41results about How to "Increase upload volume" patented technology

Weight percent ratio of a flue gas Cuo/gamma-Al2O3 catalyst based on cordierite is in that: cordierite carrier is 78.7-93.8%, Al2O3 is 5-16% and CuO is 1.2-5.3%. Cordierite honeycomb ceramic with high intensity is adopted as a substrate, which is impregnated with CuO of a certain concentration after coated with the carrier gamma-Al2O3. The invention can reduce coating crack of the gamma-Al2O3 film and increase firmness of the gamma-Al2O3 coating and uploading capacity of the gamma-Al2O3 by using a simple and effective coating method, and has advantages of enhanced denitrification activity, life and stability of the catalyst.

The invention discloses a method for preparing a monolithic catalyst for the purification of diesel exhaust, which is to synthesize metal active ingredients and SAPO-34 molecular sieves directly by an assisted hydrothermal synthesis method and load the metal active ingredients and the SAPO-34 molecular sieves on honeycomb carriers. The method comprises the following steps of: treating cordierite honeycomb ceramic carriers with a dilute nitric acid, eluting the mixture with distilled water and drying the mixture; adding a metal oxide into a phosphoric acid, stirring the solution to dissolve the metal oxide, adding an aluminum source, a silicon source and organic template into the solution and stirring the solution to obtain the mother liquor of molecular sieves; putting the cordierite honeycomb ceramic carriers and the mother liquor of molecular sieves in a reaction kettle for hydrothermal synthesis; rinsing and drying the mixture after crystallization; and preparing the catalyst by roasting crystals in an oxygen-containing atmosphere. Compared with the conventional methods for preparing catalysts, the method of the invention has a simple preparation process and can accurately control the content of the metal active ingredients. The prepared monolithic catalyst has high NOx removal activity and high recycling stability.

The invention discloses a reduced responsive drug-drug conjugate preparation method which is characterized in that the method includes the steps: preparing a camptothecin intermediate (CPT-SS) containing a reduced responsive bond; preparing a reduced responsive drug-drug conjugate (GT-CPT) or (BT-CPT). The reduced responsive drug-drug conjugate has advantages of a small-molecule prodrug and a nano-drug, the uploading capability of the reduced responsive drug-drug conjugate can be effectively improved, the reduced responsive drug-drug conjugate solves the problems of targeting delivery of a current small-molecule prodrug delivery system and controlled release of drug selectivity, and accurate diagnosis and efficient treatment of tumors are facilitated. Gemcitabine (drug) and biotin (target)molecules are introduced, fluorescence of drug molecules can be temporarily shielded, the conjugate is combined with specificities of cancer cells, so that nano-micelles are disassembled and assembled, the fluorescence of the drug molecules can be reduced, and a drug releases drug properties under stimulation response, so that accurate diagnosis and treatment of cancers are combined.

The invention discloses a preparation method of reductive-response amphipathic wormlike monomolecular prodrug. On the basis of linear structure of glucan, stimulus response of high-concentration glutathione in tumor cells is utilized to promote splitting of disulfide bonds of the amphipathic wormlike monomolecular prodrug to realize synchronous release of camptothecin (CPT) which is antitumor drug so as to act on a tumor position. The preparation method includes following steps: (1), preparing camptothecin monomer: specifically introducing disulfide-bond camptothecin CPT-SS; (2), preparing a drug initiator DEX-Br; (3), polymerizing the camptothecin monomer CPT-SS on the initiator through atom transfer radical polymerization (ATRP) to obtain a DEX-CPT-SS hydrophobic intermediate product; (4), utilizing ATRP to polymerize polyethylene glycol methacrylate (OEGMA) to obtain amphipathic segmented polymer DEX-CPT-OEGMA-SS named as DCO-SS. The obtained amphipathic wormlike monomolecular prodrug can directly form a drug monomolecular micelle in an aqueous phase, has the advantages of high drug loading capacity (higher than 23wt%), high micelle stability, sensitive stimulus-response drug release, high biocompatibility and low toxic and side effect on normal tissue. The problem that hydrophobic drug is low in molecular solubility is solved effectively, and an efficient drug delivery carrier is provided.

