181results about How to "Precision therapy" patented technology

The invention discloses a transcutaneous electrical stimulation device based on a large language model, and relates to the technical field of wearable devices. The transcutaneous electrical stimulation equipment based on the large language model comprises a data acquisition and preprocessing module, a feature extraction and fusion module, a model training and prediction module and a real-time information processing and response module, real-time data processing and intervention capabilities are integrated, human body data can be analyzed in real time, electrical stimulation parameters can be automatically adjusted, an instant treatment or adjustment scheme is provided for the problems of arrhythmia, chronic pain and the like, and the timeliness and effectiveness of treatment are greatly improved. And secondly, by fusing the physiological signal features and the symptom text features, the equipment can more comprehensively understand the health condition of the user, so that a more accurate treatment scheme is provided. Besides, the equipment also has the functions of anomaly detection and trend analysis, can predict potential health risks, and triggers an alarm in time when a serious anomaly is detected, thereby effectively guaranteeing the life safety of the user.

The invention relates to the technical field of biological medicine, and provides a targeting exosome capable of delivering nucleic acid drugs and a preparation method of the targeting exosome. The exosome comprises a fusion polypeptide, the fusion polypeptide comprises a targeting protein molecule, an exosome transmembrane protein and a nucleic acid binding domain, and the exosome can load a nucleic acid molecule through binding of the nucleic acid binding domain. According to the invention, engineering modification is carried out on the exosome, so that nucleic acid molecules can be efficiently loaded into the exosome, and meanwhile, the exosome is endowed with the capability of targeting to specific target cells, tissues and organs.

The invention relates to the technical field of oral X-ray image recognition, in particular to an intelligent oral X-ray film lesion area recognition system based on artificial intelligence. The method comprises the following steps: obtaining gray level change characteristics of each tooth region in an oral X-ray image according to gray level and gradient distribution in each tooth region; obtaining an optimal factor according to the gray change feature similarity between different regions, and further selecting a standard tooth region; obtaining a ray absorption coefficient according to the gray difference of different areas and the difference of the optimal factors; obtaining caries area possibility of the pixel points according to the positions of the pixel points in the tooth area; and the caries area is identified. According to the method, the caries area in the oral X-ray image is accurately segmented, and finally accurate treatment can be carried out on a patient.

The invention relates to the technical field of medical beauty medical instruments, and particularly discloses a radio frequency microneedle treatment device and a radio frequency energy control method, the radio frequency microneedle treatment device comprises a control module, an impedance detection module, a switch switching circuit and a microneedle array; the microneedle array comprises a plurality of microneedle electrodes, the microneedle array is divided into a plurality of positive electrode areas and a plurality of negative electrode areas, and each positive electrode area and each negative electrode area comprise at least one microneedle electrode; the impedance detection module is electrically connected with the switch switching circuit, the switch switching circuit is electrically connected with each microneedle electrode, and the impedance detection module is used for detecting impedance values of treatment area tissues corresponding to the positive electrode area and the negative electrode area; and the control module is electrically connected with the impedance detection module, sends an impedance detection signal to the impedance detection module, analyzes an impedance value distribution diagram of treatment area tissues corresponding to the microneedle array according to an impedance value detected by the impedance detection module, and selects a proper positive electrode area to be conducted with a proper negative electrode area according to the impedance value distribution diagram.

The invention discloses an osteoporosis prevention strategy analysis method and system, and belongs to the technical field of health data analys.The osteoporosis prevention strategy analysis method specifically comprises the steps that the bone mineral density of a user is measured and preprocessed, a T value is calculated and compared with a preset osteoporosis threshold value, and the osteoporosis condition is judged; for the osteoporosis user, risk self-evaluation is carried out, risk grades are divided, a personalized treatment scheme is formulated, and the effect is monitored; for non-osteoporosis users, a risk prediction model is established through an osteoporosis prediction algorithm, and risk scores are calculated and graded; formulating a prevention strategy according to the risk level, evaluating an effect and adjusting an algorithm and the strategy; according to the invention, accurate prevention and treatment of osteoporosis are realized.

