49results about How to "Precision therapy" patented technology

The invention relates to the technical field of oral X-ray image recognition, in particular to an intelligent oral X-ray film lesion area recognition system based on artificial intelligence. The method comprises the following steps: obtaining gray level change characteristics of each tooth region in an oral X-ray image according to gray level and gradient distribution in each tooth region; obtaining an optimal factor according to the gray change feature similarity between different regions, and further selecting a standard tooth region; obtaining a ray absorption coefficient according to the gray difference of different areas and the difference of the optimal factors; obtaining caries area possibility of the pixel points according to the positions of the pixel points in the tooth area; and the caries area is identified. According to the method, the caries area in the oral X-ray image is accurately segmented, and finally accurate treatment can be carried out on a patient.

The invention discloses an osteoporosis prevention strategy analysis method and system, and belongs to the technical field of health data analys.The osteoporosis prevention strategy analysis method specifically comprises the steps that the bone mineral density of a user is measured and preprocessed, a T value is calculated and compared with a preset osteoporosis threshold value, and the osteoporosis condition is judged; for the osteoporosis user, risk self-evaluation is carried out, risk grades are divided, a personalized treatment scheme is formulated, and the effect is monitored; for non-osteoporosis users, a risk prediction model is established through an osteoporosis prediction algorithm, and risk scores are calculated and graded; formulating a prevention strategy according to the risk level, evaluating an effect and adjusting an algorithm and the strategy; according to the invention, accurate prevention and treatment of osteoporosis are realized.

The invention provides organic nanoparticles with high osteogenic performance as well as a preparation method and application thereof, and belongs to the technical field of osteogenic drug preparation. The preparation method of the organic nanoparticles with high osteogenic performance comprises the following steps: (1) preparing fluorinated polyethyleneimine, preparing double bonds from the fluorinated polyethyleneimine, and then grafting a targeting peptide E7 to obtain a carrier F-PEI-E7; and (2) entrapping an osteogenesis promoting drug in the carrier F-PEI-E7 to obtain the organic nanoparticles with high osteogenesis performance. The invention provides an innovative strategy: F-PEI is used as a carrier, an osteogenesis promoting drug (beta-GP) is entrapped, and through E7 targeting peptide (EPLQLKM) modification, precise targeting delivery of the drug is realized. The organic nanoparticles are high in stability, the in-vitro osteogenesis promoting effect is equivalent to that of a classical formula for in-vitro osteogenesis induction, and the organic nanoparticles have an excellent in-vivo osteogenesis promoting effect.

The present invention discloses a transcranial magnetic stimulator, which belongs to the technical field of medical devices. It includes: a circular hole is provided on a substrate; a first rotating ring is rotatably installed in the circular hole of the substrate; a circular hole arranged eccentrically relative to the axis of the first rotating ring is provided on the first rotating ring; a first driving mechanism is installed on the substrate, which is used to control the first rotating ring to rotate around the circular hole of the substrate; a second rotating ring is rotatably installed in the circular hole of the first rotating ring; a circular hole arranged eccentrically relative to the axis of the second rotating ring is provided on the second rotating ring; a second driving mechanism is installed on the first rotating ring, which is used to control the second rotating ring to rotate around the circular hole of the first rotating ring; a shaft cylinder is rotatably installed in the circular hole of the second rotating ring; a magnetic head is installed at the lower end of the shaft cylinder. The present invention realizes the flexible movement of the magnetic head on a two-dimensional plane through a two-stage rotating ring, which greatly increases the flexibility and accuracy during treatment, helps to achieve more accurate and personalized treatment, and improves the treatment effect.

