15results about How to "Precision therapy" patented technology

The present application relates to the technical field of diagnostic markers, in particular to a marker combination and its application in diagnosing active tuberculosis and distinguishing between latent tuberculosis infection and active tuberculosis. The lectin combination provided by the present application can be used as a marker for ATB diagnosis and distinguishing between LTBI and ATB, and has high specificity and sensitivity. The lectin combination provided by the present application in combination with detection of specific antibodies of mycobacterium tuberculosis antigens can further improve the diagnostic effect. The marker and its detection products provided by the present application have good application potential in ATB diagnosis and distinguishing between LTBI and ATB, and are expected to overcome the limitations of existing diagnostic techniques, improve the diagnostic accuracy and sensitivity of tuberculosis, and provide new ideas and technical means for early detection, precise treatment and effective prevention and control of tuberculosis.

The invention provides lipid nanoparticles taking zinc phosphate as an inner core, a preparation method of the lipid nanoparticles and a medicine for treating aortic aneurysm, and relates to the technical field of biological medicines. The lipid nanoparticles provided by the invention comprise zinc phosphate nanoparticles, DOPA (Dioctyl-Phthalate Polyamide), ionizable cationic lipid, cholesterol and PEG (Polyethylene Glycol) lipid, the zinc phosphate nano-particles are inner cores of the lipid nano-particles. The lipid nanoparticles have excellent biocompatibility and safety and stable structure, and can improve the stability and delivery efficiency of nucleic acid (such as FBN1mRNA) as a carrier, thereby realizing effective treatment of diseases. According to the medicine for treating the aortic aneurysm, provided by the invention, accurate delivery of FBN1mRNA and expression in FBN1 cells can be realized, and angiogenesis and repair are promoted, so that accurate treatment of the aortic aneurysm is realized.

The invention belongs to the field of medical instruments, and discloses a medical silica gel dressing fixing adhesive tape which comprises an adhesive tape body, and the adhesive tape body sequentially comprises a carrier layer, a silica gel adhesive layer and a stripping liner from outside to inside; the carrier layer is made of an elastic breathable material, and the silica gel adhesive layer is made of medical-grade organic silica gel; a plurality of first microcapsules are dispersed in the silica gel adhesive layer, the first microcapsules are drug-loaded microcapsules, and wall materials of the drug-loaded microcapsules are made of materials responding to the pH value, enzyme concentration or temperature change of a wound environment. Enzyme or ions are released after the second microcapsule is broken, the wall material of the first microcapsule is actively degraded, cascade response of'exudate increase-developing prompt-drug accelerated release 'is realized, a large amount of drugs are quickly released when the exudate appears, and infection or inflammation is effectively controlled.

This invention discloses near-infrared II nanoparticles, their preparation method, and applications, belonging to the field of biomedical technology. The nanoparticles include a polymer shell and a near-infrared II fluorescent molecular core; the polymer shell comprises distearate phosphatidylethanolamine-polyethylene glycol. This invention achieves the batch preparation and performance optimization of near-infrared II nanoparticles through microfluidic technology. By adjusting the ratio and flow rate, the particle size and distribution can be effectively controlled. Furthermore, this invention enables precise temporal and spatial synergy between "drug" and "light," ultimately achieving complete eradication of lung infection lesions / tumors while maximizing the protection of surrounding normal tissues, thus improving treatment safety.

An electro-acupuncture stimulation system comprises a first stimulation unit, a second stimulation unit and a control unit, the first stimulation unit is used for collecting a sensing signal of a first stimulation area and performing electro-acupuncture stimulation on the first stimulation area, the second stimulation unit is used for collecting a sensing signal of a second stimulation area and performing electro-acupuncture stimulation on the second stimulation area, and the control unit controls the first stimulation unit and the second stimulation unit to perform electro-acupuncture stimulation according to the sensing signals; the control unit comprises a hierarchical coordination module for distributing off-target stimulation parameters, which is divided into a perception layer, a decision layer and an execution layer; the perception layer uploads the sensing signals of the target points to the decision layer in real time; the decision layer distributes the stimulation parameters of the off-target points based on a target point position correlation method; and the execution layer adjusts the output stimulation parameters of the adjacent target points according to the instructions of the decision layer to maintain the total stimulation energy consistent with that before off-target. The present application utilizes the synergistic effect of multiple neural pathways to enhance the contraction function of the pelvic floor muscles and improve the stimulation efficiency.