The invention provides organic nanoparticles with high osteogenic performance as well as a preparation method and application thereof, and belongs to the technical field of osteogenic drug preparation. The preparation method of the organic nanoparticles with high osteogenic performance comprises the following steps: (1) preparing fluorinated polyethyleneimine, preparing double bonds from the fluorinated polyethyleneimine, and then grafting a targeting peptide E7 to obtain a carrier F-PEI-E7; and (2) entrapping an osteogenesis promoting drug in the carrier F-PEI-E7 to obtain the organic nanoparticles with high osteogenesis performance. The invention provides an innovative strategy: F-PEI is used as a carrier, an osteogenesis promoting drug (beta-GP) is entrapped, and through E7 targeting peptide (EPLQLKM) modification, precise targeting delivery of the drug is realized. The organic nanoparticles are high in stability, the in-vitro osteogenesis promoting effect is equivalent to that of a classical formula for in-vitro osteogenesis induction, and the organic nanoparticles have an excellent in-vivo osteogenesis promoting effect.

The invention discloses an artificial antigen presenting cell for efficiently preparing a chimeric antigen receptor T cell (CAR-T) and a construction method of the artificial antigen presenting cell, and belongs to the field of cell therapy and immunotherapy, the artificial antigen presenting cell takes a K562 cell as a platform, an anti-CD3 single-chain antibody, an anti-CD28 single-chain antibody, a membrane binding type cell factor and a costimulatory ligand are stably expressed through genetic engineering, and the chimeric antigen receptor T cell (CAR-T) is obtained. And the local concentration of the anti-CD3 antibody is improved by adopting an HOTag3 tool. The multi-signal integration strategy obviously enhances the activation and proliferation capacity of the T cells, promotes the CAR-T cells to maintain a low differentiation state, and endows the CAR-T cells with excellent anti-tumor activity and durability. The artificial antigen presenting cell provides a novel efficient tool for the field of cellular immunotherapy, and is expected to promote development of more efficient and safer CAR-T therapy to cope with challenges of various malignant tumors.

The present invention discloses a transcranial magnetic stimulator, which belongs to the technical field of medical devices. It includes: a circular hole is provided on a substrate; a first rotating ring is rotatably installed in the circular hole of the substrate; a circular hole arranged eccentrically relative to the axis of the first rotating ring is provided on the first rotating ring; a first driving mechanism is installed on the substrate, which is used to control the first rotating ring to rotate around the circular hole of the substrate; a second rotating ring is rotatably installed in the circular hole of the first rotating ring; a circular hole arranged eccentrically relative to the axis of the second rotating ring is provided on the second rotating ring; a second driving mechanism is installed on the first rotating ring, which is used to control the second rotating ring to rotate around the circular hole of the first rotating ring; a shaft cylinder is rotatably installed in the circular hole of the second rotating ring; a magnetic head is installed at the lower end of the shaft cylinder. The present invention realizes the flexible movement of the magnetic head on a two-dimensional plane through a two-stage rotating ring, which greatly increases the flexibility and accuracy during treatment, helps to achieve more accurate and personalized treatment, and improves the treatment effect.

A personalized intelligent auricular point massager based on electrical stimulation disclosed by the present invention comprises a massager frame, a control module, an electrical stimulator unit, a Bluetooth module and a sensor module, the electrical stimulator unit, the Bluetooth module and the sensor module are all connected with the control module, and the Bluetooth module is in communication connection with a mobile terminal. The massager frame is manufactured through the 3D printing technology and is attached to the outline of the ear, the electrical stimulator units are embedded into key acupuncture points of the massager frame, a millimeter-level ear micro-model is constructed through the three-dimensional scanning technology, and then automatic and accurate recognition and positioning of the auricular points are achieved through the image processing and neural network technology; finally, the massager frame fitting the physiological curve of the ear is customized through the 3D printing technology, acupuncture point positioning is accurate, the personalized adaptability degree is high, the technical requirement for operators is lowered, and the treatment effect is good.