A personalized intelligent auricular point massager based on electrical stimulation disclosed by the present invention comprises a massager frame, a control module, an electrical stimulator unit, a Bluetooth module and a sensor module, the electrical stimulator unit, the Bluetooth module and the sensor module are all connected with the control module, and the Bluetooth module is in communication connection with a mobile terminal. The massager frame is manufactured through the 3D printing technology and is attached to the outline of the ear, the electrical stimulator units are embedded into key acupuncture points of the massager frame, a millimeter-level ear micro-model is constructed through the three-dimensional scanning technology, and then automatic and accurate recognition and positioning of the auricular points are achieved through the image processing and neural network technology; finally, the massager frame fitting the physiological curve of the ear is customized through the 3D printing technology, acupuncture point positioning is accurate, the personalized adaptability degree is high, the technical requirement for operators is lowered, and the treatment effect is good.

The invention relates to the technical field of medical supplies, and particularly discloses a therapeutic apparatus comprising an acupoint positioning unit comprising an excitation electrode and a measuring electrode, the excitation electrode is configured to generate current to human skin, and the measuring electrode is configured to receive the current and measure a resistance value of the skin to determine an acupoint position; the treatment unit comprises a polylactic acid layer, a temperature-sensitive hydrogel drug layer, a sensor and a plurality of microneedles, the temperature-sensitive hydrogel drug layer is arranged on the polylactic acid layer, the plurality of microneedles are arranged on the temperature-sensitive hydrogel drug layer in a rectangular array, and the sensor is arranged on the temperature-sensitive hydrogel drug layer among the plurality of microneedles; the host comprises a shell, a processor, a memory, a touch screen and an electric heater, the processor and the memory are in data connection and are both installed on a circuit board, the circuit board is arranged in the shell, the touch screen and the electric heater are installed on the shell and are in data connection with the processor, and the therapeutic instrument can achieve precise treatment and is convenient and reliable to use.

The invention discloses preparation and application of a biological material for targeted therapy of osteoarthritis, and the preparation method comprises the following steps: according to a phage screening principle, after phages are combined with cartilage cells, washing off phages which are not combined with the cartilage cells, are not firmly combined with the cartilage cells and are non-specifically combined with the cartilage cells; eluting the specifically bound bacteriophage with glycine acid; after the specific binding bacteriophage is amplified by escherichia coli, screening is carried out by utilizing a bacteriophage display technology and cartilage cells; the preparation method comprises the following steps: preparing a small-size porous microgel loaded drug by adopting a multiple Pickering emulsion template method; and grafting the screened cartilage targeting peptide to the surface of the porous hydrogel microsphere to obtain the HS-SP microsphere. According to the invention, the problem of OA targeting can be effectively solved by adopting a phage display technology, and a drug is precisely targeted and delivered to an OA lesion region; the porous hydrogel microspheres with small particle size are prepared by adopting a multiple Pickering emulsion method, so that the use of a large number of surfactants is avoided, and the efficient loading and release of drugs can be realized.

The invention discloses a laser shock wave lithotripsy imaging device, and the device comprises a laser device which is used for generating laser beams with different parameters; the laser beam expanding and collimating system is used for expanding and collimating all laser beams generated by the laser; the laser coupling part is used for guiding the expanded and collimated laser beams into a guide pipe; the far end of the catheter is used for entering a blood vessel for treatment; wherein the catheter comprises a laser shock wave optical fiber and an OCT optical fiber. According to the scheme, laser energy can be generated through a high-energy source laser, the laser energy is transmitted in the catheter and output to generate shock waves, and the shock waves can break calcification at treatment sites including one or more vasculature in the vasculature. According to the scheme, in the treatment process of the laser shock wave optical fiber, the OCT optical fiber can watch the treatment effect in real time, so that laser shock wave parameters can be adjusted at any time, and the treatment effect is improved.