The invention discloses a preparation method of a multi-stimulation-response cooperative anti-tumor polymer prodrug. The preparation method comprises the following steps: based on beta-cyclodextrin, modifying a double-sulfur-bond camptothecin monomer CPT-SS, 2-(diisopropylamino)ethyl methacrylate DPA and polyethylene glycol methacrylate OEGMA on an initiator by utilizing atom transfer radical polymerization reaction (ATRP), so as to obtain an amphiphilic polymer prodrug beta-CD-P (CPT-co-DPA-co-OEGMA). The obtained amphiphilic polymer prodrug can be directly self-assembled in a water phase toform a single-molecule medicine micelle and also can be used for physical embedding an anti-cancer drug, i.e., adriamycin. Double sulfur bonds of the single-molecule prodrug are opened under the stimulation of a tumor microenvironment condition, amphiphilic performance is changed and the anti-tumor drug is synchronously released to kill tumor cells. Therefore, the method has the advantages that the loading amount of a hydrophobic drug is improved and the selectivity of the anti-tumor drug is also increased; the cooperative treatment effect is remarkable and the safety is high.

The invention relates to the fields of chemical synthesis and biological representation, and more particularly, provides a preparation method and an application of a pH-responsive amphiphilic rod-likepolymer prodrug, which is represented as the drawing in the specification. The preparation method of the amphiphilic rod-like polymer material includes the following steps: 1) synthesizing a rod-likeATRP initiator on the basis of glucan; 2) introducing a pH-responsive hydrophobic block on the basis of ATRP reaction; 3) introducing a hydrophilic block on the basis of ATRP reaction to obtain an amphiphilic polymer material; 4) substituting an ester group on the terminal of MGMA by means of hydrazine hydrate, thus producing a pH-responsive precursor; 5) forming a hydrazone bond by means of a carbonyl group on adriamycin and an amino group on the polymer material, thus producing the pH-responsive polymer prodrug. By means of weak acidity of interior of cancer cells, the amphiphilic rod-likepolymer prodrug can selectively release a drug by means of pH-stimulating response. The polymer prodrug is high in micelle stability, is high in drug carrying capacity and enables drug release to be under stimulating response control.

The invention discloses a cellulose-based camptothecin prodrug and a preparation method thereof. The preparation method comprises the following steps: (1), preparing a drug initiator MCC-Br; (2), preparing a camptothecin monomer MABHD-CPT; (3), through an atom transfer radical polymerization (ATRP) reaction, polymerizing the hydrophobic camptothecin monomer MABHD-CPT and a hydrophilic polyethyleneglycol methacrylate OEGMA to obtain an amphiphilic polymer MCC-P(MABHD-CPT)-b-P(OEGMA), which is named as MCO. The obtained amphiphilic polymer prodrug can form a single molecular drug micelle in water, has the advantages of high micelle stability, a controllable micelle shape, high drug loading amount, low toxic and side effects, good controlled drug release and the like, effectively solves theproblem of low solubility of hydrophobic drug molecules, and provides an efficient drug delivery system.

The invention particularly relates to an acid-responsive polymer drug based on dextran and application of the acid-responsive polymer drug. In a molecular formula of the polymer drug, the value rangeof x is 3 to 30, and m and n separately indicate polymerization degrees of a hydrophobic block and a hydrophilic block. A method comprises the following synthetic steps: (1) using dextran to synthesize an ATRP initiator (Dextran-Br); (2) introducing the hydrophilic and hydrophobic blocks by utilizing ATRP polymerization reaction; (3) using N2H4-H2O to substitute an ester group on MGMA, thus obtaining an acid-responsive precursor; and (5) using amino and carbonyl on doxorubicin to react to form hydrazone bonds to synthesize an acid-responsive polymerization prodrug. In a cancer cell weak acid environment, the polymerization prodrug can be selectively released and has the advantages of higher micelle stability, high drug loading amount and the like, and can effectively overcome the defects in a drug delivery system of the nano technology that hydrophobic drug molecules are poor in solubility, high in toxicity and side effects and the like.

The invention discloses a preparation method of linear diblock polymeric prodrugs with pH simulative responsibility and in-vitro activity of the prodrugs with pH simulative responsibility. The preparation method is characterized in that with an RAFT (reversible addition and fragmentation chain transfer) polymerization reaction as a main reaction, different polymeric prodrugs are synthesized by changing the proportion of a hydrophilic block and a hydrophobic block, and folic acid is further used to partially modify and synthesize a drug delivery system with pH simulative responsibility and targeting performance. An experiment proves that the system has high drug load capacity, good water solubility and low toxic and side effects and has accurate and efficient cancer treatment potential, and the utilization rate of the drugs is effectively increased.