The invention relates to the technical field of medical supplies, and particularly discloses a therapeutic apparatus comprising an acupoint positioning unit comprising an excitation electrode and a measuring electrode, the excitation electrode is configured to generate current to human skin, and the measuring electrode is configured to receive the current and measure a resistance value of the skin to determine an acupoint position; the treatment unit comprises a polylactic acid layer, a temperature-sensitive hydrogel drug layer, a sensor and a plurality of microneedles, the temperature-sensitive hydrogel drug layer is arranged on the polylactic acid layer, the plurality of microneedles are arranged on the temperature-sensitive hydrogel drug layer in a rectangular array, and the sensor is arranged on the temperature-sensitive hydrogel drug layer among the plurality of microneedles; the host comprises a shell, a processor, a memory, a touch screen and an electric heater, the processor and the memory are in data connection and are both installed on a circuit board, the circuit board is arranged in the shell, the touch screen and the electric heater are installed on the shell and are in data connection with the processor, and the therapeutic instrument can achieve precise treatment and is convenient and reliable to use.

The invention discloses a multi-channel phase resonance transcranial ultrasonic regulation and control system and method based on 3D printing, and relates to the technical field of transcranial ultrasonic nerve regulation and control. Firstly, after three-dimensional modeling is conducted on the basis of patient head diagnosis and treatment data obtained in advance, a brain region needing to be stimulated is calibrated; then, on the basis of the acoustic theory, calculating a spatial position and an angle corresponding to the ultrasonic stimulation probe by applying an inversion technology; according to the calculation result, a personalized 3D printing helmet is designed, and a structure used for fixing an ultrasonic probe is printed on the top of the helmet; the device for fixing the ultrasonic stimulation probe adopts a special design, and the distance between the probe and the surface of a skull can be adjusted; the ultrasonic stimulation probe is composed of multiple channels and multiple array elements and can achieve phase resonance and adjust the focus position. Due to the fact that millimeter-level deviation exists in the system, a large amount of data are collected, an artificial intelligence model is established, modeling is conducted on 3D printing helmet system errors, after accurate errors are obtained, the focus position is further adjusted through the ultrasonic phase resonance technology, and accurate positioning is achieved.

The invention relates to the technical field of prostate treatment equipment, in particular to a prostate enucleation and tissue smashing integrated device based on a laser technology, the prostate enucleation and tissue smashing integrated device comprises an export pin, a tissue smashing system and a laser excision system which are sequentially arranged from front to back, and a driving motor is arranged below the tissue smashing system. According to the prostatic enucleation and tissue smashing integrated device based on the laser technology, a tube wall convex groove is formed in the outer side wall of a telescopic tube, when the telescopic tube rotates, a lower convex rod extending into the tube wall convex groove is matched, the telescopic tube can rotate and move back and forth in a reciprocating mode at the same time, a tissue suction groove can cover a wider area, and therefore the tissue suction effect is improved. And prostate tissues at different positions can be captured and sucked more easily, so that the tissues with irregular shapes can be effectively treated.

The invention discloses a gene engineering exosome and a slow release method and application thereof, the gene engineering exosome is derived from human adipose-derived stem cells, si-tgfbr2 is loaded in the gene engineering exosome, the si-tgfbr2 is specific siRNA aiming at a Tgfbr2 gene, and the gene engineering exosome can regulate and control proliferation of VSMCs, inhibit transformation of the VSMCs from a contraction phenotype to a synthetic phenotype when the VSMCs are stimulated, and inhibit the growth of the VSMCs. According to the present invention, the gene engineering exosome can be used to maintain the normal structure and the function of the blood vessel, and the sustained release effect of the content in the gene engineering exosome can be achieved by wrapping the gene engineering exosome in the PHA biodegradable material, such that the local treatment concentration can be easily stabilized, the drug administration frequency can be easily reduced, the lasting time of the treatment effect can be easily prolonged, and the treatment gene can be effectively delivered to the target cell; the treatment effect is improved; when being used for modifying a small-caliber artificial blood vessel, the small-caliber artificial blood vessel can be improved in biocompatibility and functionality, and can be prevented from being implanted into the blood vessel for remodeling unbenign hyperplasia stenosis; the invention not only provides a new thought and method for the treatment of vascular diseases, but also has important clinical application value and popularization prospect.