The invention discloses an esophageal cancer local chemotherapy device, and belongs to the technical field of chemotherapy auxiliary equipment, the esophageal cancer local chemotherapy device comprises a sealing device, the sealing device comprises a drug delivery tube, the lower end of the drug delivery tube is fixedly connected with a zigzag mounting tube, and the side wall of the zigzag mounting tube is rotatably connected with a plurality of hinge connecting rods; the lower end of the zigzag mounting tube is fixedly connected with a closed collecting film fixedly connected with the upper ends of the hinge connecting rods, the interior of the zigzag mounting tube is slidably connected with a movable block, and the device can be tightly attached to the inner wall of the esophagus through unfolding of the closed collecting film to form an effective closed structure, so that the position of medicine at the focus is locked, and the medicine is prevented from being damaged. Therefore, the local treatment effect of the medicine can be improved, meanwhile, the medicine is prevented from flowing to the stomach along with natural physiological movement of the esophagus, stimulation to the digestive tract of a patient is reduced, meanwhile, the influence on normal tissue of the patient is reduced, precise treatment is achieved, and the health of the patient is protected to the maximum extent.

The invention provides sonodynamic targeted drug-loaded nanoparticles as well as a preparation method and application thereof, and belongs to the field of targeted drug delivery preparations. The sonodynamic targeting drug-loading nanoparticle provided by the invention comprises a porous carrier, a drug loaded in the porous carrier and a targeting ligand chemically modified on the outer surface of the porous carrier, the porous carrier is a hydrogen bond organic framework; a construction unit of the hydrogen bond organic framework is a metalloporphyrin complex. After the sonodynamic targeting drug-loading nano-particle provided by the invention is injected into a 4T1 tumor-bearing BALB / c mouse body for 6 hours, fluorescence of the sonodynamic targeting drug-loading nano-particle is observed on a tumor, and a signal is continuously enhanced; after 14 days of administration, the tumor growth is obviously inhibited, and good targeting and anti-tumor effects are achieved.

The invention discloses an internet online diagnosis and treatment data processing system based on a big data model, and relates to the technical field of medical treatment, an association rule analysis module analyzes association between a disease and drug treatment by adopting a weighted improvement degree, can accurately identify a relatively good matching relationship between the disease and a drug, and improves the diagnosis and treatment efficiency. The online recommendation module dynamically analyzes the recovery effect of the medicine in different time periods based on the dynamic conditional probability by utilizing the candidate medicine pair and combining the real-time treatment condition of the patient, and the mechanism not only ensures that the recommended medicine is highly matched with the current illness state of the patient, but also improves the accuracy of the medicine recommendation; and medicine selection can be adjusted according to feedback data of the patient. The system performs weighting processing on historical data and performs optimization in combination with data sparsity, so that the problem of inaccurate recommendation caused by data sparsity or data insufficiency in a traditional system is effectively avoided.

The invention discloses a preparation method and application of an i-motif-containing DNA surface modified carbon quantum dot, and the carbon dot is prepared by the following steps: synthesizing a carbon dot, and then carrying out DNA modification. The preparation method comprises the following steps: dissolving phenylenediamine in a polymer solution, uniformly mixing, transferring the solution into a polytetrafluoroethylene inner container, putting the inner container into a stainless steel high-pressure kettle, and heating and reacting in a muffle furnace. And after the reaction is finished, cooling a reaction system to room temperature, then polymerizing DNA containing i-motif as a cross-linking agent with CDs, after the polymerization reaction is finished, freeze-drying the solution, taking out the solution, putting the solution into a dialysis bag, and carrying out dialysis purification to obtain DNA-CDs after dialysis is finished. And then carrying out bionic treatment on the MV-DNA-CDs, so as to obtain the MV-DNA-CDs disclosed by the invention. The nano-carrier prepared by the invention is high in yield and good in stability, has responsiveness and targeting property, and can be used for precise treatment of tumors.

The utility model relates to the technical field of bone trauma measurement, in particular to a measuring scale for bone trauma, which solves the problems that in the prior art, accurate measurement and positioning can not be realized, a measured value can not be accurately measured and read, and the measurement accuracy is influenced, and comprises a support, an object placing plate, a positioning assembly and a measuring assembly, the positioning assembly and the measuring assembly are movably connected to the support. The measuring assembly comprises two measuring units, and the measuring directions of the two measuring units are perpendicular to each other. The range finder is independently erected outside the first sliding rail through the supporting rod, the visual field of a doctor is not hindered, the position of the laser pen is conveniently positioned, and the laser pen is more convenient to mount and dismount due to the arrangement of the elastic clamping ring; after the laser pen is positioned at any position of the X-ray film through the positioning assembly, the difference of measurement data of different points by the measurement unit is calculated, and a doctor can accurately measure and judge various parameters of a bone trauma and the accurate position of the bone trauma in a human body.

