second reference axis; the third driving piece is connected with the second driving piece, and the third driving piece can drive the second driving piece to rotate around a third reference axis; the first reference axis is perpendicular to the second reference axis, the second reference axis is perpendicular to the third reference axis, and the gravity center of the second driving part and the gravity center of the third driving part are both located on the third reference axis. The pelvis structure is integrally arranged, the overall size of the pelvis structure can be reduced, and the stability of the robot is improved.

The invention belongs to the technical field of textile precision measurement, and discloses a textile material touch and visual comprehensive style measuring device and method, and the device comprises a platform supporting mechanism, a pressure characteristic mechanism, a drawing characteristic mechanism, and a deformation auxiliary characteristic mechanism. The pressure characteristic mechanism comprises a pressure rod arranged on the platform supporting mechanism in a lifting mode. The drawing characteristic mechanism comprises a drawing rod arranged on the platform supporting mechanism; the deformation auxiliary characteristic mechanism comprises an auxiliary supporting block connected to the platform supporting mechanism in a sliding mode, an auxiliary pressing rod is arranged above the auxiliary supporting block in a lifting mode, and the textile material passes through the contact face of the auxiliary pressing rod and the auxiliary supporting block. The device is exquisite in structure, various mechanical property indexes and surface topography information of the textile material are obtained through a single device and a single test, the efficient, accurate and convenient measurement state of the touch and visual comprehensive style of the textile material is achieved, and the device can be suitable for test characterization of various flexible materials including the textile material.

The multi-degree-of-freedom ornithopter comprises a nose, a fuselage, a left wing, a right wing and an empennage, the machine head is located at the front end of the machine body and is of a box type structure, the interior of the machine head is divided into a speed reduction chamber and a transmission chamber from front to back, the speed reduction chamber and the transmission chamber are separated through a partition plate, a speed reduction mechanism is arranged in the speed reduction chamber, and a transmission mechanism is arranged in the transmission chamber. A flapping wing driving motor is fixedly mounted at the front end of the nose and is connected with the transmission mechanism through a speed reducing mechanism; the left wing and the right wing are distributed on the two sides of the nose in a mirror symmetry mode and connected with the transmission mechanism, and a first electromagnetic type torsion driving joint is arranged between the left wing and the transmission mechanism. A second electromagnetic torsion driving joint is arranged between the right wing and the transmission mechanism; a wing flapping amplitude adjusting mechanism is arranged between the transmission mechanism and the nose box body; the empennage is located at the rear end of the fuselage, and an empennage attitude adjusting executing mechanism is arranged between the empennage and the fuselage.

The present application belongs to the technical field of bionic robot, and particularly relates to a chain belt type leg action mechanism. The technical scheme is as follows: a chain belt type leg action mechanism, comprising left and right swing power sources, the output end of the left and right swing power sources being connected with a waist fixing end, a supporting connecting rod being rotatably connected to the shell of the left and right swing power sources, further comprising a thigh base body, the other end of the supporting connecting rod being fixed with the thigh base body, a front and back swing power source being installed on the thigh base body, the output end of the front and back swing power source being provided with an output fixing disc, a driving fixing disc being fixed to the shell of the left and right swing power sources, the output fixing disc and the driving fixing disc being connected through a steel belt transmission. The chain belt type leg action mechanism can swing forward and backward, swing left and right or compound motion.

The present invention belongs to the field of exoskeleton robots, and discloses a knee joint cross four-bar exoskeleton and a design method thereof based on image registration, comprising a thigh component, a calf component, a calf-high and low-calf connecting component and a driving component, wherein the thigh component and the calf component are connected through the calf-high and low-calf connecting component, and the driving component is used to drive the calf-high and low-calf connecting component to drive the thigh component and the calf component to move, and the thigh component, the calf component, the active connecting rod component, and the driven connecting plate constitute a cross-hinge four-bar mechanism, and the length of the hinge cross four-bar mechanism is designed according to the collected bone X-ray image. The exoskeleton can be well applied in scenes such as medical rehabilitation and carrying assistance, and the "J"-shaped curve prior knowledge is added in the process of solving the instantaneous center curve of the knee joint, so that the solution is fast and the degree of dependence on data is small. The four-bar mechanism schematic diagram is designed according to the characteristics of the anterior and posterior cruciate ligaments of the knee joint, and the mechanism parameters are mapped through the X-ray image, so that the designed mechanism has the function of an artificial knee joint.