The invention discloses preparation and application of a biological material for targeted therapy of osteoarthritis, and the preparation method comprises the following steps: according to a phage screening principle, after phages are combined with cartilage cells, washing off phages which are not combined with the cartilage cells, are not firmly combined with the cartilage cells and are non-specifically combined with the cartilage cells; eluting the specifically bound bacteriophage with glycine acid; after the specific binding bacteriophage is amplified by escherichia coli, screening is carried out by utilizing a bacteriophage display technology and cartilage cells; the preparation method comprises the following steps: preparing a small-size porous microgel loaded drug by adopting a multiple Pickering emulsion template method; and grafting the screened cartilage targeting peptide to the surface of the porous hydrogel microsphere to obtain the HS-SP microsphere. According to the invention, the problem of OA targeting can be effectively solved by adopting a phage display technology, and a drug is precisely targeted and delivered to an OA lesion region; the porous hydrogel microspheres with small particle size are prepared by adopting a multiple Pickering emulsion method, so that the use of a large number of surfactants is avoided, and the efficient loading and release of drugs can be realized.

The invention discloses a laser shock wave lithotripsy imaging device, and the device comprises a laser device which is used for generating laser beams with different parameters; the laser beam expanding and collimating system is used for expanding and collimating all laser beams generated by the laser; the laser coupling part is used for guiding the expanded and collimated laser beams into a guide pipe; the far end of the catheter is used for entering a blood vessel for treatment; wherein the catheter comprises a laser shock wave optical fiber and an OCT optical fiber. According to the scheme, laser energy can be generated through a high-energy source laser, the laser energy is transmitted in the catheter and output to generate shock waves, and the shock waves can break calcification at treatment sites including one or more vasculature in the vasculature. According to the scheme, in the treatment process of the laser shock wave optical fiber, the OCT optical fiber can watch the treatment effect in real time, so that laser shock wave parameters can be adjusted at any time, and the treatment effect is improved.

The invention discloses a diabetic foot therapeutic apparatus, which relates to the field of medical instruments, solves the problem of poor therapeutic effect of the diabetic foot therapeutic apparatus, and comprises: a data acquisition module, which is used for respectively acquiring the average number ratio of sample bacteria, the pressure coefficient of an affected area, the oxygen enrichment coefficient of the affected area and the area ratio of a foot affected area to obtain affected foot monitoring data, the data analysis module is used for analyzing the sick foot monitoring data to obtain a first treatment control coefficient, a second treatment control coefficient and a third treatment control coefficient, and sick foot treatment analysis data is obtained; the treatment control module is used for controlling the ultraviolet treatment function, the negative pressure treatment function and the oxygen-enriched treatment function of the diabetic foot treatment instrument according to the diseased foot treatment analysis data, the treatment functions are automatically controlled by obtaining the treatment control coefficient, it is ensured that the treatment process is more accurate, the treatment effect is improved, and wound healing is promoted.

The invention discloses an esophageal cancer local chemotherapy device, and belongs to the technical field of chemotherapy auxiliary equipment, the esophageal cancer local chemotherapy device comprises a sealing device, the sealing device comprises a drug delivery tube, the lower end of the drug delivery tube is fixedly connected with a zigzag mounting tube, and the side wall of the zigzag mounting tube is rotatably connected with a plurality of hinge connecting rods; the lower end of the zigzag mounting tube is fixedly connected with a closed collecting film fixedly connected with the upper ends of the hinge connecting rods, the interior of the zigzag mounting tube is slidably connected with a movable block, and the device can be tightly attached to the inner wall of the esophagus through unfolding of the closed collecting film to form an effective closed structure, so that the position of medicine at the focus is locked, and the medicine is prevented from being damaged. Therefore, the local treatment effect of the medicine can be improved, meanwhile, the medicine is prevented from flowing to the stomach along with natural physiological movement of the esophagus, stimulation to the digestive tract of a patient is reduced, meanwhile, the influence on normal tissue of the patient is reduced, precise treatment is achieved, and the health of the patient is protected to the maximum extent.