The invention discloses a formula and a preparation method of a plaster. The plaster is prepared from the following raw material medicines by weight: 40g of lycopodium clavatum, 45g of loofah sponge, 50g of fructus forsythiae, 50g of raw bighead atractylodes rhizome, 50g of raw radix paeoniae alba, 50g of pawpaw, 60g of caulis spatholobi, 1000g of a hot melt adhesive matrix, 18g of laurocapram powder and 100g of far infrared ceramic powder. The traditional Chinese medicine composition is used for treating pharyngeal diseases, does not simply improve local pharyngeal lesions, focuses on local and overall dialectical combination from regulating qi, blood, yin and yang of viscera, regulates qi and blood running balance of the whole body, treats both symptoms and root causes, and is free of toxic and side effects. The traditional Chinese medicine composition can effectively treat and relieve local clinical symptoms of the pharyngeal cavity caused by different syndromes of pharyngeal diseases caused by various pathogenesis, adjust the balance of the body on the whole and improve the overall condition of the body.

The present application relates to the technical field of diagnostic markers, in particular to a marker combination and its application in diagnosing active tuberculosis and distinguishing between latent tuberculosis infection and active tuberculosis. The lectin combination provided by the present application can be used as a marker for ATB diagnosis and distinguishing between LTBI and ATB, and has high specificity and sensitivity. The lectin combination provided by the present application in combination with detection of specific antibodies of mycobacterium tuberculosis antigens can further improve the diagnostic effect. The marker and its detection products provided by the present application have good application potential in ATB diagnosis and distinguishing between LTBI and ATB, and are expected to overcome the limitations of existing diagnostic techniques, improve the diagnostic accuracy and sensitivity of tuberculosis, and provide new ideas and technical means for early detection, precise treatment and effective prevention and control of tuberculosis.

The invention provides lipid nanoparticles taking zinc phosphate as an inner core, a preparation method of the lipid nanoparticles and a medicine for treating aortic aneurysm, and relates to the technical field of biological medicines. The lipid nanoparticles provided by the invention comprise zinc phosphate nanoparticles, DOPA (Dioctyl-Phthalate Polyamide), ionizable cationic lipid, cholesterol and PEG (Polyethylene Glycol) lipid, the zinc phosphate nano-particles are inner cores of the lipid nano-particles. The lipid nanoparticles have excellent biocompatibility and safety and stable structure, and can improve the stability and delivery efficiency of nucleic acid (such as FBN1mRNA) as a carrier, thereby realizing effective treatment of diseases. According to the medicine for treating the aortic aneurysm, provided by the invention, accurate delivery of FBN1mRNA and expression in FBN1 cells can be realized, and angiogenesis and repair are promoted, so that accurate treatment of the aortic aneurysm is realized.

The invention belongs to the field of medical instruments, and discloses a medical silica gel dressing fixing adhesive tape which comprises an adhesive tape body, and the adhesive tape body sequentially comprises a carrier layer, a silica gel adhesive layer and a stripping liner from outside to inside; the carrier layer is made of an elastic breathable material, and the silica gel adhesive layer is made of medical-grade organic silica gel; a plurality of first microcapsules are dispersed in the silica gel adhesive layer, the first microcapsules are drug-loaded microcapsules, and wall materials of the drug-loaded microcapsules are made of materials responding to the pH value, enzyme concentration or temperature change of a wound environment. Enzyme or ions are released after the second microcapsule is broken, the wall material of the first microcapsule is actively degraded, cascade response of'exudate increase-developing prompt-drug accelerated release 'is realized, a large amount of drugs are quickly released when the exudate appears, and infection or inflammation is effectively controlled.