The invention provides a nano preparation for preparing a medicine for inhibiting prostatic cancer and a preparation method of the nano preparation, and relates to the technical field of nano medicinal preparations. The nano preparation comprises the following components in parts by mass: traditional Chinese medicine components and a nano carrier, the traditional Chinese medicine component comprises 15-45 parts of a Chinese yam extract, 5-15 parts of a madder extract, 8-20 parts of cuttlebone superfine powder, 10-25 parts of dragon bone superfine powder and 10-25 parts of oyster superfine powder; the nano-carrier comprises 5-20 parts of phospholipid, 2-10 parts of cholesterol, 1-5 parts of fatty acid, 3-15 parts of polyethylene glycol and 1-5 parts of a surfactant. The average particle size of the nano preparation is 80-150 nm, the polydispersity index PDI is smaller than or equal to 0.30, and the encapsulation efficiency is larger than or equal to 75%. According to the invention, active ingredients of traditional Chinese medicines are combined with a nanotechnology, so that the bioavailability and the tumor targeting property are remarkably improved, the pH-responsive release characteristic is achieved, a remarkable inhibition effect on various prostate cancer cell lines is shown, tumor growth can be effectively inhibited, metastasis can be reduced, and a good application prospect is achieved.

The invention belongs to the technical field of optical medical equipment, and particularly relates to cancerous wound LED red and blue light composite phototherapy equipment. The phototherapy device of the present invention comprises: an LED light source module configured to emit red light and blue light; the main control module is configured to generate a driving signal to control the LED light source module; the touch interaction module is configured to display the frequency, duty ratio, intensity and treatment time parameters of the current light and adjust the parameters through a touch screen or a physical key; the LED blue light and the red light are output in an independent continuous or pulsed light mode, when the LED works in a pulse mode, the instantaneous peak light power density of the red light and the blue light reaches 1000 mW / cm < 2 > or even higher, the light penetration depth is increased so as to act on deep cancerous wound tissue, and photothermal damage to fragile skin of a patient caused by continuous strong light is avoided. The invention can improve the life quality of cancer wound tumor patients and prolong the survival time of the cancer wound tumor patients, and is suitable for long-term nursing scenes of tumor wards, ultimate care institutions and bedridden patients at home.

The invention relates to the technical field of intelligent implantable medical instruments, in particular to a magnetohydrodynamic pulse negative pressure micropump system integrated with wireless parameter monitoring, which comprises a fully implantable magnetohydrodynamic intelligent sensitive micropump, an in-vitro multifunctional driving read-out unit and an intelligent terminal, the fully-implanted magnetomotive intelligent-sensitive micropump is of a hollow titanium alloy screw structure, a magnetomotive power pump module and a wireless passive sensing module are arranged in the fully-implanted magnetomotive intelligent-sensitive micropump, the fully-implanted magnetomotive intelligent-sensitive micropump can be implanted into a bone in a minimally invasive mode, pulse negative pressure is generated, and intraosseous tissue gap hydraulic data are wirelessly transmitted. The in-vitro unit provides a driving magnetic field and radio frequency energy; and the intelligent terminal realizes data display, analysis and parameter adjustment to form intelligent closed-loop control. The system realizes integration of treatment and monitoring, is minimally invasive, has no infection risk, is accurate in monitoring and efficient in treatment, solves the problem of pain points in the prior art, and has important clinical application value.

The invention discloses a bispecific fusion protein based on Th17 immune axis regulation and application of the bispecific fusion protein in combined treatment of inflammatory bowel disease and psoriasis. The fusion protein is formed by sequentially connecting a human IL-23 receptor (IL-23R) extracellular functional structural domain, a flexible connecting peptide and a human trefoil factor 3 (TFF3). According to the invention, IL-23R is specifically combined with IL-23 highly expressed at a focus part to block a cascade reaction of a Th17 inflammation axis, and TFF3 with a mucosa repair function is delivered to damaged tissues in a targeted manner. Experiments show that in a DSS-induced ulcerative colitis model and an IMQ-induced psoriasis model, the fusion protein is obviously superior to a single-target drug in the aspects of reducing disease activity index (DAI), improving skin lesion score (PASI) and promoting histopathological repair, has a synergistic effect of anti-inflammation and repair, and provides a new strategy for treatment of autoimmune diseases.

This invention provides a hydrogel-based precision delivery system for acupuncture needles, its preparation method, and its application, belonging to the field of biomedical materials technology. The hydrogel-based precision delivery system for acupuncture needles includes an acupuncture needle and a hydrogel coating. A threaded groove is formed on the needle body, and the hydrogel coating adheres to this groove. The hydrogel coating is prepared by photocrosslinking N-[2-(3,4-dihydroxyphenyl)ethyl]-2-methylacrylamide and methacrylated hyaluronic acid to obtain an adhesive hydrogel, which is then encapsulated in a liposome and loaded into the threaded groove. After drying, the hydrogel coating is formed. The hydrogel-based precision delivery system provided by this invention enables the smooth, minimally invasive delivery of drugs or biological materials to the subchondral bone via the acupuncture needle, regulating abnormal TGF-β1 secretion and constructing stem cell migration channels in the subchondral bone, achieving precise localization and treatment of the subchondral bone.