The invention relates to a macrophage-mediated drug-loaded hyaluronic acid nanohydrogel and preparation thereof. A drug-loaded hyaluronic acid nanohydrogel is obtained by synthesizing polypyrrole in situ from the interior of a hyaluronic acid nanohydrogel, and loading a drug; and the macrophage-covered drug-loaded nanohydrogel is obtained by performing co-incubation on the drug-loaded hyaluronic acid nanohydrogel and mouse macrophages. The macrophage-mediated drug-loaded nanohydrogel prepared by the method has the advantages of low toxicity, safety, avoidance of phagocytosis of a reticuloendothelial system, and specific targeting in tumor areas when used for delivery of anti-cancer drugs, and has potential application prospects in tumor treatment.

The invention discloses a preparation method of a DOC (diesel oxidation catalyst) for the exhaust gas emission of a diesel engine. The preparation method comprises the following steps: (a) weighing modified aluminum oxide, modified cerium-zirconium oxide and deionized water, carrying out ball milling for a period of time, and testing the particle size of slurry D50 which is 3-5 microns; (b) slowlydropwise adding a noble metal salt solution into the slurry so as to maintain the pH value of the slurry to be 9-10; (c) carrying out carrier coating; and (d) calcining. According to the preparationmethod, a DOC coating layer has a relatively low ignitiontemperature and can be rapidly ignited even when the exhaust gas temperature is not high; very high conversion efficiencies of HC and CO can beachieved; the exhaust gas temperature can be greatly increased, and the oxidation performance and the DPF regeneration performance can be improved; and NO in exhaust gas can be effectively convertedinto NO2, so that the regeneration of dry soot in DPF is promoted.

The present invention discloses an amphiphilic stellate camptothecin polymer prodrug and a preparation method thereof. The preparation method comprises the following steps: preparing a cyclodextrin-based stellate atom transfer radical polymerization (ATRP) initiator (CD-Br), preparing a reduction-sensitive or reduction-insensitive monomer MABHD/MAHDO, preparing a reduction-sensitive or reduction-insensitive CPT precursor, preparing a stellate polymer prodrug CD-PCPT, and then preparing the amphiphilic stellate camptothecin polymer prodrug beta-CD-PCPT-POEGMA. The obtained stellate camptothecinpolymer prodrug can self-assemble to form a drug nanomicelle, can selectively release drugs, has advantages of high micelle stability, high drug loading amount, drug release for stimulating responsecontrols, and effectively solves water solubility of hydrophobic drug molecules and characteristics of combination with nano drug delivery.

The invention relates to the field of synthesis of medicinal chemistry, and particularly relates to a preparation method of a targeted amphiphilic small molecular prodrug for pH response and collaborative treatment, which is a preparation method and application of an adriamycin-based amphiphilic small molecular prodrug for acid response. The preparation method of the amphiphilic small molecular prodrug comprises the following steps of (1) carrying out hydrophilic drug molecule methotrexate (MTX)-based chemical modification, introducing a tert-butyl oxygen carbonyl-protected pH responsive hydrazine bond to a hydroxyl part with low steric hindrance in methotrexate; and (2) introducing an adriamycin (DOX) hydrophobic drug molecule after hydrazide tert-butyl carbonyl protection and obtaining the amphiphilic small molecular prodrug for pH response. The obtained amphiphilic small molecular prodrug can be self-assembled into a drug nano-micelle, the drug can be selectively released, and the amphiphilic small molecular prodrug has the advantages of targeted delivery, high drug loading capacity, stimulus-response-controlled drug release and high micelle stability. The problems of the water solubility of the hydrophobic drug molecule and combined nanodrug delivery can be effectively solved.

The invention discloses an NFC two-dimensional code cooperative device operation and maintenance recording system and an NFC label. An operation and maintenance checking program is stored in a mobileintelligent identification terminal, an ID is set for transformer substation equipment and stored in an NFC label and a two-dimensional code, and the NFC label or the two-dimensional code enters an operation and maintenance recording server through mobile intelligent identification to carry out online checking and write operation and maintenance records of the equipment. According to the invention, the operation and maintenance server is logged in through various modes such as the NFC label, the two-dimensional code and the account verification, queuing is avoided, multiple persons are supported to compile and look up equipment operation and maintenance records online at the same time, the uploading amount and uploading efficiency of the operation and maintenance records are greatly improved, and the loss of the operation and maintenance records is avoided.