The present invention belongs to the technical field of tumor molecular biology, and specifically relates to the application of a biomarker for early screening of colorectal adenoma and colorectal cancer. The biomarker is clusterin. The present invention analyzes serum samples from normal healthy people, hyperplastic polyps, and adenomatous polyps by weak cation exchange magnetic beads (WCX-MB) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), selects differential polypeptides in significantly differentially expressed peaks, and identifies corresponding differential proteins by high-throughput sequencing, thereby exploring potential biological markers for early carcinogenesis of intestinal polyps. The biomarker provided by the present invention has good diagnostic efficacy for adenoma and colorectal cancer, which is significantly better than traditional tumor markers, and is of great significance for early screening and early diagnosis of colorectal tumors.

This invention discloses near-infrared II nanoparticles, their preparation method, and applications, belonging to the field of biomedical technology. The nanoparticles include a polymer shell and a near-infrared II fluorescent molecular core; the polymer shell comprises distearate phosphatidylethanolamine-polyethylene glycol. This invention achieves the batch preparation and performance optimization of near-infrared II nanoparticles through microfluidic technology. By adjusting the ratio and flow rate, the particle size and distribution can be effectively controlled. Furthermore, this invention enables precise temporal and spatial synergy between "drug" and "light," ultimately achieving complete eradication of lung infection lesions / tumors while maximizing the protection of surrounding normal tissues, thus improving treatment safety.

The utility model provides a kind of treatment head and treatment system, the treatment head includes treatment head body, treatment piece and at least one pair of auxiliary electrode;The treatment head body has end face;The treatment end of the treatment piece and at least one pair of the auxiliary electrode are located in the end face, at least one pair of the auxiliary electrode, setting in the treatment end periphery;At least one pair of the auxiliary electrode is used to contact with human body to constitute conducting loop;The treatment piece is used to implement treatment to the treatment area to be treated by the treatment end;The auxiliary electrode is also used to detect the current between human body and the auxiliary electrode, to detect whether the treatment end is parallelly contacted on the treatment area to be treated or not.The utility model provides a kind of structure of treatment head, can allow to judge whether the treatment end is parallelly contacted on the treatment area to be treated or not by the current value of auxiliary electrode.

An electro-acupuncture stimulation system comprises a first stimulation unit, a second stimulation unit and a control unit, the first stimulation unit is used for collecting a sensing signal of a first stimulation area and performing electro-acupuncture stimulation on the first stimulation area, the second stimulation unit is used for collecting a sensing signal of a second stimulation area and performing electro-acupuncture stimulation on the second stimulation area, and the control unit controls the first stimulation unit and the second stimulation unit to perform electro-acupuncture stimulation according to the sensing signals; the control unit comprises a hierarchical coordination module for distributing off-target stimulation parameters, which is divided into a perception layer, a decision layer and an execution layer; the perception layer uploads the sensing signals of the target points to the decision layer in real time; the decision layer distributes the stimulation parameters of the off-target points based on a target point position correlation method; and the execution layer adjusts the output stimulation parameters of the adjacent target points according to the instructions of the decision layer to maintain the total stimulation energy consistent with that before off-target. The present application utilizes the synergistic effect of multiple neural pathways to enhance the contraction function of the pelvic floor muscles and improve the stimulation efficiency.

The present invention relates to a use of adipose stem cell exosomes in hair growth, and the preparation method of the adipose stem cell exosomes is as follows: take the 3rd to 6th generation of mouse adipose stem cells of logarithmic growth and culture them with complete culture fluid containing FBS until the cell density reaches 70%-80%, switch to DMEM culture fluid containing exosome-free FBS and continue to culture for 45-50 hours, collect the supernatant culture fluid, centrifuge to remove cells and cell debris, and then use a 100kDa molecular weight ultrafiltration tube to concentrate at 1500-2500g for 30min, add exosome rapid extraction reagent to the concentrated solution for extraction, centrifuge, and collect mouse adipose stem cell exosomes. In vitro and in vivo experiments show that the mouse adipose stem cell exosomes of the present invention can significantly promote hair growth with outstanding effects.