This invention discloses a traditional Chinese medicine composition for the treatment of pelvic inflammatory disease, along with its thermosensitive gel and drug delivery device, belonging to the fields of traditional Chinese medicine and medical device technology. The traditional Chinese medicine composition is composed of Sichuan pepper, vinegar-processed corydalis, luffa cylindrica, cinnamon twig, angelica sinensis, red peony root, poria cocos, and earthworm in a specific ratio, with the core treatment principle of soothing the liver and regulating qi, promoting blood circulation and unblocking collaterals, targeting the syndrome of qi stagnation and blood stasis, and obstructed meridians. This composition can be formulated into a thermosensitive vaginal gel, using poloxamer as a matrix, exhibiting room temperature flow and body temperature solidification characteristics, which can prolong the local drug retention time. The accompanying drug delivery device has four interchangeable delivery heads: a single-point delivery head (No. 1) for deep targeted therapy, an umbrella-shaped delivery head for easy drug emptying, an array delivery head for uniform coverage of the vaginal wall, and a directional delivery head that can be adjusted at an angle to act on lesions on the lateral wall. This invention provides a more efficient and personalized solution for the treatment of chronic pelvic inflammatory disease.

The application provides a kind of with suspension function's ligature suture device and its using method, the ligature suture device includes gun handle, gun rod, push mechanism, shooting mechanism and trigger mechanism, through the cooperation of push mechanism, shooting mechanism and trigger mechanism, multiple biological clips placed in the gun rod can be sequentially shot to corresponding ligature point for ligature, multiple biological clips are strung into a biological clip group by tightening line and one-way lock, and after continuous ligature, the first and last ends are connected by the tightening line to form suspension, compared with prior art, the operation time is shortened, the treatment accuracy is improved, the local tissue is smoothly healed and repaired during operation, the postoperative complications and long-term recurrence rate are reduced, the operation process is standardized and simplified.

The application relates to the field of biotechnology, in particular to a transgenic immune effector cell and application thereof. The immune checkpoint antibody in the fusion protein expressed by the immune effector cell can relieve the immune suppression of the immune checkpoint on the immune effector cell, the cytokine can enhance the antitumor activity of the immune effector cell, and the chemokine receptor molecule can significantly improve the migration ability of the immune effector cell to the tumor site; compared with the fusion protein and the cell co-expressing the fusion protein and a chimeric antigen receptor, the immune effector cell has stronger killing effect on tumor cells, has low drug toxicity, high safety, and effectively realizes the precise treatment of a solid tumor by CART.

The utility model discloses a traditional chinese medical science package hot -compress treatment device belongs to medical instrument technical field, and this hot -compress treatment device includes hot -compress area, and the both ends of hot -compress area are connected with the connecting assembly respectively, and the hot -compress area is fixed in the patient treatment position through the connecting assembly, the hot -compress area includes a plurality of hot -compress separate areas, and is equipped with medicinal material package and heating assembly in every hot -compress separate area, and heating assembly can adjust the size of heating power according to the thickness of medicinal material package. The utility model can accurate treatment, avoid the problem of traditional equipment " thick layer cold, thin layer scalding", and energy -conserving safety reduces invalid energy consumption, reduces scalding risk, and simultaneously multi -region independent temperature control, and different heating assembly can be heated in the sub -region, improves hot -compress effect.

The utility model discloses an intelligent infusion quantity weighing system, which belongs to the technical field of intelligent medical equipment and is used for monitoring an infusion process in real time. The system comprises an intelligent unit, a bus, an ultrasonic flow sensor, a weighing device and the like. And the intelligent unit processes data by using a graph convolutional network algorithm and a wavelet convolutional neural network through a sensor data fusion module. The ultrasonic flow sensor transmits flow velocity data to the intelligent unit in real time, and the liquid flow velocity is accurately monitored. The weighing device accurately measures the inflow amount of the injection through the strain sensor, the cavity and the guide pipe. The strain sensor converts a weight change signal into a digital signal and transmits the digital signal to the intelligent unit. The system supports a wireless communication protocol, remote data transmission is achieved, and remote monitoring of medical staff is facilitated. The system can provide accurate and automatic infusion control and ensure safety and accuracy of treatment.