The invention relates to a catalyst for purifying CO in hydrogen-rich gas as well as a preparation method and application of the catalyst. The preparation method of the catalyst comprises the following steps: pretreating a pore-expanding base material; preparing a copper salt precursor, a cerium salt precursor, a metal M salt precursor with tetravalence and sepiolite powder to prepare slurry; infiltrating the pretreated pore-expanding base material by using the slurry; and drying the pore-expanding base material infiltrated with the slurry, and then roasting to obtain the CO purification catalyst in the hydrogen-rich gas. Compared with the prior art, in the preparation process of the catalyst, the pore-expanding base material participates, the preparation raw materials are low in price and easy to obtain, and the catalyst has mesh-shaped morphology, multi-level pore channels, high CO trapping capacity, low selective oxidation reaction temperature of CO in hydrogen-rich gas, high removal depth and relatively high moisture resistance.

The invention discloses a preparation method of an organic ligand modified formaldehyde purification catalyst. La accounting for 1%-10% of titanium oxide by weight is premixed with at least one of Cu, Fe and Ni and at least one of Sn and Mn and then mixed with water, water-soluble salt is prepared, titanium oxide powder is added, the mixture is dried and calcined at a high temperature, a modified catalyst carrier is prepared and added to a Pt organic solution, the mixture is dried and calcined at a high temperature, modified catalyst carrier powder is prepared and mixed with pseudo-boehmite, methylcellulose and water, modified paste is prepared, honeycomb ceramic plates are dipped in the modified paste, then dried, calcined, cooled and reduced, and the organic ligand modified formaldehyde purification catalyst is obtained. The catalyst can filter dust, eliminate peculiar smells, perform sterilization and disinfection functions and adsorb harmful gas and can also promote complete catalytic decomposition of harmful gas, so that the adsorbed harmful gas cannot cause secondary pollution, a catalyst layer is not prone to peel or crack, and the service life is long.

The invention provides a novel acid response ionic liquid microcapsule as well as a preparation method and application thereof. The ionic liquid microcapsule comprises an inner core and a shell layer, wherein the inner core is ionic liquid, and the shell layer is a metal-polyphenol network coating. The preparation method of the microcapsule comprises the following steps: adding polyphenol into the ionic liquid, and performing stirring to dissolve the polyphenol to obtain polyphenol-ionic liquid; adding the polyphenol-ionic liquid into water, and performing ultrasonic and uniform dispersing; and then adding a metal ion solution, performing whirling to uniformly mix the system, then adjusting the pH value of the system, and performing centrifuging to obtain the microcapsule. According to the ionic liquid microcapsule prepared by the method, the stability of ionic liquid droplets can be remarkably improved, and various drug molecules, especially indissolvable drugs, can be effectively loaded; and MPN of the prepared microcapsule is dissociated in an acidic microenvironment, so that the ionic liquid carries the medicines to permeate into a target tissue, and the utilization rate of the medicines is greatly improved and the efficacy of the medicines is enhanced due to the relatively strong medicine permeation effect of the ionic liquid.

The invention discloses a preparation process of a diesel DOC catalyst. The preparation process includes the specific steps of: 1, mixing aluminum oxide powder, iron oxide powder, chromium oxide powder and ionized water according to certain proportion to prepare a slurry with a solid content of 42-50%, putting the slurry into a ball mill or sand mill for grinding, and taking out the slurry from agrinding tank; 2, slowly adding a noble metal salt solution dropwise into the slurry obtained in step 1 by a pipette for full wetting, performing stirring, and then conducting standing at 30-75DEG C for 2-5h to obtain a sample; and 3, drying the sample obtained in step 2 in a vacuum drying box at 90-110DEG C for 8-12h, and then performing calcination in a muffle furnace at 520-580DEG C for 3-6h. The preparation process of the diesel DOC catalyst provided by the invention effectively improves the durability of the catalyst, and at the same time improves the conversion rate of the catalyst coating on pollutants at high temperature.