The invention discloses nanoparticles with a targeting function as well as a preparation method and application thereof, and relates to the technical field of medicines. The nano-particle has a core-shell structure, the surface of the nano-particle is loaded with alkannin and derivatives thereof, and the outside of the shell layer is coupled with a nucleic acid aptamer. The prepared nanoparticles have excellent targeting property, have no toxic effect on HUVEC cells, have good biocompatibility, can inhibit proliferation of tumor cells and promote apoptosis of the tumor cells, and have excellent glutathione (GSH) response performance; the nanoparticles and the aptamer are coupled to deliver the shikonin and the derivative of the shikonin in a targeted manner, so that tumors can be accurately treated; the preparation method is simple, convenient and easy to operate, and a strategy is provided for development of high-efficiency and low-toxicity innovative targeted drugs and precise treatment of tumors.

The invention provides a nano preparation for preparing a medicine for inhibiting prostatic cancer and a preparation method of the nano preparation, and relates to the technical field of nano medicinal preparations. The nano preparation comprises the following components in parts by mass: traditional Chinese medicine components and a nano carrier, the traditional Chinese medicine component comprises 15-45 parts of a Chinese yam extract, 5-15 parts of a madder extract, 8-20 parts of cuttlebone superfine powder, 10-25 parts of dragon bone superfine powder and 10-25 parts of oyster superfine powder; the nano-carrier comprises 5-20 parts of phospholipid, 2-10 parts of cholesterol, 1-5 parts of fatty acid, 3-15 parts of polyethylene glycol and 1-5 parts of a surfactant. The average particle size of the nano preparation is 80-150 nm, the polydispersity index PDI is smaller than or equal to 0.30, and the encapsulation efficiency is larger than or equal to 75%. According to the invention, active ingredients of traditional Chinese medicines are combined with a nanotechnology, so that the bioavailability and the tumor targeting property are remarkably improved, the pH-responsive release characteristic is achieved, a remarkable inhibition effect on various prostate cancer cell lines is shown, tumor growth can be effectively inhibited, metastasis can be reduced, and a good application prospect is achieved.

The invention relates to the technical field of biological medicine, in particular to application of an Orai1 protein inhibitor in preparation of a medicine for treating coronary artery calcification. By using the Orai1 protein inhibitor, coronary artery calcification can be accurately treated, the occurrence proportion of serious coronary artery calcification is reduced, and economic and social burdens brought by surgical treatment are relieved. Besides, the Orai1 protein inhibitor can also improve and inhibit acute myocardial ischemia symptoms caused by factors such as coronary vessel and myocardial cell calcification, calcium overload and the like, the myocardial infarction area is reduced, and death caused by acute myocardial ischemia is reduced.

The invention belongs to the technical field of optical medical equipment, and particularly relates to cancerous wound LED red and blue light composite phototherapy equipment. The phototherapy device of the present invention comprises: an LED light source module configured to emit red light and blue light; the main control module is configured to generate a driving signal to control the LED light source module; the touch interaction module is configured to display the frequency, duty ratio, intensity and treatment time parameters of the current light and adjust the parameters through a touch screen or a physical key; the LED blue light and the red light are output in an independent continuous or pulsed light mode, when the LED works in a pulse mode, the instantaneous peak light power density of the red light and the blue light reaches 1000 mW / cm < 2 > or even higher, the light penetration depth is increased so as to act on deep cancerous wound tissue, and photothermal damage to fragile skin of a patient caused by continuous strong light is avoided. The invention can improve the life quality of cancer wound tumor patients and prolong the survival time of the cancer wound tumor patients, and is suitable for long-term nursing scenes of tumor wards, ultimate care institutions and bedridden patients at home.