The invention provides a bionic blood brain barrier micro-fluidic chip device and application thereof, and belongs to the technical field of micro-fluidic chips. According to the invention, by utilizing the micro-fluidic chip design of the modularized concentration gradient generation module and the blood brain barrier bionic module and the chip design of the unique snowflake-shaped concentration gradient generation module, the concentration gradient generation and the neuroinflammation model are combined on one platform, so that the drug screening can be efficiently carried out; and the dose-effect relationship and the synergistic effect of the medicine can be accurately evaluated.

The invention belongs to the technical field of organ chips and biological manufacturing, and relates to a vascularized multi-tissue interaction organ chip based on a phase change sacrificial structure and a construction method and application thereof. According to the invention, collaborative construction of multiple tissue chambers and a blood vessel-parenchymal tissue biological interface is realized through a continuous phase change process of the sacrificial hydrogel material; according to the organ chip disclosed by the invention, an extra diaphragm or complex processing is not needed, the continuity and the bionic property of a multi-tissue interaction interface are maintained, the simulation of signal exchange and a pathological process among multiple tissues in a body is facilitated, and the organ chip has higher bionic property and applicability in applications such as complex physiological interaction modeling, drug evaluation and disease mechanism research.

The invention discloses a sea lion front fin simulating device capable of actively deforming, which belongs to the technical field of underwater navigation equipment and comprises N joint skeleton mechanisms, a driving connecting rod, a supporting shell, a bionic flexible outer skin and a driving unit. The joint framework mechanism comprises a shin rod, a supporting rod, a crank, a first fixing pin shaft, a second fixing pin shaft and a sliding pin shaft, and a plane connecting rod mechanism is formed. One end of the shank rod is connected with the supporting rod through a first fixing pin shaft, the other end of the supporting rod is connected with the crank through a second fixing pin shaft, and the other end of the crank is connected with a sliding pin shaft and can slide along the shank rod. And a driving connecting rod is connected between the sliding pin shafts of the adjacent joint framework mechanisms. The supporting shell is fixed to the shin rod to form supporting face bodies located on the two sides of the first fixing pin shaft, and the bionic flexible outer skin is installed on the supporting face bodies to form a fin-shaped surface. The driving unit is connected to the shin rod and drives the shin rod to swing around the first fixing pin shaft. Through spanwise active deformation, flexible skin hydrodynamic characteristics, a multi-joint bionic structure and rigid-flexible combined design, the propulsion efficiency and adaptability of the underwater robot are remarkably improved.

The utility model relates to the technical field of rehabilitation training instruments, in particular to a manipulator for rehabilitation training of hand and wrist joints, which comprises a frame, a finger training component, a motion disc, a first rotation driving mechanism and a second rotation driving mechanism. A first through cavity through which an arm of a patient passes and a wrist supporting piece for supporting a wrist of the patient are arranged on the motion disc; the finger training assembly is connected with the wrist supporting piece. The finger and wrist training device overcomes the defect that fingers and wrists of patients cannot be trained at the same time in the prior art, and the first rotation driving mechanism and the second rotation driving mechanism are arranged to drive the movement disc to rotate around different rotation axes. A patient can conduct finger training, wrist flexion / extension, ulnar flexion / radial flexion and wrist joint internal and external rotation training at the same time, the number of used training instruments can be reduced, coordination between the fingers and the wrist of the patient can be promoted, and the rehabilitation training effect is improved.

The utility model provides a neck structure and a robot, and relates to the technical field of robots. The neck structure comprises a head supporting piece, an adapter piece, a pair of rocker arm pieces and a pair of driving pieces, and the head supporting piece can drive the head structure to rotate around a first reference axis; the adapter is hinged to a body structure of the robot, and the adapter is hinged to a head supporting piece of the robot; the hinge joint of the adapter and the body structure is configured to enable the adapter to rotate around a second reference axis, and the hinge joint of the adapter and the head support is configured to enable the head support to rotate around a third reference axis; the driving piece is provided with an output end and can drive the output end to move along a set path; a pair of connecting ends of the head supporting piece are located on the two sides of the adapter respectively, one end of the rocker arm piece is in ball hinge with the connecting end on the corresponding side, and the other end is in ball hinge with the output end on the corresponding side. According to the neck structure, the freedom degree of the head structure can be increased, and the bionic effect is improved.