The invention discloses an esophageal fistula risk prediction method based on clinical data and iconomics characteristics, relates to the technical field of medical artificial intelligence, and combines deep learning and a traditional iconomics method to extract rich iconomics characteristics through multiple image processing technologies so as to predict the risk of esophageal fistula. The generalization ability and robustness of the model are ensured through a multi-stage feature selection strategy, and a plurality of prediction models based on different feature combinations are developed; comprising a clinical feature model, a manual radiomics model, a deep learning radiomics model, a clinical-deep learning radiomics model and a clinical-manual radiomics model, through cross validation and model optimization, the high efficiency of each model in clinical prediction is ensured, the performance of the models is comprehensively compared, and the accuracy of clinical prediction is improved. According to the esophageal fistula risk prediction method, the esophageal fistula risk prediction accuracy after the esophageal cancer patient receives radiotherapy or chemoradiotherapy is improved, a powerful basis is provided for treatment decision of the esophageal cancer patient, and the esophageal fistula risk prediction method has a wide clinical application prospect.

The invention provides sonodynamic targeted drug-loaded nanoparticles as well as a preparation method and application thereof, and belongs to the field of targeted drug delivery preparations. The sonodynamic targeting drug-loading nanoparticle provided by the invention comprises a porous carrier, a drug loaded in the porous carrier and a targeting ligand chemically modified on the outer surface of the porous carrier, the porous carrier is a hydrogen bond organic framework; a construction unit of the hydrogen bond organic framework is a metalloporphyrin complex. After the sonodynamic targeting drug-loading nano-particle provided by the invention is injected into a 4T1 tumor-bearing BALB / c mouse body for 6 hours, fluorescence of the sonodynamic targeting drug-loading nano-particle is observed on a tumor, and a signal is continuously enhanced; after 14 days of administration, the tumor growth is obviously inhibited, and good targeting and anti-tumor effects are achieved.

The invention discloses a preparation method and application of a porous GelMA microneedle for delivering AIE molecules based on HSF derived exosome. The preparation method comprises the following steps: S1, preparing TTMN molecules; s2, dispersing DPPC and Chol in chloroform, performing water bath evaporation at 50 DEG C to form a thin film, hydrating the thin film in PBS, incubating to enable DPPC and Chol to form a liposome structure again, and uniformly dispersing TTMN molecules in the liposome structure to obtain TL; s3, extracting an exosome from the HSF cells; s4, loading the TL into the exosome by utilizing an electroporation technology, so as to obtain TE; s5, preparing the GelMA; and S6, mixing the GelMA with the TE, so that the TE is uniformly dispersed in the GelMA to obtain a mixed solution, injecting the mixed solution into a microneedle mold, and irradiating with 405nm laser to obtain the porous GelMA microneedle. According to the invention, high-efficiency treatment of hypertrophic scars is realized, and the system has a remarkable drug delivery effect, an innovative photodynamic therapy, a high-efficiency scar tissue remodeling effect and good biological safety and stability, and has important clinical application value and market prospect.

The invention discloses an internet online diagnosis and treatment data processing system based on a big data model, and relates to the technical field of medical treatment, an association rule analysis module analyzes association between a disease and drug treatment by adopting a weighted improvement degree, can accurately identify a relatively good matching relationship between the disease and a drug, and improves the diagnosis and treatment efficiency. The online recommendation module dynamically analyzes the recovery effect of the medicine in different time periods based on the dynamic conditional probability by utilizing the candidate medicine pair and combining the real-time treatment condition of the patient, and the mechanism not only ensures that the recommended medicine is highly matched with the current illness state of the patient, but also improves the accuracy of the medicine recommendation; and medicine selection can be adjusted according to feedback data of the patient. The system performs weighting processing on historical data and performs optimization in combination with data sparsity, so that the problem of inaccurate recommendation caused by data sparsity or data insufficiency in a traditional system is effectively avoided.