The invention relates to the technical field of medical equipment, in particular to a portable acupuncture and massage electromagnetic head therapeutic apparatus which comprises a helmet and further comprises a gradient installation ring, the gradient installation ring gradually expands outwards in a spiral shape from top to bottom, and a plurality of iron cores are fixedly installed at the bottom of the gradient installation ring. The multiple iron cores are spirally distributed along the bottom of the gradient mounting ring, two U-shaped mounting grooves are formed in the bottom of each iron core, and magnet assemblies are arranged in the two mounting grooves respectively. The device has the advantages that the device better fits the irregular shape of the head, a magnetic field uniformly covers the whole head, it is guaranteed that the head receives a balanced magnetic field effect, a magnetic field effect blind area is avoided, the overall treatment effect is improved, the mounting groove guides the magnetic field trend, magnetic field leakage and disordered diffusion are reduced, the magnetic field acts on a treatment area more intensively, and the treatment effect is improved. The utilization efficiency of the magnetic field is improved, more magnetic energy is concentrated on a part needing treatment, the magnetic field intensity of the treatment side is improved, and therefore the treatment effect is enhanced.

The invention relates to the technical field of intelligent implantable medical instruments, in particular to a magnetohydrodynamic pulse negative pressure micropump system integrated with wireless parameter monitoring, which comprises a fully implantable magnetohydrodynamic intelligent sensitive micropump, an in-vitro multifunctional driving read-out unit and an intelligent terminal, the fully-implanted magnetomotive intelligent-sensitive micropump is of a hollow titanium alloy screw structure, a magnetomotive power pump module and a wireless passive sensing module are arranged in the fully-implanted magnetomotive intelligent-sensitive micropump, the fully-implanted magnetomotive intelligent-sensitive micropump can be implanted into a bone in a minimally invasive mode, pulse negative pressure is generated, and intraosseous tissue gap hydraulic data are wirelessly transmitted. The in-vitro unit provides a driving magnetic field and radio frequency energy; and the intelligent terminal realizes data display, analysis and parameter adjustment to form intelligent closed-loop control. The system realizes integration of treatment and monitoring, is minimally invasive, has no infection risk, is accurate in monitoring and efficient in treatment, solves the problem of pain points in the prior art, and has important clinical application value.

The utility model provides a separable aerosol sucking and dosing device. The separable aerosol sucking and dosing device comprises an atomizing device used for atomizing liquid medicine to generate aerosol. The atomization device is combined to the seat body; a containing cavity used for collecting aerosol is defined in the mist storage container, and the mist storage container is detachably combined to the base so that a user can conveniently suck the aerosol through the mouth and the nose; wherein a suction nozzle piece for a user to suck aerosol is arranged at the upper end of the aerosol storage container, and the bottom of the suction nozzle piece is closed to limit downward flowing of the aerosol; the bottom of the mist storage container is provided with an opening for the atomization device to input aerosol into the containing cavity; the particle size of the aerosol is configured in a range in which the aerosol can suspend in the cavity. The aerosol can be accurately generated through the atomization device, and the aerosol is continuously and quantitatively collected by the mist storage container, so that a user can accurately and completely suck the temporarily stored medicine aerosol, and the use is convenient.

The invention discloses a bispecific fusion protein based on Th17 immune axis regulation and application of the bispecific fusion protein in combined treatment of inflammatory bowel disease and psoriasis. The fusion protein is formed by sequentially connecting a human IL-23 receptor (IL-23R) extracellular functional structural domain, a flexible connecting peptide and a human trefoil factor 3 (TFF3). According to the invention, IL-23R is specifically combined with IL-23 highly expressed at a focus part to block a cascade reaction of a Th17 inflammation axis, and TFF3 with a mucosa repair function is delivered to damaged tissues in a targeted manner. Experiments show that in a DSS-induced ulcerative colitis model and an IMQ-induced psoriasis model, the fusion protein is obviously superior to a single-target drug in the aspects of reducing disease activity index (DAI), improving skin lesion score (PASI) and promoting histopathological repair, has a synergistic effect of anti-inflammation and repair, and provides a new strategy for treatment of autoimmune diseases.