The invention relates to the field of oral cavities, in particular to a biomarker for drug-related jawbone necrosis and application of the biomarker. The invention provides application of a biomarker to preparation of a drug-related jawbone necrosis detection product. The biomarker comprises an oral metabolite and an oral flora, the oral metabolite comprises one or a combination of more of spermine, 7-methylguanine, hypoxanthine, quinoline and taurine. And the oral flora comprises bacteria of bacteroides, peptostreptococcaceae, porphyrinomonas, butyric acid vibrio, micromonas and moniliaceae, and the oral flora comprises bacteria of bacteroides, peptostreptococcaceae, porphyrinomonas, butyric acid vibrio. According to the application, metabolite and microorganisms which are characteristic-changed in an MRONJ microenvironment are discovered, the pathogenesis that the metabolite and the microorganisms possibly participate in the MRONJ is predicted, the risk that an individual suffers from the MRONJ is expected to be judged in an early stage through oral metabolite and microorganism marker screening, occurrence of the MRONJ is prevented by adjusting a medication strategy or modifying oral flora in time, and the MRONJ is prevented from being damaged by the oral metabolite and the microorganism. Therefore, the method is of great significance to formulating a new osteoporosis clinical prevention and treatment strategy.

The invention discloses a preparation method and application of an i-motif-containing DNA surface modified carbon quantum dot, and the carbon dot is prepared by the following steps: synthesizing a carbon dot, and then carrying out DNA modification. The preparation method comprises the following steps: dissolving phenylenediamine in a polymer solution, uniformly mixing, transferring the solution into a polytetrafluoroethylene inner container, putting the inner container into a stainless steel high-pressure kettle, and heating and reacting in a muffle furnace. And after the reaction is finished, cooling a reaction system to room temperature, then polymerizing DNA containing i-motif as a cross-linking agent with CDs, after the polymerization reaction is finished, freeze-drying the solution, taking out the solution, putting the solution into a dialysis bag, and carrying out dialysis purification to obtain DNA-CDs after dialysis is finished. And then carrying out bionic treatment on the MV-DNA-CDs, so as to obtain the MV-DNA-CDs disclosed by the invention. The nano-carrier prepared by the invention is high in yield and good in stability, has responsiveness and targeting property, and can be used for precise treatment of tumors.

The utility model relates to the technical field of bone trauma measurement, in particular to a measuring scale for bone trauma, which solves the problems that in the prior art, accurate measurement and positioning can not be realized, a measured value can not be accurately measured and read, and the measurement accuracy is influenced, and comprises a support, an object placing plate, a positioning assembly and a measuring assembly, the positioning assembly and the measuring assembly are movably connected to the support. The measuring assembly comprises two measuring units, and the measuring directions of the two measuring units are perpendicular to each other. The range finder is independently erected outside the first sliding rail through the supporting rod, the visual field of a doctor is not hindered, the position of the laser pen is conveniently positioned, and the laser pen is more convenient to mount and dismount due to the arrangement of the elastic clamping ring; after the laser pen is positioned at any position of the X-ray film through the positioning assembly, the difference of measurement data of different points by the measurement unit is calculated, and a doctor can accurately measure and judge various parameters of a bone trauma and the accurate position of the bone trauma in a human body.

The invention belongs to the technical field of novel nano functional materials and electrochemical biosensor detection, and discloses a preparation method of an Au (at) Co-NC NSAs / 3D GF composite material, the composite material and application of the composite material. The method comprises the following steps: (1) putting three-dimensional graphene foam into a mixed solution in which the concentration of cobalt nitrate hexahydrate is 0.0006 mol / L to 0.1 mol / L and the concentration of dimethylimidazole is 0.0006 mol / L to 0.1 mol / L, and keeping at room temperature for 2 to 12 hours to obtain ZIF-67 nanosheet array / three-dimensional graphene foam; (2) carrying out heat treatment on the ZIF-67 nanosheet array / three-dimensional graphene foam at the temperature of 300-900 DEG C for 1-5 hours to obtain cobalt nanoparticle anchored nitrogen-doped carbon nanosheet / three-dimensional graphene foam; and (3) measuring 5-50 [mu] L of a gold nanoparticle solution with carboxyl, and dropwise adding the gold nanoparticle solution on the surface of the cobalt nanoparticle anchored nitrogen-doped carbon nanosheet / three-dimensional graphene foam to obtain the gold and cobalt nanoparticle anchored nitrogen-doped carbon nanosheet / three-dimensional graphene foam. The method is simple in process, environment-friendly and high in yield.

The invention discloses a formula and a preparation method of a plaster. The plaster is prepared from the following raw material medicines by weight: 40g of lycopodium clavatum, 45g of loofah sponge, 50g of fructus forsythiae, 50g of raw bighead atractylodes rhizome, 50g of raw radix paeoniae alba, 50g of pawpaw, 60g of caulis spatholobi, 1000g of a hot melt adhesive matrix, 18g of laurocapram powder and 100g of far infrared ceramic powder. The traditional Chinese medicine composition is used for treating pharyngeal diseases, does not simply improve local pharyngeal lesions, focuses on local and overall dialectical combination from regulating qi, blood, yin and yang of viscera, regulates qi and blood running balance of the whole body, treats both symptoms and root causes, and is free of toxic and side effects. The traditional Chinese medicine composition can effectively treat and relieve local clinical symptoms of the pharyngeal cavity caused by different syndromes of pharyngeal diseases caused by various pathogenesis, adjust the balance of the body on the whole and improve the overall condition of the body.

The present application relates to the technical field of diagnostic markers, in particular to a marker combination and its application in diagnosing active tuberculosis and distinguishing between latent tuberculosis infection and active tuberculosis. The lectin combination provided by the present application can be used as a marker for ATB diagnosis and distinguishing between LTBI and ATB, and has high specificity and sensitivity. The lectin combination provided by the present application in combination with detection of specific antibodies of mycobacterium tuberculosis antigens can further improve the diagnostic effect. The marker and its detection products provided by the present application have good application potential in ATB diagnosis and distinguishing between LTBI and ATB, and are expected to overcome the limitations of existing diagnostic techniques, improve the diagnostic accuracy and sensitivity of tuberculosis, and provide new ideas and technical means for early detection, precise treatment and effective prevention and control of tuberculosis.

The utility model provides an ultrasonic treatment and imaging integrated probe and a cavity FUS treatment system, the ultrasonic treatment and imaging integrated probe comprises a rod piece, a treatment transducer and an imaging transducer, the rod piece is of a hollow structure, and the side face of the front end of the rod piece is provided with an opening; the treatment transducer is arranged on the front portion of the rod piece and located in the hollow structure, the geometric focusing axis of the treatment transducer is located on one side of the rod piece and is emitted out of the rod piece from the opening, and the geometric focusing axis is provided with a treatment focus in the axial direction; the imaging transducer is arranged on the front portion of the rod piece and located in the hollow structure, and the imaging area of the imaging transducer covers the treatment focus. Compared with the prior art, the ultrasonic treatment and imaging integrated probe has the advantages that the treatment transducer and the imaging transducer are combined together, are driven independently and are matched with each other during use, and treatment on a patient is effectively and accurately completed.

The invention discloses a method for preparing hydrogel based on molecules containing single boric acid groups and application, and belongs to the technical field of biological medicine. The preparation method comprises the following steps: (1) dissolving a compound containing a single boric acid group and an aromatic hydrophobic group in a solvent to prepare a solution A; (2) dissolving polyvinyl alcohol in the aqueous phase solution to prepare a solution B; and (3) mixing the solution A and the solution B, and reacting to form the hydrogel. According to the invention, a prodrug modified by a boric acid group structure or a drug carrying a boric acid group structure can be directly used as a cross-linking agent for preparing hydrogel to form a drug sustained-release agent; the hydrogel can also be used as a carrier to load a second drug, and the prodrug in the hydrogel needs to release active ingredients after response of active oxygen, so that differential slow release of the two drugs can be realized.

The present invention discloses an ablation device. The ablation device comprises an ablation catheter body and a control circuit. The end of the ablation catheter body is an ablation section. The outer surface of the ablation section is provided with a plurality of electrodes distributed at intervals. Each electrode is connected to the control circuit through a wire, and the control circuit controls the on and off of each electrode. The present invention solves the technical problem that the discharge range of the ablation catheter in the prior art is uncontrollable.